1,497 results match your criteria forms covid-19


Therapeutic Nuclear Magnetic Resonance affects the core clock mechanism and associated Hypoxia-inducible factor-1.

Chronobiol Int 2021 Apr 13:1-15. Epub 2021 Apr 13.

Institute of Zoology, University Innsbruck, Innsbruck, Austria.

The influence of low intensity electromagnetic fields on circadian clocks of cells and tissues has gained increasing scientific interest, either as a therapeutic tool or as a potential environmental hazard. Nuclear Magnetic Resonance (NMR) refers to the property of certain atomic nuclei to absorb the energy of radio waves under a corresponding magnetic field. NMR forms the basis for Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy and, in a low-intensity form, for NMR therapy (tNMR). Read More

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A systematic review of health sector responses to the coincidence of disasters and COVID-19.

BMC Public Health 2021 Apr 13;21(1):709. Epub 2021 Apr 13.

Workplace Health Promotion Research Center, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: In December 2019, the Chinese city of Wuhan reported a novel pneumonia caused by COVID-19. While the COVID-19 pandemic has been increasingly affecting the world, the occurrence of disasters resulted in complex emergencies. The present review is aimed to identify the literature focused on health system response to coincidence of COVID-19 and disasters as well as describing their finding, implications and lessons-learned. Read More

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Exploring the Allosteric Territory of Protein Function.

J Phys Chem B 2021 Apr 12. Epub 2021 Apr 12.

Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01, Matrix, 138671, Singapore.

While the pervasiveness of allostery in proteins is commonly accepted, we further show the generic nature of allosteric mechanisms by analyzing here transmembrane ion-channel viroporin 3a and RNA-dependent RNA polymerase (RdRp) from SARS-CoV-2 along with metabolic enzymes isocitrate dehydrogenase 1 (IDH1) and fumarate hydratase (FH) implicated in cancers. Using the previously developed structure-based statistical mechanical model of allostery (SBSMMA), we share our experience in analyzing the allosteric signaling, predicting latent allosteric sites, inducing and tuning targeted allosteric response, and exploring the allosteric effects of mutations. This, yet incomplete list of phenomenology, forms a complex and unique allosteric territory of protein function, which should be thoroughly explored. Read More

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Media Use Among Kindergarteners From Low-Income Households During the COVID-19 Shutdown.

J Dev Behav Pediatr 2021 Apr 7. Epub 2021 Apr 7.

Crane Center for Early Childhood Research and Policy, The Ohio State University, Columbus, OH.

Objective: This study examines the media use of children from low-income homes during school closings during the COVID-19 pandemic.

Methods: Caregivers of 151 kindergarteners from low-income homes completed questionnaires as part of a larger study. Caregivers reported how much time children spent watching television/videos and using apps on the most recent weekday and weekend days. Read More

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COVID-19 as Eco-Pandemic Injustice: Opportunities for Collective and Antiracist Approaches to Environmental Health.

J Health Soc Behav 2021 Apr 12:221465211005704. Epub 2021 Apr 12.

Northeastern University, Boston, MA, USA.

The COVID-19 pandemic has coincided with a powerful upsurge in antiracist activism in the United States, linking many forms and consequences of racism to public and environmental health. This commentary develops the concept of to explain interrelationships between the pandemic and socioecological systems, demonstrating how COVID-19 both reveals and deepens structural inequalities that form along lines of environmental health. Using Pellow's critical environmental justice theory, we examine how the crisis has made more visible and exacerbated links between racism, poverty, and health while providing opportunities to enact change through . Read More

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Binding ability of arginine, citrulline, -acetyl citrulline and thiocitrulline with SARS COV-2 main protease using molecular docking studies.

Netw Model Anal Health Inform Bioinform 2021 6;10(1):28. Epub 2021 Apr 6.

Department of Studies and Research in Chemistry, University College of Science, Tumkur University, Tumkur, 572 103 India.

In this article, the binding abilities of arginine, citrulline, -acetyl citrulline and thiocitrulline on the active sites of SARS-COV-2 protease have been investigated using in-silico studies. All the above ligands bind selectively and preferentially to Cys-145 active site and also to other amino acids surrounding to it in the main protease. Of which arginine forms less number of weaker bonds compared to the other ligands, it by itself is a precursor for the formation of citrulline analogues with in the cell. Read More

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The COVID-19 hydroxychloroquine prophylaxis perception of Indian anesthesiologists: A survey-based original article.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):471-476. Epub 2020 Nov 5.

Department of Anaesthesiology, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, New Delhi, India.

Background And Aims: HCQ gained importance following the National Task Force advisory as an anti-SARS-Cov-2 (coronavirus disease-2019 [COVID-19]) drug for frontline healthcare workers (including anesthesiologists). Report of a young anesthesiologist in Assam developing cardiac arrest following HCQ intake for COVID-19 prophylaxis made us even more concerned. A conscious decision has been made by a large majority among us--to have or not to have HCQ. Read More

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November 2020

Systemic manifestations of COVID-19.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):435-442. Epub 2020 Oct 26.

Department of Neurology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Coronavirus disease 2019 (COVID-19), caused due to a novel coronavirus SARS-CoV-2, has swept across the planet and has become a public health emergency of international concern. Like other coronaviruses, it predominantly involves the respiratory system. However, several atypical manifestations of the disease have been reported worldwide in a short span of time. Read More

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October 2020

Lung ultrasonography for long-term follow-up of COVID-19 survivors compared to chest CT scan.

Respir Med 2021 Mar 31;181:106384. Epub 2021 Mar 31.

Cardio Thoracic and Vascular Department, University Hospital Policlinico of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy.

Background: While lung ultrasonography (LUS) has utility for the evaluation of the acute phase of COVID-19 related lung disease, its role in long-term follow-up of this condition has not been well described. The objective of this study is to compare LUS and chest computed tomography (CT) results in COVID-19 survivors with the intent of defining the utility of LUS for long-term follow-up of COVID-19 respiratory disease.

Methods: Prospective observational study that enrolled consecutive survivors of COVID-19 with acute hypoxemic respiratory failure (HARF) admitted to the Respiratory Intensive Care Unit. Read More

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Planetary healthy publics after COVID-19.

Lancet Planet Health 2021 Apr;5(4):e230-e236

College of Humanities, University of Exeter, Exeter, UK; Wellcome Centre for Cultures and Environments of Health, University of Exeter, Exeter, UK.

COVID-19 is a sign of a global malaise. The pandemic is an outcome of what we term a planetary dysbiosis, for which underlining drivers include inequality and the exploitation and extraction of human and non-human labours. The implication is that the usual fixes to outbreaks of infectious diseases (ie, surveillance, pharmaceutical measures, and non-pharmaceutical measures) will be insufficient without a thorough reappraisal of and investment in planetary health. Read More

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Silencing of SARS-CoV-2 with modified siRNA-peptide dendrimer formulation.

Allergy 2021 Apr 10. Epub 2021 Apr 10.

Federal Medico-biological Agency of Russia.

Background: First vaccines for prevention of Coronavirus disease 2019 (COVID-19) are becoming available but there is a huge and unmet need for specific forms of treatment. In this study we aimed to evaluate the anti-SARS-CoV-2 effect of siRNA both in vitro and in vivo.

Methods: To identify the mosteffective molecule out of a panel of 15 in silico designed siRNAs, an in vitro screening system based on vectors expressing SARS-CoV-2 genes fused with the firefly luciferase reporter gene and SARS-CoV-2-infected cells was used. Read More

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[Covid-19 in kidney transplantation: Lessons from the French Registry].

Nephrol Ther 2021 Mar 18. Epub 2021 Mar 18.

Service de néphrologie et transplantation, Centre hospitalier universitaire de Lille, Lille, France.

The Covid-19 pandemic hits the French transplant population on March 3, 2020. Very quickly, a French registry was set up on behalf of the French Society of Transplantation allowing the collection of confirmed cases of Covid-19 occurring in kidney transplant recipients in almost all French centers. The analysis of this registry in conjunction with the data from the Agence de la Biomédecine (Cristal) has enabled us to obtain instructive results. Read More

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Clinical vulnerability for severity and mortality by COVID-19 among users of alcohol and other substances.

Psychiatry Res 2021 Mar 31;300:113915. Epub 2021 Mar 31.

Center for Drug and Alcohol Research and Collaborating Center on Alcohol and Drugs, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

The COVID-19 pandemic is a public health emergency. Individuals with substance use disorder have a higher risk of infection and may suffer from more severe forms of the disease. Our goal is to investigate the prevalence of risk factors for COVID-19 severity in individuals with different substance use and explore whether specific types of substance are potentially associated with more clinical risk factors which could increase morbimortality in this population. Read More

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Particulate generation with different oxygen delivery devices.

Respir Med 2021 Apr 2;181:106386. Epub 2021 Apr 2.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Jacksonville, FL, USA.

Background: The Coronavirus pandemic has a high mortality rate in patients that are mechanically ventilated, which has led to an ever increasing interest in noninvasive forms of oxygenation. The use of these devices has the theoretical risk of increased exposure risk because of possible particulate generation. This study aimed to quantify the particulate generation associated with different oxygen devices. Read More

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Approaches to understanding COVID-19 and its neurological associations.

Ann Neurol 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurology, Center for Global Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

There is an accumulating volume of research into neurological manifestations of COVID-19. However, inconsistent study designs, inadequate controls, poorly-validated tests, and differing settings, interventions, and cultural norms weaken study quality, comparability, and thus the understanding of the spectrum, burden and pathophysiology of these complications. Therefore, a global COVID-19 Neuro Research Coalition, together with the WHO, has reviewed reports of COVID-19 neurological complications and harmonised clinical measures for future research. Read More

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[Involvement of the complement cascade in severe forms of COVID-19].

Med Sci (Paris) 2021 Apr 9. Epub 2021 Apr 9.

Innate Pharma, 117 avenue de Luminy, BP 30191, 13276 Marseille Cedex 9, France - Aix Marseille Université, CNRS, Inserm, CIML, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France - Assistance Publique des Hôpitaux de Marseille, Marseille Immunopole, Hôpital de la Timone, 264 rue Saint Pierre, 13385 Marseille Cedex 5, France.

The complement system is an essential component of the innate immune system. Its excessive activation during COVID-19 contributes to cytokine storm, disease-specific endothelial inflammation (endotheliitis) and thrombosis that comes with the disease. Targeted therapies of complement inhibition in COVID-19, in particular blocking the C5a-C5aR1 axis have to be taken into account in the establishment of potential biomarkers and development of therapeutic strategies in the most severe forms of the disease. Read More

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COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms.

Front Pharmacol 2021 23;12:633680. Epub 2021 Mar 23.

MIT Lincoln Laboratory, Lexington, MA, United States.

SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. SARS-CoV-2 infection is necessary but not sufficient for development of clinical COVID-19 disease. Currently, there are no approved pre- or post-exposure prophylactic COVID-19 medical countermeasures. Read More

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Anti-Inflammatory and Antiviral Osmotic Polymeric Film to Treat Covid-19 Early-Stage Infection.

J Inflamm Res 2021 30;14:1195-1206. Epub 2021 Mar 30.

Laboratoire SANABEL, Paris, 75011, France.

Background: Covid-19 infection starts in the nasal cavity when viral S1 and RBD proteins bind to the host cell ACE2 receptors, the virus multiplies, causes cell lysis, and enters the circulation. This triggers a strong cytokine release and inflammation of the nasal mucosa. A multitarget approach of cleaning the nasal mucosa and suppressing chances of nasal and systemic inflammation should minimize severe respiratory consequences. Read More

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