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Medium-term safety outcomes in patients undergoing tension free vaginal tape obturator for stress urinary incontinence in Murcia, Spain. Historical cohort.

Rev Colomb Obstet Ginecol 2021 Mar 30;72(1):43-52. Epub 2021 Mar 30.

Hospital General Universitario Reina Sofía de Murcia, Murcia (Spain)..

Objective: Describe the medium-term safety of the tension free vaginal tape obturator (TVT-O) procedure in terms of complications, cure and changes in quality of life (QoL) after the surgery.

Materials And Methods: Descriptive historical cohort that included women over 18 years of age who underwent TVT-O due to objectively proven stress urinary incontinence, urethral hypermobility or mixed urinary incontinence in which the stress component predominated, confirmed on urodynamic testing between July 2013-April 2017, in a reference hospital located in the city of Murcia Spain. Women with previous anti-incontinence surgery, concomitant vaginal surgery and planning pregnancy were excluded. Read More

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The Effect of Prandial Insulin Applied for Fat Protein Units on Postprandial Glucose Excursions in Type 1 Diabetes Patients with Insulin Pump Therapy: Results of a Randomized, Controlled, Cross-Over Study.

Exp Clin Endocrinol Diabetes 2021 Apr 20. Epub 2021 Apr 20.

FIDAM - Research Institute Diabetes Academy, Mergentheim, Gemany.

Objective: This randomized cross-over study aimed to compare different algorithms for calculating prandial insulin considering the fat and protein content of a standardized meal in type 1 diabetes patients using insulin pump therapy (CSII).

Methods: Twenty-six patients received a standardized evening meal for three consecutive days using different algorithms for insulin dose adjustment: A) exclusive consideration of carbohydrate content without considering fat-protein content, B) high-dose algorithm considering additional insulin for fat protein units (FPUs) with the same factor as for carbohydrates, and C) low-dose algorithm considering additional insulin for FPUs with half the factor as for carbohydrates. The primary outcome was the proportion of interstitial glucose values in the target range (≥ 70 to ≤ 180 mg/dl) during the post-prandial 12-hour follow-up period. Read More

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Tuberculosis in Myasthenia Gravis patients on immunosuppressive therapy in a high-risk area: Implications for preventative therapy.

J Neurol Sci 2021 Apr 17;425:117447. Epub 2021 Apr 17.

Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Neurology Research Group, UCT Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Electronic address:

Data regarding the risk of tuberculosis (TB) in myasthenia gravis (MG) patients receiving immunosuppressive therapy is limited, and the benefit of TB preventative therapy in these patients is uncertain. We audited observational data collected at an MG clinic in South Africa over a ~ 10-year period, of cases who received immunosuppressive therapy. The total time that the cohort was at risk (patient-years) was used as the denominator to calculate TB incidence after immunosuppressive therapy initiation. Read More

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Association of Adenoma Detection Rate and Adenoma Characteristics with Colorectal Cancer Mortality after screening colonoscopy.

Clin Gastroenterol Hepatol 2021 Apr 17. Epub 2021 Apr 17.

Dept. of Internal Medicine, Div. of Gastroenterology and Hepatology, Medical University of Vienna, Austria; Quality Assurance Working Group, Austrian Society for Gastroenterology and Hepatology, Austria. Electronic address:

Background & Aims: The adenoma detection rate (ADR) and characteristics of previously resected adenomas are associated with colorectal cancer (CRC) incidence and mortality. However, the combined effect of both factors on CRC mortality is unknown.

Patients And Methods: Using data of the Austrian quality assurance program for screening colonoscopy, we evaluated the combined effect of ADR and lesion characteristics on subsequent risk for CRC mortality. Read More

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A Survivorship-Period-Cohort Model for Cancer Survival: Application to Liver Cancer in Taiwan, 1997-2016.

Am J Epidemiol 2021 Apr 20. Epub 2021 Apr 20.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Monitoring survival in cancer is a common concern for patients, physicians, and public health researchers. The traditional cohort approach for monitoring cancer prognosis has a timeliness problem. In this paper, we propose a survivorship-period-cohort (SPC) model for examining the effects of survivorship, period, and year-of-diagnosis cohort on cancer prognosis and to predict future trends in cancer survival. Read More

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Manuscript Title: Intramedullary screw fixation of olecranon fractures reduces the risk of early unplanned reoperation: a retrospective review of 556 patients.

J Orthop Trauma 2021 Apr 19. Epub 2021 Apr 19.

Emory University School of Medicine, Department of Orthopedics University of Maryland School of Medicine, Department of Orthopedics Morehouse University School of Medicine.

Objectives: To determine the effect of intramedullary screw-based fixation on early postoperative complications after olecranon fractures. We hypothesized that intramedullary screw-based fixation results in decreased need for reoperation compared to plate and screw and tension band-based fixation. Design: Retrospective cohort. Read More

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A first pregnancy seems associated with a positive effect on the course of inflammatory bowel disease: data from a prospective pregnancy cohort.

Scand J Gastroenterol 2021 Apr 20:1-6. Epub 2021 Apr 20.

Department of Gastroenterology and Hepatology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.

The effect of pregnaSSncy on the course of inflammatory bowel disease (IBD) remains controversial. We aimed to describe the disease course before and after a first pregnancy in IBD patients. We analyzed data from a prospectively followed-up pregnancy cohort (minimal follow-up of 7 years), with clinical, biochemical and endoscopic characteristics obtained pre-pregnancy, during pregnancy and post-pregnancy. Read More

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Epidural Contrast Volume on Post-Myelogram Lumbar CT Predicts the Rate of Subsequent Blood Patch Treatment.

J Neuroimaging 2021 Apr 20. Epub 2021 Apr 20.

Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background And Purpose: Headaches due to cerebrospinal fluid (CSF) leakage are a well-known complication of dural puncture. The purpose of this study was to determine whether the presence and volume of epidural contrast on postmyelogram CTs of the lumbar spine were associated with post-dural puncture headaches (PDPHs) requiring epidural blood patch (EBP) treatment.

Methods: A retrospective case control study of all fluoroscopically guided lumbar myelograms performed over a 5-year period by a single radiology practitioner assistant was performed. Read More

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Incidence of cervical intraepithelial lesions and human papilloma virus infection in female renal transplant recipients.

Transpl Infect Dis 2021 Apr 20:e13622. Epub 2021 Apr 20.

Departments of Reproductive Biology, Mexico.

Background: Female renal transplant recipients (RTR) are at high risk of human papillomavirus (HPV)-related anogenital premalignancies and cancer. The aim of this study was to estimate the incidence of cervical intraepithelial lesions (IL) and HPV infection, and their associated factors, in Mexican RTR.

Methods: This is a prospective cohort study conducted between January 2011 and December 2017. Read More

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An extended distally based reverse posterior interosseous artery flap reconstruction for the thumb and distal defects of the fingers.

Microsurgery 2021 Apr 20. Epub 2021 Apr 20.

Department of Plastic Reconstructive Aesthetic Surgery, Osmangazi University, Faculty of Medicine, ESKİŞEHİR, Turkey.

Background: The reverse posterior interosseous artery flap is useful for covering hand defects. However, its major drawback is the short pedicle that limits the reach of the flap up to the metacarpophalangeal level. The authors performed a new modification extending the distal reach of the flap by including the recurrent branch of the posterior interosseous artery and they aimed to present the results of reconstruction with this technique. Read More

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Solid Pseudopapillary Neoplasms of the Pancreas: a Single-Center Experience and Review of the Literature.

J Gastrointest Cancer 2021 Apr 20. Epub 2021 Apr 20.

Department of HPB Surgery and Liver Transplant, Royal Free Hospital NHS Foundation Trust, London, UK.

Purpose: Pancreatic solid pseudopapillary neoplasms (SPNs) are rare borderline tumours mainly affecting young female patients. The number of patients diagnosed with SPNs has increased significantly in the last decades owing to the increased use of cross-sectional imaging investigating different abdominal symptoms, whilst a significant proportion are incidentally discovered during the process of evaluating other pathologies. We herein present our institutional experience of patients with SPN who underwent curative resection focusing on clinical, pathological features, and the long-term outcomes. Read More

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Long-term results of fluorescence and indigo carmine blue dye-navigated sentinel lymph node biopsy.

Int J Clin Oncol 2021 Apr 20. Epub 2021 Apr 20.

Department of Pathology, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

Background: Sentinel lymph node biopsy is widely applied for the management of clinically node-negative breast cancer, and a radioisotope with a blue dye are most often used as tracers. Fluorescence of indocyanine green could also potentially be used as tracer. This study aimed to demonstrate the long-term survival results of fluorescence-guided sentinel lymph node biopsy. Read More

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Telemedicine follow-up is safe and efficacious for synthetic midurethral slings: a randomized, multi-institutional control trial.

Int Urogynecol J 2021 Apr 20. Epub 2021 Apr 20.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.

Introduction And Hypothesis: The objective was to assess whether telemedicine-based follow-up is equivalent to office-based follow-up in the early postoperative period after routine synthetic midurethral sling placement.

Methods: This is a prospective, international, multi-institutional, randomized controlled trial. Patients undergoing synthetic midurethral sling placement were randomized to 3-week postoperative telemedicine versus office-based follow-up. Read More

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[Real-world analysis of obstructive respiratory tract disorders: characterization, health care and costs.]

Recenti Prog Med 2021 Apr;112(4):285-293

Fondazione Ricerca e Salute (ReS), Casalecchio di Reno (Bologna).

Introduction: This analysis has described the burden of patients with asthma, chronic obstructive pulmonary disease (COPD), asthma/COPD mixed conditions or undefined obstructive diseases (UODs), from the Italian National Health System point of view.

Methods: In the accrual period (2015), starting from the ReS database, a record linkage among demographic, pharmaceuticals, hospitalizations and outpatient specialist services databases has identified patients affected by only asthma, only COPD, asthma/COPD and UODs. From the less recent date of identification, each patient was analyzed in one previous year and in two years of follow-up (at most up to 12/31/2017). Read More

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Monocyte-to-High-Density Lipoprotein Cholesterol Ratio Is Independently Associated With All-Cause Mortality in Deceased Donor Kidney Transplant Recipients.

Exp Clin Transplant 2021 Apr 16. Epub 2021 Apr 16.

From the Department of Urology, Faculty of Medicine, Uludag University, Bursa, Turkey.

Objectives: The primary objective of this study was to evaluate the impact of monocyte-to-high-density lipoprotein cholesterol ratio on all-cause mortality in deceased donor kidney transplant recipients.

Materials And Methods: This was a retrospective observational study in which all deceased donor kidney transplant recipients were included. Relevant data for analyses included clinical and demographic features, laboratory values, number of HLA matches, occurrence of delayed graft function, cold ischemia time, and survival status. Read More

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Is treated hypertension associated with a lower one-year mortality among older residents of long-term care facilities with multimorbidity?

Pol Arch Intern Med 2021 Apr 20. Epub 2021 Apr 20.

Introduction: Long-term care facility (LTCF) residents are typically excluded from clinical trials due to multimorbidity, dementia, and frailty, so there are no clear evidence-based rules for treating arterial hypertension in this population. Moreover, the role of hypertension as mortality risk factor in LTCFs has not yet been clearly established.

Objectives: The study aimed to investigate whether treated hypertension is associated with lower mortality among older LTCF residents with multimorbidity. Read More

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Clinical Profile and Short-Term Outcome of Children with SARS-CoV-2 Related Multisystem Inflammatory Syndrome(MIS-C) Treated with Pulse Methylprednisolone.

Indian Pediatr 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics, SAT Hospital, Government Medical College Thiruvananthapuram, Kerala, India.

Background: Multi system inflammatory syndrome in children (MIS-C) is a rare, but life-threatening complication of SARS-CoV-2 infection.

Objectives: To study the clinical profile and outcome of children with MIS-C treated with methylprednisolone pulse therapy and /or IVIG.

Study Design: Observational study. Read More

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Long-term Outcome of Microscopic Transsphenoidal Surgery for Prolactinomas as an Alternative to Dopamine Agonists.

J Korean Med Sci 2021 Apr 19;36(15):e97. Epub 2021 Apr 19.

Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.

Background: Although long-term dopamine agonist (DA) therapy is recommended as a first-line treatment for prolactinoma, some patients may prefer surgical treatment because of the potential adverse effects of long-term medication, or the desire to become pregnant. This study aimed to determine whether surgical treatment of prolactinomas could be an alternative to DA therapy.

Methods: In this retrospective study, 96 consecutive patients (74 female, 22 male) underwent primary pituitary surgery without long-term DA treatment for prolactinomas at a single institution from 1990 to 2010. Read More

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Intraductal Papilloma of the Breast: Prevalence of Malignancy and Natural History Under Active Surveillance.

Ann Surg Oncol 2021 Apr 19. Epub 2021 Apr 19.

Department of Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY, USA.

Background: The optimal management of intraductal papillomas (IPs) without atypia diagnosed on needle core biopsy (NCB) is unclear. This study analyzed the malignancy risk of immediately excised IPs and characterized the behavior of IPs under active surveillance (AS).

Methods: We retrospectively reviewed the pathology and imaging records of patients diagnosed with IPs without atypia on NCB during a 10-year period (1999-2019). Read More

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Intracranial aneurysms in pediatric population: a two-center audit.

Childs Nerv Syst 2021 Apr 20. Epub 2021 Apr 20.

Department of Neurosurgery, Rouen University Hospital, 1 rue de Germont, 76000, Rouen, France.

Objective: Intracranial aneurysms (IA) in children are rare, accounting for less than 5% of all IA. Due to their scarcity, the epidemiology is poorly understood and differs from adults in term of clinical presentation, size, location, and origin. Consequently, the treatment strategies are specific and cannot be only based on data from adult series. Read More

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Comparison of clinical characteristics in patients with acute zonal occult outer retinopathy according to anti-retinal antibody status.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 19. Epub 2021 Apr 19.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Nishi 7, Kita 15, Kita-ku, Sapporo,, 060-8638, Japan.

Purpose: To evaluate the clinical characteristics of patients with acute zonal occult outer retinopathy (AZOOR), according to the presence or absence of anti-retinal antibodies (ARAs) that are frequently detected in autoimmune retinopathy.

Methods: Retrospective observational case series. This study included 33 patients with acute-stage AZOOR who had been followed up for more than 6 months after the initial visit. Read More

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Real-world Effectiveness of Human Papillomavirus Vaccination Against Cervical Cancer.

J Natl Cancer Inst 2021 Apr 20. Epub 2021 Apr 20.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Background: The primary goal of human papillomavirus (HPV) vaccination is to reduce morbidity and mortality from HPV-associated disease, especially cervical cancer. We determined the real-world effectiveness of HPV vaccination against cervical cancer.

Methods: The study included women 17-30 years living in Denmark October 2006-December 2019. Read More

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Persistent Symptoms in Patients Recovering From COVID-19 in Denmark.

Open Forum Infect Dis 2021 Apr 29;8(4):ofab042. Epub 2021 Jan 29.

Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

Background: Although persistent symptoms after coronavirus disease 2019 (COVID-19) are emerging as a major complication to the infection, data on the diversity and duration of symptoms are needed.

Methods: Patients aged ≥18 years with a positive polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 who were hospitalized at the Department of Infectious Diseases, Aarhus University Hospital, Denmark, in the period from March 11 to May 15 were offered follow-up after hospitalization. On admission, a comprehensive symptom and medical history was collected, including demographic characteristics, duration of symptoms, comorbidities, and concomitant medications. Read More

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Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma.

Sci Rep 2021 Apr 19;11(1):8425. Epub 2021 Apr 19.

Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei, 112, Taiwan, ROC.

Some patients with severe asthma experience exacerbations despite receiving multiple therapy. The risk of exacerbation and heterogeneous response to treatment may be associated with specific inflammatory molecules that are responsive or resistant to corticosteroids. We aimed to identify the independent factors predictive for the future risk of exacerbation in patients with severe asthma. Read More

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Longitudinal study of prognostic factors for localized cutaneous melanoma in patients who have been disease-free for five years.

Eur J Dermatol 2021 Apr 19. Epub 2021 Apr 19.

Department of Dermatology, Instituto Valenciano de Oncología, València, Spain, School of Medicine, Universidad Católica de Valencia, Spain.

Most relapses in melanoma patients occur during the first five years after diagnosis. Identifying characteristics associated with recurrence after this period could help delineate guidelines, specifically for follow-up protocols. Objectives: The aim of this study was to identify the prognostic factors for relapse and death caused by melanoma in patients who have been disease-free for five years. Read More

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Association between digoxin use and gastrointestinal bleeding in contemporary continuous flow left ventricular assist device support.

J Heart Lung Transplant 2021 Mar 4. Epub 2021 Mar 4.

Department of Medicine, Division of Cardiology, University of Minnesota, Minneapolis, Minnesota.

Background: Assess the association between digoxin use and gastrointestinal bleeding (GIB) in a multicenter continuous flow left ventricular assist device (LVAD) cohort.

Methods: Patients implanted with continuous flow LVADs with data on GIB and digoxin use from two centers were included in the analysis (n = 649). GIB events were captured up to 2 years of follow-up. Read More

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A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial.

Trials 2021 Apr 19;22(1):288. Epub 2021 Apr 19.

Royal College of Surgeons in Ireland, Dublin, Ireland.

Objectives: The primary objective is to demonstrate that, in patients with PCR-confirmed SARS-CoV-2 resulting in Acute Respiratory Distress Syndrome (ARDS), administration of 120mg/kg of body weight of intravenous Prolastin®(plasma-purified alpha-1 antitrypsin) reduces circulating plasma levels of interleukin-6 (IL-6). Secondary objectives are to determine the effects of intravenous Prolastin® on important clinical outcomes including the incidence of adverse events (AEs) and serious adverse events (SAEs).

Trial Design: Phase 2, randomised, double-blind, placebo-controlled, pilot trial. Read More

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The effects of wheelchair mobility skills and exercise training on physical activity, fitness, skills and confidence in youth using a manual wheelchair.

Disabil Rehabil 2021 Apr 19:1-10. Epub 2021 Apr 19.

Research Group Lifestyle and Health, HU University of Applied Sciences Utrecht, Utrecht, The Netherlands.

Purpose: To evaluate the effects of a combination of wheelchair mobility skills (WMS) training and exercise training on physical activity (PA), WMS, confidence in wheelchair mobility, and physical fitness.

Methods: outh using a manual wheelchair ( = 60) participated in this practice-based intervention, with a waiting list period (16 weeks), exercise training (8 weeks), WMS training (8 weeks), and follow-up (16 weeks). Repeated measures included: PA (Activ8), WMS (Utrecht Pediatric Wheelchair Mobility Skills Test), confidence in wheelchair mobility (Wheelchair Mobility Confidence Scale), and physical fitness (cardiorespiratory fitness, (an)aerobic performance) and were analysed per outcome parameter using a multilevel model analyses. Read More

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[Efficacy of endovascular treatment of distal aortic dissection involving abdominal visceral segment with bare-metal stents related technique].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Apr 24;49(4):380-386. Epub 2021 Apr 24.

Department of Vascular Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, China.

To investigate the effect of bare-metal stent related technique on distal aortic dissection involving abdominal visceral segment. A retrospective analysis was performed on clinical data of 33 patients with distal aortic dissection involved abdominal visceral segment, who hospitalized in the Vascular Surgery Department of Shanghai Changhai Hospital from July 2012 to September 2019. The effect of the treatment was evaluated according to the clinical and preoperative, intraoperative and follow-up imaging data derived from (aorta computed tomography angiography (CTA) and digital subtraction angiography (DSA)) as well as the changes of the maximal diameter of the aorta and the thrombosis of the false lumen of the dissection. Read More

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Injuries after Forklift Trucks Accidents - Injury Patterns, Therapy and Outcome in the Context of the Statutory Accident Insurance.

Z Orthop Unfall 2021 Apr 19. Epub 2021 Apr 19.

Department of General and Trauma Surgery, BG University Hospital, Bochum, Germany.

Introduction: The use of forklift trucks during work has a high accident potential. The aim of this study is to describe injury patterns, treatment and outcome after forklift truck accidents in the context of the employers' liability insurance association.

Methods: Retrospective data collection of all cases between 2004 and 2019. Read More

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