3,743 results match your criteria fosfomycin


Antimicrobial Dose Reduction in Continuous Renal Replacement Therapy: Myth or Real Need? A Practical Approach for Guiding Dose Optimization of Novel Antibiotics.

Clin Pharmacokinet 2021 Jun 14. Epub 2021 Jun 14.

Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy.

Acute kidney injury represents a common complication in critically ill patients affected by septic shock and in many cases continuous renal replacement therapy (CRRT) may be required. In this scenario, antimicrobial dose optimization is highly challenging as the extracorporeal circuit may cause several pharmacokinetic alterations, which add up to volume of distribution and clearance variations resulting from sepsis. Variations in CRRT settings (i. Read More

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Monitoring outpatient antibiotic utilization using reimbursement and retail sales data: a population-based comparison in France, 2012-17.

J Antimicrob Chemother 2021 Jun 13. Epub 2021 Jun 13.

Université de Paris, Epidemiology and Statistics Research Center-CRESS, INSERM, Obstetrical, Perinatal and Pediatric Epidemiology research team, F-75004, Paris, France.

Objectives: To assess whether a retail sales database could be used to monitor antibiotic utilization in the outpatient setting at the national level.

Methods: We extracted 2012-17 outpatient antibiotic extrapolated retail sales (IQVIA's Xponent) and reimbursement data from the National Health Insurance (SNDS) in metropolitan France. We compared estimates of antibiotic use and consumption [number of antibiotic drug deliveries (DrID) and defined daily doses (DID) per 1000 inhabitants per day]. Read More

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Herbal treatment with Uva Ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: A randomized controlled trial.

Clin Microbiol Infect 2021 Jun 7. Epub 2021 Jun 7.

Hannover Medical School, Institute for General Practice, Hannover, Germany; University Hospital Jena, Department of General Practice, Jena, Germany.

Objective: We explored whether initial treatment with the herbal drug Uva ursi (UU) reduces antibiotic use in women with uncomplicated UTI without increasing symptom burden and complication frequency compared with antibiotic treatment.

Methods: A double-blind randomized controlled trial was conducted in 42 family practices in Germany. The participants were adult women with suspected uncomplicated UTIs receiving either UU 105 mg 3×2 tablets for 5 days (intervention) or fosfomycin 3 g single dose (control), and their respective placebos. Read More

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Causative Agents of Urinary Tract Infections in Elderly Men with Benign Prostatic Hyperplasia: a Microbiological Evaluation.

Clin Lab 2021 Jun;67(6)

Background: Benign prostatic hyperplasia is an important risk factor for urinary tract infections. In this study, the causative agents of urinary tract infections were isolated from urine samples of benign prostatic hyperplasia patients aged 65 and older. Bacteremia risk and the patterns of antibiotic resistance were investigated to guide clinicians in empirical antibiotic treatment. Read More

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Elimination of fosfomycin during dialysis with the Genius system in septic patients.

Sci Rep 2021 Jun 8;11(1):12032. Epub 2021 Jun 8.

Department of Anesthesiology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.

To assess fosfomycin (FOS) elimination in patients with sepsis and acute kidney injury (AKI) undergoing slow-extended daily dialysis (SLEDD) with the Genius system in a prospective observational study. After ethics committee approval ten patients with sepsis and AKI stage 3 underwent daily SLEDD sessions of eight hours. FOS was applied i. Read More

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Dissemination of IncFII plasmids carrying fosA3 and bla in clinical isolates of Salmonella enteritidis.

Zoonoses Public Health 2021 Jun 4. Epub 2021 Jun 4.

Department of Food Science & Technology, School of Agriculture and Biology, State Key Lab of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, China.

Multidrug-resistant Salmonella Enteritidis (S. Enteritidis) isolates have become a significant threat to public health, and fosfomycin has been proposed as one of the therapeutic antibiotics for serious infections by resistant pathogens. In this study, a total of 501 clinical S. Read More

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The protective role of fosfomycin in lung injury due to oxidative stress and inflammation caused by sepsis.

Life Sci 2021 May 31;279:119662. Epub 2021 May 31.

Department of Pediatrics, Faculty of Medicine, Recep Tayyip Erdogan University, 53100 Rize, Turkey.

Aim: Early and prompt treatment of sepsis by effective antibiotics against susceptible organisms may be lifesaving. However, increased antibiotic resistance and side effects of chemotherapeutic agents limiting their tolerability result in a restricted use of medications. This has led to an increased search for solution oriented novel treatments and therapeutic targets, as well as investigations on the pathogenesis and physiology of sepsis. Read More

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Biosynthesis of fosfomycin in pseudomonads reveals an unexpected enzymatic activity in the metallohydrolase superfamily.

Proc Natl Acad Sci U S A 2021 Jun;118(23)

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801;

The epoxide-containing phosphonate natural product fosfomycin is a broad-spectrum antibiotic used in the treatment of cystitis. Fosfomycin is produced by both the plant pathogen and soil-dwelling streptomycetes. While the streptomycete pathway has recently been fully elucidated, the pseudomonad pathway is still mostly elusive. Read More

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Cefiderocol-Based Combination Therapy for "Difficult-to-Treat" Gram-Negative Severe Infections: Real-Life Case Series and Future Perspectives.

Antibiotics (Basel) 2021 May 29;10(6). Epub 2021 May 29.

Clinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", 70124 Bari, Italy.

Cefiderocol is a new cephalosporin displaying against extensively resistant (XDR) Gram-negative bacteria. We report our experience with cefiderocol-based combination therapies as "rescue" treatments in immunocompromised or critically ill patients or in patients with post-surgical infections who had failed previous regimens. A total of 13 patients were treated from 1 September 2020 to 31 March 2021. Read More

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Influence of Selective Agents (EMJH-STAFF), Sample Filtration and pH on Serovar Icterohaemorrhagiae Cultivation and Isolation from Swine Urine.

Vet Sci 2021 May 25;8(6). Epub 2021 May 25.

Institute for Veterinary Disease Control, Austrian Agency for Health and Food Safety (AGES), Robert Koch Gasse 17, 2340 Mödling, Austria.

spp. cause the zoonotic disease leptospirosis, which occurs in numerous mammalians worldwide. Isolation is still important for serotyping and genotyping of , which in turn is essential for epidemiological surveillance of leptospirosis and the development of diagnostic tests and vaccines. Read More

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Subsp. Associated with an Abscess in Young Roe Deer ().

Pathogens 2021 May 25;10(6). Epub 2021 May 25.

Department of Veterinary Medicine, University of Bari "Aldo Moro", Str. Prov. per Casamassima Km 3, 70010 Valenzano, BA, Italy.

Background: subsp. has been rarely documented, and very limited genomic information is available. This report describes a rare case of primary extraintestinal salmonellosis in a young roe deer, associated with subsp. Read More

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Antibiotic Resistance and Virulence Gene Patterns Associated with Avian Pathogenic (APEC) from Broiler Chickens in Qatar.

Antibiotics (Basel) 2021 May 11;10(5). Epub 2021 May 11.

Biomedical Research Center, Microbiology Department, Qatar University, Doha 2713, Qatar.

Avian Pathogenic (APEC) is the contributing agent behind the avian infectious disease colibacillosis, which causes substantial fatalities in poultry industries that has a significant impact on the economy and food safety. Several virulence genes have been shown to be concomitant with the extraintestinal survival of APEC. This study investigates the antibiotic resistance patterns and APEC-associated virulence genes content in isolated from non-healthy and healthy broiler chickens from a commercial poultry farm in Qatar. Read More

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Leafy greens as a potential source of multidrug-resistant diarrhoeagenic and .

Microbiology (Reading) 2021 Jun;167(6)

Department of Microbiology, School of Life Sciences, Central University of Rajasthan, Rajasthan, India.

A continued rise in leafy green-linked outbreaks of disease caused by pathogenic or , particularly strains exhibiting multidrug resistance (MDR), has emerged as a major threat to human health and food safety worldwide. Thus, the present study was conducted to examine antimicrobial resistance, including MDR, in diarrhoeagenic (DEC) and isolates obtained from leafy greens from rural and urban areas of India. Of the collected samples (830), 14. Read More

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Prolonged course of Fosfomycin-Trometamol for chronic prostatitis: an unknown good option.

Authors:
Eric Denes

Scand J Urol 2021 Jun 1:1-2. Epub 2021 Jun 1.

Infectious Diseases Department, ELSAN Polyclinique de Limoges, Limoges, France.

Background: Bacterial prostatitis can be difficult to treat as more and more bacteria are resistant to fluoroquinolone and/or Sulfamethoxazole-Trimethoprim which are the antibiotics of choice. Fosfomycin-Trometamol which is registered for uncomplicated urinary tract infections can be an option when other treatments can't be used.

Objective: To describe a case of prostatitis cured using a prolonged course of Fosfomycin-Trometamol. Read More

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Pharmacodynamic evaluation of suppression of in vitro resistance in Acinetobacter baumannii strains using polymyxin B-based combination therapy.

Sci Rep 2021 May 31;11(1):11339. Epub 2021 May 31.

Laboratório de Microbiologia, Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Avenida Colombo 5790, Maringá, Paraná, CEP 87020-900, Brazil.

The emergence of polymyxin resistance in Gram-negative bacteria infections has motivated the use of combination therapy. This study determined the mutant selection window (MSW) of polymyxin B alone and in combination with meropenem and fosfomycin against A. baumannii strains belonging to clonal lineages I and III. Read More

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QM/MM Study of the Fosfomycin Resistance Mechanism Involving FosB Enzyme.

ACS Omega 2021 May 3;6(19):12507-12512. Epub 2021 May 3.

Laboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Rua Augusto Corrêa, 01, 66075-110, Belém, Pará, Brasil.

Multidrug-resistant organisms contain antibiotic-modifying enzymes that facilitate resistance to a variety of antimicrobial compounds. Particularly, the fosfomycin (FOF) drug can be structurally modified by several FOF-modifying enzymes before it reaches the biological target. Among them, FosB is an enzyme that utilizes l-cysteine or bacillithiol in the presence of a divalent metal to open the epoxide ring of FOF and, consequently, inactivate the drug. Read More

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Development of antibiotic resistance in periprosthetic joint infection after total knee arthroplasty.

Bone Joint J 2021 Jun;103-B(6 Supple A):171-176

Orthomedic Offenbach, Offenbach, Germany.

Aims: The management of periprosthetic joint infection (PJI) after total knee arthroplasty (TKA) is challenging. The correct antibiotic management remains elusive due to differences in epidemiology and resistance between countries, and reports in the literature. Before the efficacy of surgical treatment is investigated, it is crucial to analyze the bacterial strains causing PJI, especially for patients in whom no organisms are grown. Read More

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Patterns of antibiotic use in hospital-acquired infections.

J Hosp Infect 2021 May 27. Epub 2021 May 27.

Direction des maladies infectieuses, Santé publique France, Saint-Maurice, France. Electronic address:

Background: Monitoring the use of antimicrobials in hospitalized patients is critical owing to the risk of resistance selection. This study aims to describe the patterns of antimicrobial prescription for the most frequent healthcare-associated infections (HAI) in France, relating drugs and microbiological data.

Methods: We used data from the 2017 point-prevalence survey of HAI and antimicrobial use in France, a large nationally representative sample survey of inpatients. Read More

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Genetic factors involved in fosfomycin resistance of multidrug-resistant Acinetobacter baumannii.

Infect Genet Evol 2021 May 27;93:104943. Epub 2021 May 27.

Department of Infectious Diseases, University of São Paulo, São Paulo, SP 05403-000, Brazil; Laboratory of Medical Investigation 49 (LIM-49), University of São Paulo, São Paulo, SP 05403-000, Brazil; Institute of Tropical Medicine, University of São Paulo, São Paulo, SP, 05403-000, Brazil. Electronic address:

The treatment of infections caused by A. baumannii is a challenge and fosfomycin has been used as a combination therapy. Moreover, data regarding the fosfomycin resistance mechanism is scarce. Read More

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Synergistic Effect of Cefazolin Plus Fosfomycin Against and in an Experimental Model.

Front Pharmacol 2021 11;12:685807. Epub 2021 May 11.

Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.

This study investigated the synergistic and activity of cefazolin plus fosfomycin against methicillin-susceptible and methicillin-resistant (MSSA and MRSA) to provide the basis for a potential treatment alternative. Antimicrobial susceptibility and synergy tests were performed with five MSSA and five MRSA isolates using the broth microdilution and chequerboard assays, respectively. The efficacy of cefazolin plus fosfomycin for the treatment of MRSA infections was assessed using the survival assay. Read More

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A Study on Multidrug-Resistant Clinical Isolates from Different Hospitals in Greater Cairo.

Microb Drug Resist 2021 May 26. Epub 2021 May 26.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Kasr Al-Aini, Cairo, Egypt.

The biological fitness cost of antibiotic resistance is a key parameter in determining the rate of appearance and spread of antibiotic-resistant bacteria in Egypt. Our study aimed to investigate the prevalence of antibiotic resistance among clinical isolates from Greater Cairo area hospitals. A total of 537 clinical isolates were recovered from samples of urine, diarrheal specimen, pus, wound culture, gastric wound, blood, drain culture, sputum, high vaginal swab, abscess, amniotic fluid, ventilator, burn swab, splenic drain culture, and unknown site of infection during different seasons. Read More

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Evaluation of sensitivity profiles to fosfomycin in bacterial urine samples from outpatients.

Eur J Obstet Gynecol Reprod Biol 2021 May 14;262:184-187. Epub 2021 May 14.

Statistics Department, Fluminense Federal University, 24210-200, Niteroi, Brazil.

Objective: To evaluate and compare the susceptibilities of bacteria found in outpatient cultures to fosfomycin and other main antibiotics commonly available in clinical practice.

Study Design: A retrospective cross-sectional study was conducted using 2,673 positive urine cultures collected between 2014 and 2017 at private laboratories located in the cities of Niterói and São Gonçalo. Susceptibilities to fosfomycin and other antibiotics were tested using the McNemar test with the level of significance set at 5 %. Read More

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Intravenous fosfomycin for the treatment of patients with bone and joint infections: a review.

Expert Rev Anti Infect Ther 2021 May 25. Epub 2021 May 25.

Alfa Institute of Biomedical Sciences, Athens, Greece.

Introduction: Fosfomycin is a wide spectrum bactericidal antibiotic with a unique mode of action, low toxicity and good penetration in tissues with deep seated infections, including bone and joint infections.

Areas Covered: Data were extracted from 19 published articles. 365 patients, with broad age range, received intravenous fosfomycin for the treatment of bone and joint infections (including arthritis, acute and chronic osteomyelitis, discitis, periprosthetic joint infection). Read More

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Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves.

J Vet Med Sci 2021 May 24. Epub 2021 May 24.

Division of Pathology and Pathophysiology, National Institute of Animal Health, National Agriculture and Food Research Organization (NARO).

One calf died (No. 1) and another was euthanized following astasia (No. 2). Read More

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Intravenous colistin in the treatment of multidrug-resistant gram-negative organism in tertiary hospital, Jazan, KSA.

J Family Med Prim Care 2021 Jan 30;10(1):333-338. Epub 2021 Jan 30.

Senior Pharmacist in KFCH, Jazan, Saudi Arabia.

Background: It was considered that the resistance of drugs such as carbapenems and cephalosporins against severe or high risk gram-negative bacteria became a tremendous confront. This might be attributed to the little amount of these drugs to be used against the multi-resistant bacteria (MRB). Therefore, Colistin, Fosfomycin, Temocillin, and Rifampicin are antibiotics that have been used as multidrug-resistant bacterial infections in the treatment of some species of bacteria such as Acinetobacter, Pseudomonas species, and Enterobacteriaceae. Read More

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January 2021

Zidovudine in synergistic combination with fosfomycin: an in vitro and in vivo evaluation against multidrug-resistant Enterobacterales.

Int J Antimicrob Agents 2021 May 16:106362. Epub 2021 May 16.

Department of Life Sciences, University of Trieste, Trieste, Italy.

Multidrug-resistant (MDR) Enterobacterales are a priority health issue with few treatment options. Recently, fosfomycin has been reconsidered for MDR bacterial infections. Zidovudine, licensed for the treatment of human immunodeficiency virus (HIV), has unexploited antibacterial properties and has been considered for drug repurposing. Read More

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Genotypic Characterization of Clinical spp. Isolates Collected From Patients With Suspected Community-Onset Sepsis, Sweden.

Front Microbiol 2021 30;12:640408. Epub 2021 Apr 30.

Systems Biology Research Centre, School of Bioscience, University of Skövde, Skövde, Sweden.

is a genus of Gram-negative bacteria known to be opportunistic pathogens that may cause a variety of infections in humans. Highly drug-resistant species, especially , have emerged rapidly and are becoming a major concern in clinical management. Although is considered the most important pathogen within the genus, the true clinical significance of the other species is likely underrecognized due to the inability of conventional microbiological methods to distinguish between the species leading to high rates of misidentification. Read More

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Spectrum of uropathogens and their susceptibility to antimicrobials in pregnant women: a retrospective analysis of 5-year hospital data.

J Int Med Res 2021 May;49(5):3000605211006540

Department of Internal Medicine, School of Medicine, The University of Jordan, Amman, Jordan.

Objective: Urinary tract infections (UTI) are common during pregnancy. Identification of antimicrobial susceptibility patterns of microorganisms in pregnant women is important to select the most appropriate antimicrobial. We assessed common uropathogens in pregnant women with UTI and antimicrobial susceptibility, to guide empirical antibiotic selection. Read More

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Colistin Resistance among Isolated from Clinical Samples in Gaza Strip.

Can J Infect Dis Med Microbiol 2021 20;2021:6634684. Epub 2021 Apr 20.

Department of Medical Laboratory Sciences Faculty of Health Sciences Islamic University of Gaza, Gaza Strip, Gaza, Palestine, State of Palestine.

Bacterial infections, especially drug-resistant infections, are a major global health issue. The emergence of multidrug-resistant (MDR) strains of and the lack of new antibiotics have worrisome prospects for all of humanity. Colistin is considered the last-line drug for MDR Gram-negative bacteria (GNB), and it is often used for treatment of respiratory infections caused by MDR-GNB. Read More

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