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Acta Chim Slov 2019 Jun;66(2):414-420

A novel nickel complex with mixed ligands [Ni(L)2(EtOH)2(MeOH)2] (HL = 3-hydroxy-2-methylquinoline-4-carboxylic acid) has been synthesized through solvothermal reaction and its crystal structure was determined by single-crystal X-ray diffraction technique. Single-crystal X-ray diffraction analyses reveals that the title compound crystallizes in the triclinic system of the P-1 space group, and exists as isolated mononuclear complex. The intermolecular hydrogen bonds lead to the formation of chains, and the layered supramolecular structure is formed by the strong ααααα stacking interactions. Read More

Wiad Lek 2021 ;74(1):64-67

I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE.

Objective: The aim: To evaluate the parameters of menstrual function in 1015 women of reproductive age and to establish the relationship between the detected menstrual disorders and the development of migraine and/or irritable bowel syndrome (IBS).

Patients And Methods: Materials and methods: During 2018-2020, a survey of women of reproductive age in the Ternopil region (Ukraine) was conducted. To interview the study respondents, we developed a questionnaire that assessed the parameters of menstrual function (age of menarche; regularity and cyclicity of menstrual changes; duration of the menstrual cycle and menstruation itself; the amount of blood loss with the pictogram, the presence of clots and their size) identify characteristic changes in health, symptoms of irritable bowel syndrome and migraine associated with the menstrual cycle. Read More

Wiad Lek 2021 ;74(1):22-27

LVIV CLINICAL EMERGENCY HOSPITAL, LVIV, UKRAINE.

Objective: The aim: A clinical evaluation of biochemical parameters especially carbohydrate and lipid metabolism, their effect on the treatment program in patients with acute complicated pancreatitis.

Patients And Methods: Material and methods: The results of complex treatment of a sample group of 127 patients with acute pancreatitis were studied. A moderately severe clinical course of the disease was found in 42 patients (33. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2021 Mar;41(3):459-463

Nanjing University of Chinese Medicine, Nanjing 210029, China.

Objective: To investigate the relationship between serum C1q tumor necrosis factor-related protein 9 (CTRP9) level and the risk of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

Objective: A total of 291 patients with T2DM underwent fundus examination, and their serum levels of CTRP9, insulin and adiponectin were measured using enzyme- linked immunosorbent assay. According to results of fundus examination, the patients were divided into DR group and non-DR (NDR) group, and logistic regression was used to analyze the relationship between serum CTRP9 levels and DR in T2DM patients. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2021 Mar;41(3):447-452

Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical College, Bengbu 233030, China.

Objective: To investigate the effect of speckle-type POZ protein (SPOP) on proliferation, apoptosis, migration and invasion of renal cell carcinoma (RCC) and explore the potential mechanisms.

Objective: Renal carcinoma cell lines (786-O, A704, and Caki-2) cultured in vitro were transfected with a SPOP-overexpressing plasmid, and the changes in proliferation of the cells were detected using colony formation and MTT assay; TUNEL assay was used to assess apoptosis of the cells. The changes in migration and invasion abilities of the cells were examined using wound healing assay and Transwell assay. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2021 Mar;41(3):336-343

Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China.

Objective: To explore the effect of estradiol (E2) binding to its receptor ERβ on the proliferation and apoptosis of C28I2 cells.

Objective: We cloned the sequence of ESR2 into a recombinant adenovirus plasmid (pAd-ESR2) and packaged the plasmid in HEK293 cells. Normal human chondrocyte C28I2 cells were transfected with Ad-ESR2 or small interfering RNA targeting ESR2-siRNA (ESR2-siRNA), and the effects of treatment with DMSO or E2 on the expression of the proteins associated with endoplasmic reticulum (ER) stress and cell apoptosis were determined using Western blotting. Read More

Kardiologiia 2021 Mar 30;61(3):96-104. Epub 2021 Mar 30.

Lomonosov Moscow State University, Faculty of Fundamental Medicine, Moscow, Russia National medical research Center of cardiology of the Ministry of healthcare, Moscow, Russia.

Selenium is an important micronutrient that is essential for the functioning of the human body. Being a component of the active center of several antioxidant enzymes selenium prevents cell injury by free radicals. Decline in selenium-containing enzymes results in progression of oxidative stress and chronic inflammation, which are considered as possible causes for the development of many cardiovascular diseases. Read More

Praxis (Bern 1994) 2021 Apr;110(5):249-250

Institut für Klinische Chemie, Universitätsspital Zürich.

CME Laboratory 63/Answers: Diagnostics of Iron Metabolism Abstract: Iron deficiency is common and affects the course of many chronic diseases. The diagnosis of absolute and manifest iron deficiency anemia can be easily made by measuring hemoglobin and serum ferritin levels. In inflammatory diseases, the diagnosis can be facilitated by additional laboratory parameters such as soluble transferrin receptor. Read More

Adv Exp Med Biol 2021 ;1256:237-264

Department of Ophthalmology, University of Florida, Gainesville, FL, USA.

Strong experimental evidence from studies in human donor retinas and animal models supports the idea that the retinal pathology associated with age-related macular degeneration (AMD) involves mitochondrial dysfunction and consequent altered retinal metabolism. This chapter provides a brief overview of mitochondrial structure and function, summarizes evidence for mitochondrial defects in AMD, and highlights the potential ramifications of these defects on retinal health and function. Discussion of mitochondrial haplogroups and their association with AMD brings to light how mitochondrial genetics can influence disease outcome. Read More

Adv Exp Med Biol 2021 ;1256:221-235

Department of Ophthalmology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.

Aberrant regulation of epigenetic mechanisms, including the two most common types; DNA methylation and histone modification have been implicated in common chronic progressive conditions, including Alzheimer disease, cardiovascular disease, and age-related macular degeneration (AMD). All these conditions are complex, meaning that environmental factors, genetic factors, and their interactions play a role in disease pathophysiology. Although genome wide association studies (GWAS), and studies on twins demonstrate the genetic/hereditary component to these complex diseases, including AMD, this contribution is much less than 100%. Read More

Adv Exp Med Biol 2021 ;1256:121-141

Section on Neuron-Glia Interactions in Retinal Disease, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Multiple lines of investigation have demonstrated that inflammation plays significant roles in etiology of age-related macular degeneration (AMD). Although interventional trials in AMD therapy targeting inflammatory pathways have been conducted, they have not yet been successful and a detailed understanding as to why some have failed is still elusive. One limitation is the relative dearth of information on how immune cells interact with retinal cells to generate AMD phenotypes at each disease stage. Read More

Adv Exp Med Biol 2021 ;1256:89-119

Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD, USA.

A healthy choroidal vasculature is necessary to support the retinal pigment epithelium (RPE) and photoreceptors, because there is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex. This relationship is compromised in age-related macular degeneration (AMD) by the dysfunction or death of the choroidal vasculature. This chapter will provide a basic description of the human Bruch's membrane and choroidal anatomy and physiology and how they change in AMD. Read More

Commun Biol 2021 Apr 12;4(1):464. Epub 2021 Apr 12.

Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.

The FliHFliI complex is thought to pilot flagellar subunit proteins from the cytoplasm to the transmembrane export gate complex for flagellar assembly in Salmonella enterica. FliI also forms a homo-hexamer to hydrolyze ATP, thereby activating the export gate complex to become an active protein transporter. However, it remains unknown how this activation occurs. Read More

Nano Lett 2021 Apr 12. Epub 2021 Apr 12.

Department of Chemistry, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang 37673, Republic of Korea.

Overlapping of Alzheimer's disease and Parkinson's disease is associated with the formation of hetero-oligomers derived from amyloid-beta and alpha-synuclein. However, the structural identity of the hetero-oligomer has yet to be elucidated, particularly at high resolution. Here, with atomic force microscopy, the surface structure of hetero-oligomer was examined with four AFM tips tethering one of the selected antibodies recognizing N-terminus or C-terminus of each peptide. Read More

Zhonghua Yi Xue Za Zhi 2021 Apr;101(14):1041-1044

Department of Pediatric Endocrinology and Genetic Metabolism, Shanghai Xinhua Children's Hospital, Shanghai Institute for Pediatric Research, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.

The clinical and biochemical data and gene sequencing results of patients with carnitine palmitoyltransferase 1A deficiency were analyzed, in order to improve the understanding of the disease. Six patients (5 males and 1 female, aged from 1 to 8 years old) with carnitine palmitoyltransferase 1A deficiency from Department of Pediatric Endocrinology and Genetic Metabolism, Xinhua Hospital between 2008 and 2019 were included. Two cases were detected by neonatal screening and had no clinical symptoms. Read More

Rev Med Chil 2020 Dec;148(12):1750-1758

BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.

Background: Cardiorespiratory fitness is a strong predictor of mortality and chronic diseases. However, its estimation is costly and time consuming which may limit it broad use in population-based studies.

Aim: To estimate the cardiorespiratory fitness of the Chilean population by using equations and to characterize fitness levels of the Chilean population by sociodemographic factors. Read More

Rev Med Chil 2020 Oct;148(10):1435-1443

Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Background: Equations for the evaluation of fat-free mass (FFM) and fat mass (FM) with Bioelectrical impedance analysis (BIA) were formulated in Caucasian populations. International recommendations suggest that population-specific equations should be formulated.

Aim: To validate an equation previously formulated in Chileans adults and compare it to a new equation generated on an independent sample. Read More

Wiad Lek 2021 ;74(3 cz 2):713-717

BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.

Objective: The aim: Determining the compliance of the developed Public Health Educational Program with the principles and basic provisions of the WHO-ASPHER Competency Framework for Public Health Workforce in the European Region.

Patients And Methods: Materials and methods: The study used bibliographic and information-analytical methods and content analysis. A comparative analysis compliance of the content of the Public Health Master's Educational Program, developed in Bogomolets National Medical University, with the provisions of the WHO-ASPHER Competency Framework for Public Health Workforce in the European Region in terms of providing academic disciplines in the ECTS credits (European credit transfer and accumulation system), has been carried out. Read More

Wiad Lek 2021 ;74(3 cz 2):690-696

PEDAGOGICAL INSTITUTE BORYS GRINCHENKO KYIV UNIVERSITY, KYIV, UKRAINE.

Objective: The aim: Studying of the aspects that influence the formation of future teachers' values to health as the basis of an active life position of an individual.

Patients And Methods: Materials and methods: To update the didactic aspects of the problem, we used the methods of analysis of normative and scientific sources, system analysis and generalizations, the results of our own empirical studies, materials of the questionnaire, active modeling of students' health value formation.

Results: Results: The formation of a value attitude to the problem of health in future teachers is carried out under the following conditions: awareness of the importance of the value of health; changing the attitude of the individual to his/her own health and the health of others; knowledge of the factors influencing health, a conscious desire to lead a healthy lifestyle and make efforts to care for health, the use in the educational process of the operational model of forming students' value attitude to health by mastering the content of the course "Health-saving technologies in education" in order to form the ability of a systematic understanding of health-saving activities. Read More

Wiad Lek 2021 ;74(3 cz 2):658-664

UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.

Objective: The aim: The identification and determination of needs that the population of older age groups have in medical and social services on the basis of health data and the results of a survey.

Patients And Methods: Material and methods: Because of bibliographic, epidemiological, medical-statistical, analytical methods the research has investigated the problems of healthy aging, tendencies in population health of the population of Ukraine of senior age groups during 2000-2017, features and tendencies of health of a sample contingent of urban population of elderly age according to appeals in health care facilities during 2009-2019. The use of the sociological method, the self-evaluation of elderly people of their own health, characteristics of lifestyle and medical activity are determined, the needs of older people in medical and social services were assessed. Read More

J Zhejiang Univ Sci B 2020 Dec.;21(12):948-954

Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

The aim of this study was to evaluate the safety of an antiviral regimen of protease inhibitors combined with Arbidol (umifenovir) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia patients. The genomic sequence of SARS-CoV-2 is highly homologous to that of SARS-CoV (Zhou et al., 2020). Read More

Mo Med 2021 Mar-Apr;118(2):113-115

Head of the South African Headache Society, the South African affiliate of the International Headache Society. He is founder and practices at The Headache Clinic in Johannesburg, South Africa.

The factors contributing to increased morbidity and mortality in SARS-CoV-2 infection are diverse, and include diabetes, obesity, Chronic Obstructive Pulmonary Disease (COPD), advanced age, and male sex. Although there is no obvious connection between these, they do have one common denominator-they all have a tendency towards lower urine pH, which may indicate a lower-than-normal tissue pH. Furthermore, it has been shown that lower pH has two important negative influences: 1) it enhances viral fusion via the endosomal route, thereby facilitating viral multiplication; and 2) it facilitates increased production of inflammatory cytokines, thereby exacerbating the cytokine storm. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2021 Apr;23(4):416-419

Department of Neurology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/Ministry of Education Key Laboratory of Child Development and Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

A boy attended the hospital at the age of 1 month due to left hand tremor for 1 week. A blood test showed a reduction in serum uric acid and a cranial MRI showed encephalomalacia, atrophy, and cystic changes. The boy had microcephalus, unusual facial features (long face, long forehead, protruded forehead, long philtrum, low nasal bridge, facial swelling, and thick lower lip), hypertonia of lower extremities, and severe global developmental delay. Read More

Pestic Biochem Physiol 2021 May 11;174:104797. Epub 2021 Feb 11.

University of Monastir, Faculty of Dental Medicine, Laboratory for Research on Biologically Compatible Compounds, LR01SE17, Avicenne Street, 5000 Monastir, Tunisia; Higher Institute of Biotechnology, University of Monastir, Taher Haddad Street, 5000, Monastie, Tunisia. Electronic address:

Tebuconazole (TEB) is a common triazole fungicide that has been widely used for the control of plant pathogenic fungi, suggesting that mammal exposure occurs regularly. Several studies demonstrated that TEB exposure has been linked to a variety of toxic effects, including neurotoxicity, immunotoxicity, reprotoxicity and carcinogenicity. However, there is a few available data regarding the molecular mechanism involved in TEB-induced toxicity. Read More

Clin Appl Thromb Hemost 2021 Jan-Dec;27:1076029621999099

Laboratory of Hemostasis and Vascular Biology, Faculty of Medical and Biological Sciences "Dr Ignacio Chávez," Universidad Michoacana de San Nicolas de Hidalgo, Morelia, Michoacan, Mexico.

Among COVID-19 hospitalized patients, high incidence of alterations in inflammatory and coagulation biomarkers correlates with a poor prognosis. Comorbidities such as chronic degenerative diseases are frequently associated with complications in COVID-19 patients. The aim of this study was to evaluate inflammatory and procoagulant biomarkers in COVID-19 patients from a public hospital in Mexico. Read More

J Zhejiang Univ Sci B 2021 Apr;22(4):318-329

Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.

With the number of cases of coronavirus disease-2019 (COVID-19) increasing rapidly, the World Health Organization (WHO) has recommended that patients with mild or moderate symptoms could be released from quarantine without nucleic acid retesting, and self-isolate in the community. This may pose a potential virus transmission risk. We aimed to develop a nomogram to predict the duration of viral shedding for individual COVID-19 patients. Read More

J Zhejiang Univ Sci B 2021 Apr;22(4):310-317

Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Since December 2019, the novel coronavirus (severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) has spread to many countries around the world, developing into a global pandemic with increasing numbers of deaths reported worldwide. To data, although some vaccines have been developed, there are no ideal drugs to treat novel coronavirus pneumonia (coronavirus disease 2019 (COVID-19)). By examining the structure of the coronavirus and briefly describing its possible pathogenesis based on recent autopsy reports conducted by various teams worldwide, this review analyzes the possible structural and functional changes of the human body upon infection with SARS-CoV-2. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):381-384

Department of Medical Intensive Care Unit, General Hospital of Southern Theatre Command; Branch of National Clinical Research Center for Geriatric Diseases (Chinese PLA General Hospital), Guangzhou Key Laboratory of Geriatric Infection and Organ Function Support, Guangzhou 510010, Guangdong, China. Corresponding author: Chen Rui, Email:

Over the last decade, chronic critically ill (CCI) has emerged as an epidemic in intensive care unit (ICU) survivors worldwide. Advances in ICU technology and implementation of care bundles has significantly decreased early deaths of critically ill patients, and have allowed them to survive previously lethal multiple organ failure (MOF). However, more and more survivors leave persistent low grade organ dysfunctions, depend on continues organ support, need to stay in ICU, and become CCI patients. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):299-304

Trauma Center, Zhenjiang First People's Hospital, Zhenjiang 212000, Jiangsu, China. Corresponding author: Wang Peng, Email:

Objective: To explore the risk factors of acute respiratory distress syndrome (ARDS) secondary to severe multiple trauma and the role of clinical guidance.

Methods: The clinical data of 115 patients with severe multiple trauma admitted to the trauma center of Zhenjiang First People's Hospital from December 2017 to September 2020 were retrospectively analyzed. According to whether ARDS occurred within 1 week of the disease course, the patients were divided into ARDS group and non-ARDS group. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):165-172

Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.

Cardioembolic stroke (CS) is the one of the most severe and requiring dynamic monitoring among the all subtypes of ischemic stroke. Patients with CS require joint treatment with cardiologists. CS is characterized by a greater severity of neurological deficits, a high risk of repeated acute cerebral circulatory disorders and fatal outcomes. Read More