270 results match your criteria formulation piroxicam

Efficient Prediction of In Vitro Piroxicam Release and Diffusion From Topical Films Based on Biopolymers Using Deep Learning Models and Generative Adversarial Networks.

J Pharm Sci 2021 Feb 3. Epub 2021 Feb 3.

School of Computing, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.

The purpose of this study was to simultaneously predict the drug release and skin permeation of Piroxicam (PX) topical films based on Chitosan (CTS), Xanthan gum (XG) and its Carboxymethyl derivatives (CMXs) as matrix systems. These films were prepared by the solvent casting method, using Tween 80 (T80) as a permeation enhancer. All of the prepared films were assessed for their physicochemical parameters, their in vitro drug release and ex vivo skin permeation studies. Read More

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February 2021

Nanovesicle formulation enhances anti-inflammatory and safe use of piroxicam.

Pharm Nanotechnol 2021 Jan 29. Epub 2021 Jan 29.

Drug Delivery and Nanotechnology Research Unit (RUNDD), Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Enugu State. Nigeria.

Background: Enhanced utilization of certain drugs may be possible through the development of alternative delivery forms. Adverse gastrointestinal tract effects such as irritation and ulceration have limited wider applications of NSAIDs in antiiflammatory therapy. This challenge may be overcome through nano topical formulations. Read More

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January 2021

Co-amorphous formation of piroxicam-citric acid to generate supersaturation and improve skin permeation.

Eur J Pharm Sci 2021 Mar 6;158:105667. Epub 2020 Dec 6.

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan; Center for Transdermal Drug Delivery, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan.

The objective of this study was to prepare a co-amorphous formulation of piroxicam (PIR), a non-steroidal anti-inflammatory drug, and citric acid (CA), and evaluate its skin permeation ability. A spray-drying method was employed to prepare the co-amorphous formulation and its physical properties were characterized. X-ray powder diffraction and thermal analysis confirmed a homogeneous amorphous state, and the infrared spectra revealed intermolecular interactions between PIR and CA, suggesting formation of a co-amorphous formulation of PIR and CA. Read More

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Electrospun Gelatin Nanocontainers for Enhanced Biopharmaceutical Performance of Piroxicam: In Vivo and In Vitro Investigations.

Int J Nanomedicine 2020 10;15:8819-8828. Epub 2020 Nov 10.

Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore 54000, Pakistan.

Background: Piroxicam exhibits low oral bioavailability, due to its meager solubility in water. The intent of this study was to ameliorate the bioavailability of the drug by employing a solubility-enhancing encapsulation technique.

Methods: Seven samples were formulated with piroxicam and gelatin using both solvent evaporation and electrospraying together. Read More

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December 2020

Microparticle fabricated from a series of symmetrical lipids based on dihydroxyacetone form textured architectures.

J Control Release 2021 Feb 12;330:1071-1079. Epub 2020 Nov 12.

Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, United States of America; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, United States of America. Electronic address:

We report the synthesis of a series of symmetrical lipids composed of dihydroxyacetone and even‑carbon fatty acids (eight to sixteen carbons), both components of the human metabolome, and characterize their formulation into porous microparticles through spontaneous emulsification without the use of additional porogens. Lipid hydrolysis products were identified by H NMR to validate lipid degradation into the parent metabolic synthons. Microparticle architecture, as determined by scanning electron microscopy, was lipid-length dependent, with shorter alkyl chains forming tight structures and longer alkyl chains forming larger pores with plate-like lipid architectures. Read More

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February 2021

Investigation of Pectin-Hydroxypropyl Methylcellulose-Coated Floating Beads for Pulsatile Release of Piroxicam.

Turk J Pharm Sci 2020 Oct 30;17(5):542-548. Epub 2020 Oct 30.

Borgaon (Meghe) Institute of Pharmaceutical Education and Research, Wardha, Maharashtra, India.

Objectives: The aim of the present study was to prepare pectin-hydroxypropyl methylcellulose-coated floating beads for pulsatile release of piroxicam in the treatment of early morning inflammation.

Materials And Methods: Piroxicam-loaded beads were prepared from sodium alginate and hydroxypropyl methylcellulose (HPMC) in different concentrations of calcium carbonate using the ionotropic gelation method. In order to avoid drug release in the upper part of the gastrointestinal tract, the beads were coated with a pectin-HPMC layer using the dip coating method. Read More

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October 2020

Development of piroxicam mini-tablets enabled by spherical cocrystallization.

Int J Pharm 2020 Nov 9;590:119953. Epub 2020 Oct 9.

Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

We examined the potential of the spherical cocrystallization (SCC) technology in simultaneously enhancing tablet manufacturability and dissolution of poorly soluble drugs by developing a mini-tablet formulation of piroxicam. The manufacturing of mini-tablets using a direct compression (DC) process is more challenging than conventional tablets because of the much stricter requirement on the micromeritic properties of formulated powders. The SCC process in this work involved two steps: 1) preparing a new piroxicam-ferulic acid (PRX-FA) cocrystal, and 2) forming spherical agglomerates with the aid of a suitable bridging liquid. Read More

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November 2020

Formulation and optimization of quinoa starch nanoparticles: Quality by design approach for solubility enhancement of piroxicam.

Saudi Pharm J 2020 Aug 24;28(8):927-935. Epub 2020 Jun 24.

Guru Jambheshwar University of Science and Technology, Hisar 125 001, India.

In the present study piroxicam loaded starch nanoparticles were prepared to enhance the solubility of piroxicam by nanoprecipitation technique. The preparation of nanoparticles was carried out as per central composite experimental design protocol, having concentration of starch and drug as independent variables and particle size and polydispersity index (PdI) as dependent variables. The particle size and PdI of piroxicam loaded starch nanoparticles was found to be between 282-870 nm and 0. Read More

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Profiles Drug Subst Excip Relat Methodol 2020 18;45:199-474. Epub 2019 Dec 18.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

A comprehensive profile of piroxicam including the nomenclatures, formulae, elemental composition, appearance, uses and applications. The methods which were utilized for the preparation of the drug substance and their respective schemes are outlined. The physical characteristics of the drug including the ionization constant, solubility, x-ray powder diffraction pattern, differential scanning calorimetry, thermal behavior and spectroscopic studies are described. Read More

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Lornoxicam controlled release transdermal gel patch: Design, characterization and optimization using co-solvents as penetration enhancers.

PLoS One 2020 27;15(2):e0228908. Epub 2020 Feb 27.

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

The aim of the current study was to develop membrane-based transdermal patches of lornoxicam gel using oleic acid (OA)and propylene glycol (PG) as penetration enhancers to improve drug delivery across the skin and to evaluate in vivo analgesic and anti-inflammatory activity. For this purpose, nine formulations were developed in accordance with 32 factorial design using Design Expert® 11. The concentration of propylene glycol (X1) and oleic acid (X2) were selected as independent variable whereas Q10 (Y1), flux (Y2) and lag time (Y3) were considered as the response variables. Read More

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Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery.

Drug Deliv 2020 Dec;27(1):269-282

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly-ε-caprolactone (PCL) nanoparticles (NPs) offer potential advantages over conventional oral delivery. Read More

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December 2020

Detection of low dose of piroxicam polymorph in pharmaceutical tablets by surface-enhanced Raman chemical imaging (SER-CI) and multivariate analysis.

Int J Pharm 2020 Jan 3;574:118913. Epub 2019 Dec 3.

University of Liege (ULiege), CIRM, Vibra-Sante Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, CHU, B36, B-4000 Liege, Belgium.

This study demonstrates, for the first time, the ability of surface-enhanced Raman chemical imaging (SER-CI) combined with multivariate analysis to detect low levels (0.1% (w/w)) of a polymorphic form in a pharmaceutical mixture. In the studied formulation, piroxicam was used as a model molecule to develop this approach. Read More

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January 2020

Development, characterization and evaluation of ginger extract loaded microemulsion: In vitro and Ex vivo release studies.

Pak J Pharm Sci 2019 Jul;32(4(Supplementary)):1873-1877

Faculty of Pharmacy, Gomal University Dera Ismail Khan, KPK, Pakistan.

Zingeber officinale (ginger) has been used for a long time in conventional medicine for the management of many diseases most important of which is inflammatory diseases. The aim of this study was formulation of topical microemulsion system to enhance the solubility, stability and release profile of ginger extract, as it is unstable in the presence of light, air, heat and long term storage. The solubility of ginger extract in different oils, surfactants, and cosurfactants was determined in order to find the optimal components for microemulsion. Read More

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Development, characterization and evaluation of in-vitro anti-inflammatory activity of ginger extract based micro emulsion.

Pak J Pharm Sci 2019 May;32(3 Special):1327-1332

Faculty of Pharmacy, Gomal University Dera Ismail Khan, Pakistan.

Zingeber officinale is a commonly used plant which has been shown to possess anti-inflammatory activity. The active compounds present in ginger are gingerols, shagaols and paradol. The aim of this study was formulation of topical microemulsion system to enhance the solubility and stability of ginger extract, as it is unstable in the presence of light, air, heat and long term storage, and to evaluate its anti-inflammatory activity. Read More

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Compounded Cyclophosphamide and Piroxicam for the Treatment of a Canine Peripheral Nerve Sheath Tumor: A Case Report.

Int J Pharm Compd 2019 Sep-Oct;23(5):358-364

Sour Lake, Texas.

For many people, companion animals are family members and partners in life. The diagnosis of a life-threatening illness in a beloved pet can present challenges for the patient and cause stress and grief for its owner. A successful therapeutic outcome often requires the use of commercially manufactured medications that are not produced in the doses or dosage forms tolerated by veterinary patients or are unavailable to, unaffordable for, and/or inaccessible by owners. Read More

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October 2019

Effect of casting solvent, film-forming agent and solubilizer on orodispersible films of a polymorphic poorly soluble drug: an / study.

Drug Dev Ind Pharm 2019 Nov 2;45(11):1751-1769. Epub 2019 Sep 2.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University , Cairo , Egypt.

In the current work, a full factorial experimental design was utilized to formulate piroxicam into orodispersible films while investigating the effects of some formulation factors on the properties of the resulting films. These factors were () the casting solvent: water and acetone/water mixture; () the film-forming agent: HPMC K4M and Na-alginate; () the solubilization system: no solubilizer, L-arginine, poloxamer and L-arginine/poloxamer mixture. Sixteen formulation runs were prepared by solvent casting method to obtain 10 mg piroxicam dosage units. Read More

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November 2019

Justification of Biowaiver and Dissolution Rate Specifications for Piroxicam Immediate Release Products Based on Physiologically Based Pharmacokinetic Modeling: An In-Depth Analysis.

Mol Pharm 2019 09 22;16(9):3780-3790. Epub 2019 Aug 22.

Department of Pharmaceutical Analysis, Wuya College of Innovation , Shenyang Pharmaceutical University , No. 103, Wenhua Road , Shenyang 110016 , PR China.

A quantitative prediction of human pharmacokinetic (PK) profiles has become an increasing demand for the reduction of the clinical failure of drug formulations. The existing in vitro and in vivo correlation (IVIVC) methodology could achieve this goal, but the development of IVIVC for immediate release (IR) products is challenging. Herein, we report that for certain weakly acidic biopharmaceutical classification system (BCS) class II molecules (piroxicam, PIRO), physiologically based PK (PBPK) modeling could be used as a tool to quantitatively predict PK in beagle dogs and to conduct an interspecies extrapolation to humans. Read More

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September 2019

A combination therapy of nanoethosomal piroxicam formulation along with iontophoresis as an anti-inflammatory transdermal delivery system for wound healing.

Int Wound J 2019 Oct 8;16(5):1144-1152. Epub 2019 Aug 8.

Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.

Inflammation accounts as one of the major phases in wound healing, while prolonged and chronic inflammation may lead to adverse pathological conditions. Therefore, transdermal delivery of nonsteroidal anti-inflammatory (NSAIDs) such as encapsulated piroxicam into a nanocarrier seems to be promising. For the first time, a nanoethosomal piroxicam of <200 nm was prepared and combined with iontophoresis. Read More

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October 2019

New local treatment for photoaging using a formulation containing piroxicam 0.8% and sunscreen.

J Int Med Res 2019 Jul 6;47(7):3127-3132. Epub 2019 Jun 6.

1 Dermatologic Clinic, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

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Proniosomal gel for transdermal delivery of lornoxicam: optimization using factorial design and in vivo evaluation in rats.

Daru 2019 Jun 30;27(1):59-70. Epub 2019 Jan 30.

Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.

Objective: Clinical utility of lornoxicam in oral therapy is primarily restricted by the low solubility and gastric adverse effects. This study evaluated the prospective of optimized proniosomal gel to improve the clinical efficacy of lornoxicam and compare with oral therapy.

Methods: Proniosomes were formulated by coacervation phase separation technique using span 60, lecithin and cholesterol. Read More

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Development of novel pH-sensitive nanoparticles loaded hydrogel for transdermal drug delivery.

Drug Dev Ind Pharm 2019 Apr 28;45(4):629-641. Epub 2019 Jan 28.

a Department of Pharmacy , Quaid.i.Azam University , Islamabad , Pakistan.

Objective: Difference of pH that exists between the skin surface and blood circulation can be exploited for transdermal delivery of drug molecules by loading drug into pH-sensitive polymer. Eudragit S100 (ES100), a pH-sensitive polymer having dissolution profile above pH 7.4, is used in oral, ocular, vaginal and topical delivery of drug molecules. Read More

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[Optimization of Nasal Drug Absorption from Powder Formulations: The Feasibility of Controlling Drug Absorption by the Use of Pharmaceutical Excipients].

Akiko Tanaka

Yakugaku Zasshi 2018 ;138(12):1467-1472

Department of Biopharmaceutics, Kyoto Pharmaceutical University.

Nasal application of powder formulations has garnered attention because of its significant potential for systemic drug delivery. Because a powder drug must first diffuse from the formulation and dissolve in the nasal cavity fluid before transepithelial permeation, dissolution and diffusion are distinct but important factors for nasal drug absorption. Since the formulation is directly administered onto the nasal mucosal surface, the effect of excipients on drug absorption may be significant. Read More

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February 2019

Application of a Refined Developability Classification System.

J Pharm Sci 2019 03 30;108(3):1090-1100. Epub 2018 Oct 30.

Institute of Pharmaceutical Technology, Goethe University Frankfurt, Frankfurt am Main, Germany. Electronic address:

In 2010, the Developability Classification System was proposed as an extension of the Biopharmaceutics Classification System to align the classification system with the need for early evaluation of drug candidates according to their developability as oral formulations. Recent work on the Developability Classification System has resulted in the refined developability classification system (rDCS), consisting of standard investigations to estimate drug candidate solubility and permeability and offering customized investigations that are triggered when there is a potential for supersaturation/precipitation (e.g. Read More

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Pectin, beta-cyclodextrin, chitosan and albumin based gastroprotective systems for piroxicam maleate: Synthesis, characterization and biological evaluation.

Int J Biol Macromol 2019 Feb 16;122:127-136. Epub 2018 Oct 16.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Lucknow 226028, Uttar Pradesh, India.; Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy, Moga 142001, Punjab, India. Electronic address:

In order to optimize drug action, new drug formulations have been developed based upon the prodrug approach. This study was inspired by the increasing interest in the field of macromolecular prodrugs and Piroxicam maleate was used as a model drug. A total of five prodrugs were synthesized using beta cyclodextrin, chitosan, pectin, egg albumin, bovine serum albumin. Read More

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February 2019

Development of Biodegradable Injectable In situ Forming Implants for Sustained Release of Lornoxicam.

Curr Drug Deliv 2019 ;16(1):66-78

Department of Pharmaceutics, Anand Pharmacy College, Anand- 388 001, Gujarat, India.

Objective: The focus of this study was to develop in situ injectable implants of Lornoxicam which could provide sustained drug release.

Methods: Biodegradable in situ injectable implants were prepared by polymer precipitation method using polylactide-co-glycolide (PLGA). An optimized formulation was obtained on the basis of drug entrapment efficiency, gelling behavior and in vitro drug release. Read More

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Polysaccharides based gastroretentive system to sustain piroxicam release: Development and in vivo prolonged anti-inflammatory effect.

Int J Biol Macromol 2018 Dec 29;120(Pt B):2303-2312. Epub 2018 Aug 29.

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fisciano, (SA), Italy.

A gastro-retentive delivery system loaded with piroxicam with a bimodal release profile in gastrointestinal-tract was developed. Piroxicam is characterized by high oral absorption, long half-life, but its elimination is impaired in elderly patients. To overcome fluctuations in plasma levels, floating gastro-retentive gel-beads with sustained release properties were manufactured using prilling. Read More

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December 2018

Aspartame as a co-former in co-amorphous systems.

Int J Pharm 2018 Oct 31;549(1-2):380-387. Epub 2018 Jul 31.

Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.

Co-amorphous drug delivery systems are a promising approach to improve the dissolution rate and therefore potentially the oral bioavailability of poorly-water soluble drugs. Several low molecular weight excipients, for instance amino acids, have previously been shown to stabilize the amorphous form and increase the dissolution rate of drugs. In this study, the feasibility of aspartame, a methyl ester of the aspartic acid-phenylalanine dipeptide, as a co-former was investigated and compared with the respective single amino acids, both alone and in combination. Read More

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October 2018

UV-vis Imaging of Piroxicam Supersaturation, Precipitation, and Dissolution in a Flow-Through Setup.

Anal Chem 2018 06 18;90(11):6413-6418. Epub 2018 May 18.

Department of Pharmacy, Faculty of Health and Medical Sciences , University of Copenhagen , Universitetsparken 2 , DK-2100 Copenhagen Ø , Denmark.

Evaluation of drug precipitation is important in order to address challenges regarding low and variable bioavailability of poorly water-soluble drugs, to assess potential risk of patient safety with infusion therapy, and to explore injectable in situ suspension-forming drug delivery systems. Generally, drug precipitation is assessed in vitro through solution concentration analysis methods. Dual-wavelength UV-vis imaging is a novel imaging technique that may provide an opportunity for simultaneously monitoring changes in both solution and solid phases during precipitation. Read More

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Relating the tableting behavior of piroxicam polytypes to their crystal structures using energy-vector models.

Int J Pharm 2018 May 26;543(1-2):46-51. Epub 2018 Mar 26.

Department of Pharmacy, University of Copenhagen, 2100 Copenhagen Ø, Denmark; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. Electronic address:

Piroxicam crystallises into two polytypes, α and α with crystal structures that contain identical molecular layers but differ in the way that these layers are stacked. In spite of having close structural similarity, the polytypes have significantly different powder tabletting behaviour: α forms only weak tablets at low pressures accompanied by extensive capping and lamination, which make it impossible to form intact tablets above 100 MPa, while α exhibits superior tabletability over the investigated pressure range (up to 140 MPa). The potential structural origin of the different behaviour is sought using energy-vector models, produced from pairwise intermolecular interaction energies calculated using the PIXEL method. Read More

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Triple-component nanocomposite films prepared using a casting method: Its potential in drug delivery.

J Food Drug Anal 2018 04 21;26(2):887-902. Epub 2017 Mar 21.

Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan. Electronic address:

The purpose of this study was to fabricate a triple-component nanocomposite system consisting of chitosan, polyethylene glycol (PEG), and drug for assessing the application of chitosan-PEG nanocomposites in drug delivery and also to assess the effect of different molecular weights of PEG on nanocomposite characteristics. The casting/solvent evaporation method was used to prepare chitosan-PEG nanocomposite films incorporating piroxicam-β-cyclodextrin. In order to characterize the morphology and structure of nanocomposites, X-ray diffraction technique, scanning electron microscopy, thermogravimetric analysis, and Fourier transmission infrared spectroscopy were used. Read More

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