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Minimally Invasive Surgery for Intraocular Lens Removal and Intrascleral Intraocular Lens Fixation with Trabeculectomy in a Patient with Dislocated Intraocular Lens and Elevated Intraocular Pressure.

Case Rep Ophthalmol 2021 May-Aug;12(2):538-542. Epub 2021 Jun 11.

Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.

A 88-year-old female who was being treated for end-stage pseudoexfoliation syndrome was referred to our hospital for treatment of dislocated intraocular lens (IOL) and the elevated intraocular pressure (IOP) and in the right eye (RE). At the first visit to our hospital, best-corrected visual acuity (BCVA) was 0.2 in the RE and 0. Read More

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Improvement in the appearance of cellulite and skin laxity resulting from a single treatment with acoustic subcision: Findings from a multicenter pivotal clinical trial.

Lasers Surg Med 2021 Jul 5. Epub 2021 Jul 5.

SkinCare Physicians of Chestnut Hill, Chestnut Hill, Massachusetts, USA.

Introduction And Objectives: Surface depressions and skin laxity together play a role in the appearance of cellulite. Cellulite depressions can be improved through disruption of the subcutaneous fibrous structures. Some currently utilized approaches accomplish this through invasive techniques requiring local anesthesia and potential down time. Read More

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Laser-induced choroidal neovascularization: A case report and some reflection on animal models for age-related macular degeneration.

Medicine (Baltimore) 2021 Jun;100(23):e26239

Department of Ophthalmology, the First Affiliated Hospital of Soochow University.

Rationale: Laser induced maculopathy includes retinal photoreceptor disruption, macular hole, macular hemorrhage, and rarely choroidal neovascularization (CNV). Here we report a case of laser induced CNV that was treated by intravitreal anti-vascular endothelial growth factor (VEGF) injection and resulted in visual improvement and CNV resolution during 1-year follow up. In addition, the case of laser induced CNV treated with intravitreal anti-VEGF injections are reviewed for the first time in literature. Read More

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Secondary choroidal neovascularization due to choroidal osteoma after 9 years follow-up.

BMC Ophthalmol 2021 May 31;21(1):242. Epub 2021 May 31.

Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China.

Background: Choroidal osteoma is a benign intraocular tumor that can increase risk of developing choroidal neovascularization. The visual prognosis is influenced by the tumor location, decalcification status, overlying RPE atrophy, presence of choroidal neovascularization, persistence of subretinal fluid and occurrence of subretinal hemorrhages.

Case Presentation: The authors present a 40-year-old woman diagnosed with choroidal osteoma of the right eye. Read More

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Squat and smile assessment in predicting healing of lower limb fractures fixed with a SIGN nail.

J Clin Orthop Trauma 2021 Aug 7;19:34-41. Epub 2021 May 7.

School of Public Health and Community Medicine, BP Koirala Institute of Health Sciences, Dharan, 56700, Koshi, Nepal.

Background: Irrespective of the treatment method, union is the ultimate goal of any fracture treatment. However, nowadays, rather than the physician-based clinico-radiological methods, the patient-reported outcome measurements assessing their quality of life and function are gaining much popularity. This is specifically true in the part of the world where the patient needs almost complete degree of hip/knee flexion - for social, cultural, religious or occupational reason(s). Read More

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Defective Endothelialization of Pipeline Embolization Device after Flow Diverter Therapy: An Autopsy Case Report.

NMC Case Rep J 2021 Apr 2;8(1):33-37. Epub 2021 Apr 2.

Department of Neuroendovascular Therapy, Juntendo University Faculty of Medicine, Tokyo, Japan.

The authors report a rare autopsy case. A 59-year-old woman underwent flow diverter (FD) therapy using a pipeline embolization device (PED) for a large paraclinoid internal carotid artery aneurysm. Follow-up magnetic resonance (MR) examinations were performed 6 months after the treatment. Read More

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Multimodal Imaging Findings and Treatment with Dexamethasone Implant in Three Cases of Idiopathic Macular Telangiectasia Type 1.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):92-97. Epub 2021 Apr 6.

Di.N.O.G.Mi, Clinica Oculistica, Università di Genova, Ospedale Policlinico San Martino IRCCS, Genova, Italy.

This is a report of 3 patients diagnosed with idiopathic macular telangiectasia type 1 (MacTel 1) at Medical Retina Center of the University of Eye Clinic of Genova and then prospectically followed for a mean time of 26 months between 2016 and 2019. It is the first report of patients affected by MacTel 1 treated with dexamethasone (DEX) implant as a first choice of treatment. Aim of our study is to better characterize the disease using a multimodal wide-field imaging and to determine efficacy of DEX implant on MacTel 1 in terms of central macular thickness (CMT) and best-corrected visual acuity (BCVA). Read More

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Deep-learning-based cardiovascular risk stratification using coronary artery calcium scores predicted from retinal photographs.

Lancet Digit Health 2021 05;3(5):e306-e316

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore.

Background: Coronary artery calcium (CAC) score is a clinically validated marker of cardiovascular disease risk. We developed and validated a novel cardiovascular risk stratification system based on deep-learning-predicted CAC from retinal photographs.

Methods: We used 216 152 retinal photographs from five datasets from South Korea, Singapore, and the UK to train and validate the algorithms. Read More

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Evaluation of Accuracy of Preoperative Planning of the Femurofibular Angle in Open-Wedge High Tibial Osteotomy for Mild Medial Knee Osteoarthritis.

Biomed Res Int 2021 18;2021:8813300. Epub 2021 Feb 18.

Department of Knee Surgery, Luoyang Orthopedic-Traumatological Hospital (Henan Orthopedic Hospital), Qiming Southern Road, Luoyang, Henan 471002, China.

Objective: The purpose of this study was to evaluate the usefulness of preoperative planning of the femurofibular angle (FFA) in medial open-wedge high tibial osteotomy (OWHTO) for mild medial knee osteoarthritis.

Methods: Thirty-two patients (32 knees) with mild medial knee OA were retrospectively reviewed. The patients underwent preoperative planning of the FFA for OWHTO. Read More

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Long-term follow-up of retinal sensitivity assessed by microperimetry in patients with internal limiting membrane peeling.

Eur J Ophthalmol 2021 Feb 24:1120672121997300. Epub 2021 Feb 24.

Department of Ophthalmology, Intercommunal Hospital Center and Henri Mondor Hospital, Paris-Est Créteil University (UPEC, Paris XII University), Creteil, France.

Purpose: To evaluate anatomical and functional changes in patients with vitreomacular interface disease after internal limiting membrane (ILM) peeling, using microperimetry along with usual clinical and multimodal retinal imaging.

Methods: Patients with vitreomacular interface disease requiring vitrectomy underwent multimodal retinal evaluation, including visual acuity assessment, fundus color photograph, Spectral-Domain Optical Coherence Tomography, Optical Coherence Tomography-Angiography, and microperimetry. They were examined at baseline (M0), 6 months (M6) and 18 months (M18) after surgery. Read More

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February 2021

Application of a Proposed Multi-Positional Circumferential Arm Liposuction Method and Quantification of its Clinical Efficacy Evaluation.

Aesthetic Plast Surg 2021 06 2;45(3):1115-1124. Epub 2021 Feb 2.

The 16th Department, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 33, BaDaChu Road, Shijingshan District, Beijing, 100144, China.

Background: Upper arm liposuction mainly focuses on the posterolateral region, which may lead to a lack of harmony between the aspirated and unaspirated areas. In addition, the treatment effect of arm liposuction is often evaluated only by preoperative and postoperative photograph comparison and simple measurement; quantitative research on this topic is still lacking.

Methods: The multi-positional circumferential arm liposuction (MCAL) technique was proposed and applied to a total of 34 females in our hospital from 2017 to 2019. Read More

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Hi-def memories of lo-def scenes.

Psychon Bull Rev 2021 Jun 14;28(3):928-936. Epub 2021 Jan 14.

Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 N Charles St, Baltimore, MD, 21218, USA.

The study of visual memory is typically concerned with an image's content: How well, and with what precision, we can recall which objects, people, or features we have seen in the past. But images also vary in their quality: The same object or scene may appear in an image that is sharp and highly resolved, or it may appear in an image that is blurry and faded. How do we remember those properties? Here six experiments demonstrate a new phenomenon of "vividness extension": a tendency to (mis)remember images as though they are "enhanced" versions of themselves - that is, sharper and higher quality than they actually appeared at the time of encoding. Read More

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Lifestyle and Mediterranean diet adherence in a cohort of Southern Italian patients with Multiple Sclerosis.

Mult Scler Relat Disord 2021 Jan 22;47:102636. Epub 2020 Nov 22.

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

Background/objectives: Several studies supported the beneficial effects of the Mediterranean diet (MeDi) on chronic diseases. In Multiple Sclerosis (MS), the MeDi might interfere with systemic inflammatory state, gut microbiota, and comorbidities. The Med Diet Score (MDS) estimates the adherence to the MeDi and the cardiovascular (CV) risk. Read More

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January 2021

Reliability Between In-Person and Still Photograph Assessment of Facial Function in Facial Paralysis Using the eFACE Facial Grading System.

Facial Plast Surg Aesthet Med 2021 Sep 16;23(5):344-349. Epub 2020 Dec 16.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.

Assessing facial function using high-quality photographs would improve long-term and objective outcomes tracking in facial palsy, facilitate automated facial grading using artificial intelligence algorithms, and allow for remote follow up. To determine agreement between in-person and photographic electronic facial function scale (eFACE) assessments, and evaluate inter-rater reliability of photographic eFACE evaluation. Retrospective review of eFACE scores from in-person interviews and standardized photographs using the Massachusetts Eye and Ear (MEE) Standard Facial Palsy Dataset. Read More

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September 2021

Surgical Outcomes of Unilateral Marcus Gunn Jaw Winking Ptosis Correction: A Novel Whitnall's Ligament Approach.

Korean J Ophthalmol 2021 02 11;35(1):18-25. Epub 2020 Dec 11.

Department of Orbit & Oculoplasty and Reconstructive Surgery, Regional Institute of Ophthalmology, Medical College and Hospital, Calcutta, India.

Purpose: To evaluate the surgical, functional, and cosmetic outcome in moderate to severe ptosis with Marcus Gunn jaw winking phenomenon and recurrence of disease after ptosis correction. This procedure has been emphasized on a child.

Methods: This was a prospective, non-comparative, interventional study conducted over 4 years on 30 people. Read More

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February 2021

The effect of immediate post-operative knee range of motion photographs on post-operative range of motion after total knee arthroplasty : An assessor-blinded randomized controlled clinical trial in sixty patients.

Int Orthop 2021 01 24;45(1):101-107. Epub 2020 Nov 24.

Department of Orthopedics, Chulabhorn International College of Medicine, Thammasat University, Khlong Luang, Pathum Thani, 12120, Thailand.

Purpose: We attempted to determine the effect of immediate post-operative knee range of motion (ROM) photographs on improving ROM after total knee arthroplasty (TKA).

Methods: Sixty patients, scheduled for unilateral primary TKA, were randomized into two groups. The photo group (n = 30) were immediately shown post-TKA knee ROM photographs as motivation for rehabilitation. Read More

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January 2021

Ultrasound findings in a case of Eales' disease and ocular trauma with anterior chamber cholesterolosis.

BMC Ophthalmol 2020 Oct 6;20(1):393. Epub 2020 Oct 6.

State Key Laboratory of Ophthalmology, Department of Glaucoma, Zhongshan Ophthalmic Center, Sun Yat-sen University, 7 Jinsui Road, Guangzhou, 510623, China.

Background: Anterior chamber cholesterolosis is a rare phenomenon which occurs mostly in chronically blind eyes. We present the anterior and posterior ultrasound findings in a case of anterior chamber cholesterolosis secondary to Eales' disease and ocular trauma, which may contribute to the understanding of the potential mechanism of this phenomenon.

Case Presentation: A 48-year-old man presented with "sparking" right eye, which appeared soon after the ocular trauma. Read More

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October 2020


Retina 2021 May;41(5):1010-1017

Department of Ophthalmology, Vita-Salute San Raffaele University, Milan, Italy. Romano is now with the Eye Clinic, Department of Biomedical and Clinical Science, Luigi Sacco University Hospital, Milan, Italy; and.

Purpose: To assess ellipsoid zone (EZ) alterations in Best vitelliform macular dystrophy using spectral-domain optical coherence tomography.

Methods: Prospective, observational case series. Forty-three patients (43 eyes) underwent complete ophthalmological examination at baseline and at 24 months: best-corrected visual acuity (BCVA), biomicroscopy, fundus photography, and spectral-domain optical coherence tomography were performed. Read More

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Ayurvedic visha hara (antitoxic) chikitsa in recurrent dyshidrotic eczema skin disease: A case report.

J Ayurveda Integr Med 2021 Jan-Mar;12(1):156-160. Epub 2020 Aug 27.

Department of Agada Tantra Evumvyavhara Ayurveda, Sushrutha Ayurvedic Medical College & Hospital, Bengaluru, karnataka, 560105, India.

Dyshidrotic eczema is a chronic, enigmatic condition that usually affects the hands and feet that probably accounts for about 5%-20% of hand eczemas. In Ayurveda various skin manifestation are mentioned under different chapter & context like kushtha, visarpa, kshudra kushtha, vidradi, krimi roga, keeta visha (insect bite), Garavisha &Dooshi visha (latent toxicity).Visphota variety of kushtha is characterized by pustules which are either white or reddish in appearance. Read More

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SCORE2 Report 13: Intraretinal Hemorrhage Changes in Eyes With Central or Hemiretinal Vein Occlusion Managed With Aflibercept, Bevacizumab or Observation. Secondary Analysis of the SCORE and SCORE2 Clinical Trials.

Am J Ophthalmol 2021 02 20;222:185-193. Epub 2020 Aug 20.

The Emmes Company, LLC, Rockville, Maryland, USA.

Purpose: To investigate the relationship between intraretinal macular hemorrhage and visual acuity outcomes in eyes with central retinal vein occlusion or hemiretinal vein occlusion managed with aflibercept, bevacizumab, or observation.

Design: Retrospective analysis of data from 2 randomized clinical trials.

Methods: A total of 362 participants were randomized in the Study of Comparative Treatments for Retinal Vein Occlusion 2, and 88 participants randomized to observation in the Standard Care vs Corticosteroid in Retinal Vein Occlusion Study. Read More

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February 2021

Evaluating the Effectiveness of Small-Group Training in Teaching Medical Students Integral Clinical Eye Examination Skills.

J Acad Ophthalmol 2020 Jan;12(1):e79-e86

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

Objective: The aim of this study is to evaluate the effectiveness of an interactive, small-group ophthalmology clinical training session by assessing medical students' self-confidence with eye examination skills and long-term retention of direct ophthalmoscopy skills.

Methods: The second-year medical students participated in a one-time small-group clinical training session that taught essential components of the eye examination. Students reported their confidence with each component in pre- and postsession surveys. Read More

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January 2020

Incidence and Outcome of Uveitic Glaucoma in Eyes With Intermediate, Posterior, or Panuveitis Followed up to 10 Years After Randomization to Fluocinolone Acetonide Implant or Systemic Therapy.

Am J Ophthalmol 2020 11 3;219:303-316. Epub 2020 Jul 3.

Center for Clinical Trials and Evidence Synthesis, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; The Johns Hopkins University School of Medicine Wilmer Eye Institute, Baltimore, Maryland, USA.

Purpose: To evaluate long-term risk and outcomes of glaucoma in eyes with intermediate, posterior, and panuveitis managed with systemic or fluocinolone acetonide (0.59 mg, "implant") therapy.

Design: Prospective Follow-up of the Multicenter Uveitis Steroid Treatment (MUST) Clinical Trial Cohort. Read More

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November 2020

High adherence and low dropout rate in a virtual clinical study of atopic dermatitis through weekly reward-based personalized genetic lifestyle reports.

PLoS One 2020 2;15(7):e0235500. Epub 2020 Jul 2.

LEO Innovation Lab, Copenhagen, Denmark.

Introduction: Clinical trials often suffer from significant recruitment barriers, poor adherence, and dropouts, which increase costs and negatively affect trial outcomes. The aim of this study was to examine whether making it virtual and reward-based would enable nationwide recruitment, identify patients with variable disease severity, achieve high adherence, and reduce dropouts.

Methods: In a siteless, virtual feasibility study, individuals with atopic dermatitis (AD) were recruited online. Read More

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September 2020

Retinal Specialist versus Artificial Intelligence Detection of Retinal Fluid from OCT: Age-Related Eye Disease Study 2: 10-Year Follow-On Study.

Ophthalmology 2021 01 27;128(1):100-109. Epub 2020 Jun 27.

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.

Purpose: To evaluate the performance of retinal specialists in detecting retinal fluid presence in spectral domain OCT (SD-OCT) scans from eyes with age-related macular degeneration (AMD) and compare performance with an artificial intelligence algorithm.

Design: Prospective comparison of retinal fluid grades from human retinal specialists and the Notal OCT Analyzer (NOA) on SD-OCT scans from 2 common devices.

Participants: A total of 1127 eyes of 651 Age-Related Eye Disease Study 2 10-year Follow-On Study (AREDS2-10Y) participants with SD-OCT scans graded by reading center graders (as the ground truth). Read More

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January 2021

Remote monitoring of clubfoot treatment with digital photographs in low resource settings: Is it accurate?

PLoS One 2020 15;15(5):e0232878. Epub 2020 May 15.

Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom.

Background: Clinical examination and functional assessment are often the first steps to assess outcome of clubfoot treatment. Clinical photographs may be an adjunct used to assess treatment outcomes in lower resourced settings where physical review by a specialist is limited. We aimed to evaluate the diagnostic performance of photographic images of patients with clubfoot in assessing outcome following treatment. Read More

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Comparison of the Progression of Localized Retinal Nerve Fiber Layer Defects in Red-free Fundus Photograph, En Face Structural Image, and OCT Angiography Image.

J Glaucoma 2020 08;29(8):698-703

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.

Precis: This study demonstrated the high topographic correlation between the red-free fundus photographs and en face structural images in eyes with glaucomatous progression.

Purpose: The purpose of this study was to compare the progression of localized retinal nerve fiber layer (RNFL) defects in red-free fundus photographs, en face structural images, and optical coherence tomography angiography (OCTA) images.

Methods: We performed a retrospective, comparative study on 45 glaucomatous eyes showing RNFL defect widening in red-free photography. Read More

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Use of teledermatology by dermatology hospitalists is effective in the diagnosis and management of inpatient disease.

J Am Acad Dermatol 2021 Jun 7;84(6):1547-1553. Epub 2020 May 7.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Background: Patient outcomes are improved when dermatologists provide inpatient consultations. Inpatient access to dermatologists is limited, illustrating an opportunity to use teledermatology. Little is known about the ability of dermatologists to accurately diagnose disease and manage inpatients with teledermatology, particularly when using nondermatologist-generated clinical data. Read More

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Carotid Web Misdiagnosis.

World Neurosurg 2020 08 24;140:128-130. Epub 2020 Apr 24.

Department of Neurology, Yancheng City No. 1 People's Hospital, Yancheng, Jiangsu, China. Electronic address:

Background: A carotid web (CW), an atypical fibromuscular dysplasia, is rare and may cause ischemic stroke. It is challenging to recognize a CW promptly and treat it accordingly. We report a case of an initially misdiagnosed CW. Read More

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Nodular Classic Kaposi's Sarcoma Treated With Neodymium-Doped Yttrium Aluminum Garnet Laser Delivered Through a Tilted Angle: Outcome and 12-Month Follow Up.

Lasers Surg Med 2020 12 10;52(10):979-983. Epub 2020 Apr 10.

Dermatology Clinic, University of Catania, Catania, Italy.

Background And Objectives: Classic Kaposi's sarcoma (KS) is a multifocal angioproliferative disorder with a long and indolent course typically affecting the lower extremities of elderly men. Multiple nodules with a rapid growth may sometimes develop, causing pain, bleeding, and discomfort on walking. In such cases, immediate intervention using different methods, including laser therapy, is advisable. Read More

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December 2020

Association of 2-Year Progression Along the AREDS AMD Scale and Development of Late Age-Related Macular Degeneration or Loss of Visual Acuity: AREDS Report 41.

JAMA Ophthalmol 2020 06;138(6):610-617

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.

Importance: The Age-Related Eye Disease Study age-related macular degeneration (AREDS AMD) scale is designed to classify AMD severity. The present cohort study explored whether 2-year progression along this scale was useful for estimating the risk of future progression to late AMD or best-corrected visual acuity (BCVA) loss.

Objective: To assess whether 2-year progression along the AREDS AMD scale can be used to estimate the probability of long-term clinically meaningful outcome measures for clinical trials or epidemiologic studies. Read More

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