118,876 results match your criteria forward


Investigating the underlying biomechanical mechanisms leading to falls in long-term ankle-foot orthosis and functional electrical stimulator users with chronic stroke.

Gait Posture 2021 Nov 20;92:144-152. Epub 2021 Nov 20.

School of Biological and Health System Engineering, Arizona State University, Tempe, AZ, USA. Electronic address:

Background: Ankle-foot-orthoses (AFOs) and functional electrical stimulators (FES) are commonly prescribed to treat foot-drop in individuals with stroke. Despite well-established positive impacts of AFO and FES devices on balance and gait, AFO and FES-users still fall at a high rate.

Objective: The objective of this study was to investigate 1) the underlying biomechanical mechanisms leading to a fall in long-term AFO and FES-users with chronic stroke and 2) the impacts of AFOs and FES devices on fall outcomes and compensatory stepping response of long-term users with chronic stroke. Read More

View Article and Full-Text PDF
November 2021

Uncertainty-aware convolutional neural network for COVID-19 X-ray images classification.

Comput Biol Med 2021 Nov 23;140:105047. Epub 2021 Nov 23.

Maulana Azad National Institute of Technology, Bhopal, MP, 462003, India.

Deep learning (DL) has shown great success in the field of medical image analysis. In the wake of the current pandemic situation of SARS-CoV-2, a few pioneering works based on DL have made significant progress in automated screening of COVID-19 disease from the chest X-ray (CXR) images. But these DL models have no inherent way of expressing uncertainty associated with the model's prediction, which is very important in medical image analysis. Read More

View Article and Full-Text PDF
November 2021

A Year Into the Pandemic: An Update on Women in Science, Technology, Engineering, Math, and Medicine (STEMM).

Ann Am Thorac Soc 2021 Nov 30. Epub 2021 Nov 30.

University of Florida, 3463, Health Outcomes and Biomedical Informatics, Gainesville, Florida, United States.

The coronavirus pandemic revealed long-standing, unaddressed fissures in our systems, including dramatic gender inequities in science, technology, engineering, mathematics and medicine (STEMM) fields. Women have disproportionately carried the burden of child care and other caregiving responsibilities during the pandemic, and there are strong indications that the pandemic will likely exacerbate pre-existing disparities in the pipeline of women in STEMM and in leadership positions. Based on a literature review, our own experiences and the experiences of our colleagues, we review promising strategies that have been implemented by funding bodies, journals, professional societies, and colleges/universities as well as additional strategies that might be helpful for these entities to implement in order to move forward with policies in place that address gender inequities and rebuild our institutional systems better. Read More

View Article and Full-Text PDF
November 2021

TAVI and risk scores: Looking back while moving forward.

Kardiol Pol 2021 ;79(11):1195-1196

Division of Cardiology, Cardiovascular and Thoracic Department, University of Turin, Città della Salute e della Scienza, Turin, Italy.

View Article and Full-Text PDF
January 2021

Design and Modeling of Bioreactor Utilizing Electrophoresis and Di-electrophoresis Techniques for Regenerating Reabsorption Function of Human Kidney PCT in Microfluidics Environment.

IEEE Trans Nanobioscience 2021 Nov 30;PP. Epub 2021 Nov 30.

The need for innovation in medical device technology is immense; especially to replace the dialysis techniques the necessity is extremely high. The available techniques that promised to replace dialysis have not yet geared up to the marketization level. The utilization of live kidney cells makes these devices costly, delicate, and unreliable. Read More

View Article and Full-Text PDF
November 2021

Whole Body Center of Mass Feedback in a Reflex-Based Neuromuscular Model Predicts Ankle Strategy During Perturbed Walking.

IEEE Trans Neural Syst Rehabil Eng 2021 Nov 30;PP. Epub 2021 Nov 30.

Active prosthetic and orthotic devices have the potential to increase quality of life for individuals with impaired mobility. However, more research into human-like control methods is needed to create seamless interaction between device and user. In forward simulations the reflex-based neuromuscular model (RNM) by Song and Geyer shows promising similarities with real human gait in unperturbed conditions. Read More

View Article and Full-Text PDF
November 2021

Loss-rescaling VQA: Revisiting Language Prior Problem from a Class-imbalance View.

IEEE Trans Image Process 2021 Nov 30;PP. Epub 2021 Nov 30.

Recent studies have pointed out that many well-developed Visual Question Answering (VQA) models are heavily affected by the language prior problem, which refers to making predictions based on the co-occurrence pattern between textual questions and answers instead of reasoning visual contents. To tackle it, most existing methods focus on enhancing visual feature learning to reduce this superficial textual shortcut influence on VQA model decisions. However, limited effort has been devoted to providing an explicit interpretation for its inherent cause. Read More

View Article and Full-Text PDF
November 2021

Spin Crossover of Thiophosgene via Multidimensional Heavy-Atom Quantum Tunneling.

J Am Chem Soc 2021 Nov 30. Epub 2021 Nov 30.

Laboratory of Physical Chemistry, ETH Zürich, 8093 Zürich, Switzerland.

The spin-crossover reaction of thiophosgene has drawn broad attention from both experimenters and theoreticians as a prime example of radiationless intramolecular decay via intersystem crossing. Despite multiple attempts over 20 years, theoretical predictions have typically been orders of magnitude in error relative to the experimentally measured triplet lifetime. We address the T → S transition by the first application of semiclassical golden-rule instanton theory in conjunction with on-the-fly electronic-structure calculations based on multireference perturbation theory. Read More

View Article and Full-Text PDF
November 2021

Peptide-Derived Biosensors and Their Applications in Tumor Immunology-Related Detection.

Anal Chem 2021 Nov 30. Epub 2021 Nov 30.

Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China.

Small-molecular targeting peptides possess features of biocompatibility, affinity, and specificity, which is widely applied in molecular recognition and detection. Moreover, peptides can be developed into highly ordered supramolecular assemblies with boosting binding affinities, diverse functions, and enhanced stabilities suitable for biosensors construction. In this Review, we summarize recent progress of peptide-based biosensors for precise detection, especially on tumor-related analysis, as well as further provide a brief overview of the progress in tumor immune-related detection. Read More

View Article and Full-Text PDF
November 2021

Establishing a risk assessment framework for point-of-care ultrasound.

Eur J Pediatr 2021 Nov 30. Epub 2021 Nov 30.

Department of Paediatrics, Division of Neonatology, Loma Linda University School of Medicine, CA, USA, and Depart of Pediatrics - Neonatology and Paediatric Cardiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Point-of-care ultrasound (POCUS) refers to the use of portable ultrasound (US) applications at the bedside, performed directly by the treating physician, for either diagnostic or procedure guidance purposes. It is being rapidly adopted by traditionally non-imaging medical specialties across the globe. Recent international evidence-based guidelines on POCUS for critically ill neonates and children were issued by the POCUS Working Group of the European Society of Pediatric and Neonatal Intensive Care (ESPNIC). Read More

View Article and Full-Text PDF
November 2021

A biomimetic nanocomposite made of a ginger-derived exosome and an inorganic framework for high-performance delivery of oral antibodies.

Nanoscale 2021 Nov 30. Epub 2021 Nov 30.

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province 110016, PR China.

For inflammatory bowel disease (IBD) therapy, systemic exposure of anti-TNF-α antibodies brought by current clinical injection always causes serious adverse effects. Colon-targeted delivery of anti-TNF-α antibodies through the oral route is of great importance but remains a formidable challenge. Here, we reported a biomimetic nanocomposite made of a ginger-derived exosome and an inorganic framework for this purpose. Read More

View Article and Full-Text PDF
November 2021

Dissociation of HCl in water nanoclusters: an energy decomposition analysis perspective.

Phys Chem Chem Phys 2021 Nov 30. Epub 2021 Nov 30.

Kenneth S. Pitzer Center for Theoretical Chemistry, Department of Chemistry, University of California, Berkeley, California 94720, USA.

As known, small HCl-water nanoclusters display a particular dissociation behaviour, whereby at least four water molecules are required for the ionic dissociation of HCl. In this work, we examine how intermolecular interactions promote the ionic dissociation of such nanoclusters. To this end, a set of 45 HCl-water nanoclusters with up to four water molecules is introduced. Read More

View Article and Full-Text PDF
November 2021

Which of the five classical ballet positions is the most demanding for the dancer's body? An electromyography-based study to determine muscular activity.

Acta Bioeng Biomech 2020 ;22(4):3-14

Department of Biomechanics, Chair of Theory and Methodology of Sport, Poznan University of Physical Education, Poznań, Poland.

Purpose: The study aimed to determine which of the five classical ballet positions is the most demanding regarding muscular activity, values of external rotation in the hip joints, angular values of foot progression as well as the inclination (tilt) of the pelvis in the sagittal plane.

Methods: In this cross-sectional study, 14 female pre-professional ballet dancers (aged 11-16) participated. Participants were tasked with the sequential adoption of five classical ballet positions (CP1-CP5). Read More

View Article and Full-Text PDF
January 2020

Marker-assisted forward breeding to develop a drought-, bacterial-leaf-blight-, and blast-resistant rice cultivar.

Plant Genome 2021 Nov 29:e20170. Epub 2021 Nov 29.

International Rice Research Institute, South Asia Regional Centre, Varanasi, India.

Among the different challenges related to rice (Oryza sativa L.) cultivation, drought, bacterial leaf blight (BLB), and blast are the key stresses that significantly affect grain yield (GY) in rice. To ameliorate this issue, marker-assisted forward breeding (MAFB) coupled with a simultaneous crossing approach was used to combine three drought tolerant quantitative trait loci (QTL)-qDTY , qDTY , and qDTY -four BLB genes-Xa4, xa5, xa13, and Xa21-and one blast-resistance gene, Pi9, in the elite rice cultivar Lalat. Read More

View Article and Full-Text PDF
November 2021

Efficient Polyester Hydrogenolytic Deconstruction via Tandem Catalysis.

Angew Chem Int Ed Engl 2021 Nov 29. Epub 2021 Nov 29.

Northwestern University, Department of Chemistry, 2145 Sheridan Rd., 60208-3113, Evanston, UNITED STATES.

Using a mechanism-based solvent-free tandem catalytic approach, commodity polyester plastics such as polyethylene terephthalate (PET), polybutylene terephthalate (PBT), and polyethylene naphthalate (PEN) are rapidly and selectively deconstructed by combining the two air- and moisture-stable catalysts, Hf(OTf) 4 and Pd/C, under 1 atm H 2 , affording terephthalic acid (or naphthalene dicarboxylic acid for PEN) and ethane (or butane for PBT) in essentially quantitative yield. This process is effective for both laboratory grade and waste plastics, and comingled polypropylene remains unchanged. Combined experimental and DFT mechanistic analyses indicate that Hf(OTf) 4 catalyzes a mildly exergonic retro-hydroalkoxylation reaction in which an alkoxy C-O bond is first cleaved, yielding a carboxylic acid and alkene, and this process is closely coupled to an exergonic olefin hydrogenation step, driving the overall reaction forward. Read More

View Article and Full-Text PDF
November 2021

The Impact of Racial and Non-racial Discrimination on Health Behavior Change Among Visible Minority Adults During the COVID-19 Pandemic.

J Racial Ethn Health Disparities 2021 Nov 29. Epub 2021 Nov 29.

Faculty of Health Sciences, University of Lethbridge, M3083 Markin Hall, 4401 University Drive, Lethbridge, AB, T1K 3M4, Canada.

Introduction: Pre-pandemic health behavior has been put forward as a reason for excess COVID-19 infection and death in some racialized groups. At the same time, scholars have labeled racism the other pandemic and argued for its role in the adverse COVID-19 outcomes observed. The purpose of this study was to examine the impact of discrimination on health behavior change among racialized adults in the early stages of the pandemic. Read More

View Article and Full-Text PDF
November 2021

Translation, Cultural Adaptation and Validation of the Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS) in Italian.

Aesthetic Plast Surg 2021 Nov 29. Epub 2021 Nov 29.

Department of Otolaryngology-Head and Neck Surgery, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

Backgrounds: Rhinoplasty necessarily concerns functional and cosmetic aspects, and outcomes of both should be assessed in each patient. There has been a lack in the literature in Italian for a comprehensive tool for assessing both aspects of rhinoplasty. The objective is to translate and validate the Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS) into Italian. Read More

View Article and Full-Text PDF
November 2021

Prevalence and risk factors of hypertension among college freshmen in China.

Sci Rep 2021 Nov 29;11(1):23075. Epub 2021 Nov 29.

School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, Hubei, China.

Hypertension is the leading single contributor to all-cause death and disability worldwide. However, there is scarce evidence on the prevalence and risk factors of hypertension for Chinese youth. This study aimed to investigate the prevalence of hypertension among Chinese college freshmen and to identify the influencing factors. Read More

View Article and Full-Text PDF
November 2021

Global, regional and national burden of bladder cancer and its attributable risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease study 2019.

BMJ Glob Health 2021 Nov;6(11)

Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, USA

Introduction: The current study determined the level and trends associated with the incidence, death and disability rates for bladder cancer and its attributable risk factors in 204 countries and territories, from 1990 to 2019, by age, sex and sociodemographic index (SDI; a composite measure of sociodemographic factors).

Methods: Various data sources from different countries, including vital registration and cancer registries were used to generate estimates. Mortality data and incidence data transformed to mortality estimates using the mortality to incidence ratio (MIR) were used in a cause of death ensemble model to estimate mortality. Read More

View Article and Full-Text PDF
November 2021

Spatial and seasonal change in algal community structure and its interaction with nutrient dynamics in a gravel-bed urban river.

J Hazard Mater 2021 Nov 15:127775. Epub 2021 Nov 15.

State Key Laboratory of Lake and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, PR China.

Harmful algal blooms frequently occur in urban rivers due to intense human activities. However, little is known about the change in algal community structure and its interactions with nutrient dynamics in gravel-bed urban rivers. In present study, water samples were collected from a gravel-bed River Xin'an, China for five months over four seasons and a rainy month to measure algal community structure, dissolved nitrogen gas (N) and Argon (Ar) concentrations, and other water quality parameters. Read More

View Article and Full-Text PDF
November 2021

Ionic surfactants as assembly crosslinkers triggered supramolecular membrane with 2D↔3D conversion under multiple stimulus.

J Colloid Interface Sci 2021 Nov 19. Epub 2021 Nov 19.

Fujian Provincial University Engineering Research Center of Industrial Biocatalysis, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, PR China. Electronic address:

Hypothesis: General strategies leading to 2D assemblies promise a significant step forward in the development of supramolecular materials with diversity and superiority. Considering molecular packing parameter indicates a connection between molecular geometry and aggregate morphology, we predict the introduction of ionic surfactants as assembly crosslinker would be endowed to develop a methodology of 2D supramolecular assembles.

Experiments: In this work, by introducing ionic surfactants such as sodium dodecylsulfate (SDS), the molecular packing parameter P in bolaamphiphile (A2G) system was increased, which successfully manipulated the transformation of the 3D vesicles into 2D membranes. Read More

View Article and Full-Text PDF
November 2021

Nutrigenetics and nutrigenomics-A personalized approach to nutrition.

Adv Genet 2021 28;108:277-340. Epub 2021 Oct 28.

Cardiff Metropolitan University, Cardiff, United Kingdom. Electronic address:

The prevalence of non-communicable diseases has been on an upward trajectory for some time and this puts an enormous burden on the healthcare expenditure. Lifestyle modifications including dietary interventions hold an immense promise to manage and prevent these diseases. Recent advances in genomic research provide evidence that focussing these efforts on individual variations in abilities to metabolize nutrients (nutrigenetics) and exploring the role of dietary compounds on gene expression (nutrigenomics and nutri-epigenomics) can lead to more meaningful personalized dietary strategies to promote optimal health. Read More

View Article and Full-Text PDF
October 2021

Reverse Shoulder Arthroplasty After Prior Rotator Cuff Repair: A Matched Cohort Analysis.

J Am Acad Orthop Surg 2021 Nov 18. Epub 2021 Nov 18.

From the Department of Orthopedic Surgery, Mayo Clinic, Jacksonville, FL (Marigi, Crowe, and Schoch), Exactech Inc (Tams), Department of Orthopaedics and Rehabilitation (King and Wright), University of Florida, Gainesville, FL, the Department of Orthopedic Surgery, Hopital Ambroise Paré, Boulogne-Billancourt, France (Werthel), and the Department of Orthopaedics, Medical University of South Carolina, Charleston, SC (Friedman and Eichinger).

Introduction: Rotator cuff repair (RCR) is commonly performed before reverse shoulder arthroplasty (RSA) with conflicting evidence on the effect on arthroplasty outcomes. The purpose of this investigation was to evaluate the effect of a prior RCR on the outcomes and complications of primary RSA.

Methods: Between 2007 and 2017, 438 RSAs performed in patients with a prior RCR and 876 case-matched controls were identified from a multicenter database. Read More

View Article and Full-Text PDF
November 2021

Fabrication of periodic microscale stripes of silver by laser interference induced forward transfer and their SERS properties.

Nanotechnology 2021 Nov 29. Epub 2021 Nov 29.

International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun University of Science and Technology, 7089 Weixing Road, Changchun 130022, P. R. China, Changchun, Jilin, 130022, CHINA.

The micro-stripe structure was prepared by laser interference induced forward transfer (LIIFT) technique, composed of Ag nano-particles (NPs). The effects of the film thickness with the carbon nano-particles mixed polyimide ([email protected]), Ag film thickness, and laser fluence were studied on the transferred micro-stripe structure. The periodic Ag micro-stripe with good resolution was obtained in a wide range of [email protected] film thickness from ~ 0. Read More

View Article and Full-Text PDF
November 2021

Managing secondary fungal infections in severe COVID-19: how to move forward?

Lancet Respir Med 2021 Nov 26. Epub 2021 Nov 26.

Department of Internal Medicine, Radboud University Medical Center, 6500 HB Nijmegen, Netherlands; Radboudumc-CWZ Center of Expertise for Mycology, Radboud University Medical Center, 6500 HB Nijmegen, Netherlands.

View Article and Full-Text PDF
November 2021

Establishment of quantitative RNAi-based forward genetics in Entamoeba histolytica and identification of genes required for growth.

PLoS Pathog 2021 Nov 29;17(11):e1010088. Epub 2021 Nov 29.

Department of Microbiology and Molecular Genetics, University of California, Davis, California, United States of America.

While Entamoeba histolytica remains a globally important pathogen, it is dramatically understudied. The tractability of E. histolytica has historically been limited, which is largely due to challenging features of its genome. Read More

View Article and Full-Text PDF
November 2021

Change in treatment burden among people with multimorbidity: Protocol of a follow up survey and development of efficient measurement tools for primary care.

PLoS One 2021 29;16(11):e0260228. Epub 2021 Nov 29.

School of Primary Care, Population Sciences, and Medical Education, University of Southampton, Southampton, United Kingdom.

Background: Treatment burden is the effort required of patients to look after their health and the impact this has on their functioning and wellbeing. It is likely treatment burden changes over time as circumstances change for patients and health services. However, there are a lack of population-level studies of treatment burden change and factors associated with this change over time. Read More

View Article and Full-Text PDF
November 2021

Predictability effects and parafoveal processing in older readers.

Psychol Aging 2021 Nov 29. Epub 2021 Nov 29.

School of Psychology.

Normative aging is accompanied by visual and cognitive changes that impact the systems that are critical for fluent reading. The patterns of eye movements during reading displayed by older adults have been characterized as demonstrating a trade-off between longer forward saccades and more word skipping versus higher rates of regressions back to previously read text. This pattern is assumed to reflect older readers' reliance on top-down contextual information to compensate for reduced uptake of parafoveal information from yet-to-be fixated words. Read More

View Article and Full-Text PDF
November 2021

Post-Coronavirus Disease-2019 (COVID-19): Toward a Severe Multi-Level Health Crisis?

Med Sci (Basel) 2021 Nov 8;9(4). Epub 2021 Nov 8.

Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CREMI, CHU de Québec-Université Laval Research Center, 2705 Boul. Laurier, Quebec City, QC G1V 4G2, Canada.

There were already numerous challenges facing the healthcare system prior to the ongoing coronavirus disease-2019 (COVID-19) pandemic. Although we look forward to ending this pandemic, it is still expected that the healthcare system will face further challenges leading to a multi-level health crisis. Indeed, after the COVID-19 pandemic, there will still be COVID-19 active cases and those left with health problems following COVID-19 infection who will be of a particular impact. Read More

View Article and Full-Text PDF
November 2021

Genetics & Epigenetics of Hereditary Deafness: An Historical Overview.

Audiol Res 2021 Nov 17;11(4):629-635. Epub 2021 Nov 17.

Clinical Genetics Unit, Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy.

Hearing loss (HL) is one of the most common sensory impairments worldwide and represents a critical medical and public health issue. Since the mid-1900s, great efforts have been aimed at understanding the etiology of both syndromic and non-syndromic HL and identifying correlations with specific audiological phenotypes. The extraordinary discoveries in the field of molecular genetics during the last three decades have contributed substantially to the current knowledge. Read More

View Article and Full-Text PDF
November 2021