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Successful Reuse of Kidney Graft After Early Recurrence of Primary Focal and Segmental Glomerulosclerosis.

Am J Kidney Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Nephrology, Dialysis, Transplantation, and Apheresis, Lille University, Regional and University Hospital Center of Lille, F-59037 Lille, France.

Primary focal and segmental glomerulosclerosis (pFSGS) frequently recurs after transplantation and is associated with a poor prognosis. We describe here the successful kidney graft reuse in an adult recipient, eight months after early pFSGS recurrence resistant to all available therapeutics. Patient 1, a 23-year-old man, followed for kidney failure secondary to pFSGS, was first transplanted in 2018 with a deceased donor graft. Read More

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The instep flap for anterior ankle coverage with bone and hardware exposure.

Eur J Orthop Surg Traumatol 2021 Jun 12. Epub 2021 Jun 12.

Division of Orthopaedic and Trauma Surgery, Sahel General Hospital, University Medical Centre, PO Box 99/25., Ghoubeiry, Beirut, Lebanon.

Purpose: The instep medial plantar flap is a well-known flap based on the medial plantar artery of the foot and usually used for coverage of soft tissue defects of the heel area. It has seldom been reported for coverage of anterior ankle area with exposure of the bone and metallic hardware after open reduction and internal fixation of distal tibial fractures. The primary purpose of this study is to evaluate the feasibility and viability of this flap as well as its reliability saving the internal fixation devices and efficiency protecting bone healing; the secondary purpose is to assess the condition of the flap and its cosmetic appearance, as well as occurrence of complications related to its harvesting. Read More

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Severe Calcaneus Injury Probability Curves Due to Under-Body Blast.

Ann Biomed Eng 2021 Jun 11. Epub 2021 Jun 11.

Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD, 20723, USA.

The lower extremity is the most frequently injured body region to mounted soldiers during underbody blast (UBB) events. UBB events often produce large deformations of the floor and subsequent acceleration of the lower limb that are not sufficiently mitigated by the combat boot, leaving the calcaneus bone vulnerable to injury. Biomechanical experiments simulating UBB loading scenarios were conducted in a laboratory environment using isolated postmortem human subject (PMHS) leg components. Read More

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Calcaneal fractures: 3D-printing model to assist spatial weaving of percutaneous screws versus conventional open fixation-a retrospective cohort study.

Int Orthop 2021 Jun 11. Epub 2021 Jun 11.

Department of Foot and Ankle Surgery, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.

Purpose: This study compared the clinical effectiveness and wound complications of a three-dimensional model-assisted spatial weaving screw fixation (3D-SWSF) versus open reduction and internal fixation (ORIF) via an L-shaped extensile lateral approach for calcaneal fractures.

Methods: This single-centre retrospective cohort study was conducted with two cohort groups in which patients with Sanders II and III calcaneal fractures underwent 3D-SWSF or conventional ORIF. The clinical outcome measures included operation duration, time to operation, wound complications, blood loss volume, hospital stays, American Orthopedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot score, and visual analog scale (VAS) score. Read More

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Feasibility of a home-based foot-ankle exercise programme for musculoskeletal dysfunctions in people with diabetes: randomised controlled FOotCAre (FOCA) Trial II.

Sci Rep 2021 Jun 11;11(1):12404. Epub 2021 Jun 11.

Department of Physical Therapy, Speech, and Occupational Therapy, Faculdade de Medicina, Universidade de São Paulo, Rua Cipotânea, 51, Cidade Universitária, São Paulo, SP, 05360-160, Brazil.

This study sought to assess the feasibility of design, adherence, satisfaction, safety and changes in outcomes followed by a home-based foot-ankle exercise guided by a booklet in individuals with diabetic peripheral neuropathy (DPN). 20 participants were allocated usual care [control group (CG)] or usual care plus home-based foot-ankle exercises [intervention group (IG)] for 8 weeks. For feasibility, we assessed contact, preliminary screening and recruitment rates, adherence, and using a 5-point Likert scale to satisfaction and safety of the booklet. Read More

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Effect of meteorological factors and air pollutants on fractures: a nationwide population-based ecological study.

BMJ Open 2021 Jun 11;11(6):e047000. Epub 2021 Jun 11.

Artificial Intelligence and Big-Data Convergence Center, Gachon University Gil Medical Center, Incheon, South Korea

Objective: To determine the association of meteorological factors and air pollutants (MFAPs) with fracture and to estimate the effect size/time lag.

Design: This is a nationwide population-based ecological study from 2008 to 2017.

Setting: Eight large metropolitan areas in Korea. Read More

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Prevalence of leg ulcers in the province of Cuenca: A study in Primary Care.

Enferm Clin (Engl Ed) 2021 Jun 8. Epub 2021 Jun 8.

Centro de Salud de Tarancón, Servicio de Salud de Castilla-La Mancha (SESCAM), Cuenca, Spain.

Objective: To determine the prevalence of leg ulcers, and to describe the affected patients, wounds, and treatment.

Method: Observational, cross-sectional prevalence study. An ad hoc online questionnaire was sent to all nurses attending Primary Care centres of the "Gerencia de Atención Integrada de Cuenca" (Integrated Care Management of Cuenca, Spain). Read More

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Ten-year revision rates of contemporary total ankle arthroplasties equal 22%. A meta-analysis.

Foot Ankle Surg 2021 Jun 6. Epub 2021 Jun 6.

Department of Orthopedics, Xpert Orthopedics and Specialized Centre of Orthopedic Research and Education (SCORE), Laarderhoogtweg 12, 1101 EA Amsterdam, The Netherlands.

Background: The National Institute for Health and Care Excellence criterion for hip replacements is a (projected) revision rate of less than 5% after 10 years. No such criterion is available for ankle prostheses. The objective of the current study is to compare survival rates of contemporary primary ankle prostheses to the hip-benchmark. Read More

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Chimeric enterovirus 71 virus-like particle displaying conserved coxsackievirus A16 epitopes elicits potent immune responses and protects mice against lethal EV71 and CA16 infection.

Vaccine 2021 Jun 8. Epub 2021 Jun 8.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China. Electronic address:

Hand-foot-and-mouth disease (HFMD) is an infectious disease of infants and young children frequently caused by the enterovirus A species, mainly enterovirus 71 (EV71) and coxsackievirus A16 (CA16). In this study, we prepared the EV71 virus-like particle (EV71-VLP) and its chimeras using recombinant baculovirus (Bac-P1-3CD) co-expressing EV71 P1 (under polyhedrin promoter) and 3CD (under CMV-IE promoter) proteins in Sf9 cells. EV71-VLP chimera ChiEV71(1E)-VLP or ChiEV71(4E)-VLP displayed single CA16 PEP71 epitope in VP1 or four conserved CA16 neutralizing epitopes (PEP71 in VP1, aa136-150 in VP2, aa176-190 in VP3 and aa48-62 in VP4) by substitution of the corresponding regions of EV71 structure proteins, respectively. Read More

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Distal Tibial Reconstruction in the Management of Primary Bone Tumors in Children and Adolescents.

Foot Ankle Int 2021 Jun 11:10711007211012690. Epub 2021 Jun 11.

Department of Oncology and Surgical Oncology for Children and Youth, Institute of Mother and Child, Warsaw, Poland.

Background: Distal tibial primary bone tumors are rare, and options for limb salvage surgery are limited and challenging. Importantly, local control has shown to be crucial and necessary for cure, and radical surgery is one of the most important components of therapy for some bone sarcomas. We investigated the feasibility and functional and oncological outcomes of distal tibial reconstruction using endoprosthesis in children with malignant bone tumors. Read More

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Outcomes of Percutaneous Calcaneoplasty for Insertional Achilles Tendon Problems.

Foot Ankle Int 2021 Jun 11:10711007211004963. Epub 2021 Jun 11.

Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi (SA), Italy.

Background: Percutaneous procedures have been used recently to treat insertional Achilles tendon problems. The present study reports our results of this treatment approach.

Methods: Patients undergoing percutaneous calcaneoplasty for insertional Achilles tendon problems were retrieved. Read More

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Characterization of arrhythmias, evaluation of cardiac biomarkers and their association with survival in calves suffering from foot-and-mouth disease.

J Vet Cardiol 2021 Apr 18;36:64-76. Epub 2021 Apr 18.

Indian Veterinary Research Institute, Regional Campus, Hebbal, Bengaluru, Karnataka, 560024, India.

Introduction: Foot-and-mouth disease (FMD) causes mortality in calves due to myocarditis; however, the effects of FMD virus on cardiac arrhythmogenesis and Purkinje cells are unknown. Identifying diagnostic and prognostic markers in FMD-affected calves may be useful in disease management in the endemic countries.

Materials And Methods: A total of 81 FMD-affected calves were prospectively monitored till death or recovery. Read More

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Effects of additional load at different heights on gait initiation: A statistical parametric mapping of center of pressure and center of mass behavior.

PLoS One 2021 11;16(6):e0242892. Epub 2021 Jun 11.

Physical Education Department, Federal University of São Carlos, São Carlos, Brazil.

The purpose of this study was to investigate the effects of different vertical positions of an asymmetrical load on the anticipatory postural adjustments phase of gait initiation. Sixty-eight college students (32 males, 36 females; age: 23.65 ± 3. Read More

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Treatment of High-Energy Intra-Articular Fractures of Tibia with Ilizarov External Fixator in Adults: A Tertiary Center Experience.

Int J Clin Pract 2021 Jun 11:e14488. Epub 2021 Jun 11.

Dow University of Health Sciences, Karachi, Pakistan.

Objective: To evaluate the clinical and radiological outcomes of the Ilizarov fixator in the proximal and distal fractures of the tibia.

Materials And Methodology: This retrospective study reviewed 59 patients having high-energy intra-articular proximal and distal tibia fractures associated with severe soft-tissue injury, who were managed surgically with an Ilizarov fixator. The functional outcome was evaluated by using the American Orthopaedic Foot and Ankle Society scoring system (AOFAS) and the Association for the Study and Application of the Method of Ilizarov (ASAMI) Italy scoring system for tibial plateau and plafond fractures respectively. Read More

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VEGF-VEGFR2 inhibitor-associated hyaline occlusive glomerular microangiopathy: a Japanese single-center experience.

Clin Exp Nephrol 2021 Jun 11. Epub 2021 Jun 11.

Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.

Background: Inhibitors of vascular endothelial growth factor (VEGF)-VEGF receptor 2 (VEGFR2) signaling, such as bevacizumab (Bmab), are used for the treatment of various advanced cancers. However, these inhibitors induce renal thrombotic microangiopathy (TMA). Recently, two European cohort studies showed a distinctive histopathological pseudothrombotic pattern different from TMA in Bmab-treated patients. Read More

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Evolutionary and Ecological Drivers Shape the Emergence and Extinction of Foot-and-Mouth Disease Virus Lineages.

Mol Biol Evol 2021 Jun 11. Epub 2021 Jun 11.

The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, United Kingdom.

Livestock farming across the world is constantly threatened by evolutionary turnover of foot-and-mouth disease virus (FMDV) strains in endemic systems, the underlying dynamics of which remain to be elucidated. Here, we map the eco-evolutionary landscape of co-circulating FMDV lineages within an important endemic virus pool encompassing Western, Central and parts of Southern Asia, reconstructing the evolutionary history and spatial dynamics over the last 20 years that shapes the current epidemiological situation. We demonstrate that new FMDV variants periodically emerge from Southern Asia, precipitating waves of virus incursions that systematically travel in a westerly direction. Read More

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Sociodemographic and clinical correlates of gabapentin receipt with and without opioids among a national cohort of patients with HIV.

AIDS Care 2021 Jun 11:1-11. Epub 2021 Jun 11.

Yale School of Medicine, New Haven, CT, USA.

Gabapentin is commonly prescribed for chronic pain, including to patients with HIV (PWH). There is growing concern regarding gabapentin's potential for harm, particularly in combination with opioids. Among PWH, we examined factors associated with higher doses of gabapentin receipt and determined if receipt varied by opioid use. Read More

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Cellular reprogramming of diabetic foot ulcer fibroblasts triggers pro-healing miRNA-mediated epigenetic signature.

Exp Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Wound Healing and Regenerative Medicine Research Program, Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Diabetic foot ulcers (DFUs), a prevalent complication of diabetes, constitute a major medical challenge with a critical need for development of cell-based therapies. We previously generated induced pluripotent stem cells (iPSCs) from dermal fibroblasts derived from the DFU patients, location-matched skin of diabetic patients and normal healthy donors and re-differentiated them into fibroblasts. To assess the epigenetic microRNA (miR) regulated changes triggered by cellular reprogramming, we performed miRs expression profiling. Read More

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Correlation of medial longitudinal arch morphology with body characteristics and locomotive function in community-dwelling older women: A cross-sectional study.

J Orthop Surg (Hong Kong) 2021 May-Aug;29(2):23094990211015504

School of Rehabilitation, Osaka Kawasaki Rehabilitation University, Osaka, Japan.

Purpose: This cross-sectional study aimed to investigate the effects of foot arch deformities on physical characteristics, muscular strength, and motor function in older women depending on the presence or absence of pain.

Methods: Overall, 145 community-dwelling women aged 65 to 90 years were included in this study. We measured the foot arch height ratio (AHR, dorsal height/truncated foot length) and classified participants with AHR values above, below, or within 1. Read More

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Zhuifeng Tougu capsules improve rheumatoid arthritis symptoms in rats by regulating the toll-like receptor 2/4-nuclear factor kappa-B signaling pathway.

J Tradit Chin Med 2021 Jun;41(3):447-454

Postdoctoral Research Workstation, Hinye Pharmaceutical Co. Ltd., Hinye Pharmaceutical Co., Ltd., Changsha 410331, China.

Objective: To investigate the efficacy of Zhuifeng tougu capsules (, ZFTG) in the treatment of rheumatoid arthritis (RA) in rats and study its mechanism, focusing on the toll-like receptor 2/4-nuclear factor kappa-B (TLR2/4-NF-κB) signaling pathway.

Methods: Type Ⅱ collagen and an artificial climate box were used to construct the rat model of collagen-induced arthritis with wind-cold-dampness arthralgia syndrome. The rats were divided randomly into a control group, wind-cold-dampness syndrome model group, and high-, medium-, and low-dose ZFTG groups. Read More

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Mosaic RASopathy due to KRAS variant G12D with segmental overgrowth and associated peripheral vascular malformations.

Am J Med Genet A 2021 Jun 11. Epub 2021 Jun 11.

Institute of Human Genetics, University Hospital Magdeburg, Magdeburg, Germany.

Oncogenic RAS variants lead to constitutive overactivation and increased signal transduction into downstream pathways. They are found as somatic driver events in various types of human cancer. In a somatic mosaic status, the same RAS variants have been associated with a wide spectrum of focal or segmental tissue dysplasia and overgrowth including various types of congenital nevi, vascular malformations, and other changes (mosaic RASopathies). Read More

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Os Vesalianum Pedis in a Young Adult: A Case Report and Literature Review.

Cureus 2021 May 7;13(5):e14896. Epub 2021 May 7.

Orthopedics, General Hospital of Patras "Agios Andreas", Patras, GRC.

Os vesalianum pedis is a rare accessory foot ossicle. It is usually asymptomatic, however, it can be an infrequent cause of lateral foot pain. We present the case of a 19-year-old healthy male with lateral foot pain after an inversion-type injury. Read More

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Follow the Shoestring: A Unique Case of Bullet Extraction.

Cureus 2021 May 5;13(5):e14862. Epub 2021 May 5.

Emergency Medicine, Saint Louis University School of Medicine, St. Louis, USA.

Firearm-related injuries and deaths remain a major issue in the United States. Gunshot injuries to the foot can be particularly difficult to manage when they occur as they can cause fractures or devastating neurovascular damage. There are limited reasons for routine bullet removal in most cases. Read More

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A novel concept for low-cost non-electronic detection of overloading in the foot during activities of daily living.

R Soc Open Sci 2021 Jun 9;8(6):202035. Epub 2021 Jun 9.

Centre for Biomechanics and Rehabilitation Technologies, Staffordshire University, Stoke-on-Trent, UK.

Identifying areas in the sole of the foot which are routinely overloaded during daily living is extremely important for the management of the diabetic foot. This work showcases the feasibility of reliably detecting overloading using a low-cost non-electronic technique. This technique uses thin-wall structures that change their properties differently when they are repeatedly loaded above or below a tuneable threshold. Read More

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A Rare Case of Invasive Keratinizing Squamous Cell Carcinoma of the Foot.

Int Med Case Rep J 2021 4;14:381-384. Epub 2021 Jun 4.

Department of Infectious Diseases, Saint Vincent Hospital, Worcester, MA, 01608, USA.

Lower extremity soft-tissue lesions are frequently encountered in clinical practice. Cellulitis, osteomyelitis, and diabetic foot ulcerations remain the top differentials. The acuity of illness, imaging studies, and deep wound cultures are helpful in most cases. Read More

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Lower extremity reamputation in people with diabetes: a systematic review and meta-analysis.

BMJ Open Diabetes Res Care 2021 Jun;9(1)

Department of Surgery, USC Keck School of Medicine, Los Angeles, California, USA.

In this study, we determined the reamputation-free survival to both limbs and to the contralateral limb only following an index amputation of any-level and assessed whether reamputation rates have changed over time. We completed a systematic search using PubMed and screened a total of 205 articles for data on reamputation rates. We reported qualitative characteristics of 56 studies that included data on reamputation rates and completed a meta-analysis on 22 of the studies which enrolled exclusively participants with diabetes. Read More

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Risk Factors for Nonunion After First Metatarsophalangeal Joint Arthrodesis With a Dorsal Locking Plate and Compression Screw Construct: Correction of Hallux Valgus Is Key.

J Foot Ankle Surg 2021 May 11. Epub 2021 May 11.

Trauma and Orthopaedics Department, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom; University of Liverpool, Liverpool, United Kingdom.

First metatarsophalangeal joint (MTPJ) arthrodesis is currently the gold standard technique for advanced hallux rigidus. This retrospective study aimed to identify the risk factors for nonunion after first MTPJ arthrodesis with a dorsal locking plate and compression screw construct. Between April 2014 and April 2019, 165 consecutive patients (28 men and 137 women; mean age, 60 (range, 28-84) years) who underwent 178 primary first MTPJ arthrodeses were retrospectively reviewed. Read More

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A meta-analysis of the efficacy and safety of adjuvant sorafenib for hepatocellular carcinoma after resection.

World J Surg Oncol 2021 Jun 10;19(1):168. Epub 2021 Jun 10.

Department of Oncology, The Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Nanchang, 330006, Jiangxi Province, People's Republic of China.

Background: Sorafenib was reported as a useful adjuvant treatment in patients with hepatocellular carcinoma who underwent surgical resection. However, its therapeutic value remains controversial. This meta-analysis examined the available data regarding the efficacy and safety of sorafenib in patients with hepatocellular carcinoma after radical surgery. Read More

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Vaccination coverage estimates and utilization patterns of inactivated enterovirus 71 vaccine post vaccine introduction in Ningbo, China.

BMC Public Health 2021 Jun 10;21(1):1118. Epub 2021 Jun 10.

Ningbo Municipal Center for Disease Prevention and Control, Institute of Immunization and Prevention, Yongfeng Road, Haishu District, Ningbo, 315010, China.

Background: In China, enterovirus 71 (EV71) is the major etiological agents of hand foot mouth disease that poses severe risks to children's health. Since 2015, three inactivated EV71 vaccines have been approved for use. Previous studies indicated the high willingness of EV71 vaccination in eastern China. Read More

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