152 results match your criteria forms gabapentin

A Comprehensive Enhanced Recovery Pathway for Rotator Cuff Surgery Reduces Pain, Opioid Use, and Side Effects.

Clin Orthop Relat Res 2021 08;479(8):1740-1751

Department of Orthopedic Surgery, Sport Medicine, Hospital for Special Surgery, New York, NY, USA.

Background: Patients often have moderate to severe pain after rotator cuff surgery, despite receiving analgesics and nerve blocks. There are many suggested ways to improve pain after rotator cuff surgery, but the effects of adopting a pathway that includes formal patient education, a long-acting nerve block, and extensive multimodal analgesia are unclear.

Questions/purposes: (1) Does adoption of a clinical pathway incorporating patient education, a long-acting nerve block, and preemptive multimodal analgesia reduce the worst pain during the first 48 hours after surgery compared with current standard institutional practices? (2) Does adoption of the pathway reduce opioid use? (3) Does adoption of the pathway reduce side effects and improve patient-oriented outcomes?

Methods: From September 2018 to January 2020, 281 patients scheduled for arthroscopic ambulatory rotator cuff surgery were identified for this paired sequential prospective cohort study. Read More

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Gabapentinoid Abuse in France: Evidence on Health Consequences and New Points of Vigilance.

Front Psychiatry 2021 3;12:639780. Epub 2021 Feb 3.

Centre d'Evaluation et Information sur la Pharmacodépendance-Addictovigilance, Service de Pharmacologie Médicale et Clinique, CHU de Toulouse, Toulouse, France.

Gabapentinoid drugs (gabapentin and pregabalin) are widely used worldwide for epileptic and pain disorders. First signals of gabapentinoid abuse occurred in the last decade. This study aims to describe clinical characteristics of gabapentinoid use related disorders and health consequences in France. Read More

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February 2021

Cost-effectiveness of alcohol use treatments in patients with alcohol-related cirrhosis.

J Hepatol 2021 Jun 14;74(6):1286-1294. Epub 2020 Dec 14.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Background & Aims: Alcohol use treatment such as medication-assisted therapies (MATs) and counseling are available and effective in promoting alcohol abstinence. We sought to explore the cost-effectiveness of different alcohol use treatments among patients with compensated alcohol-related cirrhosis (AC).

Methods: We simulated a cohort of patients with compensated AC receiving care from a hepatology clinic over their lifetimes. Read More

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Gabapentin-induced myositis in a patient with spinal cord injury - a case report.

Qatar Med J 2020 9;2020(2):30. Epub 2020 Nov 9.

Physical Medicine and Rehabilitation Department, Qatar Rehabilitation Institute, Hamad Medical Corporation, Doha, Qatar.

Myositis and rhabdomyolysis are the same forms of myopathy, with rhabdomyolysis being a more severe form of myopathy. Gabapentin is frequently used in patients with spinal cord injury for neuropathic pain. We report a case of probable gabapentin-induced myositis in a patient with spinal cord injury who was on an increasing dose of gabapentin. Read More

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November 2020

Chronic Pain Treatment Strategies in Parkinson's Disease.

Neurol Int 2020 Nov 18;12(3):61-76. Epub 2020 Nov 18.

Department of Anesthesiology, Louisiana State University Shreveport, Shreveport, LA 71103, USA.

Neurological disorders, including Parkinson's disease (PD), have increased in prevalence and are expected to further increase in the coming decades. In this regard, PD affects around 3% of the population by age 65 and up to 5% of people over the age of 85. PD is a widely described, physically and mentally disabling neurodegenerative disorder. Read More

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November 2020

Pharmacological Management of Painful Peripheral Neuropathies: A Systematic Review.

Pain Ther 2021 Jun 3;10(1):55-68. Epub 2020 Nov 3.

Medical School, University of Cyprus, Nicosia, Cyprus.

Introduction: Peripheral neuropathic pain (PNP) arises either acutely or in the chronic phase of a lesion or disease of the peripheral nervous system and is associated with a notable disease burden. The management of PNP is often challenging. The aim of this systematic review was to evaluate current evidence, derived from randomized controlled trials (RCTs) that have assessed pharmacological interventions for the treatment of PNP due to polyneuropathy (PN). Read More

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US FDA-validated green GC-MS method for analysis of gabapentin, tramadol and/or amitriptyline mixtures in biological fluids.

Bioanalysis 2020 Nov 29;12(21):1521-1533. Epub 2020 Oct 29.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St., 62514, Beni-Suef, Egypt.

Mixtures of gabapentin, tramadol and/or amitriptyline are usually recommended for treatment of neuropathic pain. A novel GC-MS/MS method was developed to assess the studied mixture whether in pure forms or human biological fluids (plasma/urine). The chromatographic detection was performed using MS detector applying the selected ion-monitoring mode. Read More

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November 2020

Neuronal Adenylyl Cyclase Targeting Central Plasticity for the Treatment of Chronic Pain.

Neurotherapeutics 2020 07 15;17(3):861-873. Epub 2020 Sep 15.

Institute of Brain Research, Qingdao International Academician Park, Qingdao, Shandong, China.

Chronic pain is a major health problem and the effective treatment for chronic pain is still lacking. The recent crisis created by the overuse of opioids for pain treatment has clearly shown the need for non-addictive novel pain medicine. Conventional pain medicines usually inhibit peripheral nociceptive transmission and reduce central transmission, especially pain-related excitatory transmission. Read More

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Putative roles of SLC7A5 (LAT1) transporter in pain.

Neurobiol Pain 2020 Aug-Dec;8:100050. Epub 2020 Jun 30.

Department of Pharmacology, University of Arizona, United States.

Large amino acid transporter 1 (LAT1), also known as SLC7A5, is an essential amino acid transporter that forms a heterodimeric complex with the glycoprotein cell-surface antigen heavy chain (4F2hc (CD98, SLC3A2)). Within nociceptive pathways, LAT1 is expressed in the dorsal root ganglia and spinal cord. Although LAT1 expression is upregulated following spinal cord injury, little is known about LAT1 in neuropathic pain. Read More

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Effectiveness of pregabalin as a secondary treatment for neuropathic pain from postherpetic neuralgia.

Proc (Bayl Univ Med Cent) 2020 Jul 29;33(3):469-470. Epub 2020 May 29.

Department of Medical Education, Texas Tech University Health Sciences CenterLubbockTexas.

Herpes zoster or shingles causes a severe painful rash that spreads along dermatomes in the face or chest wall, which leads to a condition known as postherpetic neuralgia (PHN). There is no cure for PHN, but there are many treatments to reduce pain duration and severity. In this case report, we describe a patient treated for PHN using pregabalin (Lyrica) after failure with gabapentin. Read More

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Pregabalin and gabapentin for pain.

BMJ 2020 Apr 28;369:m1315. Epub 2020 Apr 28.

James Cook University Hospital, Middlesbrough, UK.

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Misuse of prescription medicines is as prevalent as the use of recreational drugs and novel psychoactive substances in Singapore: an unrecognised public health issue?

Singapore Med J 2020 Mar 17. Epub 2020 Mar 17.

Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, St Thomas' Hospital, London, UK.

Introduction: Misuse of prescription medicines and the harms associated with such use are growing threats across the world. There is currently, however, limited data on the extent of prescription medicine misuse in Singapore and whether this is a current threat in the country.

Methods: An online survey, limited to 1,000 individuals (aged 21 years and over) who were residents in Singapore, was administered through a survey panel company in September 2015. Read More

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Theoretical mechanistic insight into the gabapentin lactamization by an intramolecular attack: Degradation model and stabilization factors.

J Pharm Biomed Anal 2020 Jan 30;178:112900. Epub 2019 Sep 30.

Nano Science and Technology Research Center, Razi University, Kermanshah, Iran; Department of Organic Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.

Purpose: Gabapentin is degraded directly into a high toxicity form known as gabapentin lactam (gaba-L) with a maximizing desire in mild pH and low humidity. This study reports the lactamization process of gabapentin, along with a detailed analysis of the energy landscape, geometry, and thermodynamic and kinetic preference of the process. To investigate the effect of the acidic/basic conditions on the energy landscape, the energy profiles were investigated for both protonation and deprotonation forms of gabapentin. Read More

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January 2020

A rare complication of knee hematoma after genicular nerve radiofrequency ablation.

Pain Rep 2019 May-Jun;4(3):e736. Epub 2019 Apr 5.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Background: Genicular nerve radiofrequency ablation (RFA) is an intervention to treat patients with chronic knee pain who have failed previous conservative, pharmacologic, and surgical interventions. Vascular complications following interventional procedures of the knee are extremely rare. A delay in diagnosis may be detrimental for the viability of the affected limb and may ultimately require amputation. Read More

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Suprachoroideal haemorrhage in postoperative period of antiglaucoma surgery, case report.

Cesk Slov Oftalmol 2019 ;75(2):92-98

Suprachoroidal haemorrhage (SCH) is a serious complication of intraocular procedures. Physiologically there is only a minimal amount of fluid in the suprachoroid space, pathologically the fluid volume increases, which causes ablation of the choroid. SCH could be divided into different cathegories, according to the character of the fluid into serous and haemorrhagic; by the time of occurrence in relation to the surgery into peroperative and postoperative. Read More

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November 2019

Plasticity in zwitterionic drugs: the bending properties of Pregabalin and Gabapentin and their hydrates.

IUCrJ 2019 Jul 22;6(Pt 4):630-634. Epub 2019 May 22.

Synthesis and Solid State Pharmaceutical Centre (SSPC), University of Limerick, Limerick, Ireland.

The investigation of mechanical properties in molecular crystals is emerging as a novel area of interest in crystal engineering. Indeed, good mechanical properties are required to manufacture pharmaceutical and technologically relevant substances into usable products. In such endeavour, bendable single crystals help to correlate microscopic structure to macroscopic properties for potential design. Read More

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Use of Gabapentin in the Treatment of Substance Use and Psychiatric Disorders: A Systematic Review.

Front Psychiatry 2019 7;10:228. Epub 2019 May 7.

Department of Psychiatry, Interfaith Medical Center, Brooklyn, NY, United States.

Gabapentin (GBP) is an anticonvulsant medication that is also used to treat restless legs syndrome (RLS) and posttherapeutic neuralgia. GBP is commonly prescribed off-label for psychiatric disorders despite the lack of strong evidence. However, there is growing evidence that GBP may be effective and clinically beneficial in both psychiatric disorders and substance use disorders. Read More

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Evidence of human-like Ca channels and effects of Ca channel blockers in Acanthamoeba castellanii.

Chem Biol Drug Des 2019 03 29;93(3):351-363. Epub 2019 Jan 29.

The Aga Khan University, Karachi, Pakistan.

The evolution of voltage-gated calcium channel (Cav) in eukaryotes is an area of interest for biologists worldwide. The CLAN CL0030 and its family Ion_Trans 2 PF 07885 have been known to be present in prokaryotes, but the origin of these ion channels in Acanthamoeba spp. is yet to be determined. Read More

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Beyond Estrogen: Treatment Options for Hot Flashes.

Clin Ther 2018 10 12;40(10):1778-1786. Epub 2018 Sep 12.

Department of Internal Medicine, Alpert Medical School at Brown University, Providence, Rhode Island.

Nonhormonal medications and complementary and alternative therapies are used by many women seeking relief from bothersome hot flashes. However, health care professionals may be less familiar with these treatment modalities. Although estrogen remains the most effective medication to reduce hot flashes, its potential harmful effects have led investigators to examine other treatments for hot flashes, and many women seek alternative forms of relief. Read More

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October 2018

Development of spectrofluorimetric method for determination of certain antiepileptic drugs through condensation with ninhydrin and phenyl acetaldehyde.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 7;204:48-54. Epub 2018 Jun 7.

Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.

A new and simple spectrofluorimetric method was developed and validated for determination of gabapentin and pregabalin in their pure forms and pharmaceutical formulations with high sensitivity and selectivity. The proposed method was based on the formation of fluorescent products as a result of condensation reaction of investigated drugs with ninhydrin and phenyl acetaldehyde in Teorell and Stenhagen buffer medium. The fluorescent products had emission maxima at 470 nm after excitation at 375 nm. Read More

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November 2018

The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions.

Cell Rep 2018 02;22(9):2307-2321

Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

α2δ-1, commonly known as a voltage-activated Ca channel subunit, is a binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it is unclear how α2δ-1 contributes to neuropathic pain and gabapentinoid actions. Here, we show that Cacna2d1 overexpression potentiates presynaptic and postsynaptic NMDAR activity of spinal dorsal horn neurons to cause pain hypersensitivity. Read More

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February 2018

Low doses of amitriptyline, pregabalin, and gabapentin are preferred for management of neuropathic pain in India: is there a need for revisiting dosing recommendations?

Korean J Pain 2017 Jul 30;30(3):183-191. Epub 2017 Jun 30.

Medical Affairs Department, Wockhardt Limited, Wockhardt Towers, Bandra Kurla Complex, Mumbai, India.

Background: Current therapy for the treatment of neuropathic pain is often unsatisfactory. Considerable variation in treatment pattern still exists in spite of availability of sufficient literature from various guidelines. Recent Indian market data suggested that the utilization (sale) of drugs such as amitriptyline, pregabalin, and gabapentin was more for low-dose unit packs than that of the high-dose unit packs, raising the belief that these drugs are prescribed at a lower dose than is actually recommended in the guidelines. Read More

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Advances in the management of diabetic neuropathy.

Minerva Med 2017 Oct 25;108(5):419-437. Epub 2017 May 25.

First Department of Medicine, Semmelweis University, Budapest, Hungary.

The authors review current advances in the therapy of diabetic neuropathy. The role of glycemic control and management of cardiovascular risk factors in the prevention and treatment of neuropathic complications are discussed. As further options of pathogenetically oriented treatment, recent knowledge on benfotiamine and alpha-lipoic acid is comprehensively reviewed. Read More

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October 2017

Stacking-cyclodextrin-microchip electrokinetic chromatographic determination of gabapentinoid drugs in pharmaceutical and biological matrices.

J Chromatogr A 2017 Jun 26;1503:65-75. Epub 2017 Apr 26.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

A facile, rapid, and highly sensitive microchip-based electrokinetic chromatographic method was developed for the simultaneous analysis of two gabapentinoid drugs, gabapentin (GPN) and pregabalin (PGN). Both drugs were first reacted with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) via nucleophilic substitution reactions to yield highly fluorescent products with λ 470/540nm. Analyses of both fluorescently labeled compounds were achieved within 200s in a poly(methyl methacrylate) (PMMA) microchip with a 30mm separation channel. Read More

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Efficacy of Transversus Abdominis Plane Steroid Injection for Treating Chronic Abdominal Pain.

Pain Pract 2018 01 5;18(1):48-52. Epub 2017 May 5.

Medical School, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.

Background: Historically, transversus abdominis plane (TAP) block has been performed to treat acute abdominal pain that accompanies a variety of surgical procedures. This study represents an innovative approach in which the TAP block was performed on patients experiencing chronic abdominal pain who had failed other forms of pain management.

Objective: To evaluate the efficacy of the TAP block procedure in patients experiencing chronic abdominal pain. Read More

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January 2018

Gabapentinoids for chronic low back pain: a protocol for systematic review and meta-analysis of randomised controlled trials.

BMJ Open 2016 11 10;6(11):e013200. Epub 2016 Nov 10.

Department of Anesthesiology, McMaster University, Michael DeGroote School of Medicine, Hamilton, Ontario, Canada.

Introduction: Chronic low back pain (CLBP) is a common condition and causes significant pain, distress and disability across the world. It is multifactorial in aetiology and is challenging to manage. Although the underlying mechanism of pain is predominantly non-specific, many argue that there is a substantial neuropathic pain element. Read More

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November 2016

Neuropathic Pain.

Semin Neurol 2016 Oct 23;36(5):462-468. Epub 2016 Sep 23.

Division of Neurological Pain Research and Therapy, Department of Neurology, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.

Diagnosing neuropathic pain and distinguishing it from nociceptive pain can be challenging, but is essential because both forms of pain require different treatment strategies. The diagnosis of neuropathic pain is primarily based on clinical findings. Therefore, a careful, focused history and an examination of the signs characteristic of neuropathic pain are crucial. Read More

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October 2016

Gabapentin and pregabalin for the treatment of chronic pruritus.

J Am Acad Dermatol 2016 Sep 17;75(3):619-625.e6. Epub 2016 May 17.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Chronic pruritus is a distressing symptom that is often refractory to treatment. Patients frequently fail topical therapies and oral over-the-counter antihistamines, prompting the clinician to consider alternative therapies such as neuroactive agents. Herein, the use of gabapentin and pregabalin, 2 medications well known for treating neuropathic pain and epilepsy that are occasionally used for relieving chronic pruritus is explored. Read More

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September 2016

Ice Pick Headache.

Curr Pain Headache Rep 2016 May;20(5):30

Jefferson Headache Center, 900 Walnut St. Suite 200, Philadelphia, PA, 19107, USA.

Ice pick headache, also called idiopathic or primary stabbing headache, is a unique headache type associated with ultra-brief stabs of pain, most commonly in the frontal or temporal area. It occurs predominantly in women and is estimated to affect 2-35% of the population. Unlike other headache types of short duration, such as short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT), ice pick headache is not associated with any cranial autonomic symptoms but has been known to occur with nausea, vomiting, photophobia, and dizziness. Read More

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