113,436 results match your criteria forensic


Recent sample pretreatment methods for determination of selective serotonin reuptake inhibitors (SSRIs) in biological samples.

J Pharm Biomed Anal 2021 Sep 8;206:114364. Epub 2021 Sep 8.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China. Electronic address:

Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (FLU), sertraline (SER), paroxetine (PAR), fluvoxamine (FLV) and citalopram (CIT) have been the first treatment drugs for pregnant and breastfeeding women. Quantitative analysis of SSRIs in biological samples is extremely needed in public health and clinical practice. During the analysis, sample pretreatment is an important step that can obtain an accurate quantitative analysis of SSRIs in the complex samples. Read More

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September 2021

The first case of C4-Blast related death in Malaysia: A multidisciplinary approach illustrated with emphasis on conjoint anthropologic and radiologic expertise in forensic identification of skeletal remains.

J Forensic Leg Med 2021 Sep 15;83:102253. Epub 2021 Sep 15.

National Institute of Forensic Medicine (NIFM), Hospital Kuala Lumpur, Ministry of Health Malaysia, Malaysia.

Background: Blast related deaths are often shrouded by diagnostic and medicolegal complexities requiring multidisciplinary expertise in order to gauge accurate identification of the victims and document scientific investigations comprehensively. In the advent of more sophisticated technology, anthropologic methods can now be applied into post mortem imaging interpretation. The traditional imaging roles of characterizing osseous fragmentation, detecting and localizing foreign bodies can be expanded to simulate and support physical anthropologic examination to assist in documentation for court proceedings. Read More

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September 2021

RMplex: An efficient method for analyzing 30 Y-STRs with high mutation rates.

Forensic Sci Int Genet 2021 Sep 11;55:102595. Epub 2021 Sep 11.

Department of Genetic Identification, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address:

Y-chromosomal short tandem repeats (Y-STRs) with high mutation rates are recognized as valuable genetic markers for differentiating paternally related men, who typically cannot be separated with standard Y-STRs, and were shown to provide paternal lineage differentiation on a higher resolution level than standard Y-STRs. Both features make Y-STRs with high mutation rates relevant in criminal casework, particularly in sexual assault cases involving highly unbalanced male-female DNA mixtures that often fail autosomal forensic STR profiling for the male donor. Previously, the number of known Y-STRs with mutation rates higher than 10 per locus per generation termed rapidly mutating Y-STRs (RM Y-STRs) was limited to 13, which has recently been overcome by the discovery and characterization of 12 additional RM Y-STRs. Read More

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September 2021

Unexpected death in a young child associated with anomalous aortic origin of the left main coronary artery without physical exertion: A case of an anomalous coronary artery with highly abundant elastic fibers.

Leg Med (Tokyo) 2021 Sep 15;53:101965. Epub 2021 Sep 15.

Tokyo Medical Examiner's Office, Tokyo Metropolitan Government, Tokyo, Japan.

Sudden death due to anomalous aortic origin of a coronary artery is far less common among young children in the absence of exercise stress. This report describes the case of a 2-year-old boy with a lower respiratory tract infection who suffered sudden cardiac arrest in his bed at home. The autopsy revealed that the left coronary artery (LCA) originated from the right sinus of Valsalva with an acute angle takeoff and traveled between the aorta and the pulmonary trunk (an interarterial course). Read More

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September 2021

Splenic peliosis associated with spontaneous rupture and massive bleeding.

Leg Med (Tokyo) 2021 Sep 15;53:101966. Epub 2021 Sep 15.

Department of Legal Medicine, International University of Health and Welfare, Japan.

We report findings from an autopsy case who died from massive bleeding because of splenic peliosis. The case subject was an 80-year-old man who had diabetes mellitus and who was receiving hemodialysis and anticoagulant therapy. Postmortem computed tomography demonstrated massive intra-abdominal hemorrhage especially seen around the spleen. Read More

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September 2021

Biotypic classification of facial profiles using discrete cosine transforms on lateral radiographs.

Arch Oral Biol 2021 Aug 27;131:105249. Epub 2021 Aug 27.

University of Pernambuco, Pernambuco Dental School, Oswaldo Cruz University Hospital, Department of Oral and Maxillofacial Surgery and Traumatology, Recife, PE 50100-130, Brazil. Electronic address:

Objective: The aim of the study was to use discrete cosine transforms to graph soft tissue curves in lateral cephalometric radiographs and, with the obtained mathematical values, to group these curves by both traditional biotypes and cluster systems, in order to evaluate discriminatory capacity in terms of accuracy.

Design: A sample of 625 lateral radiographs of adult patients (319 women and 306 men) was classified by facial biotype based on the ANB angle and mandibular plane angle. The curves of the facial profile were digitized with 50 equidistant points and discrete cosine transform was applied to analyze these curves mathematically for the determination of the accuracy of the classification of traditional biotypes. Read More

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A formalized model of the Trace.

Forensic Sci Int 2021 Aug 17;327:110941. Epub 2021 Aug 17.

University of Lausanne, Batochime, Lausanne, Switzerland.

This work proposes a formalized model, grounded in forensic science, to support a unified understanding of the Trace across scientific disciplines. The model is precisely defined in mathematical terms that reflect the dynamics of an offense as expressed in Locard's Exchange principle. Specifically, this mathematical approach represents the Trace as the modification of a Scene, subsequently perceptible, resulting from the Event under investigation. Read More

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Persistent Biliary Hypoxia and Lack of Regeneration Are Key Mechanisms in the Pathogenesis of Post-transplant Non-anastomotic Strictures.

Hepatology 2021 Sep 20. Epub 2021 Sep 20.

Department of Anatomical, Forensic Medicine and Orthopedic sciences, Sapienza University of Rome, Rome, Italy.

Background & Aims: Non-anastomotic biliary strictures (NAS) are a major cause of morbidity after orthotopic liver transplantation (OLT). Although ischemic injury of peribiliary glands (PBGs) and peribiliary vascular plexus (PVP) during OLT has been associated with the later development of NAS, the exact underlying mechanisms remain unclear. We hypothesized that bile ducts of patients with NAS suffer from ongoing biliary hypoxia and lack of regeneration from PBG stem/progenitor cells. Read More

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September 2021

Predictors of sick leave days in patients affected by major depressive disorder receiving antidepressant treatment in general practice setting in Germany.

Int J Psychiatry Clin Pract 2021 Sep 20:1-10. Epub 2021 Sep 20.

Hospital for Psychiatry, Psychotherapy and Psychosomatic Medicine, Werneck, Germany.

Objective: To identify sick leave days (SLD) predictors after starting antidepressant (AD) treatment in patients affected by major depressive disorder (MDD), managed by general practitioners, with a focus on different AD therapeutic approaches.

Methods: Retrospective study on German IQVIA Disease Analyser database. 19-64 year old MDD patients initiating AD treatment between July-2016 and June-2018 were grouped by therapeutic approach (AD monotherapy versus combination/switch/add-on). Read More

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September 2021

Characterization of Equine Liver Microsomes Generated Metabolites of Growth Hormone Secretagogue Small Molecule Ibutamoren.

Rapid Commun Mass Spectrom 2021 Sep 20:e9201. Epub 2021 Sep 20.

Equine Forensic Unit, Central Veterinary Research Laboratory, Dubai, United Arab Emirates.

Rationale: Interest in growth hormone secretagogues has intensified during the past several years based on capable, ever-widening investigational applications of recombinant growth hormone in animals and humans. Ibutamoren is a potent, long-acting, selective, and orally-active non-peptide growth hormone secretagogue, which poses a great potential for abuse as a performance-enhancing agent in sports.

Methods: To support drug metabolism and pharmacokinetic studies of chiral pharmaceuticals, it is necessary to combine the resolving power of HPLC with the sensitivity of mass spectrometric techniques. Read More

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September 2021

A Presumed Synonymous Mutation of PKD2 Caused Autosomal Dominant Polycystic Kidney Disease in a Chinese Family.

Curr Med Sci 2021 Sep 20. Epub 2021 Sep 20.

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Objective: Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by the pathogenic mutation of PKD1 or PKD2 gene and usually affects bilateral kidneys. Synonymous mutations are generally assumed to be neutral as they do not alter amino acids. Herein, we described an extremely rare ADPKD child caused by a heterozygous synonymous mutation of PKD2 gene accompanied by massive proteinuria and congenital solitary kidney. Read More

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September 2021

Activation of Type I and Type II Interferon signaling in SARS-CoV-2-positive thyroid tissue of patients dying from COVID-19.

Thyroid 2021 Sep 19. Epub 2021 Sep 19.

University of Pisa, Department of Surgical, Medical, Molecular Pathology and Critical Area, Pisa, Italy;

Background: Thyroid dysfunctions have been reported after SARS-CoV-2 infection. However, the biological mechanisms behind these conditions remain unexplored. Herein, we report on changes of the immune transcriptome in autoptic thyroid tissues of people who have died from COVID-19. Read More

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September 2021

Why are we vaccinating children against COVID-19?

Toxicol Rep 2021 14;8:1665-1684. Epub 2021 Sep 14.

Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003, Heraklion, Greece.

This article examines issues related to COVID-19 inoculations for children. The bulk of the official COVID-19-attributed deaths per capita occur in the elderly with high comorbidities, and the COVID-19 attributed deaths per capita are negligible in children. The bulk of the normalized post-inoculation deaths also occur in the elderly with high comorbidities, while the normalized post-inoculation deaths are small, but not negligible, in children. Read More

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September 2021

Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats.

Anal Cell Pathol (Amst) 2021 8;2021:7852710. Epub 2021 Sep 8.

Institute of Forensic Science, Ministry of Public Security People's Republic of China, No. 17 Nanli Mulidi, Beijing 100038, China.

An increasing number of people are in a state of stress due to social and psychological pressures, which may result in mental disorders. Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related behaviors but also with stress-induced mental disorders. To explore the effect of stress on dopaminergic neuron and potential mechanism, we established stressed rat models of different time durations and observed pathological changes in dopaminergic neurons of the ventral tegmental area (VTA) through HE and thionine staining. Read More

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September 2021

Colonoscopy quality across Europe: a report of the European Colonoscopy Quality Investigation (ECQI) Group.

Endosc Int Open 2021 Oct 16;9(10):E1456-E1462. Epub 2021 Sep 16.

Gastroenterology Unit, Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, Bologna, Italy.

The European Colonoscopy Quality Investigation (ECQI) Group comprises expert colonoscopists and investigators with the aim of raising colonoscopy standards. We assessed the levels of monitoring and achievement of European Society of Gastrointestinal Endoscopy (ESGE) performance measures (PMs) across Europe using responses to the ECQI questionnaires. The questionnaire comprises three forms: institution and practitioner questionnaires are completed once; a procedure questionnaire is completed on multiple occasions for individual total colonoscopies. Read More

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October 2021

A Perspective on the Integration of eHealth in Treatment of Offenders: Combining Technology and the Risk-Need-Responsivity Model.

Front Psychiatry 2021 1;12:703043. Epub 2021 Sep 1.

Department of Research, Stichting Transfore, Deventer, Netherlands.

While there are multiple ways in which eHealth interventions such as online modules, apps and virtual reality can improve forensic psychiatry, uptake in practice is low. To overcome this problem, better integration of eHealth in treatment is necessary. In this perspective paper, we describe how the possibilities of eHealth can be connected to the risk-need-responsivity (RNR) model. Read More

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September 2021

[Involuntary psychiatric care for incarcerated people: a descriptive study of 73 consecutive judge-ordered discharges from psychiatric hospitalisation in France].

Encephale 2021 Sep 16. Epub 2021 Sep 16.

Inserm, U1172 - Lille Neuroscience & Cognition, University Lille, CHU de Lille, 59000 Lille, France; Centre national de ressources et de résilience Lille-Paris (CN2R), 59000 Lille, France.

Introduction: The procedure of involuntary psychiatric hospitalization has been recently modified in France. Indeed, since 2011, a liberty and custody judge is appointed for each measure, to guarantee the rights of psychiatric inpatients and to prevent abusive hospitalizations. As a result, if procedural errors are noted, the liberty and custody judge may order the immediate ending of the psychiatric hospitalization. Read More

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September 2021

PET neuroimaging reveals upregulation of dopamine D2 receptor contributes to amygdaloid dysfunction in rat acute restraint stress model.

Biochem Biophys Res Commun 2021 Sep 15. Epub 2021 Sep 15.

Department of Forensic Pathology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610064, China; Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, College of Forensic Medicine, Hebei Medical University, Shijiazhuang, 050017, China. Electronic address:

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September 2021

Which illicit drugs are injected in Oslo? A study based on analysis of drug residues in used injection equipment and self-reported information.

Scand J Public Health 2021 Sep 18:14034948211043984. Epub 2021 Sep 18.

Section of Drug Abuse Research, Department of Forensic Sciences, Oslo University Hospital, Norway.

Background: People who inject drugs (PWID) have a high risk of premature death due to fatal overdoses. Newly emerged fentanyls, much more potent than heroin and other opioids, may increase this risk further. Therefore, precise information on injected drugs is critical to improving prevention strategies. Read More

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September 2021

Metal and metalloids concentration in Galapagos fish liver and gonad tissues.

Mar Pollut Bull 2021 Sep 16;173(Pt A):112953. Epub 2021 Sep 16.

Department of Obstetrics and Gynecology, Pediatrics, Preventive Medicine and Public Health, Toxicology, Legal and Forensic Medicine and Parasitology, Spain. Electronic address:

The Galapagos Islands are one of the best-preserved archipelagos in the world. We sampled individuals of six demersal and three pelagic species. The metal concentration of liver and gonad tissues were analyzed by Inductively Coupled Plasma Optical Spectrometry. Read More

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September 2021

Chemical mixtures in human post-mortem tissues assessed by a combination of chemical analysis and in vitro bioassays after extraction with silicone.

Environ Int 2021 Sep 16;157:106867. Epub 2021 Sep 16.

Department Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstraße 15, 04318 Leipzig, Germany; Eberhard Karls University Tübingen, Environmental Toxicology, Centre for Applied Geosciences, Schnarrenbergstr. 94-96, 72076 Tübingen, Germany. Electronic address:

Passive equilibrium sampling of chemical mixtures from different human post-mortem tissues (liver, brain (cerebrum and cerebellum), adipose tissue) and blood was combined with instrumental analysis using direct sample introduction (DSI) GC-MS/MS and bioanalytical profiling using in vitro bioassays targeting the activation of the aryl hydrocarbon receptor (AhR-CALUX), the adaptive stress response (AREc32) and cytotoxicity. The tissues stemmed from pathology samples collected in two German cities and covered males and females aged 21 to 100 with a mean age of 67 years. Neutral organic chemicals were extracted using polydimethylsiloxane (PDMS) at mass ratios of tissue to PDMS of approximately 6 for blood, 3 for adipose tissue and 10 for liver and brain. Read More

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September 2021

Potential role of dietary chitosan nanoparticles against immunosuppression, inflammation, oxidative stress, and histopathological alterations induced by pendimethalin toxicity in Nile tilapia.

Fish Shellfish Immunol 2021 Sep 16. Epub 2021 Sep 16.

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.

A 21-days feeding screening period was conducted to highlight the protective efficacy of dietary chitosan nanoparticles (CSNPs) on pendimethalin (PD)-induced toxicity in Nile tilapia (Oreochromis niloticus). Hematology, non-specific immune response, the antioxidative enzymes [superoxide dismutase (SOD) and catalase (CAT), glutathione reduced (GSH), and glutathione peroxidase (GPx)] in the liver and anterior kidney, changes of pro-inflammatory cytokine genes [interleukins-8 (IL-8), interleukins-1β (IL-1β), and tumor necrosis-α (TNF-α)] in the anterior kidney and histopathological alterations were assessed. Fish (50 ± 7. Read More

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September 2021

Identification of a Slovenian prewar elite couple killed in the Second World War.

Forensic Sci Int 2021 Sep 9;327:110994. Epub 2021 Sep 9.

Institute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia. Electronic address:

Genetic identification of a Slovenian prewar elite couple killed in 1944 was performed by typing autosomal and Y-chromosomal STRs, and phenotypic HIrisPlex SNPs for hair and eye color prediction were analyzed for the female skeleton using next-generation sequencing (NGS) technology. The clandestine grave containing the couple's skeletal remains was found in 2015 and only the partial remains were found. Living distant relatives could be found only for the male victim. Read More

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September 2021

The biasing impact of irrelevant contextual information on forensic odontology radiograph matching decisions.

Forensic Sci Int 2021 Sep 10;327:110997. Epub 2021 Sep 10.

Forensic Odontology Unit/Adelaide Dental School, The University of Adelaide, Australia. Electronic address:

The potential biasing effect of irrelevant context information on the forensic odontology method of radiograph-based identification has never been empirically investigated despite being a recognized problem in other forensic science disciplines. This study examines the effect of irrelevant context information on the probability judgment of match (JOM) of practicing forensic odontologist and dentist participants who were asked to match pairs of dental radiographs supplemented with irrelevant case information. The irrelevant case information contained domain task-irrelevant context information which varied in strength (strong or weak). Read More

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September 2021

Biomarkers of response to rapid-acting antidepressants.

Eur Neuropsychopharmacol 2021 Sep 15;53:101-103. Epub 2021 Sep 15.

Mental Health Department, Unitat de Neurociència Traslacional, Parc Tauli University Hospital, Institut d'Investigació i Innovació Sanitària Parc Taulí (I3PT), Barcelona, Spain; CIBERSAM, Carlos III Health Institute, Madrid, Spain; Department of Psychiatry and Forensic Medicine, School of Medicine Bellaterra, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address:

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September 2021

Are body dysmorphic symptoms dimensional or categorical in nature? A taxometric investigation in adolescents.

Psychiatry Res 2021 Sep 4;305:114201. Epub 2021 Sep 4.

Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, London, UK; OCD, BDD and Related Disorders Clinic for Young People, South London and Maudsley NHS Foundation Trust, London, UK. Electronic address:

Body dysmorphic disorder (BDD) is a debilitating mental health condition which usually emerges during adolescence and is characterised by distressing and impairing appearance concerns. It is currently unclear whether body dysmorphic concerns represent an extreme manifestation of normal appearance concerns (a dimensional conceptualisation), or whether they are qualitatively distinct (a categorical conceptualisation). This study aimed to determine whether body dysmorphic symptoms are dimensional or categorical in nature by investigating the latent structure using taxometric procedures. Read More

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September 2021

Recent forensic applications of enhanced chromatographic separation methods.

J Sep Sci 2021 Sep 17. Epub 2021 Sep 17.

Department of Forensic Science, The George Washington University, Washington, DC, 20007, United States.

This study reviews the recent applications of enhanced separation methods employed in forensic analysis utilizing gas chromatography, liquid chromatography, and supercritical fluid chromatography published between 2015 to 2020, except papers previously covered in relevant review articles. Applications of enhanced chromatographic separation methods to arson investigations, environmental forensics, sexual assault investigations, drug analysis, and toxicology are discussed. Future directions for enhanced chromatographic separation methods in forensic science are also explored. Read More

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September 2021