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Clinical correlates of social cognition after an ischemic stroke: preliminary findings.

Dement Neuropsychol 2021 Apr-Jun;15(2):223-229

Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais - Belo Horizonte, MG, Brazil.

The co-occurrence of post-stroke behavioral disorders and cognitive impairment has been extensively investigated. However, studies usually do not include social cognition among the assessed cognitive domains.

Objective: To investigate the potential association between facial emotion recognition, a measure of social cognition, and behavioral and cognitive symptoms in the subacute phase of ischemic stroke. Read More

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October 2020

MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis.

Biochim Biophys Acta Gene Regul Mech 2021 Jul 30:194734. Epub 2021 Jul 30.

Faculty of Pharmacy in Hradec Králové, Department of Biochemical Sciences, Charles University, Hradec Králové, Czech Republic. Electronic address:

Glutathione peroxidase 7 (GPx7) acts as an intracellular stress sensor/transmitter and plays an important role in adipocyte differentiation and the prevention of obesity related pathologies. For this reason, finding the regulatory mechanisms that control GPx7 expression is of great importance. As microRNAs (miRNAs) could participate in the regulation of GPx7 expression, we studied the inhibition of GPx7 expression by four selected miRNAs with relation to obesity and adipogenesis. Read More

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Prognostic and clinicopathological significance of TMEFF2, SMOC-2, and SOX17 expression in endometrial carcinoma.

Exp Mol Pathol 2021 Jul 30:104670. Epub 2021 Jul 30.

Department of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Egypt.

Background there is a need for novel biomarkers and targeting therapies for predicting Endometrial carcinoma (EC) progression and recurrence. TMEFF2 is a gene that was found to play a role in EMT. SMOC-2 is expressed in embryogenesis and it was identified as a recent stem cell-related gene that has a role in cancer progression. Read More

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Salivary High-Risk Human Papillomavirus DNA as a Biomarker for Human Papillomavirus-Driven Head and Neck Cancers.

J Mol Diagn 2021 Jul 26. Epub 2021 Jul 26.

Saliva & Liquid Biopsy Translational Laboratory, School of Biomedical Science, Faculty of Health, Queensland University of Technology (QUT), Queensland, Australia; Translational Research Institute, Queensland, Australia. Electronic address:

High-risk human papillomavirus (HR-HPV) infection is one of the major risk factors for head and neck cancers (HNC). Despite the rising incidence, biomarkers for detection, prognostication and disease monitoring of HPV-driven HNC (HPV-HNC) are lacking. To evaluate the capacity of salivary HR-HPV DNA as a biomarker for HPV-HNC, salivary HR-HPV status of 491 primary HNC patients and 10 recurrent HNC patients was investigated at diagnosis using qPCR and MassARRAY. Read More

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Immunohistological score of transcription factor 21 had a positive correlation with its urinary excretion and proteinuria in immunoglobulin A nephropathy.

Histol Histopathol 2021 Jul 29:18367. Epub 2021 Jul 29.

Department of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba. Ibaraki, Japan.

Transcription factor 21 (TCF21) contributes to mammalian nephrogenesis, and especially to glomerular maturation. Our previous study suggested its influence on glomerular injury, showing that TCF21 expression in podocytes had a positive correlation with the urinary protein value and also with the urinary TCF21 concentration. We now focus on its influence on the clinical course of immunoglobulin A nephropathy (IgAN), as patients with IgAN constitute the largest population of individuals with primary chronic glomerulonephritis in the world. Read More

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Galectin-3 and Estrogen Receptor Alpha as Prognostic Markers in Prolactinoma: Preliminary Results From a Pilot Study.

Front Endocrinol (Lausanne) 2021 12;12:684055. Epub 2021 Jul 12.

Pituitary Unit, Division of Endocrinology and Metabolism, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Introduction: Prolactin-secreting pituitary tumors (PRL-omas) are generally benign neoplasia. However, a percentage of cases show aggressive behavior. Prognostic markers may allow for the identification of aggressive cases. Read More

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Impact of e-cigarettes on colonic mucosa and the role of recovery: involvement of oxidative and inflammatory pathway.

Environ Sci Pollut Res Int 2021 Jul 26. Epub 2021 Jul 26.

Department of Human Anatomy & Embryology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Electronic cigarettes (e-cigarettes) (EC) are often advertised as a safer alternative to conventional cigarettes. Its widespread use has led to increased interest in its adverse health effects, thanks to few restrictions and a lack of regulatory guidelines. The study aimed to evaluate the influence of exposure to e-cigarette aerosol inhalation in rat colon model and conduct a follow-up after cessation of exposure. Read More

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Bone Marrow Mesenchymal Stem Cell Condition Medium Loaded on PCL Nanofibrous Scaffold Promoted Nerve Regeneration After Sciatic Nerve Transection in Male Rats.

Neurotox Res 2021 Jul 26. Epub 2021 Jul 26.

Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Nowadays, researchers pay a vast deal of attention to neural tissue regeneration due to its tremendous effect on the patient's life. There are many strategies, from using conventional autologous nerve grafts to the newly developed methods for reconstructing damaged nerves. Among the various therapeutic methods, incorporating highly potent biomolecules and growth factors, the damaged nerve site would promote nerve regeneration. Read More

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The serum CK17 and CK19 expressions in cervical cancer patients and their prognostic value.

Am J Transl Res 2021 15;13(6):6439-6445. Epub 2021 Jun 15.

Department of Pathology, Zhejiang North Medical Center (Huzhou Central Hospital) Huzhou 313003, Zhejiang Province, China.

Objective: This study was designed to quantify the serum CK17 and CK19 expressions in cervical cancer (CC) patients and determine their predictive value.

Methods: A total of 124 CC patients admitted to Zhejiang North Medical Center (Huzhou Central Hospital) between November 2014 and November 2017 were recruited for the study and placed in a research group (the Res group), and 99 healthy individuals during the same period were also recruited for the study and placed in a control group (the Con group). Their serum CK17 and CK19 expressions were quantified, and the diagnostic significance of the two for CC was analyzed. Read More

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Unresponsive thin endometrium caused by Asherman syndrome treated with umbilical cord mesenchymal stem cells on collagen scaffolds: a pilot study.

Stem Cell Res Ther 2021 07 22;12(1):420. Epub 2021 Jul 22.

Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, NO.3 Qingchun East Road, Shangcheng District, Hangzhou, 310016, People's Republic of China.

Background: Unresponsive thin endometrium caused by Asherman syndrome (AS) is the major cause of uterine infertility. However, current therapies are ineffective. This study is to evaluate the effect of transplantation with collagen scaffold/umbilical cord mesenchymal stem cells (CS/UC-MSCs) on this refractory disease. Read More

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A recurrent familial partial lipodystrophy due to a monoallelic or biallelic LMNA founder variant highlights the multifaceted cardiac manifestations of metabolic laminopathies.

Eur J Endocrinol 2021 Jul 1. Epub 2021 Jul 1.

E Nobécourt, Endocrinology, Diabetes and Nutrition, Centre Hospitalier Universitaire de La Reunion Sites Sud Saint-Pierre, Saint-Pierre, Réunion.

Aims: LMNA-linked Familial Partial Lipodystrophy type 2 (FPLD2) leads to insulin resistance-associated metabolic complications and cardiovascular diseases. We aimed to characterise the disease phenotype in a cohort of patients carrying an LMNA founder variant.

Methods: We collected clinical and biological data from patients carrying the monoallelic or biallelic LMNA p. Read More

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A Pilot Clinical Study of Hyperacute Serum Treatment in Osteoarthritic Knee Joint: Cytokine Changes and Clinical Effects.

Curr Issues Mol Biol 2021 Jul 9;43(2):637-649. Epub 2021 Jul 9.

Department of Sport Physiology, University of Physical Education, 44 Alkotás utca, 1123 Budapest, Hungary.

The serum fraction of platelet-rich fibrin (hyperacute serum) has been shown to improve cartilage cell proliferation in in vitro osteoarthritic knee joint models. We hypothesize that hyperacute serum may be a potential regenerative therapeutic for osteoarthritic knees. In this study, the cytokine milieu at the synovial fluid of osteoarthritic knee joints exposed to hyperacute serum intraarticular injections was investigated. Read More

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Serum midkine as non-invasive biomarker for detection and prognosis of non-small cell lung cancer.

Sci Rep 2021 Jul 16;11(1):14616. Epub 2021 Jul 16.

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

Lung cancer continues to be the leading cause for cancer-related deaths in men and women worldwide. Sufficient screening tools enabling early diagnosis are essential to improve patient outcomes. The aim of this study was to evaluate serum midkine (S-MK) both as a diagnostic and prognostic biomarker in non-small cell lung cancer (NSCLC). Read More

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Association between expressed breast milk feeding and breastfeeding duration in Hong Kong mothers.

Women Birth 2021 Jul 5. Epub 2021 Jul 5.

School of Nursing, Faculty of Health and Social Development, University of British Columbia, Kelowna, BC, Canada.

Background: Expressed breast milk feeding has increased substantially in the past two decades. Once used primarily for preterm infants, feeding expressed breast milk is now more common in mothers giving birth to healthy term infants. However, the effect of expressed breast milk feeding on breastfeeding duration is unclear. Read More

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Anti-TGFβ (Transforming Growth Factor β) Therapy With Betaglycan-Derived P144 Peptide Gene Delivery Prevents the Formation of Aortic Aneurysm in a Mouse Model of Marfan Syndrome.

Arterioscler Thromb Vasc Biol 2021 Jun 24:ATVBAHA121316496. Epub 2021 Jun 24.

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of Barcelona, Spain (C.A., I.R.-R., K.D.R., V.C., G.E.).

Objective: We investigated the effect of a potent TGFβ (transforming growth factor β) inhibitor peptide (P144) from the betaglycan/TGFβ receptor III on aortic aneurysm development in a Marfan syndrome mouse model. Approach and Results: We used a chimeric gene encoding the P144 peptide linked to apolipoprotein A-I via a flexible linker expressed by a hepatotropic adeno-associated vector. Two experimental approaches were performed: (1) a preventive treatment where the vector was injected before the onset of the aortic aneurysm (aged 4 weeks) and followed-up for 4 and 20 weeks and (2) a palliative treatment where the vector was injected once the aneurysm was formed (8 weeks old) and followed-up for 16 weeks. Read More

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AS1 expression in prostate cancer and its effects on proliferation and invasion of prostate cancer cells.

Cancer Biomark 2021 Jun 12. Epub 2021 Jun 12.

Department of Urology Surgery, Qingdao Women and Children's Hospital, Qingdao, Shandong, China.

This paper aimed at investigating AS1 expression in prostate cancer (PCa) and its effects on the proliferation and invasion of prostate cancer cells (PCCs). The prostate tissues and the matched adjacent normal prostate tissues excised and preserved during radical prostatectomy in our hospital were collected. The LncRNA NCK1-AS1 expression was detected. Read More

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The effect of pantoprazole and somatostatin combined with thrombin in the treatment of non-esophagogastric varicosity upper gastrointestinal bleeding.

Am J Transl Res 2021 15;13(5):5484-5490. Epub 2021 May 15.

Department of Gastroenterology, The Third Hospital of Inner Mongolia Medical University (Inner Mongolia Baogang Hospital) Baotou 014010, Inner Mongolia Autonomous Region, China.

Objective: To explore the effect of pantoprazole and somatostatin combined with thrombin in the treatment of non-esophagogastric varicosity upper gastrointestinal bleeding (UGB) as well as its influence on serum hs-CRP and coagulation function.

Methods: From June 2016 to May 2018, patients with upper gastrointestinal hemorrhage due to non-esophagogastric varices in our hospital were selected as research subjects. After screening, they were randomly divided into the combined group (57 cases) and the control group (57 cases). Read More

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CircRNA CircRIMS is Overexpressed in Esophageal Squamous Cell Carcinoma and Downregulate miR-613 Through Methylation to Increase Cell Proliferation.

Cancer Manag Res 2021 9;13:4587-4595. Epub 2021 Jun 9.

Department of Gastroenterology, General Hospital of Eastern Theater Command, Nanjing City, Jiangsu Province, 210002, People's Republic of China.

Purpose: CircRNA CircRIMS has been characterized as an oncogenic circRNA in gastric cancer, while its role in other cancers is unknown. This study aimed to explore the role of CircRIMS in esophageal squamous cell carcinoma (ESCC).

Patients And Methods: Tissues collected from 60 ESCC patients were subjected to extractions of total RNA and RT-qPCRs to analyze the differential expression of CircRIMS and miR-613. Read More

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CD117/c-KIT Expression in Phyllodes Tumor of the Breast and Its Correlation With Morphology and Clinical Outcome.

Cureus 2021 May 9;13(5):e14914. Epub 2021 May 9.

Pathology, Liaquat National Hospital and Medical College, Karachi, PAK.

Introduction Breast phyllodes tumor's (PT) clinical behavior is difficult to predict on histology. There is limited amount of data available on the role of biological markers. The objective of this study was to assess the expression of CD117 (c-KIT) in PT of the breast and its relationship with morphology and clinical outcome. Read More

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Integrating serum microRNAs and electronic health records improved the diagnosis of tuberculosis.

J Clin Lab Anal 2021 Jun 9:e23871. Epub 2021 Jun 9.

Department of Clinical Laboratory, Key Clinical Laboratory of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Background: To verify the differential expression of miR-30c and miR-142-3p between tuberculosis patients and healthy controls and to investigate the performance of microRNA (miRNA) and subsequently models for the diagnosis of tuberculosis (TB).

Methods: We followed up 460 subjects suspected of TB, and finally enrolled 132 patients, including 60 TB patients, 24 non-TB disease controls (TB-DCs), and 48 healthy controls (HCs). The differential expression of miR-30c and miR-142-3p in serum samples of the TB patients, TB-DCs, and HCs were identified by reverse transcription-quantitative real-time PCR. Read More

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[Using Immunohistochemical Markers and Clinicopathological Factors to Predict the Prognostic Survival of Different Types of Endometrial Cancer Recurrence].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 May;52(3):489-496

Department of Gynecology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China.

Objective: To probe for factors that can be used effectively to predict the prognostic survival of patients with endometrial cancer recurrence.

Methods: The clinicopathological data of 473 patients with stage Ⅰ to Ⅲ endometrial cancer who underwent standard surgical treatment from October 2013 to May 2019 were retrospectively collected, and post-operative recurrence of the patients were followed up. Overall recurrence includes local recurrence and poor prognosis recurrence. Read More

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Effects of bevacizumab combined with oxaliplatin intrathoracic injection on tumor markers and survival rate in patients with malignant pleural effusion of lung cancer.

Am J Transl Res 2021 15;13(4):2899-2906. Epub 2021 Apr 15.

Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University Nanning 530021, Guangxi, China.

Objective: This study aims to explore the therapeutic effects of bevacizumab combined with oxaliplatin on patients with malignant pleural effusion of lung cancer.

Methods: A total of 109 patients with malignant pleural effusion of lung cancer admitted to our hospital from March 2015 to April 2017 were selected as research objects. Among them, 59 patients treated with bevacizumab combined with oxaliplatin intrathoracic injection were enrolled in the observation group, and another 50 patients treated with oxaliplatin intrathoracic injection were enrolled in the regular group. Read More

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The Effects of LIT and MLR-Bf on Immune Biomarkers and Pregnancy Outcomes in Women With Previous Early Recurrent Miscarriage: A Retrospective Study.

Front Immunol 2021 4;12:642120. Epub 2021 May 4.

Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.

Immunological failure during pregnancy is considered one of the etiologies of recurrent miscarriage (RM). The decreased production of mixed lymphocyte reaction-blocking factors (MLR-Bf) may play a major role in this condition. Lymphocyte immunotherapy (LIT), which induces the production of MLR-Bf, has been used in treating RM patients since 1984. Read More

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High expression of cell adhesion molecule 2 unfavorably impacts survival in non-small cell lung cancer patients with brain metastases.

J Thorac Dis 2021 Apr;13(4):2437-2446

Department of Medical Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.

Background: Lung cancer is one kind of malignant tumor with a high risk for morbidity and mortality compared to other solid organ malignancies. Brain metastases occur in 30-55% of non-small cell lung cancer (NSCLC) patients. Prognosis of NSCLC patients with brain metastases is very poor. Read More

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TERTp mutations and p53 expression in head and neck cutaneous basal cell carcinomas with different aggressive features.

Sci Rep 2021 May 17;11(1):10395. Epub 2021 May 17.

FMUP-Faculty of Medicine, University of Porto, Porto, Portugal.

Cutaneous basal cell carcinoma (cBCC) is an economic burden to health services, due to its great morbidity and increasing incidence in old people. Infiltrative cBCCs and cBCCs with micronodular pattern are considered as more aggressive. The role of p53 expression and TERTp mutation on cBCC behavior remains to be clarified. Read More

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CD4CD25CD127 regulatory T cells associated with the effect of CD19 CAR-T therapy for relapsed/refractory B-cell acute lymphoblastic leukemia.

Int Immunopharmacol 2021 Jul 11;96:107742. Epub 2021 May 11.

Hematology Department, the Second Hospital of Anhui Medical University (SHAMU), Hefei, Anhui Province, China; Hematologic Diseases Research Center of Anhui Medical University, Hefei, Anhui Province, China. Electronic address:

Background: CD19-specific chimeric antigen receptor T-cell (CAR-T) therapy has shown promising clinical outcomes in relapsed/refractory acute B-cell lymphoblastic leukemia (R/R B-ALL) patients. However, some patients did not respond to this therapy or relapsed after remission. Regulatory T cells (Tregs) have shown great importance in promoting tumor escape, but little is known about their role in R/R B-ALL patients with CAR-T therapy. Read More

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Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy.

Sci Rep 2021 May 11;11(1):10012. Epub 2021 May 11.

Department of Otolaryngology-Head and Neck Surgery, Lady Davis Institute for Medical Research and Segal Cancer Centre, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, 3755 Côte Ste-Catherine Road, Montreal, QC, H3T 1E2, Canada.

In addition to chronic infection with human papilloma virus (HPV) and exposure to environmental carcinogens, genetic and epigenetic factors act as major risk factors for head and neck cancer (HNC) development and progression. Here, we conducted a systematic review in order to assess whether DNA hypermethylated genes are predictive of high risk of developing HNC and/or impact on survival and outcomes in non-HPV/non-tobacco/non-alcohol associated HNC. We identified 85 studies covering 32,187 subjects where the relationship between DNA methylation, risk factors and survival outcomes were addressed. Read More

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A partial loss-of-function variant in gene in a Chinese cohort with idiopathic hypogonadotropic hypogonadism.

Transl Androl Urol 2021 Apr;10(4):1676-1687

Institute of Urology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Idiopathic hypogonadotropic hypogonadism (IHH) is a rare genetic disease attributed to the disorder of hypothalamic-pituitary-gonadal axis. Mutations in the gene are one of the most common genetic causes of IHH. Herein, we aimed to investigate variants in a Chinese cohort with IHH, and to characterize them at the molecular level. Read More

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Salivary Porphyromonas gingivalis predicts outcome in oral squamous cell carcinomas: a cohort study.

BMC Oral Health 2021 05 3;21(1):228. Epub 2021 May 3.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospita1 of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, People's Republic of China.

Background: Studies suggest Porphyromonas gingivalis (Pg) increased the incidence of oral squamous cell carcinoma (OSCC). However, fimA genotypes distribution of Pg, the origination of Pg in tissue, and its prognostic value are inconclusive. We aimed to investigate the frequency of fimA genotypes in OSCC patients, study the association between Pg and OSCC, and explore the prognostic value of Pg. Read More

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Follicular dendritic cell sarcoma of the tonsil: case report and review of literature.

Int J Clin Exp Pathol 2021 15;14(4):493-500. Epub 2021 Apr 15.

Department of Pathology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai, People's Republic of China.

Objective: To explore the clinicopathologic features, immunophenotype, differential diagnosis, and prognosis of tonsil follicular dendritic cell sarcoma (FDCS).

Methods: In the Department of Pathology, the affiliated Yantai Yuhuangding Hospital of Qingdao University, in 2019, a case of tonsil FDCS was diagnosed and retrospectively analyzed to summarize its clinical and pathologic characteristics. Relevant literature was reviewed. Read More

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