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DNA walker-mediated biosensor for target-triggered triple-mode detection of Vibrio parahaemolyticus.

Biosens Bioelectron 2021 May 7;186:113305. Epub 2021 May 7.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, State Key Laboratory Base of Novel Functional Materials and Preparation Science, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China.

Herein, we have constructed a target-triggered and DNA walker-mediated biosensor with triple signal (BTS) outputs mode for sensitive and reliable detection of pathogenic bacteria. Vibrio parahaemolyticus (VP) being the detection target model, the aptamer conformational changes induced by VP have been designed to activate the DNA walk on the modifiable and conductive surface of FeO nanoparticles to generate triple signal outputs, including electrochemiluminescence (ECL), fast scan cyclic voltammetry (FSCV) and fluorescent pixel counting (FLPC). Limits of quantification (LOQ) of VP were as low as 1 CFU⋅mL by ECL with a linear range of 1-10 CFU⋅mL, 1 CFU⋅mL by FSCV with a linear range of 1-10 CFU⋅mL, and 10 CFU⋅mL by FLPC with a linear range of 10-10 CFU⋅mL respectively, all squared correlation coefficients R being > 0. Read More

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Overexpression of SlGSNOR impairs in vitro shoot proliferation and developmental architecture in tomato but confers enhanced disease resistance.

J Plant Physiol 2021 Apr 30;261:153433. Epub 2021 Apr 30.

Department of Plant Breeding and Genetics, Faculty of Crop and Food Sciences, PMAS Arid Agriculture University Rawalpindi, Rawalpindi, 46300, Pakistan. Electronic address:

The pervasive presence of nitric oxide (NO) in cells and its role in modifying cystein residues through protein S-nitrosylation is a remarkable redox based signalling mechanism regulating a variety of cellular processes. S-NITROSOGLUTATHIONE REDUCTASE (GSNOR) governs NO bioavailability by the breakdown of S-nitrosoglutathione (GSNO), fine-tunes NO signalling and controls total cellular S-nitrosylated proteins. Most of the published data on GSNOR functional analysis is based on the model plant Arabidopsis with no previous report for its effect on in vitro regeneration of tissue cultured plants. Read More

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Protective effects of natural products against drug-induced nephrotoxicity: a review in recent years.

Food Chem Toxicol 2021 May 11:112255. Epub 2021 May 11.

Chinese Veterinary Medicine Innovation Center, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. Electronic address:

Drug-induced nephrotoxicity (DIN) is a major cause of kidney damage and is associated with high mortality and morbidity, which limits the clinical use of certain therapeutic or diagnostic agents, such as antineoplastic drugs, antibiotics, immunosuppressive agents, non-steroidal anti-inflammatory drugs (NSAIDs), and contrast agents. However, in recent years, a number of studies have shown that many natural products (NPs), including phytochemicals, various plants extracts, herbal formulas, and NPs derived from animals, confer protective effects against DIN through multi-targeting therapeutic mechanisms, such as inhibition of oxidative stress, inflammation, apoptosis, fibrosis, and necroptosis, regulation of autophagy, maintenance of cell polarity, etc., by regulating multiple signaling pathways and novel molecular targets. Read More

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Global Endocrinology: Global perspectives in endocrinology: Coverage of iodized salt programs and iodine status in 2020.

Eur J Endocrinol 2021 May 1. Epub 2021 May 1.

M Andersson, Nutrition Research Unit, University Children's Hospital Zurich , Zurich, Switzerland.

Iodine deficiency has multiple adverse effects on growth and development. Diets in many countries cannot provide adequate iodine without iodine fortification of salt. In 2020, 124 countries have legislation for mandatory salt iodization and 21 have legislation allowing voluntary iodization; as a result, 88% of the global population uses iodized salt. Read More

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Synchrony and Perturbation Transmission in Trophic Metacommunities.

Am Nat 2021 Jun 19;197(6):E188-E203. Epub 2021 Apr 19.

AbstractIn a world where natural habitats are ever more fragmented, the dynamics of metacommunities are essential to properly understand species responses to perturbations. If species' populations fluctuate asynchronously, the risk of their simultaneous extinction is low, thus reducing the species' regional extinction risk. However, identifying synchronizing or desynchronizing mechanisms in systems containing several species and when perturbations affect multiple species is challenging. Read More

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Protein kinase inhibitors for the treatment of prostate cancer.

Expert Opin Pharmacother 2021 May 14:1-11. Epub 2021 May 14.

Genitourinary Cancers, Inova Medical Group, Inova Schar Cancer Institute, Fairfax, VA, USA.

Introduction: Protein kinases have emerged as targetable pathways used in metastatic prostate cancer given their role in prostatic tumor growth, proliferation and metastases. Protein kinase inhibitors are small molecules that target varying pathways including the breakpoint cluster region (BCR)-Abelson tyrosine kinase (ABL), colony stimulating factor-1 receptor (CSF1R), vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) and phosphoinositide 3-kinase (PI3K) pathways and have been studied in prostate cancer trials with variable results. In particular, cabozantinib when used in combination trials and ipatasertib, when used with abiraterone in patients who harbor phosphatase and tensin homologue (PTEN) loss, have been promising. Read More

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Social Needs, Chronic Conditions, and Health Care Utilization among Medicaid Beneficiaries.

Popul Health Manag 2021 May 14. Epub 2021 May 14.

Brown School of Social Work, Washington University in St. Louis, St. Louis, Missouri, USA.

Health care organizations are increasingly assessing patients' social needs (eg, food, utilities, transportation) using various measures and methods. Prior studies have assessed social needs at the point of care and many studies have focused on correlates of 1 specific need (eg, food). This comprehensive study examined multiple social needs and medical and pharmacy claims data. Read More

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CAR T-Cell Therapy in Hematologic Malignancies: Clinical Role, Toxicity, and Unanswered Questions.

Am Soc Clin Oncol Educ Book 2021 Mar;41:1-20

Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.

At the time of writing, five anti-CD19 CAR T-cell products are approved by the U.S. Food and Drug Administration for seven different indications in lymphoid malignancies, including B-cell non-Hodgkin lymphoma, pediatric B-cell acute lymphoblastic leukemia, and multiple myeloma. Read More

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Exploring Plant Performance, Fruit Physicochemical Characteristics, Volatile Profiles, and Sensory Properties of Day-Neutral and Short-Day Strawberry Cultivars Grown in Texas.

J Agric Food Chem 2021 May 14. Epub 2021 May 14.

Department of Nutrition and Food Sciences, Texas Woman's University, 304 Administration Drive, Denton, Texas 76204, United States.

To assist increasing annual acreage of Texas-grown (U.S.A. Read More

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Gut colonization in preterm infants supplemented with bovine colostrum in the first week of life: An explorative pilot study.

JPEN J Parenter Enteral Nutr 2021 May 14. Epub 2021 May 14.

Comparative Paediatrics and Nutrition, Department of Veterinary and Animal Sciences.

Background: In the first weeks after birth, enteral feeding and bacterial colonization interact to influence gut maturation in preterm infants. Bovine colostrum (BC) has been suggested as a relevant supplementary diet when own mother's milk (MM) is insufficient or absent. In a pilot trial whether the supplement type, BC or human donor milk (DM), affects gut colonization in preterm infants during the first week of life was tested. Read More

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Fermented Duckweed as a Potential Feed Additive with Poultry Beneficial Bacilli Probiotics.

Probiotics Antimicrob Proteins 2021 May 14. Epub 2021 May 14.

Health Promoting Naturals Laboratory, School of Environmental and Biological Sciences, Rutgers State University, New Brunswick, NJ, USA.

In this study, the duckweed varieties Lemna minor, Spirodela polyrhiza, and a commercially processed duckweed food supplement were investigated as potential substrates for the propagation of two probiotic Bacillus strains, B. subtilis KATMIRA1933 and B. amyloliquefaciens B-1895. Read More

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Towards an enhanced indication of provisioning ecosystem services in agro-ecosystems.

Environ Monit Assess 2021 May 14;193(Suppl 1):269. Epub 2021 May 14.

Leibniz Centre for Agricultural Landscape Research (ZALF), Eberswalder Straße 84, 15374, Müncheberg, Germany.

Provisioning ecosystem services play a vital role in sustaining human well-being. Agro-ecosystems contribute a significant share of these services, besides food and fodder and also fuel and fibre as well as regulating and cultural ecosystem services. Until now, the indication of provisioning ecosystem services of agro-ecosystems has been based almost only on yield numbers of agricultural products. Read More

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A Primer on RECIST 1.1 for Oncologic Imaging in Clinical Drug Trials.

Radiol Imaging Cancer 2021 May;3(3):e210008

From the Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Suite 1621, Los Angeles, CA 90095-1721 (K.R., M.D., V.S., A.G., R.D., J.G.); and Department of Radiology, Beth Israel Lahey Health, Burlington, Mass (M.B.A.).

Drug discovery and approval in oncology is mediated by the use of imaging to evaluate drug efficacy in clinical trials. Imaging is performed while patients receive therapy to evaluate their response to treatment. Response criteria, specifically Response Evaluation Criteria in Solid Tumors version 1. Read More

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Association of Vitamin D status with Visceral Adiposity Index and Lipid Accumulation Product Index among a Group of Iranian People.

Clin Nutr Res 2021 Apr 26;10(2):150-160. Epub 2021 Apr 26.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran 14167-53955, Iran.

There is a growing body of evidence linking vitamin D and its antiadipogenic activity with body composition. The aim of this study was to investigate the association between vitamin D levels, visceral adiposity index (VAI), and lipid accumulation product index among a group of Iranian people. This cross-sectional study was conducted with 270 Iranian adults. Read More

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Genetic Variations in Thiamin Transferase and the Risk of Hypertension in Koreans.

Clin Nutr Res 2021 Apr 19;10(2):140-149. Epub 2021 Apr 19.

Department of Food Science and Nutrition, Keimyung University, Daegu 42601, Korea.

Hypertension is a major health issues globally. Multiple genetic and environmental factors are involved in hypertension etiology. Solute carrier family 35 member F3 (SLC35F3) is a type of transporter uptakes thiamin across the cellular and mitochondrial membrane. Read More

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Changes of Lipopolysaccharide-Induced Acute Kidney and Liver Injuries in Rats Based on Metabolomics Analysis.

J Inflamm Res 2021 6;14:1807-1825. Epub 2021 May 6.

Department of Pharmacy, The First Hospital of Jilin University, Changchun, 130021, People's Republic of China.

Background: The bacterial endotoxin lipopolysaccharide (LPS) was the classic inducer to establish many inflammatory disease models, especially multiple organ injury. Evidences indicated that the mechanism that causes inflammation response is not just related to cytokine release. The main aim of this study was to better elucidate the possible links between metabolic changes and the pathogenesis of LPS-induced acute liver and kidney in order to understand the mechanisms and screening therapeutic targets for developing early diagnostic strategies and treatments. Read More

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Exploratory dietary patterns and cognitive function in the "Seguimiento Universidad de Navarra" (SUN) Prospective Cohort.

Eur J Clin Nutr 2021 May 13. Epub 2021 May 13.

Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra-IdiSNA, Pamplona, Spain.

Background: Dementia is projected to affect 135 million by 2050. Diet is a pertinent target for primary prevention, but firm recommendations for dementia prevention are not available yet. Our aim was to address the association between exploratory (empirically derived) dietary patterns (DP) and changes in the Spanish Telephone Interview for Cognitive Status (STICS-m, maximum score = 41 points) over 6 years. Read More

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Phospholipids (PLs) know-how: exploring and exploiting phospholipase D for its industrial dissemination.

Crit Rev Biotechnol 2021 May 13:1-22. Epub 2021 May 13.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, Wuxi, P. R. China.

Owing to their numerous nutritional and bioactive functions, phospholipids (PLs), which are major components of biological membranes in all living organisms, have been widely applied as nutraceuticals, food supplements, and cosmetic ingredients. To date, PLs are extracted solely from soybean or egg yolk, despite the diverse market demands and high cost, owing to a tedious and inefficient manufacturing process. A microbial-based manufacturing process, specifically phospholipase D (PLD)-based biocatalysis and biotransformation process for PLs, has the potential to address several challenges associated with the soybean- or egg yolk-based supply chain. Read More

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Survey of New Zealand poultry consumers handling of raw poultry and food safety awareness to provide insight into risk factors for campylobacteriosis.

J Food Prot 2021 May 13. Epub 2021 May 13.

Lincoln University.

New Zealand (NZ) has a high rate of reported campylobacteriosis cases. Cross-contamination in home kitchens during poultry handling is considered to be the main factor in campylobacteriosis transmission. The main aim of this study was to measure NZ consumers' food safety awareness and self-reported food safety practices associated with handling raw poultry. Read More

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Histamine Limits by Country: A Survey and Review.

J Food Prot 2021 May 13. Epub 2021 May 13.


Histamine is a biogenic amine and a food safety hazard, and it is the only biogenic amine regulated by statute or HACCP Guidance. This paper reviews the regulations for histamine levels in fish in countries around the world, including maximum limits or levels and sampling procedures in different fish preparations. The maximum histamine levels, sampling plans, and fish products are listed. Read More

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First Report of Causing Leaf Spot of Tartary Buckwheat () in China.

Plant Dis 2021 May 13. Epub 2021 May 13.

School of Life Science, Hunan University of Science and Technology, Xiangtan, Hunan, China, China.

Buckwheat (Fagopyrum tataricum) is recognized as a healthy food with abundant nutrients and high levels of rutin. In April and May of 2020, an unknown tartary buckwheat leaf spot distinct from Nigrospora leaf spot (Shen et al. 2020) was observed in Xiangxiang, Hunan, China (27°49'54″N, 112°span style="font-family:'Times New Roman'; color:#0000ff">18'48″E. Read More

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Potential Environmental Health Risk Analysis of Neonicotinoids and a Synergist.

Environ Sci Technol 2021 May 13. Epub 2021 May 13.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.

The extensive use of neonicotinoid pesticides has led to their widespread presence in the environment, resulting in considerable safety risks to the ecosystem and human health. In this study, we investigated the biotransformation behavior of a cocktail of multiple neonicotinoids and piperonyl butoxide (PBO) synergist and their potential environmental health risk. It was found that neonicotinoids with a cyano group, such as acetamiprid and thiacloprid, tended to accumulate in liver and spleen tissues, while others with nitro groups (imidacloprid, thiamethoxam, clothianidin, dinotefuran, and nitenpyram) were mostly excreted in urine. Read More

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Prostaglandin E attenuates macrophage-associated inflammation and prostate tumour growth by modulating polarization.

J Cell Mol Med 2021 May 13. Epub 2021 May 13.

Wuxi School of Medicine, Jiangnan University, Wuxi, China.

Alternative polarization of macrophages regulates multiple biological processes. While M1-polarized macrophages generally mediate rapid immune responses, M2-polarized macrophages induce chronic and mild immune responses. In either case, polyunsaturated fatty acid (PUFA)-derived lipid mediators act as both products and regulators of macrophages. Read More

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Recent Innovations in Emulsion Science and Technology for Food Applications.

J Agric Food Chem 2021 May 13. Epub 2021 May 13.

Department of Food Science, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.

Emulsion technology has been used for decades in the food industry to create a diverse range of products, including homogenized milk, creams, dips, dressings, sauces, desserts, and toppings. Recently, however, there have been important advances in emulsion science that are leading to new approaches to improving food quality and functionality. This article provides an overview of a number of these advanced emulsion technologies, including Pickering emulsions, high internal phase emulsions (HIPEs), nanoemulsions, and multiple emulsions. Read More

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Psychological functioning and well-being before and after bariatric surgery; what is the benefit of being self-compassionate?

Br J Health Psychol 2021 May 12. Epub 2021 May 12.

Department of Health Psychology, Faculty of Medical Sciences, University of Groningen, University Medical Center Groningen, The Netherlands.

Objective: To investigate whether patients' psychological well-being (depression, quality of life, body image satisfaction) and functioning (self-efficacy for eating and exercising behaviours and food cravings) improve 12 months after bariatric surgery and whether self-compassion is associated with better psychological outcomes and lower weight after bariatric surgery.

Design: Longitudinal, prospective observational study.

Methods: Bariatric patients (n = 126, 77. Read More

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Association between Food Insecurity, Mental Health, and Intentions to Leave the US Army in a Cross-Sectional Sample of US Soldiers.

J Nutr 2021 May 12. Epub 2021 May 12.

US Army Public Health Center, Behavioral and Social Health Outcomes Program, Aberdeen Proving Ground, Aberdeen, MD, USA.

Background: Previous research has demonstrated that certain groups in the United States are at a greater risk for food insecurity. However, food insecurity has not been sufficiently characterized in active duty military populations.

Objectives: The primary objective of this study was to determine the prevalence of marginal food insecurity at a large US Army installation. Read More

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Habitual Intake of Dietary Advanced Glycation End Products Is Not Associated with Arterial Stiffness of the Aorta and Carotid Artery in Adults: The Maastricht Study.

J Nutr 2021 May 12. Epub 2021 May 12.

Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.

Background: Advanced glycation end products (AGEs), a heterogeneous group of bioactive compounds, are thought to contribute to arterial stiffness, which in turn is a causal factor in the pathogenesis of stroke, myocardial infarction, and heart failure. Whether AGEs derived from food also contribute to arterial stiffness is not clear.

Objectives: We investigated whether higher intake of dietary AGEs is associated with arterial stiffness. Read More

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Antineoplastic effects of auranofin in human pancreatic adenocarcinoma preclinical models.

Surg Open Sci 2019 Oct 3;1(2):56-63. Epub 2019 Jul 3.

Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612.

Background: Auranofin, a Food and Drug Administration-approved anti-rheumatic agent with anticancer properties for lung and ovarian cancer, has never been studied for pancreatic cancer. We hypothesize that auranofin may prevent pancreatic ductal adenocarcinoma progression by inhibition of Txnrd1 and HIF-1α.

Methods: sensitivity of human pancreatic ductal adenocarcinoma cell lines was determined based on IC50. Read More

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October 2019

Effect of Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula on Gut Microbiome and Metabolome at 4 Months of Age.

Curr Dev Nutr 2021 May 2;5(5):nzab027. Epub 2021 Apr 2.

Medical and Scientific Affairs, Reckitt|Mead Johnson Nutrition Institute, Evansville, IN, USA.

Background: Milk fat globule membrane (MFGM) and lactoferrin (LF) are human-milk bioactive components demonstrated to support gastrointestinal and immune development. Significantly fewer diarrhea and respiratory-associated adverse events through 18 mo of age were previously reported in healthy term infants fed a cow-milk-based infant formula with an added source of bovine MFGM and bovine LF through 12 mo of age.

Objectives: The aim was to compare microbiota and metabolite profiles in a subset of study participants. Read More

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