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Adverse Events Associated With Synthetic Male Slings: An Analysis of the FDA MAUDE Database.

Int Neurourol J 2021 May 5. Epub 2021 May 5.

Division of Urology, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Purpose: We sought to describe and analyze the adverse events associated with synthetic male slings reported to the Food and Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database.

Methods: We queried the MAUDE database for all entries including the terms "Male Sling," "Invance," "Virtue," or "Advance" from January 1st, 2009 to December 31st, 2018. We collected and analyzed information about the event type, date received, report source, source type, and manufacturer. Read More

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Finding the Sweet Spot: Measurement, Modification, and Application of Sweet Hedonics in Humans.

Adv Nutr 2021 May 6. Epub 2021 May 6.

Department of Nutrition Science, Purdue University, West Lafayette, IN, USA.

Sweetness is a sensation that contributes to the palatability of foods, which is the primary driver of food choice. Thus, understanding how to measure the appeal (hedonics) of sweetness and how to modify it are key to effecting dietary change for health. Sweet hedonics is multidimensional so can only be captured by multiple approaches including assessment of elements such as liking, preference, and consumption intent. Read More

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Sodium metabisulfite as a cytotoxic food additive induces apoptosis in HFFF2 cells.

Food Chem 2021 Apr 20;358:129910. Epub 2021 Apr 20.

Department of Analytical Chemistry, University of Valencia, Dr. Moliner 50, 46100 Burjassot, Valencia, Spain. Electronic address:

Sodium metabisulfite (SMB), an antioxidant agent, is extensively used as a preservative in food industry. The current study was aimed to clarify its potential toxic effects on human fetal foreskin fibroblasts (HFFF2) cells, in vitro. Subsequently, MTT results illustrated that exposure to SMB significantly (p < 0. Read More

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Characterization of a novel carboxylesterase with catalytic activity toward di(2-ethylhexyl) phthalate from a soil metagenomic library.

Sci Total Environ 2021 Apr 21;785:147260. Epub 2021 Apr 21.

Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address:

A novel carboxylesterase gene estyz5 was isolated from a soil metagenomic library. The recombinant enzyme EstYZ5 is 298 amino acids in length with a predicted molecular weight of 32 kDa. Sequence alignment and phylogenetic analysis revealed that EstYZ5 belongs to the hormone-sensitive lipase (HSL) family with a deduced catalytic triad of Ser144-Glu238-His268. Read More

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Eusocial insect declines: Insecticide impairs sperm and feeding glands in bumblebees.

Sci Total Environ 2021 Apr 10;785:146955. Epub 2021 Apr 10.

Institute of Bee Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland; Agroscope, Swiss Bee Research Centre, Bern, Switzerland. Electronic address:

Insecticides are contributing to global insect declines, thereby creating demand to understand the mechanisms underlying reduced fitness. In the eusocial Hymenoptera, inclusive fitness depends on successful mating of male sexuals (drones) and efficient collaborative brood care by female workers. Therefore, sublethal insecticide effects on sperm and glands used in larval feeding (hypopharyngeal glands (HPG)) would provide key mechanisms for population declines in eusocial insects. Read More

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Dietary acid load and lung cancer risk: A case-control study in men.

Cancer Treat Res Commun 2021 Apr 25;28:100382. Epub 2021 Apr 25.

Unit of Thoracic Oncology, National Cancer Institute, Joanicó 3265, Montevideo 11600, Uruguay.

Background: Dysregulation of the endogenous acid-base balance can contribute to inflammation and cancer development if metabolic acidosis is sustained. The epidemiologic evidence on the association between diet-dependent acid load and cancer risk is scarce and inconsistent. We aim to explore the possible role of dietary acid load in lung cancer (LC) risk. Read More

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Laryngeal cleft: A literature review.

Am J Otolaryngol 2021 Apr 20;42(6):103072. Epub 2021 Apr 20.

Department of Otolaryngology - Head and Neck Surgery, Drexel University College of Medicine, United States of America; Lankenau Institute for Medical Research, United States of America. Electronic address:

Introduction: Laryngeal cleft is a congenital condition in which an opening in the posterior laryngotracheal wall allows food and liquid to pass from the esophageal lumen to the airway and causes aspiration. The severity of a laryngeal cleft is measured using the Benjamin-Inglis system, and can be managed conservatively or with a variety of surgical options With increased awareness, higher suspicion among primary physicians, advanced technology and improved intensive neonatal care services, more babies with laryngeal clefts survive in the modern era. Therefore, the focus has shifted from infant survival to treatment of laryngeal clefts and the challenging, complex medical conditions they create. Read More

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Exposure estimates of phthalates and DINCH from foods and personal care products in comparison with biomonitoring data in 24-hour urine from the Norwegian EuroMix biomonitoring study.

Environ Int 2021 May 3;155:106598. Epub 2021 May 3.

Norwegian Institute of Public Health, Division of Infection Control and Environmental Health, 0403 Oslo, Norway. Electronic address:

Phthalates are diesters of phthalic acid and have been widely used as plasticizers in polyvinyl chloride (PVC) plastics. Phthalates are also used as excipients in pharmaceuticals and personal care products (PCPs). Phthalates can migrate from the plastic into the air, water and food, and humans can be exposed via multiple pathways such as dermal, oral and inhalation. Read More

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Effects of soil type, moisture content and organic amendment rate on dimethyl disulfide distribution and persistency in soil.

Environ Pollut 2021 Apr 30;285:117198. Epub 2021 Apr 30.

State Key Laboratory for Biology of Plant Disease and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. Electronic address:

Understanding the distribution and persistence of the fumigant dimethyl disulfide (DMDS) under different soil conditions would contribute to a more environmentally sustainable use of this gas. We determined the effects of soil type, soil moisture content and soil organic amendment rate on DMDS distribution and persistency using soil columns in the laboratory. The peak concentrations of DMDS at 60 cm soil depth in sandy loam soil, black soil and red loam soil were 1. Read More

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Contrasting the assembly of phytoplankton and zooplankton communities in a polluted semi-closed sea: Effects of marine compartments and environmental selection.

Environ Pollut 2021 Apr 29;285:117256. Epub 2021 Apr 29.

State Environmental Protection Key Laboratory of Coastal Ecosystem, National Marine Environmental Monitoring Center, Dalian, 116023, China.

Understanding the underlying mechanisms of community assembly is a major challenge in microbial ecology, particularly in communities composed of diverse organisms with different ecological characteristics. However, very little is known about the effects of marine compartments in shaping marine planktonic communities; primarily, how they are related to organism types and environmental variables. In this study, we used multiple statistical methods to explore the mechanisms driving phytoplankton and zooplankton metacommunity dynamics at the regional scale in the Bohai Sea, China. Read More

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Polychlorinated biphenyls (PCBs) in the colostrum samples from the Yangtze River Region: Exposure profile and risk assessment.

Environ Pollut 2021 Apr 29;285:117253. Epub 2021 Apr 29.

Interdisciplinary Research Academy (IRA), Zhejiang Shuren University, Hangzhou, 310015, China.

Polychlorinated biphenyls (PCBs) may transfer into the neonates through the placental transfer and via breastfeeding after the delivery, thus might be harmful to the infant. Sixty colostrum samples in the Yangtze River Region were collected to investigate the concentration, distribution pattern, and enantiomer characteristic of the PCB exposure. Among all samples, over 90% of pollutants were tetra-to hepta-chlorinated PCBs. Read More

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Evaluation of volatile flavor compounds in bacon made by different pig breeds during storage time.

Food Chem 2021 Apr 9;357:129765. Epub 2021 Apr 9.

University of Liège, Gembloux Agro-Bio Tech, Unit of Food Science and Formulation, Passage des Déportés 2, Gembloux B-5030, Belgium.

The oxidation and volatile constituents of bacon (which made of white pig (Duroc × Landrace × Yorkshire) and black pig (Beijing Black × Yorkshire)) during refrigerated storage were analyzed by thiobarbituric acid reactive substances (TBARS), total thiol groups, gas chromatography-mass spectrometry (GC-MS) and gas chromatography coupling with ion mobility spectrometry (GC-IMS). The TBARS value of tested samples increased while the total thiol groups decreased during 60 days storage (P < 0.05). Read More

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Metabolic engineering of Bacillus subtilis for enhancing riboflavin production by alleviating dissolved oxygen limitation.

Bioresour Technol 2021 Apr 29;333:125228. Epub 2021 Apr 29.

Key Laboratory of Industrial Biotechnology of the Ministry of Education, Laboratory of Applied Microorganisms and Metabolic Engineering, School of Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address:

Riboflavin, an essential vitamin for animals, is used widely in the pharmaceutical industry and as a food and feed additive. The microbial synthesis of riboflavin requires a large amount of oxygen, which limits the industrial-scale production of the vitamin. In this study, a metabolic engineering strategy based on transcriptome analysis was identified as effective in increasing riboflavin production. Read More

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Exploring the interactions of naringenin and naringin with trypsin and pepsin: Experimental and computational modeling approaches.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 21;258:119859. Epub 2021 Apr 21.

School of Medical Engineering, Xinxiang Medical University, Xinxiang, Henan 453003, PR China. Electronic address:

Naringenin and naringin are two natural compounds with important health benefits, whether as food or drug. It is necessary to study the interactions between naringenin/naringin and digestive proteases, such as trypsin and pepsin. In this study, the bindings of naringenin and naringin to trypsin and pepsin were investigated using multi-spectroscopy analysis and computational modeling approaches. Read More

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Effect of high concentration of ammonium on production of n-caproate: Recovery of a high-value biochemical from food waste via lactate-driven chain elongation.

Waste Manag 2021 May 3;128:25-35. Epub 2021 May 3.

Key Laboratory of Environmental and Applied Microbiology, Environmental Microbiology Key Laboratory of Sichuan Province; Chengdu Institute of Biology, Chinese Academy of Sciences. Chengdu, 610041, PR China; University of Chinese Academy of Sciences, Beijing 100864, PR China.

Ammonium accumulation is inevitable during the fermentation of food waste (FW), challenging the application of chain elongation process upgrading FW into the high-value biochemical n-caproate, which is a medium chain carboxylate. This study is the first to investigate ammonium inhibition of lactate-driven chain elongation process. The short-term exposure of a Clostridium IV-dominated chain elongating reactor microbiome at an ammonium concentration of 1-4 g L linearly decreased n-caproate production by 25-80%. Read More

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Chicken production, flock size, management systems, and challenges in the Dodoma region in Tanzania.

Poult Sci 2021 Mar 18;100(6):101136. Epub 2021 Mar 18.

Tanzania Veterinary Laboratory Agency (TVLA) - Tanzania Vaccine Institute (TVI), Kibaha - Bagamoyo via Baobab Road, Mitamba Area, P. O. Box 30137, Kibaha, Pwani.

Dodoma's population is growing rapidly creating a high demand for food security like chicken products. However, the distribution of chickens' management systems, breed of chicken kept, and challenges facing chicken production in Dodoma are less documented. This study focused on finding out the productivity of chicken in terms of flock size and how it is affected by the management system, types/breed of chicken keeping, and evaluating the challenges facing chicken production in Dodoma. Read More

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Evaluation of multi blade shear (MBS) for determining texture of raw and cooked broiler breast fillets with the woody breast myopathy.

Poult Sci 2021 Mar 12;100(6):101123. Epub 2021 Mar 12.

Poultry Sciences Department, University of Georgia, 110 Cedar St, Athens, GA, 30602, USA. Electronic address:

The objective of this study was to evaluate a novel multi-blade Shear (MBS) method for measuring texture properties of both raw and cooked broiler fillets (pectoralis major) with the woody breast (WB) myopathy. A total of 180 broiler breast fillets (60 normal [NOR], 60 moderate WB [MOD], and 60 severe WB [SEV]) in two meat states (fresh never-frozen, n = 144; frozen/thawed, n = 36) were chosen based on their WB scores. In each trial, half of the fillets were used for measuring raw meat texture and the other half for cooked meat texture measurement. Read More

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Effects of lyophilized black mulberry water extract on lipid oxidation, metmyoglobin formation, color stability, microbial quality and sensory properties of beef patties stored under aerobic and vacuum packaging conditions.

Meat Sci 2021 Apr 20;178:108522. Epub 2021 Apr 20.

Ordu University, Faculty of Agriculture, Department of Food Engineering, Ordu, Turkey.

The objective was to determine the effects of different concentrations of lyophilized black mulberry water extract (BMWE) on lipid oxidation, metmyoglobin (MMb) formation, color stability, microbial quality, and sensory properties of aerobic (AP) and vacuum (VP) packaged beef patties during 15 days of chilled storage. Compared to control, incorporating of BMWE decreased (P < .01) the pH, thiobarbituric acid reactive substances (TBARS), MMb, and hue angle values of both AP and VP beef patties, while improving the redness (a*) and chroma values (P < . Read More

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Synergistic inactivation of bacteria based on a combination of low frequency, low-intensity ultrasound and a food grade antioxidant.

Ultrason Sonochem 2021 Apr 16;74:105567. Epub 2021 Apr 16.

Department of Food Science and Technology, University of California, Davis, CA, USA; Department of Biological and Agricultural Engineering, University of California, Davis, CA, USA. Electronic address:

This study evaluated a synergistic antimicrobial treatment using a combination of low frequency and a low-intensity ultrasound (LFU) and a food-grade antioxidant, propyl gallate (PG), against a model gram-positive (Listeria innocua) and the gram-negative bacteria (Escherichia coli O157:H7). Bacterial inactivation kinetic measurements were complemented by characterization of biophysical changes in liposomes, changes in bacterial membrane permeability, morphological changes in bacterial cells, and intracellular oxidative stress upon treatment with PG, LFU, and a combination of PG + LFU. Combination of PG + LFU significantly (>4 log CFU/mL, P < 0. Read More

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Impurity profiling of Compound Amino Acid Injection (6AA) using ion-pair high performance liquid chromatography coupled with corona-charged aerosol detection and high resolution mass spectrometry.

J Pharm Biomed Anal 2021 Apr 24;201:114099. Epub 2021 Apr 24.

Institute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 1, Tian Tan Xi Li, 100050, Beijing, PR China. Electronic address:

The complex industrial production process of amino acids (AAs) leads to the existence of a certain amount of impurities in Compound Amino Acid Injection (6AA). It is difficult to obtain its comprehensive and systematic impurity profile using conventional ultraviolet (UV) detectors due to lack of a suitable chromophore in the structures of AAs and their impurities. In our study, a universal ion-pair high performance liquid chromatography (HPLC) method combined with high resolution mass spectrometer (HRMS) and charged aerosol detection (CAD) was developed to identify and determine the content of impurities in Compound Amino Acid Injection (6AA), respectively. Read More

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Advances in the separation of gangliosides by counter-current chromatography (CCC).

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Apr 9;1174:122701. Epub 2021 Apr 9.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5, Canada.

Gangliosides play critical roles in the development of many progressive diseases. Due to their structural diversity, efficient methods are needed to separate individual gangliosides for studies of their functions, and for use as standards in the analysis of ganglioside mixtures. This proof-of-concept study reports a useful analytical-semi-preparative scale counter-current chromatography (CCC) enrichment of multiple ganglioside homologues of various species and classes at the milligram level. Read More

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Non-target bioanalytical eight-dimensional hyphenation including bioassay, heart-cut trapping, online desalting, orthogonal separations and mass spectrometry.

J Chromatogr A 2021 Apr 20;1647:462154. Epub 2021 Apr 20.

Chair of Food Science, Institute of Nutritional Science, and Interdisciplinary Research Center (iFZ), Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany. Electronic address:

It is still a challenge to discover and identify individual bioactive compounds directly in multicomponent mixtures. Current workflows are too tedious for routine use. Hence, the hyphenation of separation and detection techniques is a powerful tool to maximize the information obtained by a single sample run. Read More

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Fabrication and characterization of basil essential oil microcapsule-enriched mayonnaise and its antimicrobial properties against Escherichia coli and Salmonella Typhimurium.

Food Chem 2021 Apr 23;359:129940. Epub 2021 Apr 23.

Ankara University, Faculty of Engineering, Department of Food Engineering, 06830 Gölbaşı/Ankara, Turkey.

Nowadays, as consumers tend to avoid foods containing synthetic preservatives, technologically processed plant extracts can be a good alternative to these preservatives. In this study, previously obtained basil essential oil microcapsules (BEOM) were added to mayonnaise in order to produce a microbiologically safe product with improved physicochemical properties. Mayonnaises were prepared with 0%, 0. Read More

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Effect of potato apical leaf curl disease on glycemic index and resistant starch of potato (Solanum tuberosum L.) tubers.

Food Chem 2021 Apr 23;359:129939. Epub 2021 Apr 23.

ICAR-Central Potato Research Institute, Shimla 171001, Himachal Pradesh, India.

Tomato leaf curl New Delhi virus-potato (ToLCNDV-potato) causes potato apical leaf curl disease which severely affects nutritional parameters such as carbohydrate, protein, and starch biosynthesis thereby altering glycemic index (GI) and resistant starch (RS) of potato. ToLCNDV-potato virus was inoculated on potato cultivars (Kufri Pukhraj [susceptible]; Kufri Bahar [resistant]) and various quality parameters of potato tuber were studied. There was a significant (P < 0. Read More

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Determination of Mn(II) and Mn(VII) in beverage samples using magnetic dispersive micro-solid phase extraction coupled with solidified floating organic drop microextraction followed by graphite furnace atomic absorption spectrometry.

Food Chem 2021 Apr 28;359:129958. Epub 2021 Apr 28.

College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, PR China.

Magnetic dispersive micro-solid phase extraction (MDMSPE) was coupled with solidified floating organic drop microextraction (SFODME) for direct separation and preconcentration of Mn(II) and Mn(VII) before graphite furnace atomic absorption spectrometry determination. MDMSPE involved use of magnetic ZnFeO nanotubes for adsorbing Mn(VII). Sorbent was isolated from aqueous phase by an external magnet. Read More

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Application of benchtop NIR spectroscopy coupled with multivariate analysis for rapid prediction of antioxidant properties of walnut (Juglans regia).

Food Chem 2021 Apr 22;359:129928. Epub 2021 Apr 22.

School of Food and Biological Engineering Jiangsu University, Xuefu Road 301, Zhenjiang 213013, China. Electronic address:

Benchtop near-infrared (NIR) spectroscopy coupled with multivariate analysis was used for the classification and prediction of antioxidant properties of walnut. Total phenolic content (TPC), total flavonoid content (TFC), ABTS assay and FRAP assay were performed spectrophotometrically. The synergy interval partial least square coupled competitive adaptive reweighted sampling (Si-CARS-PLS) was used for the prediction. Read More

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Photostability of l-tryptophan in aqueous solution: Effect of atmosphere and antioxidants addition.

Food Chem 2021 Apr 24;359:129949. Epub 2021 Apr 24.

Université de Haute-Alsace, CNRS, IS2M UMR 7361, F-68100 Mulhouse, France; Université de Strasbourg, F-67000, France. Electronic address:

l-Tryptophan (l-Trp) is an amino acid important in nutrition, and mainly provided by food supplements. However, it is known to be unstable under light irradiation, which is an issue for the nutrition and feed industry. In the present study, the photostability of l-Trp was studied in acidic aqueous solutions under air and under an inert atmosphere, N. Read More

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Novel strategy of natural antioxidant nutrition quality evaluation in food: Oxidation resistance mechanism and synergistic effects investigation.

Food Chem 2021 Apr 24;359:129768. Epub 2021 Apr 24.

Center for Advanced Analytical Science, School of Chemistry and Chemical Engineering c/o School of Civil Engineering, Guangzhou University, Guangzhou 510006, PR China; State Key Laboratory of Electroanalytical Chemistry, c/o Engineering Laboratory for Modern Analytical Techniques, CAS Center for Excellence in Nanoscience, Changchun Institute of Applied Chemistry, Changchun 130022, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR China.

Effective evaluation methods for assessing the nutritional quality of foods that eliminate free radicals (i.e., foods that are classified as antioxidants) have long attracted the attention of scientists and the populace. Read More

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Magnetic molecularly imprinted polymer nanoparticles for the extraction and clean-up of thiamethoxam and thiacloprid in light and dark honey.

Food Chem 2021 Apr 23;359:129936. Epub 2021 Apr 23.

Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

In this work, new selective and sensitive dual-template molecularly imprinted polymer nanoparticles (MIPs) were synthesized and characterized. Sorbent MIPs were investigated for simultaneous extraction and clean-up of thiamethoxam and thiacloprid from light and dark honey samples. In this study, ultra-high-performance liquid chromatography-tandem mass spectrometry triple-quadrupole (UHPLC-MS/MS) (QQQ) was used to detect and quantify the pesticides. Read More

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Validated B vitamin quantification from lentils by selected reaction monitoring mass spectrometry.

Food Chem 2021 Apr 20;359:129810. Epub 2021 Apr 20.

Crop Development Centre, Department of Plant Sciences, University of Saskatchewan, Saskatoon S7N 5A8, Canada.

A validated method for B vitamin separation and quantification from lentil seeds using ultra high performance liquid chromatography-selected reaction monitoring mass spectrometry (UHPLC-SRM MS) was reported. The use of three enzymes (acid phosphatase, β-glucosidase, and rat serum) with a 4 h incubation was sufficient to convert bound B vitamins into their free forms. Twenty B vitamers were selected and a 5-min UHPLC-SRM MS method was optimized for rapid analysis. Read More

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