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Retention forces between primary and secondary CAD/CAM manufactured telescopic crowns: an in vitro comparison of common material combinations.

Clin Oral Investig 2021 Apr 8. Epub 2021 Apr 8.

Section for Digital Implant- and Reconstructive Dentistry [DIRecD], Department of Reconstructive Dentistry and Gerodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland.

Objectives: To analyze the retention forces between primary and secondary telescopic crowns milled from various materials and to compare them with the retention forces between cast telescopic crowns made of precious metal alloys.

Materials And Methods: Primary and secondary crowns (N = 60; n = 10 per group) were fabricated using various material combinations (1: zirconia [ZIR]/polyether ether ketone [PEEK]; 2: titanium grade IV [TI]/PEEK; 3: PEEK/PEEK; 4: non-precious alloy [NPA]/PEEK; 5:NPA/NPA), while precious alloy (PA) was used for the control group (6: PA/PA). The retention forces at 10, 1000, 5000, and 10,000 connection and disconnection cycles and the relative weights were analyzed, applying nonparametric repeated measures ANOVA and post hoc Mann-Whitney and Wilcoxon signed-rank tests (α < 0. Read More

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A Novel Evaluation Method for Detecting Defects of the Bonded Orthodontic Bracket-Tooth Interface.

Biomed Res Int 2021 15;2021:6634595. Epub 2021 Mar 15.

Operative and Esthetic Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: Orthodontic patients are at high risk to develop caries. This study is introducing a clinical method detecting interfacial defects between ceramic brackets and enamel utilizing optical coherent tomography in addition to using the nanoleakage expression in vitro test.

Methods: Transbond XT primer and moisture insensitive primer (MIP) were bonded to 75 human premolar enamel surfaces and divided into (XTD), (MIPD), and (MIPW) groups. Read More

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Influence of material type, thickness and storage on fracture resistance of CAD/CAM occlusal veneers.

J Mech Behav Biomed Mater 2021 Mar 29;119:104485. Epub 2021 Mar 29.

Operative Dentistry Department, Faculty of Dentistry, Mansoura University, Egypt.

Objectives: The present study aimed to evaluate the effect of restoration thickness, CAD/CAM material, and 6 months of artificial saliva storage on the fracture resistance of occlusal veneers.

Materials And Methods: A total of 84 intact maxillary molars were sectioned 4.0 mm occlusal to the cementoenamel junction to expose the dentine. Read More

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Multi-joint biomechanics during sloped walking in patients with developmental dysplasia of the hip.

Clin Biomech (Bristol, Avon) 2021 Mar 28;84:105335. Epub 2021 Mar 28.

Program in Physical Therapy, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Department of Orthopaedic Surgery, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA; Division of Biostatistics, Washington University in St. Louis, St. Louis, MO, USA; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

Background: Developmental dysplasia of the hip is characterized by abnormal acetabular and femoral geometries that alter joint loading and increase the risk of hip osteoarthritis. Current understanding of biomechanics in this population remains isolated to the hip and largely focused on level-ground walking, which may not capture the variable loading conditions that contribute to symptoms and intra-articular damage.

Methods: Thirty young adult females (15 with dysplasia) underwent gait analysis during level, 10° incline, and 10° decline walking while whole-body kinematics, ground reaction forces, and electromyography (EMG) were recorded. Read More

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Influence of the Bar Position on Joint-Level Biomechanics During Isometric Pulling Exercises.

J Strength Cond Res 2021 Mar 31. Epub 2021 Mar 31.

Department of Physical Therapy, Program in Exercise Science, Marquette University, Milwaukee, Wisconsin; Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, Texas; and Department of Intercollegiate Athletics, Marquette University, Milwaukee, Wisconsin.

Abstract: Ahn, N, Kim, H, Krzyszkowski, J, Roche, S, and Kipp, K. Influence of the bar position on joint-level biomechanics during isometric pulling exercises. J Strength Cond Res XX(X): 000-000, 2021-The purpose of this study was to investigate the influence of the bar position on ankle, knee, and hip net joint moments (NJMs), relative muscular effort (RME), and vertical ground reaction forces (GRFs) during isometric pulling exercises, such as the isometric midthigh pull. Read More

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Stability and validity of intact parathyroid hormone levels in different sample types and storage conditions.

J Clin Lab Anal 2021 Apr 1:e23771. Epub 2021 Apr 1.

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: Several pre-analytical factors can affect the measurement of intact Parathyroid Hormone (IPTH). In this study, we have investigated the effects of using different types of tubes, time elapsed before separation, and storage conditions over time on the measured values of IPTH.

Method: Blood samples from 30 subjects were collected into plain, SST, and EDTA tubes. Read More

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Preseason Upper Extremity Range of Motion and Strength in Relation to In-Season Injuries in NCAA Division I Gymnasts.

Orthop J Sports Med 2021 Jan 20;9(1):2325967120977090. Epub 2021 Jan 20.

Department of Physical Therapy, University of Florida, Gainesville, Florida, USA.

Background: Gymnastics is a demanding sport that places unique forces on the upper extremity. The repetitive nature of the sport and the high-impact forces involved may predispose the gymnast to overuse injuries. Risk factors for injuries in gymnastics are not well understood. Read More

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January 2021

Molecular Fluctuations as a Ruler of Force-Induced Protein Conformations.

Nano Lett 2021 Apr 25;21(7):2953-2961. Epub 2021 Mar 25.

Department of Physics, Randall Centre for Cell and Molecular Biophysics and London Centre for Nanotechnology, King's College London, Strand, WC2R 2LS London, United Kingdom.

Molecular fluctuations directly reflect the underlying energy landscape. Variance analysis examines protein dynamics in several biochemistry-driven approaches, yet measurement of probe-independent fluctuations in proteins exposed to mechanical forces remains only accessible through steered molecular dynamics simulations. Using single molecule magnetic tweezers, here we conduct variance analysis to show that individual unfolding and refolding transitions occurring in dynamic equilibrium in a single protein under force are hallmarked by a change in the protein's end-to-end fluctuations, revealing a change in protein stiffness. Read More

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Relationship between duty factor and external forces in slow recreational runners.

BMJ Open Sport Exerc Med 2021 3;7(1):e000996. Epub 2021 Mar 3.

Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium.

Objectives: Recreational runners show a large interindividual variation in spatiotemporal characteristics. This research focused on slow runners and intended: (1) to document the variance in duty factor (DF) between runners in a real-life running setting and (2) examine whether the interindividual variation in DF and stride frequency (SF) relates to differences in external loading parameters between runners.

Methods: Spatiotemporal characteristics of 23 slow runners (ie, <2. Read More

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Spatial velocity correlations in inertial systems of active Brownian particles.

Soft Matter 2021 Mar 18. Epub 2021 Mar 18.

School of Sciences and Technology, University of Camerino, Via Madonna delle Carceri, I-62032, Camerino, Italy.

Recently, it has been discovered that systems of active Brownian particles (APB) at high density organise their velocities into coherent domains showing large spatial structures in the velocity field. This collective behavior occurs spontaneously, i.e. Read More

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[Reference values in isometric strength diagnostics : Measurement of core strength values in patients with back pain].

Orthopade 2021 Mar 15. Epub 2021 Mar 15.

Sportprävention, Sportrehabilitation, BG Klinikum Hamburg, Bergedorfer Str. 10, 21033, Hamburg, Deutschland.

Objective: Isometric strength testing is known as a valid and reliable tool in the context of functional diagnostics and quality control for chronic low back pain rehabilitation, but reference values differ markedly between varied assessment devices, depending on their biomechanical lever arm framework. This study aimed to evaluate sex and age-specific isometric peak force reference values of trunk muscle functions in all dimensions using the Myoline® test device (Diers, Schlangenbad, Germany).

Material And Methods: In a retrospective cross-sectional study, data of 678 (541 females, 137 males) age-clustered (18-35, 36-50, 51-65 years) low back pain patients (ICD-10: M54) were analyzed referring to their absolute (N) and body weight related (N/kg) isometric maximum peak forces in all spatial dimensions (flexion, extension, rotation, lateral flexion) and the corresponding ratios (M ± SD, 95% CI), accompanied by sex and age-related effect analyses (two-way ANOVA). Read More

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Evidence of gene nucleotide composition favoring replication and growth in a fastidious plant pathogen.

G3 (Bethesda) 2021 Mar 14. Epub 2021 Mar 14.

Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720, USA.

Nucleotide composition (GC content) varies across bacteria species, genome regions, and specific genes. In Xylella fastidiosa, a vector-borne fastidious plant pathogen infecting multiple crops, GC content ranges between ∼51-52%; however, these values were gathered using limited genomic data. We evaluated GC content variations across X. Read More

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[Effect of Janus kinase/signal transduction and activator of transcription 3 pathway inhibitor on skeletal muscle function in severely burned rats and the mechanism].

Zhonghua Shao Shang Za Zhi 2021 Mar 3;37(3):1-8. Epub 2021 Mar 3.

Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.

To observe the functional changes of skeletal muscle in severely burned rats, and investigate the possible effects and mechanisms of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway inhibitors on skeletal muscle function. The experiment research method was applied. One hundred and twenty male Wistar rats of 8-weeks-old were divided into sham injury group, simple burn group, and burn+JAK/STAT3 inhibitor group according to the random number table, with 40 rats in each group. Read More

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Observational or Genetically Predicted Higher Vegetable Intake and Kidney Function Impairment: An Integrated Population-Scale Cross-Sectional Analysis and Mendelian Randomization Study.

J Nutr 2021 Mar 9. Epub 2021 Mar 9.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Background: Further exploration of the possible effects of vegetable intake on kidney function is warranted.

Objective: We aimed to study the causality of the association between vegetable intake and kidney function by implementing Mendelian randomization (MR) analysis.

Methods: This study comprised a cross-sectional dietary investigation using UK Biobank data and MR analysis. Read More

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Not as simple as it seems: Front foot contact kinetics, muscle function and ball release speed in cricket pace bowlers.

J Sports Sci 2021 Mar 9:1-9. Epub 2021 Mar 9.

Centre for Exercise and Sports Science Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia.

This study investigated the relationship between front foot contact (FFC) ground reaction forces (GRF) during the delivery stride, lower-limb strength, eccentric dexterity and power, and ball release speed (BRS) among pace bowlers. Thirteen high-level male pace bowlers performed double and single leg drop landings; isometric mid-thigh pull; countermovement jump; and pace bowling (two-over bowling spell measuring BRS and FFC GRF). The relationship between assessed variables and BRS was determined via frequentist and Bayesian multiple linear regression. Read More

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Influence of sports background on the bouncing mechanism of running.

Sports Biomech 2021 Mar 5:1-12. Epub 2021 Mar 5.

Department of Systems Medicine and Centre of Space Biomedicine, University of Rome Tor Vergata, Rome, Italy.

During running, the mechanical energy of the centre of mass of the body (COM) oscillates throughout the step like a spring-mass system, where part of its mechanical energy is stored during negative phases to be released during the following positive phases. This storage-release of energy improves muscle-tendon efficiency, which is related to lower-limb stiffness. This study explores the effect of sports background on the bouncing mechanism, by examining differences in stiffness and step spatiotemporal parameters between swimmers and football athletes. Read More

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Laser retrieval of cemented zirconia single unit implant restoration: A pilot study: Part I - Force values.

Int J Prosthodont 2021 Mar 3. Epub 2021 Mar 3.

Purpose: To measure the retrieval force required to remove 1.5-mm-thick CAD/CAM zirconia copings cemented on zirconia (Zr) and titanium (Ti) stock implant abutments after a single application of erbium-doped yttrium scandium gallium garnet (Er:YSGG) laser.

Materials And Methods: A total of 60 monolithic Zr copings were cemented on Zr and Ti implant abutments with either a resin-modified glass-ionomer (RelyX Luting Plus Cement, 3M ESPE; Rx) or a zinc oxide eugenol cement (Temp-Bond, Kerr; Tb). Read More

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Exploring spatiotemporal effects of the driving factors on COVID-19 incidences in the contiguous United States.

Sustain Cities Soc 2021 May 19;68:102784. Epub 2021 Feb 19.

School of Architecture, Planning and Environmental Policy, University College Dublin Richview, Clonskeagh, Dublin, D14 E099, Ireland.

Since December 2019, the world has witnessed the stringent effect of an unprecedented global pandemic, coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of January 29,2021, there have been 100,819,363 confirmed cases and 2,176,159 deaths reported. Among the countries affected severely by COVID-19, the United States tops the list. Read More

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Experimental evaluation of icodextrin delivery as pressurized aerosol (PIPAC): Antiadhesive and cytotoxic effects.

Eur J Surg Oncol 2021 Feb 17. Epub 2021 Feb 17.

Dept. of General, Visceral and Transplant Surgery, Germany; National Center for Pleura and Peritoneum (NCPP.), Germany.

Background: Icodextrin (IDX) is an antiadhesive polymer that can be used as a carrier solution for intraperitoneal (IP) delivery of chemotherapeutic drugs.

Methods: We investigated the suitability of IDX solution as a carrier of Cisplatin and Doxorubicin for delivery as pressurized intraperitoneal aerosol chemotherapy (PIPAC). We examined the sprayability of IDX, the aerosol characteristics, the stability of the molecule after aerosolization, the effects of IDX on the adhesion of MKN45 human gastric cancer cells, the synergistic effect of aerosolized IDX with Cisplatin and Doxorubicin, and the chemical stability of IDX, Cisplatin, and Doxorubicin in combination. Read More

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February 2021

The effect of asymmetrical gait induced by unilateral knee brace on the knee flexor and extensor muscles.

Med Biol Eng Comput 2021 Mar 24;59(3):711-720. Epub 2021 Feb 24.

Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Selangor Darul Ehsan, Malaysia.

Asymmetrical stiff knee gait is a mechanical pathology that can disrupt lower extremity muscle coordination. A better understanding of this condition can help identify potential complications. This study proposes the use of dynamic musculoskeletal modelling simulation to investigate the effect of induced mechanical perturbation on the kneeand to examine the muscle behaviour without invasive technique. Read More

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O-Ring Attachments on One-Piece Mini Dental Implants: In-Vitro Analysis of Retention Force Reproducibility Using Different Pristine Matrix-O-Ring Combinations.

Int J Prosthodont 2021 Feb 23. Epub 2021 Feb 23.

Purpose: To analyze the influence of pristine matrix and O-ring dimensions on retention force and reproducibility in single one-piece mini dental implants (MDIs) with ball patrices under in vitro conditions.

Materials And Methods: Three different matrix and O-ring combinations (MH1-MH3) were evaluated (n = 50 per group) on 1.8-mm-diameter implants. Read More

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February 2021

Effect of Direct Composite and Indirect Ceramic Onlay Restorations on Fracture Resistance of Endodontically Treated Maxillary Premolars.

Front Dent 2020 Apr 23;17(8):1-8. Epub 2020 Apr 23.

Fixed Prosthodontics Department, Tehran Dental Branch, Islamic Azad University, Tehran, Iran.

Objectives: Fracture of endodontically treated restored teeth is a common concern. Premolars are subjected to high shear and tensile forces. This study aimed to assess the fracture resistance and fracture mode of endodontically treated premolars restored with direct and indirect onlay restorations. Read More

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Load to failure of high-density polymers for implant-supported fixed, cantilevered prostheses with titanium bases.

Int J Prosthodont 2021 Feb 19. Epub 2021 Feb 19.

Purpose: To analyze the load to failure of different CAD/CAM high-density polymers (HDPs) and zirconia when titanium (Ti) bases were included in a cantilevered situation.

Materials And Methods: Five specimens were fabricated from five different CAD/CAM polymethyl methacrylate (PMMA) HDPs (Copratemp [CT]; Tempo-CAD [TC]; TD Dental [TD]; M-PM Disc-Pink [MPM]; M-PM Disc-White [MPMW]), and five specimens were prepared from a 3Y-TZP zirconia (FireZr [FZR]) (control). Ti bases (D Master Dental Implants) were cemented onto the specimens (8 mm [thickness] × 7 mm [width] × 30 mm [length]). Read More

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February 2021

Change in attitudes and perceptions of undergraduate health profession students towards inter-professional education following an educational experience in post natal care.

Med J Armed Forces India 2021 Feb 2;77(Suppl 1):S173-S179. Epub 2021 Feb 2.

Statistician (Community Medicine), DM Wayanad Institute of Medical Sciences, Wayanad, Kerala, India.

Background: Inter-professional Education (IPE) has been identified as an educational program aimed at increasing collaboration among health professionals, and improving health care outcomes. IPE programs have been incorporated in several countries and have shown positive results. The same may not be true for Asian cultures which are typically more hierarchical than others. Read More

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February 2021

Interprofessional simulation education to enhance teamwork and communication skills among medical and nursing undergraduates using the TeamSTEPPS® framework.

Med J Armed Forces India 2021 Feb 2;77(Suppl 1):S42-S48. Epub 2021 Feb 2.

Professor Emeritus, University of British Columbia, DR. TMA Pai Endowment Chair in Interprofessional Education & Practice, MAHE, Founding Chair, Canadian Interprofessional Health Collaborative, 3350 West 37th Avenue, Vancouver, B.C, V6N2V6, Canada.

Background: Learning in silos during the undergraduate years results in ineffective collaborative practice leading to adverse events. Simulation training using the Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS)® framework has been shown to be effective in enhancing teamwork skills among healthcare professionals. This study aims to evaluate an interprofessional simulation education (IPSE) module for undergraduate medical and nursing students on teamwork and communication skills using the TeamSTEPPS® framework. Read More

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February 2021

The effect of Plasmodium vivax infection on SOCS gene expression in Anopheles dirus (Diptera: Culicidae).

Trop Biomed 2020 Jun;37(2):397-408

Faculty of Medical Technology, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

The Anopheles dirus mosquito is a primary malaria vector that transmits many species of Plasmodium parasites in Thailand and is widely spread across its geographic area. In the current study, the levels of expression of the suppressor of cytokine signaling (SOCS) gene in An. dirus mosquitoes infected with P. Read More

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Mechanical Stress Analysis of Different Configurations of the All-on-4 Concept in Atrophic Mandible: A 3D Finite Element Study.

Int J Oral Maxillofac Implants 2021 Jan-Feb;36(1):75-85

Purpose: This study evaluated the mechanical behavior of different configurations of the All-on-4 treatment concept designed with straight short (6-mm-length), straight standard (11-mm-length), or tilted standard (30-degree angled; 11-mm-length) posterior implants.

Materials And Methods: The All-on-4 configurations were performed in atrophic mandible models and consisted of anterior straight standard and posterior tilted standard implants (H1 model), anterior straight standard and posterior straight short implants (H2 model), and anterior and posterior straight standard implants (H3 model). Three oblique forces of 100 N were simulated in the posterior region of the prosthetic bar. Read More

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February 2021

Evaluation of Fracture Load of Cement-, Screw-, and Multiscrew-Retained Abutments for Implant-Supported Fixed Partial Dentures.

Int J Oral Maxillofac Implants 2021 Jan-Feb;36(1):55-58

Purpose: The purpose of this in vitro study was to evaluate the load-to-fracture values of cement-, screw-, and multiscrew-retained abutments for implant-supported fixed partial dentures (FPDs).

Materials And Methods: Thirty-six implants with a diameter and length of 4.5 and 13 mm, respectively, were used to prepare 18 samples of FPDs. Read More

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February 2021

Olfactory Dysfunction Among Asymptomatic Patients with SARS CoV2 Infection: A Case-Control Study.

Indian J Otolaryngol Head Neck Surg 2021 Feb 10:1-6. Epub 2021 Feb 10.

Department of Internal Medicine, Armed Forces Medical College, Pune, Maharashtra 411040 India.

Olfactory dysfunction (hyposmia, anosmia) is a well-recognized symptom in patients with coronavirus disease-19 (COVID-19). Studies of olfactory dysfunction in asymptomatic patients have not been reported. We conducted a study looking for the presence of olfactory dysfunction with an objective assessment tool in asymptomatic Covid 19 and compared it with patients with mild COVID-19 and age-matched controls. Read More

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February 2021

Making the Grade: An Exploration of Incline Running on a Bodyweight-Supportive Treadmill.

J Sport Rehabil 2021 Feb 12:1-5. Epub 2021 Feb 12.

Context: Bodyweight-supporting treadmills are popular rehabilitation tools for athletes recovering from impact-related injuries because they reduce ground reaction forces during running. However, the overall metabolic demand of a given running speed is also reduced, meaning athletes who return to competition after using such a device in rehabilitation may not be as fit as they had been prior to their injury.

Objective: To explore the metabolic effects of adding incline during bodyweight-supported treadmill running. Read More

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February 2021