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Oral ferroportin inhibitor vamifeport for improving iron homeostasis and erythropoiesis in β-thalassemia: current evidence and future clinical development.

Expert Rev Hematol 2021 Jul 29:1-12. Epub 2021 Jul 29.

Professor of Internal Medicine, Department of Clinical Sciences and Community, University of Milan, Milan, Italy.

Introduction: In β-thalassemia, imbalanced globin synthesis causes reduced red blood cell survival and ineffective erythropoiesis. Suppressed hepcidin levels increase ferroportin-mediated iron transport in enterocytes, causing increased iron absorption and potentially iron overload. Low hepcidin also stimulates ferroportin-mediated iron release from macrophages, increasing transferrin saturation (TSAT), potentially forming non-transferrin-bound iron, which can be toxic. Read More

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An MSN-based synergistic nanoplatform for root canal biofilm eradication Fenton-enhanced sonodynamic therapy.

J Mater Chem B 2021 Jul 29. Epub 2021 Jul 29.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedical Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.

The validity and biocompatibility of irrigating agents are imperative for the success of root canal therapy. The imperfections in the currently available irrigants highlight the fact that more advanced technologies and strategies are required for complete disinfection in endodontic treatments. In the present study, a Fenton reaction-enhanced antimicrobial sonodynamic therapy (SDT) platform was fabricated for root canal disinfection. Read More

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Functional and mutational analysis after radiation and cetuximab treatment on prostate carcinoma cell line DU145.

Radiat Oncol 2021 Jul 28;16(1):137. Epub 2021 Jul 28.

Department of Urology, Otto-von-Guericke-University Magdeburg, University Hospital, Magdeburg, Germany.

Background: Epidermal Growth Factor Receptor is often overexpressed in advanced prostate carcinoma. In-vitro-studies in prostate carcinoma cell line DU145 have demonstrated increased sensibility to radiation after cetuximab treatment, but clinical data are not sufficient to date.

Methods: We analyzed effects of radiation and cetuximab in DU145 and A431 using proliferation, colony-forming-unit- and annexin-V-apoptosis-assays. Read More

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A novel gain-of-function sodium channel β2 subunit mutation in idiopathic small fiber neuropathy.

J Neurophysiol 2021 07 28. Epub 2021 Jul 28.

Department of Neurology, Yale University School of Medicine, New Haven, CT, United States.

Small fiber neuropathy (SFN) is a common condition affecting thinly myelinated Aδ and unmyelinated C fibers, often resulting in excruciating pain and dysautonomia. SFN has been associated with several conditions, but a significant number of cases have no discernible cause. Recent genetic studies have identified potentially pathogenic gain-of-function mutations in several the pore-forming voltage-gated sodium channel α subunits (Nas) in a subset of patients with SFN, but the auxiliary sodium channel β subunits have been less implicated in the development of the disease. Read More

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Effects of curcumin-mediated antimicrobial photodynamic therapy associated to different chelators against Enterococcus faecalis biofilms.

Photodiagnosis Photodyn Ther 2021 Jul 25:102464. Epub 2021 Jul 25.

Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo. Electronic address:

Background: The aim of this study was to evaluate the curcumin-mediated antimicrobial photodynamic therapy (aPDT) action combined or not with ethylenediaminetetraacetic acid (EDTA) and hydroxyethylidene bisphosphonate (HEBP) on Enterococcus faecalis biofilms.

Methods: Enterococcus faecalis biofilms were grown on dentin bovine discs in brain heart infusion (BHI) medium with 1% glucose, in aerobic conditions at 37°C for 7 days. Then, they were randomly distributed to one of experimental conditions, as follows: control, 75 J. Read More

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Exercise Training Improves Functions of Endothelial Progenitor Cells in Patients with Metabolic Syndrome.

Arq Bras Cardiol 2021 Jul;117(1):108-117

Qinhuangdao First Hospital,Qinhuangdao - China.

Background: Endothelial progenitor cells (EPCs) play an important role in maintaining endothelial function. Metabolic syndrome (MetS) is associated with EPC dysfunction. Although physical exercise has a beneficial impact on EPC activity, its mechanism is not completely clear yet. Read More

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A Wearable Ultrasonic Neurostimulator Part I: a 1D CMUT Phased Array System for Chronic Implantation in Small Animals.

IEEE Trans Biomed Circuits Syst 2021 Jul 27;PP. Epub 2021 Jul 27.

In this work, we present a wireless ultrasonic neurostimulator, aiming at a truly wearable device for brain stimulation in small behaving animals. A 1D 5-MHz capacitive micromachined ultrasonic transducer (CMUT) array is adopted to implement a head-mounted stimulation device. A companion ASIC with integrated 16-channel high-voltage (60 V) pulsers was designed to drive the 16-element CMUT array. Read More

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Effect of substitution on the superconducting phase of transition metal dichalcogenide Nb(Se[Formula: see text]S[Formula: see text])[Formula: see text] van der Waals layered structure.

Sci Rep 2021 Jul 26;11(1):15215. Epub 2021 Jul 26.

Extreme Conditions Physics Research Laboratory (ECPRL) and Physics of Energy Materials Research Unit, Department of Physics, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

By means of first-principles cluster expansion, anisotropic superconductivity in the transition metal dichalcogenide Nb(Se[Formula: see text]S[Formula: see text])[Formula: see text] forming a van der Waals (vdW) layered structure is observed theoretically. We show that the Nb(Se[Formula: see text]S[Formula: see text])[Formula: see text] vdW-layered structure exhibits minimum ground-state energy. The Pnnm structure is more thermodynamically stable when compared to the 2H-NbSe[Formula: see text] and 2H-NbS[Formula: see text] structures. Read More

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Clostridium culturomicium sp. nov. and Clostridium jeddahitimonense sp. nov., novel members of the Clostridium genus isolated from the stool of an obese Saudi Arabian.

Curr Microbiol 2021 Jul 23. Epub 2021 Jul 23.

Aix Marseille University, RD, AP-HM, MEPHI, Marseille, France.

Taxono-genomics is an innovative concept coined for the description of new bacterial species. Phenotypic characteristics were combined with a genomic approach to describe two new species within the Clostridium senso stricto genus: Clostridium culturomicium strain CL-6 and Clostridium jeddahitimonense strain CL-2, both isolated from the gut microbiota of an obese man from Saudi Arabia. Strains CL-6 and CL-2 shared a similarity of 98. Read More

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Volatile phenolics: A comprehensive review of the anti-infective properties of an important class of essential oil constituents.

Phytochemistry 2021 Jul 23;190:112864. Epub 2021 Jul 23.

Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa; SAMRC Herbal Drugs Research Unit, Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa. Electronic address:

Historically, essential oils and their lead molecules have been extensively recognised for their anti-infective properties. In this context, certain volatile phenolics (VPs) have emerged as important antimicrobial compounds with excellent inhibitory activity against pathogenic bacteria and fungi, which further extends to drug-resistant and biofilm-forming micro-organisms. In this review, we aim to collate and discuss a number of published papers on the anti-infective activities of naturally occurring VPs with special emphasis on eugenol, isoeugenol, thymol and carvacrol, using Scopus Web of Science and PubMed databases. Read More

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The Impact of COVID-19 on Hand Trauma.

Hand (N Y) 2021 Jul 26:15589447211028918. Epub 2021 Jul 26.

Australian Research Collaboration on the Hand, Mudgeeraba, QLD, Australia.

Background: The Coronavirus Disease 2019 (COVID-19) pandemic has had a dramatic impact on individual and societal behaviors, as well as on health care systems. It confers a unique opportunity to examine the relationship among disease, policies, and patterns of activity, as well as their impacts on surgical unit functionality. This study aims to compare the distribution and patterns of injury at a tertiary hand surgery trauma center before and during the COVID-19 pandemic. Read More

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[Research progress on mechanism of myokines regulating bone tissue cells].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul;35(7):923-929

Department of Orthopedics and Traumatology, Wuxi Affiliated Hospital, Nanjing University of Traditional Chinese Medicine, Wuxi Jiangsu, 214071, P.R.China.

Objective: To review the effects and mechanisms of various myokines secreted by skeletal muscle on various bone tissue cells.

Methods: Literature related to myokines and their regulation of bone tissue cells was reviewed and analyzed comprehensively in recent years.

Results: Bone and skeletal muscle are important members of the motor system, and they are closely related in anatomy, genetics, and physiopathology. Read More

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Risk Factors of Pulmonary Arterial Hypertension and Its Relationship With Atrial Fibrillation in Patients With Obstructive Hypertrophic Cardiomyopathy.

Front Cardiovasc Med 2021 7;8:666431. Epub 2021 Jul 7.

Department of Cardiovascular Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital, Beijing, China.

Pulmonary arterial hypertension (PH) is a common complication in patients with obstructive hypertrophic cardiomyopathy (OHCM). The risk factor of PH in patients with OHCM has not been fully elucidated, and even atrial fibrillation (AF) was considered a risk factor of PH. Thus, our study aimed to investigate risk factors of PH and the relationship between PH and AF in patients with OHCM. Read More

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Highly Specific and Sensitive Detection of by Portable Cas12a-UPTLFA Platform.

Front Microbiol 2021 7;12:700016. Epub 2021 Jul 7.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.

The recent discovery of collateral cleavage activity of class-II clustered regularly interspaced short palindromic repeats-CRISPR-associated protein (CRISPR-Cas) makes CRISPR-based diagnosis a potential high-accuracy nucleic acid detection method. Colloidal gold-based lateral flow immunochromatographic assay (LFA), which has been combined with CRISPR/Cas-based nucleic detection, usually associates with drawbacks of relative high background and the subjectivity in naked-eye read-out of the results. Here, we developed a novel system composed of Cas12a-based nucleic acid detection and up-converting phosphor technology (UPT)-based LFA (UPT-LFA), termed Cas12a-UPTLFA. Read More

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Synergetic antimicrobial effect of chlorin e6 and hydrogen peroxide on multi-species biofilms.

Biofouling 2021 Jul 26:1-10. Epub 2021 Jul 26.

Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Antimicrobial photodynamic therapy (aPDT) has been considered as a potential alternative to antibiotics for the treatment of biofilm infections. There is evidence that an additional HO enhances the antimicrobial efficacy of aPDT. However, the minimum HO concentration to achieve this synergistic effect is unclear. Read More

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Structural basis for the hyperthermostability of an archaeal enzyme induced by succinimide formation.

Biophys J 2021 Jul 21. Epub 2021 Jul 21.

Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India. Electronic address:

Stability of proteins from hyperthermophiles (organisms existing under boiling water conditions) enabled by a reduction of conformational flexibility is realized through various mechanisms. A succinimide (SNN) arising from the post-translational cyclization of the side chains of aspartyl/asparaginyl residues with the backbone amide -NH of the succeeding residue would restrain the torsion angle Ψ and can serve as a new route for hyperthermostability. However, such a succinimide is typically prone to hydrolysis, transforming to either an aspartyl or β-isoaspartyl residue. Read More

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Antiproliferative Properties and G-Quadruplex-Binding of Symmetrical Naphtho[1,2-b:8,7-b']dithiophene Derivatives.

Molecules 2021 Jul 16;26(14). Epub 2021 Jul 16.

Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche "STEBICEF", University of Palermo, Viale delle Scienze-Ed. 17, 90128 Palermo, Italy.

G-quadruplex (G4) forming sequences are recurrent in telomeres and promoter regions of several protooncogenes. In normal cells, the transient arrangements of DNA in G-tetrads may regulate replication, transcription, and translation processes. Tumors are characterized by uncontrolled cell growth and tissue invasiveness and some of them are possibly mediated by gene expression involving G-quadruplexes. Read More

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Pyroptosis in Cancer: Friend or Foe?

Cancers (Basel) 2021 Jul 20;13(14). Epub 2021 Jul 20.

Melanoma and Sarcoma Medical Oncology Unit, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

Pyroptosis is an inflammatory form of programmed cell death that is mediated by pore-forming proteins such as the gasdermin family (GSDMs), including GSDMA-E. Upon cleavage by activated caspases or granzyme proteases, the N-terminal of GSDMs oligomerizes in membranes to form pores, resulting in pyroptosis. Though all the gasdermin proteins have been studied in cancer, the role of pyroptosis in cancer remains mysterious, with conflicting findings. Read More

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Design, Hemiysnthesis, crystal structure and anticancer activity of 1, 2, 3-triazoles derivatives of totarol.

Bioorg Chem 2021 Jul 14;115:105165. Epub 2021 Jul 14.

Laboratoire de Synthèse Organique et Physico-Chimie Moléculaire, Département de Chimie, Faculté des Sciences, Semlalia, Université Cadi-Ayyad, B.P 2390, Marrakech 40001, Morocco. Electronic address:

A new series of diverse triazoles linked to the hydroxyl group of totarol were synthesized using click chemistry approach. The structures of these compounds were elucidated by HRMS, IR and NMR spectroscopy. The structure of compound 3 g was also confirmed by x-ray single crystal diffraction. Read More

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Cell Type-Specific Arousal-Dependent Modulation of Thalamic Activity in the Lateral Geniculate Nucleus.

Cereb Cortex Commun 2021 16;2(2):tgab020. Epub 2021 Mar 16.

Department of Physiology, Anatomy and Neuroscience, Faculty of Sciences, University of Szeged, 6726 Szeged, Hungary.

State-dependent thalamocortical activity is important for sensory coding, oscillations, and cognition. The lateral geniculate nucleus (LGN) relays visual information to the cortex, but the state-dependent spontaneous activity of LGN neurons in awake behaving animals remains controversial. Using a combination of pupillometry, extracellular, and intracellular recordings from identified LGN neurons in behaving mice, we show that thalamocortical (TC) neurons and interneurons are distinctly correlated to arousal forming two complementary coalitions. Read More

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The synthesis and characterization of a new diphosphine-protected gold hydride nanocluster.

J Chem Phys 2021 Jul;155(3):034307

Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.

Gold is the most inert metal and does not form a bulk hydride. However, gold becomes chemically active in the nanometer scale and gold nanoparticles have been found to exhibit important catalytic properties. Here, we report the synthesis and characterization of a highly stable ligand-protected gold hydride nanocluster, [AuH(dppee)] [dppee = bis(2-diphenylphosphino) ethyl ether]. Read More

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Comparison of antimicrobial efficacy of Calcipex and Metapex in endodontic treatment of chronic apical periodontitis: a randomised controlled trial study protocol.

BMJ Open 2021 Jul 21;11(7):e048947. Epub 2021 Jul 21.

Pathology and laboratory medicine, The Aga Khan University Hospital Main Campus, Karachi, Pakistan.

Introduction: Various intracanal medicaments have been used in cases of chronic apical periodontitis for appropriate disinfection of the root canal system to eliminate microbes especially from the inaccessible areas. Calcium hydroxide is the most common intracanal medicament available in various forms, but its effectiveness with or without iodoform using microbial culture is unknown. Therefore, our aim is to compare the antimicrobial efficacy of Calcipex and Metapex in endodontic treatment of teeth presenting with chronic apical periodontitis by assessing the bacterial load reduction. Read More

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Oral manifestations in paediatric patients with hepatobiliary diseases: a review.

J Biol Regul Homeost Agents 2021 May-Jun;35(3 Suppl. 1):117-125

Department of Surgical, Medical, Molecular and Critical Area Pathology, Unit of Pediatric Dentistry, University of Pisa, Pisa, Italy.

It is well known that greenish pigmentation of the teeth is seen in children following remission of severe jaundice and clinical and serum bilirubin, a degradation product of haemoglobin, may be permanently trapped in forming dental hard tissues causing discolouration and enamel and dentine hypoplasia. Neonatal jaundice is the most common cause of hyperbilirubinemia and pigmentation of the deciduous teeth is the consequence of this condition. Various hepatobiliary pathologies may have a clinical finding in the oral cavity; furthermore, oral manifestations of hepatic pathologies are not just limited to the pigmentation of the deciduous teeth but also the permanent dentition and the mucous membranes can be affected. Read More

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A Comparison of Colonizing Ability Between Enteritidis and Heidelberg in Broiler Chickens Challenged Through Feed Administration.

Foodborne Pathog Dis 2021 Jul 20. Epub 2021 Jul 20.

Department of Poultry Science, Auburn University, Auburn, Alabama, USA.

With over 1 million estimated cases per year in the United States, foodborne salmonellosis is an important public health issue. Chicken products are frequent sources of foodborne infection. These bacteria readily colonize the gastrointestinal tract of broiler chickens, and feed is a known vector. Read More

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Mapping Human Pluripotent Stem Cell-derived Erythroid Differentiation by Single-cell Transcriptome Analysis.

Genomics Proteomics Bioinformatics 2021 Jul 17. Epub 2021 Jul 17.

CAS Key Laboratory of Genome Science and Information, Beijing Institute of Genomics, Chinese Academy of Sciences/China National Center of Bioinformation, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100190, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; Beijing Key Laboratory of Genome and Precision Medicine Technologies, Beijing, 100101, China. Electronic address:

There is an imbalance between the supply and demand of functional red blood cells (RBCs) in clinical applications. This imbalance can be addressed by regenerating RBCs using several in vitro methods. Induced pluripotent stem cells (iPSCs) can handle the low supply of cord blood and the ethical issues in embryonic stem cell research and provide a promising strategy to eliminate immune rejection. Read More

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Colletotrichum fioriniae infecting invasive Japanese hop (Humulus scandens) in the United States.

Plant Dis 2021 Jul 19. Epub 2021 Jul 19.

USDA-ARS Foreign Disease-Weed Science Research Unit, 57689, 1301 Ditto Ave., Fort Detrick, Maryland, United States, 21702;

Japanese hop (Humulus scandens) is a non-native, invasive plant that colonizes disturbed riparian areas throughout the eastern United States and Canada, forming dense, monocultural stands that displace native plant communities due to a high reproductive rate, rapid growth, climbing bines, and dense shading (Balogh and Dancza 2008). It is capable of serving as a reservoir for agronomically important plant pathogens, such as the Tomato spotted wilt virus and powdery mildew species that infect commercial hemp and hop fields (Yoon et al. 2018; Weldon et al. Read More

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Large Differences in the Haptophyte Mitochondrial Genomes Driven by Repeat Amplifications.

Front Microbiol 2021 2;12:676447. Epub 2021 Jul 2.

CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.

The haptophyte is a well-known species for its pivotal role in global carbon and sulfur cycles and for its capability of forming harmful algal blooms (HABs) with serious ecological consequences. Its mitochondrial genome (mtDNA) sequence has been reported in 2014 but it remains incomplete due to its long repeat sequences. In this study, we constructed the first full-length mtDNA of , which was a circular genome with a size of 43,585 bp by applying the PacBio single molecular sequencing method. Read More

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The Interplay between Chronic Pain, Opioids, and the Immune System.

Neuroscientist 2021 Jul 16:10738584211030493. Epub 2021 Jul 16.

Global Institute on Addictions, Miami, FL, USA.

Chronic pain represents one of the most serious worldwide medical problems, in terms of both social and economic costs, often causing severe and intractable physical and psychological suffering. The lack of biological markers for pain, which could assist in forming clearer diagnoses and prognoses, makes chronic pain therapy particularly arduous and sometimes harmful. Opioids are used worldwide to treat chronic pain conditions, but there is still an ambiguous and inadequate understanding about their therapeutic use, mostly because of their dual effect in acutely reducing pain and inducing, at the same time, tolerance, dependence, and a risk for opioid use disorder. Read More

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The inhibitory receptor CD300a is essential for neutrophil mediated clearance of urinary tract infection in mice.

Eur J Immunol 2021 Jul 15. Epub 2021 Jul 15.

The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, The Hebrew University Medical School, Jerusalem, Israel.

Neutrophils play a crucial role in immune defense against and clearance of uropathogenic Escherichia coli (UPEC) mediated urinary tract infection (UTI), the most common bacterial infection in healthy humans. CD300a is an inhibitory receptor which binds phosphatidylserine (PS) and phosphatidylethanolamine (PE), presented on the membranes of apoptotic cells. CD300a binding to PS and PE, also known as the 'eat me' signal, mediates immune tolerance to dying cells. Read More

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Factors Controlling Persistent Needle Crystal Growth: The Importance of Dominant One-Dimensional Secondary Bonding, Stacked Structures, and van der Waals Contact.

Cryst Growth Des 2021 Jun 21;21(6):3449-3460. Epub 2021 May 21.

School of Chemistry, National University of Ireland, Galway H91TK33, Ireland.

Needle crystals can cause filtering and handling problems in industrial settings, and the factors leading to a needle crystal morphology have been investigated. The crystal growth of the amide and methyl, ethyl, isopropyl, and t-butyl esters of diflunisal have been examined, and needle growth has been observed for all except the t-butyl ester. Their crystal structures show that the t-butyl ester is the only structure that does not contain molecular stacking. Read More

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