2,122 results match your criteria fourth decades

Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells.

Cell Death Dis 2021 Apr 9;12(4):386. Epub 2021 Apr 9.

Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, GA, USA.

The present study aims to understand the mechanism of the lens epithelial cell's strong anti-apoptotic capacity and survival in the mature human lens that, on the one hand, maintains lens transparency over several decades, while on the other hand, increases the risk of posterior capsule opacification (PCO). Here we compared FHL124 cells and HeLa cells, spontaneously immortalized epithelial cell lines derived from the human lens and cervical cancer cells, respectively, of their resistance to TNFα-mediated cell death. TNFα plus cycloheximide (CHX) triggered almost all of HeLa cell death. Read More

View Article and Full-Text PDF

Intracranial 131I-chTNT Brachytherapy in Patients with Deep-Seated Glioma: A Single-center Experience with 10-Year Follow-up from China.

Nuklearmedizin 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurosurgery, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China.

Objective:  The intracranial brachytherapy has been applied for decades, however, no results with long-term follow-up have been reported. This study investigated the long-term efficiency of intra-tumoral injection of I-chTNT in patients with deep-seated glioma.

Method:  Thirty-five patients undergoing I-chTNT brachytherapy between December 2004 and May 2009 were enrolled. Read More

View Article and Full-Text PDF

Case report of a novel phenotype in 18q deletion syndrome.

Rom J Morphol Embryol 2020 Jul-Sep;61(3):905-910

Department of Anatomy, Department of Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania;

The latest decades are characterized by an enormous progression in the field of human genetics. In consequences, for various phenotypic manifestations, genetic testing could identify a specific underlying cause. An estimated incidence for all types of 18q deletions is one in 55 000 births predominant on females. Read More

View Article and Full-Text PDF

Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity.

Aging Dis 2021 Apr 1;12(2):597-613. Epub 2021 Apr 1.

4Department of Endocrinology and Metabolism, The Third Hospital of Hebei Medical University, Shijiazhuang, China.

In recent decades, the incidence and diagnosis of thyroid cancer have risen dramatically, and thyroid cancer has now become the most common endocrine cancer in the world. The onset of thyroid cancer is insidious, and its progression is slow and difficult to detect. Therefore, early prevention and treatment have important strategic significance. Read More

View Article and Full-Text PDF

The Essential Involvement of the Omentum in the Peritoneal Defensive Mechanisms During Intra-Abdominal Sepsis.

Front Immunol 2021 18;12:631609. Epub 2021 Mar 18.

Department of Microbiology and Immunology, Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing, China.

Although the abilities of the omentum to alleviate inflammation and prevent infection have been revealed over the past decades, the underlying mechanisms remain largely unelucidated. Here, we demonstrated that the mortality of mice exposed to cecal ligation and puncture (CLP) and omentectomy was remarkably increased compared to those treated with CLP alone. Moreover, the efficacy of the omentum was associated with an impairment in intraperitoneal bacterial clearance together with an increase in the expression of proinflammatory cytokines. Read More

View Article and Full-Text PDF

Dentinogenic ghost cell tumor - Case report of a rare entity.

Int J Surg Case Rep 2021 Feb 15;81:105651. Epub 2021 Feb 15.

Department of Head and Neck Surgery, Instituto Português de Oncologia de Lisboa Francisco Gentil, Portugal.

Introduction: Dentinogenic ghost cell tumor (DGCT) is an entity with about 60 cases reported in the literature. It is a benign odontogenic tumor, despite being locally invasive and associated with a risk of local recurrence.

Presentation Of Case: A 47-year-old woman presented with a 2-year-old expansive bone lesion. Read More

View Article and Full-Text PDF
February 2021

Impact of Multidisciplinary Team Management on the Survival Rate of Head and Neck Cancer Patients: A Cohort Study Meta-analysis.

Front Oncol 2021 8;11:630906. Epub 2021 Mar 8.

Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Head and neck cancer (HNC) is one of the more common malignant tumors that threaten human health worldwide. Multidisciplinary team management (MDTM) in HNC treatment has been introduced in the past several decades to improve patient survival rates. This study reviewed the impact of MDTM on survival rates in patients with HNC compared to conventional treatment methods. Read More

View Article and Full-Text PDF

A new species of Macrothrix (Crustacea, Branchiopoda, Macrothricidae) from the Neotropics with description of the marthae-group.

Zootaxa 2021 Feb 4;4926(1):zootaxa.4926.1.6. Epub 2021 Feb 4.

Laboratório de Taxonomia Animal, Unidade Acadêmica Especial de Ciências Biológicas, Universidade Federal de Jataí-UFJ, BR 364 km 195 n°3800, CEP 75801-615, Jataí, GO, Brazil. Programa de Pós-Graduação em Zoologia, Universidade de Brasília-UnB, Campus Universitário Darcy Ribeiro, CEP 70910-900, Brasília, Brazil..

Publications of the last three decades demonstrated the existence of some compact species groups within the Macrothrix Baird genus (Cladocera: Macrothricidae). Many species were included in hirsuticornis-group, laticornis-group, rosea-triserialis-group and paulensis-group, but not in Macrothrix marthae group. It has a peculiar set of morphological traits not observed in any other species, so far. Read More

View Article and Full-Text PDF
February 2021

Paediatric unicystic ameloblastoma - A report of 2 cases.

Indian J Dent Res 2020 Nov-Dec;31(6):987-990

Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Karnataka, India.

Unicytic ameloblastoma is a variant of ameloblastoma encompassing about 6% of ameloblastomas. They represent cystic lesions that reveal clinical and radiographic features of a cyst, but the histopathological features demonstrate a typical ameloblastomatous epithelium lining the cyst. Plexiform unicystic ameloblastoma, a variant of unicystic ameloblastoma refers to the pattern of proliferation where one or more nodules of ameloblastomatous epithelium project from the cystic lining into the lumen demonstrating an edematous plexiform pattern. Read More

View Article and Full-Text PDF

A first insight into the genome of Prototheca wickerhamii, a major causative agent of human protothecosis.

BMC Genomics 2021 Mar 9;22(1):168. Epub 2021 Mar 9.

Department of Medical Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, I. Miecznikowa 1, 02-096, Warsaw, Poland.

Background: Colourless microalgae of the Prototheca genus are the only known plants that have consistently been implicated in a range of clinically relevant opportunistic infections in both animals and humans. The Prototheca algae are emerging pathogens, whose incidence has increased importantly over the past two decades. Prototheca wickerhamii is a major human pathogen, responsible for at least 115 cases worldwide. Read More

View Article and Full-Text PDF

Lipid Metabolism in Cancer Cells.

Adv Exp Med Biol 2021 ;1316:49-69

Department of Immunology, The Fourth Military Medical University, Xi'an, People's Republic of China.

Metabolic reprogramming is one of the most critical hallmarks in cancer cells. In the past decades, mounting evidence has demonstrated that, besides the Warburg Effect, lipid metabolism dysregulation is also one of the essential characteristics of cancer cell metabolism. Lipids are water-insoluble molecules with diverse categories of phosphoglycerides, triacylglycerides, sphingolipids, sterols, etc. Read More

View Article and Full-Text PDF

First Into the Lifeboats: Protecting Medical Student Education During the Hahnemann University Hospital Closure.

Acad Med 2021 Mar 16. Epub 2021 Mar 16.

V.D. Weber was senior vice dean for educational and academic affairs and professor of medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, at the time of writing. The author is dean, Boonshoft School of Medicine, Wright State University, Dayton, Ohio. D.C. Farabaugh is associate dean for clinical education and associate professor of obstetrics and gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania. A.C. Fuchs is senior associate dean for student affairs and associate professor of medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania. R.C. Smith is director of the division of clinical education, Drexel University College of Medicine, Philadelphia, Pennsylvania. J.E. Kocsis is a fourth-year medical student, Drexel University College of Medicine, Philadelphia, Pennsylvania.

The announcement of the closure of Philadelphia's Hahnemann University Hospital in June 2019 sent shock waves through the academic community. The closure had a devastating impact on the residents and fellows who trained there, the patients who had long received their care there, and faculty and staff who had provided care there for decades. Since its beginnings, the hospital, established as part of Hahnemann Medical College in 1885, was a major site for medical student education. Read More

View Article and Full-Text PDF

Primary thymus tumors: retrospective case analysis at a reference center in Latin America, 2011-2019.

BMC Cancer 2021 Mar 16;21(1):279. Epub 2021 Mar 16.

Faculty of Health Sciences, Universidad Icesi, Calle 18 # 122-135, Cali, 7600032, Colombia.

Background: Thymic tumors are unusual neoplasms, representing 0.2 to 1.5% of tumors in humans, but correspond to 20% of mediastinal tumors and 50% of those that occur in the anterior mediastinum. Read More

View Article and Full-Text PDF

Premature or early bilateral oophorectomy: a 2021 update.

Climacteric 2021 Mar 15:1-8. Epub 2021 Mar 15.

Women's Health Research Center, Mayo Clinic, Rochester, MN, USA.

In this invited review, we discuss some unresolved and controversial issues concerning premature (<40 years) or early (40-45 years) bilateral oophorectomy. First, we clarify the terminology. Second, we summarize the long-term harmful consequences of bilateral oophorectomy. Read More

View Article and Full-Text PDF

A reassessment of several erstwhile methods for isolating DNA fragments from agarose gels.

3 Biotech 2021 Mar 23;11(3):138. Epub 2021 Feb 23.

Key Lab of Endemic and Ethnic Diseases of the Ministry of Education of China in Guizhou Medical University, Guiyang, 550004 Guizhou People's Republic of China.

Molecular biology research often requires extraction of DNA fragments from agarose gels. In the past decades, there have been many methods developed for this purpose. Currently most researchers, especially novices, use commercial kits for this extraction, although these kits cost money and the procedures involved are not necessarily easier than some erstwhile methods. Read More

View Article and Full-Text PDF

Recent Advances in Silicon-Based Electrodes: From Fundamental Research toward Practical Applications.

Adv Mater 2021 Mar 8:e2004577. Epub 2021 Mar 8.

School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

The increasing demand for higher-energy-density batteries driven by advancements in electric vehicles, hybrid electric vehicles, and portable electronic devices necessitates the development of alternative anode materials with a specific capacity beyond that of traditional graphite anodes. Here, the state-of-the-art developments made in the rational design of Si-based electrodes and their progression toward practical application are presented. First, a comprehensive overview of fundamental electrochemistry and selected critical challenges is given, including their large volume expansion, unstable solid electrolyte interface (SEI) growth, low initial Coulombic efficiency, low areal capacity, and safety issues. Read More

View Article and Full-Text PDF

Defects engineered three-dimensional VSemicroflower/nanosheets on carbon cloth by chemical vapor deposition for high-performance hydrogen evolution reaction.

Nanotechnology 2021 Mar 8. Epub 2021 Mar 8.

School of Microelectronics, Shandong University, Jinan, Shandong, CHINA.

In the past decades, defects engineering is becoming an effective strategy to significantly improve the hydrogen evolution reaction (HER) efficiency of electrocatalysts. In this work, a facile chemical vapor deposition (CVD) method is firstly adopted here for demonstrating the defect engineering in the high-efficient HER electrocatalysts of vanadium diselenide (VSe2) nanostructures. For practical applications, conductive substrate of carbon cloth (CC) is selected as the growth substrate. Read More

View Article and Full-Text PDF

DNA building blocks for AFM tip functionalization: An easy, fast and stable strategy.

Methods 2021 Mar 5. Epub 2021 Mar 5.

Institute of Biophysics, Johannes Kepler University, Gruberstrasse 40, 4020 Linz, Austria. Electronic address:

Biosensing atomic force microscopy (AFM) offers the unique feature to determine the energy landscape of a bimolecular interaction at the real single molecule level. Furthermore, simultaneous and label-free mapping of molecular recognition and the determination of sample topography at the nanoscale gets possible. A prerequisite and one of the major parts in biosensing AFM are the bio-functionalized AFM tips. Read More

View Article and Full-Text PDF

Molecular Approaches Using Body Fluid for the Early Detection of Pancreatic Cancer.

Kennichi Satoh

Diagnostics (Basel) 2021 Feb 22;11(2). Epub 2021 Feb 22.

Division of Gastroenterology, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyaginoku, Sendai, Miyagi 983-8536, Japan.

Pancreatic ductal adenocarcinoma (PDAC) is the most malignant form of gastrointestinal tumor and is the fourth leading cause of deaths due to cancer in Japan. This cancer shows a poor outcome due to the difficulty of its early diagnosis and its rapid growth. Once this disease becomes clinically evident, it is frequently accompanied by distant metastasis at the time of diagnosis. Read More

View Article and Full-Text PDF
February 2021

Evolution of IgA nephropathy in Singapore over four decades and a comparison of two cohorts from the first and fourth decade.

Clin Nephrol 2021 Feb 19. Epub 2021 Feb 19.

Objective: In this study, we trace the changes in the clinical and histological pattern of IgA nephritis (IgAN) in Singapore as it has evolved over 4 decades and compare the clinical, demographic, histological, and renal outcome of patients with IgAN from the 1 decade and the 4 decade.

Materials And Methods: This is a retrospective study of all histologically proven IgAN diagnosed between 1976 and 2018. Clinical, laboratory, and histological characteristics between the 1 and the 4 decade, including treatment which could influence the disease progression and renal outcome of these two groups, were compared. Read More

View Article and Full-Text PDF
February 2021

The Comeback of the IUD in Twenty-First Century USA.

J Hist Med Allied Sci 2021 Apr;76(2):191-216

Department of Humanities and Social Sciences, University of California, San Francisco, USA.

From 1995 to 2014, intrauterine devices (IUDs) rose from ranking 10th (out of 11) among contraceptive methods to being the fourth most popular, outnumbered only by the pill, sterilization, and condoms. In 1995, the IUD had been largely abandoned by American doctors; two decades later, major medical associations promoted it as a "first line" method for prospective users of all ages. This paper explains the rapid and dramatic increase in intrauterine contraception by exploring three influential factors from the 1970s-1980s - the Dalkon Shield disaster, the lack of innovation in contraceptive research and development, and the moral panic over teen pregnancy in America - that created circumstances by the early 2000s in which health care providers became more receptive to long-acting reversible contraception. Read More

View Article and Full-Text PDF

Perioperative comparison of video-assisted thoracic surgery and open lobectomy for pT1-stage non-small cell lung cancer patients in China: a multi-center propensity score-matched analysis.

Transl Lung Cancer Res 2021 Jan;10(1):402-414

Department of Thoracic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Compared with open surgery, video-assisted thoracic surgery (VATS) has innovated the concept of the minimally invasive approach for non-small cell lung cancer (NSCLC) patients in past decades. This present study aimed to compare the perioperative and lymph node dissection outcomes between VATS lobectomy and open lobectomy for pathological stage T1 (pT1) NSCLC patients from both surgical and oncologic perspectives.

Methods: This was a retrospective multicenter study. Read More

View Article and Full-Text PDF
January 2021

Evaluating the resilience of water resources management scenarios using the evidential reasoning approach: The Zarrinehrud river basin experience.

J Environ Manage 2021 Apr 5;284:112025. Epub 2021 Feb 5.

Professor, School of Civil Engineering, College of Engineering, University of Tehran, Tehran, Iran. Electronic address:

This paper introduces a new methodology for quantifying the total resilience of water resources management scenarios. The climate change impacts on water supply and demand have been investigated using a calibrated soil and water assessment tool (SWAT) and a MODSIM water allocation model. Several criteria have been defined to measure five aspects of water resources systems resilience. Read More

View Article and Full-Text PDF

Clear Cell Meningioma in the Central Nervous System: Analysis of Surveillance, Epidemiology, and End Results Database.

Front Oncol 2020 22;10:592800. Epub 2021 Jan 22.

Computational Systems Biology Lab, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, United States.

Background: Clear cell meningioma (CCM) is a rare subtype of meningioma, accounting for approximately 0.2% of all meningiomas. The present study aimed to analyze the epidemiology and outcome of CCMs using the Surveillance, Epidemiology, and End Results (SEER) database. Read More

View Article and Full-Text PDF
January 2021

Incidence, Predictors, and Mortality in Patients With Liver Cancer After Fontan Operation.

J Am Heart Assoc 2021 Feb 4;10(4):e016617. Epub 2021 Feb 4.

Center for Cerebral and Cardiovascular Disease Information National Cerebral and Cardiovascular Center Suita Osaka Japan.

Background Liver cancer (LC) is a serious late complication after the Fontan operation. However, the incidence, predictors, and prognosis remain unknown. The purpose of our study was to determine these clinical characteristics. Read More

View Article and Full-Text PDF
February 2021

Long progression-free survival with cabozantinib in a heavily pretreated patient with metastatic renal cell carcinoma: a case report.

Tumori 2021 Feb 1:300891621990732. Epub 2021 Feb 1.

Department of Oncology and Haematology, Modena University Hospital, Modena, Italy.

Renal cell carcinoma accounts for 3% of all tumors. Over the last decades, the prognosis of metastatic renal cell carcinoma (mRCC) has improved owing to the approval of several drugs such as tyrosine kinase inhibitors and immunotherapy. The median progression-free survival (PFS) does not exceed 8 months with the available drugs in pretreated patients with mRCC. Read More

View Article and Full-Text PDF
February 2021

Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma.

Nat Rev Gastroenterol Hepatol 2021 Jan 28. Epub 2021 Jan 28.

Department of Radiology, University of Pisa School of Medicine, Pisa, Italy.

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality and has an increasing incidence worldwide. Locoregional therapies, defined as imaging-guided liver tumour-directed procedures, play a leading part in the management of 50-60% of HCCs. Radiofrequency is the mainstay for local ablation at early stages and transarterial chemoembolization (TACE) remains the standard treatment for intermediate-stage HCC. Read More

View Article and Full-Text PDF
January 2021