246,802 results match your criteria followedresults initially

Stability study over time of clinical solutions of ziv-aflibercept prepared in infusion bags using a proper combination of physicochemical and functional strategies.

J Pharm Biomed Anal 2021 Jun 16;203:114209. Epub 2021 Jun 16.

Department of Analytical Chemistry, Sciences Faculty, Instituto de Investigación Biosanitaria (ibs.Granada), University of Granada, E-18071, Granada, Spain. Electronic address:

A range of biopharmaceutical products are used to target Vascular Endothelial Growth Factor (VEGF), including Eylea® (aflibercept, AFL) and Zaltrap® (ziv-aflibercept, ziv-AFL). The first is indicated for ophthalmological diseases such as neovascular (wet) age-related macular degeneration, while the second is used in the treatment of metastatic colorectal cancer. The stability of AFL in prefilled syringes has been widely studied; however, no research has yet been done on the stability of ziv-AFL in polyolefin infusion bags. Read More

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Septic arthritis of native joints due to Mycobacterium avium complex: A systematic review of case reports.

Semin Arthritis Rheum 2021 Jun 9;51(4):813-818. Epub 2021 Jun 9.

Pali Momi Medical Center, Hawai'i Pacific Health, 98-1079 Moanalua Road, Suite 300, Aiea, Honolulu 96701, HI, USA. Electronic address:

Introduction: While MAC native joint septic arthritis is historically considered a rare entity, the number of reported cases have increased in recent decades. However, no comprehensive review of this topic has been conducted.

Objectives: To conduct a systematic review of cases of MAC native joint septic arthritis reported in the literature and summarize the presentations, baseline characteristics, risk factors, diagnosis, treatment, and treatment outcomes. Read More

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Interleukin-6 (IL-6) inhibitors as therapeutic agents for coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.

J Infect Public Health 2021 Jun 15;14(8):1001-1009. Epub 2021 Jun 15.

Faculty of Medicine, Duta Wacana Christian University, Yogyakarta, Indonesia; Bethesda Hospital, Yogyakarta, Indonesia.

Introduction: Preliminary studies showed that coronavirus disease 2019 (COVID-19) disrupts body immune system, including dysregulation of cytokine interleukin-6 (IL-6). IL-6 inhibitors agents have been used as treatment options for COVID-19, yet their benefit as therapeutic agents remains unclear.

Objective: We performed a systematic review and meta-analysis to synthesize the available evidence on the potential therapeutic effect of IL-6 inhibitor agents for the treatment of COVID-19. Read More

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Well-differentiated liposarcoma of the cheek misdiagnosed for lipoma: A case report.

Int J Surg Case Rep 2021 Jun 16;84:106116. Epub 2021 Jun 16.

Oral and Maxillofacial Surgery Department, CHU Ibn Rochd, Casablanca, Morocco; Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.

Introduction: Liposarcoma is the most common sarcoma entity and accounts for 17% to 30% of soft tissue sarcomas. There are several histological types including well-differentiated liposarcoma. This paper aims to underline the interest of immunohistochemical and cytogenetic studies to diagnose well-differentiated liposarcoma and to show the delicacy of performing a surgical procedure in the cheek area. Read More

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A modeling methodology to predict the generation of wasted plastic pesticide containers: An application to Greece.

Waste Manag 2021 Jun 18;131:177-186. Epub 2021 Jun 18.

Department of Environmental Engineering, Democritus University of Thrace, Xanthi 67132, Greece. Electronic address:

Plant protection products (pesticides) are used throughout the world in the form of various types, such as insecticides, fungicides, herbicides etc. High Density Polyethylene is the principal material that those containers are made of. The aim of the study was to determine the factors that statistically affect the generation of the resulting wasted plastic pesticide containers after pesticide application. Read More

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Mechanism of As(III) removal properties of biochar-supported molybdenum-disulfide/iron-oxide system.

Environ Pollut 2021 Jun 16;287:117600. Epub 2021 Jun 16.

Department of Civil and Environmental Engineering, Shantou University, Shantou, 515063, China. Electronic address:

Sulfate (SO) and hydroxyl-based (HO) radical are considered potential agents for As(III) removal from aquatic environments. We have reported the synergistic role of SO and HO radicals for As(III) removal via facile synthesis of biochar-supported SO species. MoS-modified biochar (MoS/BC), iron oxide-biochar ([email protected]), and MoS-modified iron oxide-biochar (MoS/[email protected]) were prepared and systematically characterized to understand the underlying mechanism for arsenic removal. Read More

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There is no gene for CVID - novel monogenetic causes for primary antibody deficiency.

Curr Opin Immunol 2021 Jun 18;72:176-185. Epub 2021 Jun 18.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany; DZIF - German Center for Infection Research, Satellite Center Freiburg, Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, Albert-Ludwigs University, Freiburg, Germany; RESIST - Cluster of Excellence 2155 to Hanover Medical School, Satellite Center Freiburg, Freiburg, Germany. Electronic address:

'There is no gene for fate' (citation from the movie 'GATTACA') - and there is no gene for CVID. Common Variable ImmunoDeficiency (CVID) is the most prevalent primary immunodeficiency in humans. CVID is characterized by an increased susceptibility to infections, hypogammaglobulinemia, reduced switched memory B cell numbers in peripheral blood and a defective response to vaccination, often complicated by autoimmune and autoinflammatory conditions. Read More

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Recognition of Hematopoietic Stem Cell Transplant and Cellular Therapy Expertise to Promote Care Accessibility: A Formally Credentialed Area of Focus Competence in Canada.

Transplant Cell Ther 2021 Jun 18. Epub 2021 Jun 18.

University of Calgary, Alberta, Canada; Division of Nephrology, University of Ottawa, Ontario, Canada; Section of Pediatric Oncology/BMT, Departments of Oncology or Pediatrics, Cumming School of Medicine.

Background: Hematopoietic stem cell transplantation (HSCT) and cellular therapy (CT) exploit the therapeutic potential of manipulated or unmanipulated hematopoietic cells to treat diseases. While initially dedicated to the treatment of hematological malignancies and disorders, its efficacy is currently being investigated in several diseases and cancers. Indications are currently booming. Read More

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The treatment landscape of metastatic prostate cancer.

Cancer Lett 2021 Jun 18. Epub 2021 Jun 18.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

The treatment landscape of metastatic prostate cancer has evolved significantly over the past two decades. Several landmark phase 3 trials led to new drug approvals and rapid changes in therapy options for patients, including drugs with distinct mechanisms of action (e.g. Read More

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Not lowering the bar, just providing a step stool.

Autophagy 2021 Jun 21:1-2. Epub 2021 Jun 21.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

There have been a couple of times when we have reviewed papers that are essentially publishable as initially submitted; the "criticisms" were more along the lines of constructive suggestions that the authors might want to consider when they submitted a revised version of the paper, but those changes were not required. However, a much more common experience is for the authors to receive a series of comments from multiple reviewers. Most of those comments are critical for the authors to address, to ensure that the data in the paper are of sufficient quality and rigor, with adequate controls, to support the stated conclusions. Read More

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Impact of lay navigation on utilization and Medicare spending for cancer survivors in the "Deep South".

J Cancer Surviv 2021 Jun 21. Epub 2021 Jun 21.

UAB Division of Preventative Medicine, University of Alabama at Birmingham (UAB), MT 636, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.

Purpose: Though lay navigation programs have proven beneficial for individuals during cancer treatment, little is known about the effects of lay navigation on health care utilization and Medicare spending among older adults during cancer survivorship.

Methods: This retrospective cohort study used administrative claims data to evaluate a lay navigation program implemented from 2012 to 2015 at 12 academic and community cancer centers in the Southeast. Medicare beneficiaries age ≥65 years navigated during survivorship were compared to propensity score-matched, non-navigated cancer survivors. Read More

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[CAR T-cell therapy for malignant B-cell lymphoma : A new treatment paradigm].

Internist (Berl) 2021 Jun 21;62(6):589-596. Epub 2021 Jun 21.

Uniklinik Köln, Medizinische Klinik 1, 50937, Köln, Deutschland.

Following the first demonstration of efficacy of anti-CD19-directed chimeric antigen receptor (CAR) T cells in a patient with relapsed chronic lymphocytic leukemia (CLL) in 2011, pivotal studies for this innovative therapy were initially conducted in multiple relapsed or refractory (r/r) childhood and young adult acute B‑cell leukemia and in aggressive adult B‑cell lymphoma. The studies demonstrated efficacy even in chemotherapy-refractory disease, resulting in the first approval of autologous and genetically engineered T cells for the treatment of r/r B‑cell acute lymphoblastic leukemia (B-ALL) in the US for the product tisagenlecleucel (Kymriah®, Novartis) back in 2018. Approval for the treatment of r/r aggressive B‑cell lymphoma followed shortly thereafter for tisagenlecleucel and axicabtagene ciloleucel (Yescarta, Kite/Gilead). Read More

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Observation of Negative Terahertz Photoconductivity in Large Area Type-II Dirac Semimetal PtTe_{2}.

Phys Rev Lett 2021 Jun;126(22):227402

Department of Physics, Shanghai University, Shanghai 200444, China.

As a newly emergent type-II Dirac semimetal, platinum telluride (PtTe_{2}) stands out from other two dimensional noble-transition-metal dichalcogenides for the unique band structure and novel physical properties, and has been studied extensively. However, the ultrafast response of low energy quasiparticle excitation in terahertz frequency remains nearly unexplored yet. Herein, we employ optical pump-terahertz probe (OPTP) spectroscopy to systematically study the photocarrier dynamics of PtTe_{2} thin films with varying pump fluence, temperature, and film thickness. Read More

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Frequency of back pain occurrence among high school youth including their physical activity.

Minerva Pediatr (Torino) 2021 Jun 21. Epub 2021 Jun 21.

Department of Adapted Physical Activity and Sport, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland.

Introduction: Back pain diseases are among frequently reported health problems. Unfortunately, more often this problem also affects young people, high school students. Lifestyle that people are representing nowadays has a negative impact on their spine. Read More

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Onasemnogene abeparvovec-xioi: a gene replacement strategy for the treatment of infants diagnosed with spinal muscular atrophy.

Drugs Today (Barc) 2021 Jun;57(6):387-399

Biomedical Sciences Graduate School, The Ohio State University, Columbus, Ohio, USA.

In May of 2019, the adeno-associated virus (AAV)-based gene therapy onasemnogene abeparvovec-xioi (Zolgensma) became the second Food and Drug Administration (FDA)-approved gene therapy with designated use for infants diagnosed with spinal muscular atrophy (SMA). The decision came nearly 10 years after results of the first preclinical models were initially reported. While the journey was an arduous one, the approval was an indication of the remarkable success of the first in-human clinical trials. Read More

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Cochlear implant surgery: Learning curve in virtual reality simulation training and transfer of skills to a 3D-printed temporal bone - A prospective trial.

Cochlear Implants Int 2021 Jun 19:1-8. Epub 2021 Jun 19.

Copenhagen Hearing and Balance Centre, Department of Otorhinolaryngology-Head & Neck Surgery and Audiology, Rigshospitalet, Copenhagen, Denmark.

Objective: Mastering Cochlear Implant (CI) surgery requires repeated practice, preferably initiated in a safe - i.e. simulated - environment. Read More

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Polyneuropathy: A Rare and Challenging Presentation of Essential Mixed Cryoglobulinemia.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211026503

Indiana University, Indianapolis, IN, USA.

A 49-year-old male presented with acute chronic sensory motor bilateral lower extremity polyneuropathy. Electromyography showed bilateral acute sensory motor axonal polyneuropathy. Lumbar spine magnetic resonance imaging showed diffuse bone marrow replacement and bilateral ankylosing spondylitis. Read More

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Modulation of Dopamine for Adaptive Learning: A Neurocomputational Model.

Comput Brain Behav 2021 Mar 12;4(1):34-52. Epub 2020 Jun 12.

Department of Psychological & Brain Sciences, University of California, Santa Barbara.

There have been many proposals that learning rates in the brain are adaptive, in the sense that they increase or decrease depending on environmental conditions. The majority of these models are abstract and make no attempt to describe the neural circuitry that implements the proposed computations. This article describes a biologically detailed computational model that overcomes this shortcoming. Read More

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Rapid visual field progression in a patient with glaucoma as the presenting manifestation of sarcoidosis.

Am J Ophthalmol Case Rep 2021 Sep 5;23:101132. Epub 2021 Jun 5.

Department of Ophthalmology, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

Purpose: To report a case of accelerated visual field progression secondary to a new orbital apex lesion in a patient with a longstanding history of fatigue and cough.

Observations: A 73-year-old myopic female with known open angle glaucoma presented with accelerated unilateral visual field progression. Maximally tolerated medical therapy was instituted over a period of 1-2 years with imminent discussions of surgical intervention. Read More

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September 2021

Bilateral vision loss as the initial presentation for central nervous system involvement of mantle cell lymphoma: A case series.

Am J Ophthalmol Case Rep 2021 Sep 3;23:101131. Epub 2021 Jun 3.

Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.

Purpose: Mantle cell lymphoma is a rare aggressive subtype of non-Hodgkins B cell lymphoma. It typically presents with asymptomatic monoclonal lymphocytosis, lymphadenopathy or bulky extranodal disease. Mantle cell lymphoma rarely affects the central nervous system. Read More

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September 2021

Urate Crystals; Beyond Joints.

Front Med (Lausanne) 2021 4;8:649505. Epub 2021 Jun 4.

Department of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Gout is the most common inflammatory arthropathy caused by the deposition of monosodium urate (MSU) crystals. The burden of gout is substantial with increasing prevalence of gout globally. The prevalence of Gout in the United States has increased by over 7% in the last two decades. Read More

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Biosensor Technologies for Early Detection and Quantification of Plant Pathogens.

Front Chem 2021 2;9:636245. Epub 2021 Jun 2.

Centre for Planetary Health and Food Security, Griffith University, Nathan, QLD, Australia.

Plant pathogens are a major reason of reduced crop productivity and may lead to a shortage of food for both human and animal consumption. Although chemical control remains the main method to reduce foliar fungal disease incidence, frequent use can lead to loss of susceptibility in the fungal population. Furthermore, over-spraying can cause environmental contamination and poses a heavy financial burden on growers. Read More

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An Update on the Outcomes of Patients Treated with Urolift for Benign Prostatic Hyperplasia.

Res Rep Urol 2021 11;13:347-355. Epub 2021 Jun 11.

Department of Urology, Montefiore Medical Center, Bronx, NY, USA.

Benign prostatic hyperplasia (BPH) is a ubiquitous urologic disease affecting aging men. Patients often experience bothersome lower urinary tract symptoms (LUTS) that warrant urologic evaluation and management. Routinely, patients are initially treated with medical therapies with the goal of both relaxing the bladder neck and shrinking the prostate in order to relieve obstruction secondary to prostatic enlargement. Read More

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Identification of NAA40 as a Potential Prognostic Marker for Aggressive Liver Cancer Subtypes.

Front Oncol 2021 2;11:691950. Epub 2021 Jun 2.

Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus.

Liver hepatocellular carcinoma (LIHC) is a leading cause of cancer-related mortality. In this study we initially interrogated the Cancer Genome Atlas (TCGA) dataset to determine the implication of N-terminal acetyltransferases (NATs), a family of enzymes that modify the N-terminus of the majority of eukaryotic proteins, in LIHC. This examination unveiled NAA40 as the NAT family member with the most prominent upregulation and significant disease prognosis for this cancer. Read More

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Case Report: Solitary Extramedullary Plasmacytoma in the Cervix Misdiagnosed as Cervical Cancer.

Front Oncol 2021 4;11:685070. Epub 2021 Jun 4.

Department of Radiology, The First People's Hospital of Zunyi, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Solitary plasmacytoma (SP) is a malignant tumor caused by the monoclonal proliferation of plasma cells, representing less than 5% of plasma cell tumors. SP can be categorized into two groups: solitary bone plasmacytoma (SBP) and solitary extramedullary plasmacytoma (SEP). SEP most commonly occurs in the head and neck and is rarely located in the reproductive system. Read More

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Leiomyosarcoma of Nose a Very Rare Tumor Case Report: Unusual Case Leiomyosarcoma Inferior Turbinate.

Himanshu Thakkar

Indian J Otolaryngol Head Neck Surg 2021 Jun 28;73(2):137-139. Epub 2020 Feb 28.

ENT and Dental Surgical Hospital, 202-Lifeline Building, Vidyanagar Main Road, Rajkot, Gujarat 360001 India.

Leiomyosarcoma (LMS) accounts for approximately 7% of all soft tissue sarcomas and occurs most frequently in the gastrointestinal tract and uterus. In the head and neck, however, LMS makes up only 2.3%. Read More

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Corticosteroids in Covid-19 pandemic have the potential to unearth hidden burden of strongyloidiasis.

IDCases 2021 12;25:e01192. Epub 2021 Jun 12.

Department of General Medicine, All India Institute of Medical Sciences, Bhopal, India.

COVID-19 pandemic has posed formidable public health and clinical challenges to the entire humanity. A significant proportion of the COVID-19 patients have been provided immunosuppressive agents, particularly corticosteroids, as a part of management of moderate to severe COVID-19 disease. This has the drawback of development of strongyloides hyperinfection to disseminated infection in latent strongyloides infection patients. Read More

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Analyzing Consequence Variables Within the High-Probability Instructional Sequence for a Child Diagnosed With CHARGE Syndrome.

Behav Anal Pract 2021 Jun 12;14(2):352-359. Epub 2021 Jan 12.

Department of Behavior Analysis, Simmons University, 300 The Fenway, Boston, MA 02115 USA.

Many individuals with developmental disabilities exhibit noncompliance during intensive instruction. As a treatment for noncompliance, the high-probability instructional sequence (high-p sequence) consists of delivering several high-p instructions before a low-p instruction. The purpose of this study was to extend the research on comparing consequences for high-p demands-namely, praise, edibles, and videos-with an 11-year-old girl diagnosed with CHARGE syndrome. Read More

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Catatonia in a 6-year-old Patient Following Disseminated Group A Streptococcus Infection.

Innov Clin Neurosci 2021 Jan-Mar;18(1-3):17-20. Epub 2021 Jan 1.

Drs. Cawkwell and Shaw and Mr. Mayor are with the Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, at the Stanford University School of Medicine in Palo Alto, California.

Pediatric catatonia is a complex entity that is easily missed in the hospital setting and seldom reported in the literature. Here, we present the case of a 6-year-old previously healthy female patient who was initially thought to have intractable delirium secondary to disseminated Group A streptococcus (GAS) infection. Careful examination, utilization of the Pediatric Catatonia Rating Scale, and lorazepam challenge were key to elucidating the diagnosis. Read More

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January 2021