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Choroidal thickness changes in children with chronic heart failure due to dilated cardiomyopathy.

Int Ophthalmol 2021 May 9. Epub 2021 May 9.

Department of Cardiology, Children's Memorial Health Institute, Warsaw, Poland.

Purpose: To evaluate choroidal thickness (CTh) in children with chronic heart failure (CHF) secondary to dilated cardiomyopathy (DCM) using spectral domain optical coherence tomography (SD-OCT) and to compare their values to those of healthy children.

Methods: Sixty eyes of thirty children (mean age 9.9 ± 3. Read More

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Comparison between Widefield Optical Coherence Tomography Devices in Eyes with High Myopia.

Diagnostics (Basel) 2021 Apr 6;11(4). Epub 2021 Apr 6.

Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Sacco Hospital, University of Milan, via G.B Grassi 74, 20157 Milan, Italy.

Background: To compare four different optical coherence tomography (OCT) devices for visualization of retinal and subretinal layers in highly myopic eyes.

Methods: In this prospective, observational, cross-sectional study, consecutive patients with high myopia and control subjects were imaged by four OCT devices: Spectralis OCT2, PlexElite 2.0 100 kHz, PlexElite 2. Read More

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Comparison of choroidal thicknesses in patients with coronary artery disease and patients at risk of coronary artery disease.

Int Ophthalmol 2021 Mar 16. Epub 2021 Mar 16.

Department of Cardiology, Darıca Farabi Training and Research Hospital, Darıca, Kocaeli, Turkey.

Purpose: The study aimed to compare choroidal thicknesses (CTh) in patients with coronary artery disease (CAD) and patients at risk of coronary artery disease and investigate whether thinning of the choroid can be used as a biomarker for development of coronary artery disease in patients at risk.

Materials And Methods: The study group was composed of 103 eyes of 53 patients with coronary artery disease, and the control group was composed of 62 eyes of 32 patients with diabetes mellitus, hypertension and/or hyperlipidemia without coronary artery disease. CAD was diagnosed in patients with one of the following: myocardial infarction with/without ST segment elevation, clinically proven history of cardiac catheterization testifying greater than 50% obstruction in at least one coronary artery, revascularization operations. Read More

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Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma.

Am J Ophthalmol 2021 Jan 30;226:172-181. Epub 2021 Jan 30.

Departments of Ophthalmology and Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Purpose: To test the hypothesis that visual field (VF) progression can be predicted from baseline and longitudinal optical coherence tomography (OCT) structural measurements.

Design: Prospective cohort study.

Methods: A total of 104 eyes (104 patients) with ≥3 years of follow-up and ≥5 VF examinations were enrolled. Read More

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January 2021

Retinal microvascular abnormalities in patients after COVID-19 depending on disease severity.

Br J Ophthalmol 2020 Dec 16. Epub 2020 Dec 16.

Ophthalmology Service, Vall d'Hebron University Hospital, Barcelona, Catalunya, Spain.

Background: Global pandemic SARS-CoV-2 causes a prothrombotic state without fully elucidated effects. This study aims to analyse and quantify the possible retinal microvascular abnormalities.

Materials And Methods: Case-control study. Read More

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December 2020

Effectiveness of Low Vision Rehabilitation Using Microperimetric Acoustic Biofeedback Training in Patients with Central Scotoma.

Curr Eye Res 2021 May 18;46(5):731-738. Epub 2020 Oct 18.

Department of Ophthalmology, School of Medicine, Ankara University, Ankara, Turkey.

Purpose: To evaluate the efficacy of visual rehabilitation with microperimeter biofeedback in patients with central scotoma.

Materials And Methods: 35 consecutive patients with central scotoma (17 age-related macular degeneration (AMD), 14 Stargardt disease, and 4 cone dystrophy) were included in the study. Visual acuity, reading performance by Minnesota Low Vision Reading Test (MNREAD), quality of life by 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25), and fixation analysis by MAIA microperimeter were evaluated before and 1 month after training. Read More

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Alterations of the foveal central bouquet associated with cystoid macular edema.

Can J Ophthalmol 2020 08 7;55(4):301-309. Epub 2020 Apr 7.

Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA; Greater Los Angeles VA Healthcare Center, Los Angeles, CA. Electronic address:

Objective: The central bouquet (CB) of the fovea comprises a dense array of cone photoreceptors intertwined with Müller cells. The aim of this investigation was to study visual outcomes and structural alterations in the foveal CB associated with cystoid macular edema (CME) of different etiologies.

Design: Retrospective case series. Read More

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Microvascular retinal changes in pre-clinical diabetic retinopathy as detected by optical coherence tomographic angiography.

Graefes Arch Clin Exp Ophthalmol 2020 Mar 2;258(3):513-520. Epub 2020 Jan 2.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karis-University, Mannheim, Germany.

Purpose: To investigate microvascular abnormalities in diabetic patients without conventional clinical signs of diabetic retinopathy (DR).

Methods: In this cross-sectional observational cohort study, the study group included randomly chosen participants of a community-based cohort with diabetes type 2 without DR, and the control group consisted of non-diabetic individuals from a population-based study. All participants underwent optical coherence tomographic angiography (OCTA). Read More

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Analysis of Hyperreflective Dots Within the Central Fovea in Healthy Eyes Using En Face Optical Coherence Tomography.

Invest Ophthalmol Vis Sci 2019 10;60(13):4451-4461

Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States.

Purpose: The purpose of this retrospective study was to describe and quantify superficial hyperreflective dots within the central fovea and correlate them with age, using en face and cross-sectional B-scan optical coherence tomography (OCT).

Methods: Healthy eyes, evaluated with a spectral domain instrument (primary cohort) at the Stein Eye Institute (UCLA) and with a swept source instrument (secondary cohort) at the Vitreous Retina Macula Consultants of New York, were included in this study. En face OCT images (3 × 3 mm) segmented at the level of the superior vascular plexus were acquired, and hyperreflective dots in the foveal avascular zone were quantified by two different methodologies. Read More

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October 2019

Optical coherence tomography angiography findings in preeclampsia.

Eye (Lond) 2019 12 17;33(12):1946-1951. Epub 2019 Jul 17.

Department of Ophthalmology, Adana City Training and Research Hospital, Adana, Turkey.

Objectives: To investigate vascular density analysis in the superficial (SCP) and deep capillary plexus (DCP), foveal avascular zone (FAZ), peripapillary vascular density analysis (PPCVD), and peripapillary retinal nerve fiber thickness analysis (PPRNFL) using optical coherence tomography angiography (OCTA) in pregnant women with preeclampsia and to compare the obtained values with healthy pregnant and nonpregnant healthy individuals.

Methods: A total of 98 pregnant women (55 had preeclampsia, 43 were healthy pregnant women) and 38 healthy nonpregnant women of reproductive age were included in the study. The patients were divided into three groups. Read More

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December 2019

Analysis of macular, foveal, and retinal nerve fiber layer thickness in children with unilateral anisometropic amblyopia and their changes following occlusion therapy.

Indian J Ophthalmol 2019 07;67(7):1016-1022

School Screening Project Coordinator, Sankara Eye Hospital, Harakere, Shimoga, Karnataka, India.

Purpose: To analyze macular thickness (MT), foveal thickness (FT), and retinal nerve fibre layer thickness (RNFLT) in children with unilateral anisometropic amblyopia and their changes following occlusion therapy.

Methods: A prospective, longitudinal, and comparative study of 60 children aged between 5 and 18 years consisted of two groups, group 1: 30 children with unilateral anisometropic amblyopia; group 2: 30 normal children. Best corrected visual acuity (BCVA), a detailed ocular examination, spectral domain optical coherence tomography for MT, FT, and RNFLT in both eyes were done at visit one (baseline) and every 3 months for a year following occlusion therapy (initiated one month after first visit) in group 1. Read More

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Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing.

Exp Eye Res 2019 07 8;184:234-242. Epub 2019 May 8.

Departments of Ophthalmology and Visual Sciences, The University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA; Institute for Vision Research, The University of Iowa, Iowa City, IA, 52242, USA. Electronic address:

The human retina is a complex tissue responsible for detecting photons of light and converting information from these photons into the neurochemical signals interpreted as vision. Such visual signaling not only requires sophisticated interactions between multiple classes of neurons, but also spatially-dependent molecular specialization of individual cell types. In this study, we performed single-cell RNA sequencing on neural retina isolated from both the fovea and peripheral retina in three human donors. Read More

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First-Year Outcomes of Cataract Surgery Combined with Intravitreal Ranibizumab Injection in Wet Age-Related Macular Degeneration

Turk J Ophthalmol 2019 02;49(1):15-19

Muğla Sıtkı Koçman University Faculty of Medicine, Department of Ophthalmology, Muğla, Turkey

Objectives: To compare the first-year results of patients with active neovascular age-related macular degeneration (nAMD) under intravitreal ranibizumab (IVR) treatment who did and did not undergo cataract surgery.

Materials And Methods: The records of 72 patients with active nAMD were reviewed retrospectively. Group 1 consisted of 23 patients who underwent uncomplicated cataract surgery and continued with IVR treatment and group 2 consisted of 49 patients without cataract who received only IVR treatment. Read More

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February 2019

Evaluation of choroidal thickness measurements in patients with marked nasal septal deviation.

Braz J Otorhinolaryngol 2020 Mar - Apr;86(2):242-246. Epub 2018 Dec 31.

Istanbul Kanuni Sultan Süleyman Training and Research Hospital, Department of Otorhinolaryngology, Istanbul, Turkey.

Introduction: Chronic upper airway obstruction due to marked nasal septal deviation may cause chronic hypoxia. It may change the balance of the sympathetic-parasympathetic system and may affect blood flow in the choroid.

Objective: To assess choroidal thickness measurements of patients with marked nasal septal deviation. Read More

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Midterm Results after Open versus Arthroscopic Transosseous Repair for Foveal Tears of the Triangular Fibrocartilage Complex.

J Wrist Surg 2018 Sep 10;7(4):292-297. Epub 2018 Apr 10.

Department of Orthopaedic Surgery, Saiseikai Shimonoseki General Hospital, Yamaguchi, Japan.

 Various surgical procedures for foveal tears of the triangular fibrocartilage complex (TFCC) have been reported, and the procedures can be grossly divided into open and arthroscopic repair. The surgical results of both procedures were compared.  Twenty-nine patients underwent repair of a TFCC foveal tear. Read More

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September 2018

Choroidal vascularity index changes after vitreomacular surgery.

Acta Ophthalmol 2018 Dec 31;96(8):e950-e955. Epub 2018 May 31.

National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.

Purpose: To study the structural changes in the choroid using swept-source (SS) optical coherence tomography (OCT), a tool for the choroidal vascularity index (CVI) following epiretinal membrane removal.

Methods: Fifty-two eyes of 26 patients were evaluated in this prospective, single-centre, observational study. Twenty-six eyes underwent vitrectomy for epiretinal membrane removal (VT-group), and the control group consisted of 26 corresponding fellow eyes (F-group). Read More

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December 2018

Pimasertib-associated ophthalmological adverse events.

Acta Ophthalmol 2018 Nov 16;96(7):712-718. Epub 2018 Jan 16.

Department of Ophthalmology, Leiden University Medical Centre, Leiden, the Netherlands.

Purpose: To analyse ophthalmological adverse events associated with mitogen-activated protein kinase kinase (MEK) inhibition with pimasertib treatment for metastatic cutaneous melanoma (CM).

Methods: In this prospective observational, cohort-based, cross-sectional study, eight patients treated with the MEK inhibitor pimasertib received a complete ophthalmic examination. This included Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, visual field testing, colour vision testing, slit-lamp examination, applanation tonometry, indirect ophthalmoscopy, digital colour fundus photography and optical coherence tomography (OCT). Read More

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November 2018

Parafoveal letter-position coding in reading.

Mem Cognit 2018 05;46(4):589-599

Aix-Marseille Université, Marseille, France.

The masked-priming lexical decision task has been the paradigm of choice for investigating how readers code for letter identity and position. Insight into the temporal integration of information between prime and target words has pointed out, among other things, that readers do not code for the absolute position of letters. This conception has spurred various accounts of the word recognition process, but the results at present do not favor one account in particular. Read More

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Müller glial cells of the primate foveola: An electron microscopical study.

Exp Eye Res 2018 02 11;167:110-117. Epub 2017 Dec 11.

Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany.

Previous studies on the ultrastructure of the primate foveola suggested the presence of an inverted cone-like structure which is formed by 25-35 specialized Müller cells overlying the area of high photoreceptor density. We investigated the ultrastructure of the Müller cells in the foveola of a human and macaque retina. Sections through the posterior poles of an eye of a 40 years-old human donor and an eye of an adult cynomolgus monkey (Macaca fascicularis) were investigated with transmission electron microscopy. Read More

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February 2018

Comparison of Naso-temporal Asymmetry During Monocular Smooth Pursuit, Optokinetic Nystagmus, and Ocular Following Response in Strabismic Monkeys.

Strabismus 2017 06 2;25(2):47-55. Epub 2017 May 2.

a College of Optometry , University of Houston , Houston , TX.

Purpose: Under monocular viewing conditions, humans and monkeys with infantile strabismus exhibit asymmetric naso-temporal (N-T) responses to motion stimuli. The goal of this study was to compare and contrast these N-T asymmetries during 3 visually mediated eye tracking tasks-optokinetic nystagmus (OKN), smooth pursuit (SP) response, and ocular following responses (OFR).

Methods: Two adult strabismic monkeys were tested under monocular viewing conditions during OKN, SP, or OFR stimulation. Read More

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Incidence, mechanism and outcomes of schisis retinal detachments revealed through a prospective population-based study.

Br J Ophthalmol 2017 08 5;101(8):1022-1026. Epub 2017 Jan 5.

Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Aim: To determine the incidence, presentation and outcomes of progressive sight-threatening retinal detachment (RD) complicating degenerative retinoschisis.

Methods: We conducted the first prospective population-based epidemiological study of progressive schisis detachment over a 1-year period (2014-2015) in the UK. Case ascertainment was via monthly British Ophthalmological Surveillance Unit reporting cards sent to all ophthalmologists in the UK. Read More

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Effect of leaking perifoveal microaneurysms on resolution of diabetic macular edema treated by combination therapy using anti-vascular endothelial growth factor and short pulse focal/grid laser photocoagulation.

Jpn J Ophthalmol 2017 Jan 11;61(1):51-60. Epub 2016 Oct 11.

Department of Ophthalmology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Purpose: The effect of combination therapy using intravitreal ranibizumab (IVR) injections and short pulse focal/grid laser photocoagulation was evaluated for the treatment of diabetic macular edema (DME).

Methods: The current investigation was a preliminary single-arm, open-label, prospective clinical study conducted on 21 eyes at 4 sites in Japan. Treatment protocol consisted of two phases. Read More

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January 2017

Principles in Skull Base Reconstruction following Expanded Endoscopic Approaches.

J Neurol Surg B Skull Base 2016 Aug 26;77(4):358-63. Epub 2016 Feb 26.

Department of Neurosurgery, Christian Medical College, Vellore, India.

Objectives: This study aims to describe the types of anterior skull base defects following expanded endoscopic approaches (EEA) and to outline the techniques involved in the repair of these defects.

Design: We retrospectively analyzed 63 cases of endoscopic skull base reconstruction (ESBR) following tumor excision, done from September 2011 to January 2015. These tumors consisted of 14 pituitary adenomas, 20 craniopharyngiomas, and 29 other miscellaneous tumors. Read More

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[Foveolar effects of dexamethasone intravitreal implant in central retinal vein occlusion].

Vestn Oftalmol 2016 Mar-Apr;132(2):21-25

Ufa Eye Research Institute, 90 Pushkina St., Ufa, Russian Federation, 450008.

Aim: To evaluate functional and morphometric parameters of the central retina in patients with postocclusive macular edema treated with dexamethasone intravitreal implant injection.

Material And Methods: We examined 5 patients (5 eyes) with newly diagnosed central retinal vein occlusion complicated by macular edema, including 4 men and 1 woman aged 55.8±3. Read More

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Choroidal thickness in obese women.

BMC Ophthalmol 2016 May 4;16(1):48. Epub 2016 May 4.

Department of Internal Medicine, Kırıkkale University School of Medicine, Kırıkkale, Turkey.

Background: Excessive weight is a well-known risk factor for microvascular diseases. Changes in thickness in a vascular tissue, such as the choroid, can be useful to evaluate the effect of obesity on the microvascular system. The aim of this study was to evaluate the choroidal thickness (CT) changes in obese women, using optical coherence tomography (OCT). Read More

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High-Resolution Imaging of Parafoveal Cones in Different Stages of Diabetic Retinopathy Using Adaptive Optics Fundus Camera.

PLoS One 2016 8;11(4):e0152788. Epub 2016 Apr 8.

Ocular Imaging Reading and Research Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, United States of America.

Purpose: To assess cone density as a marker of early signs of retinopathy in patients with type II diabetes mellitus.

Methods: An adaptive optics (AO) retinal camera (rtx1™; Imagine Eyes, Orsay, France) was used to acquire images of parafoveal cones from patients with type II diabetes mellitus with or without retinopathy and from healthy controls with no known systemic or ocular disease. Cone mosaic was captured at 0° and 2°eccentricities along the horizontal and vertical meridians. Read More

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Functionally Guided Retinal Protective Therapy for Dry Age-Related Macular and Inherited Retinal Degenerations: A Pilot Study.

Invest Ophthalmol Vis Sci 2016 Jan;57(1):265-75

Ojai Retinal Technologies, LLC, Ojai, California, United States 3EyEngineering, Inc., Ojai, California, United States 4Santa Clara University, Dynamics and Control Systems Laboratory, Santa Clara, California, United States.

Purpose: To review the results of retinal function testing in eyes undergoing panmacular subthreshold diode micropulse laser (SDM) prophylaxis for chronic progressive retinal disease.

Methods: The records of all patients undergoing prophylactic panmacular SDM for high-risk age-related macular degeneration (AMD) and inherited photoreceptor degenerations (IRDs) examined by pattern electroretinography (PERG), automated microperimetry (AMP), and Central Vision Analyzer (CVA) testing before and after treatment were reviewed.

Results: A total of 158 consecutive eyes of 108 patients with AMD and 10 consecutive eyes of 8 patients with IRDs, evaluated both before and after SDM by PERG, were eligible for study. Read More

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January 2016

The Effects of Diabetic Retinopathy and Pan-Retinal Photocoagulation on Photoreceptor Cell Function as Assessed by Dark Adaptometry.

Invest Ophthalmol Vis Sci 2016 Jan;57(1):208-17

Department of Ophthalmology and Visual Sciences W. K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, Michigan, United States.

Purpose: The pathophysiology of vision loss in persons with diabetic retinopathy (DR) is complex and incompletely defined. We hypothesized that retinal pigment epithelium (RPE) and rod and cone photoreceptor dysfunction, as measured by dark adaptometry, would increase with severity of DR, and that pan-retinal photocoagulation (PRP) would exacerbate this dysfunction.

Methods: Dark adaptation (DA) was measured in subjects with diabetes mellitus and healthy controls. Read More

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January 2016

Effect of leaking capillaries and microaneurysms in the perifoveal capillary network on resolution of macular edema by anti-vascular endothelial growth factor treatment.

Jpn J Ophthalmol 2016 Mar 22;60(2):86-94. Epub 2016 Jan 22.

Department of Ophthalmology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Purpose: To investigate the effect of leaking capillaries and microaneurysms (MAs) in the perifoveal capillary network (PCN) on the treatment of fovea-involving macular edema (ME) secondary to branch retinal vein occlusion (BRVO) by intravitreal ranibizumab (IVR) injections combined with focal, grid, and scatter laser photocoagulation.

Methods: Retrospective comparative case series. The MA (+) group consisted of 12 patients with leaking MAs in the PCN and the MA (-) group contained 11 patients without. Read More

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Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity.

J Ocul Pharmacol Ther 2016 Apr 15;32(3):178-83. Epub 2016 Jan 15.

2 Faculty of Medicine and Dentistry, Policlinic Umberto I, Rome University La Sapienza , Rome, Italy .

Purpose: To evaluate the effects of a food supplement containing forskolin, homotaurine, carnosine, folic acid, vitamins B1, B2, B6, and magnesium in patients with primary open angle glaucoma (POAG) already in treatment and compensated by intraocular pressure (IOP)-lowering drugs, during a period of 12 months.

Methods: Twenty-two patients (44 eyes) with POAG, with their IOP compensated by topical drugs, were enrolled and randomly assigned to the food supplement or control treatment group. The additional food supplement treatment consisted of 2 tablets per day (1 in the morning, 1 in the evening) given for 1 year of a balanced association of homotaurine, Coleus forskohlii root extract, L-carnosine, folic acid, vitamins B1, B2, B6, and magnesium. Read More

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