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Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA): Early diagnosis, treatment and outcomes.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 16;261:12-16. Epub 2021 Apr 16.

Department of Urology, Children's Medicine Affiliated to Chongqing Medical University, Chongqing, PR China; Paediatrics Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Centre for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, PR China; Chongqing Key Laboratory of Paediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, PR China. Electronic address:

Objective: To describe and summarize the early diagnosis, treatment and outcomes of obstructed hemivagina and ipsilateral renal anomaly (OHVIRA).

Methods: Data from patients with OHVIRA treated at the study centre over the last decade were analysed retrospectively, including demographic characteristics, symptoms, diagnosis, treatment and outcomes. Relevant published literature was also reviewed in this study. Read More

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Novel PD-1 inhibitor prolgolimab: expanding non-resectable/metastatic melanoma therapy choice.

Eur J Cancer 2021 Apr 16;149:222-232. Epub 2021 Apr 16.

JSC BIOCAD, Saint Petersburg, Russia.

Background: Prolgolimab is an IgG1 anti-PD-1 (programmed cell death protein 1) monoclonal antibody containing the Fc-silencing 'LALA' mutation. We assessed the efficacy and safety of two dosing regimens of prolgolimab in patients with advanced melanoma in a multicenter open-label parallel-arm phase II trial (MIRACULUM). We present the final analysis after 1 year of follow-up and additional efficacy results from 2 years of follow-up. Read More

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Prognostic Impacts of β-Blockers in Acute Coronary Syndrome Patients without Heart Failure Treated by Percutaneous Coronary Intervention.

Pharmacol Res 2021 Apr 16:105614. Epub 2021 Apr 16.

Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, China. Electronic address:

Background: The use of β-blockers for acute coronary syndrome (ACS) patients without heart failure (HF) is controversial, and lacks of evidence in the era of reperfusion and intensive secondary preventions. This study aimed to investigate the prognostic impacts of β-blockers on patients with ACS but no HF treated by percutaneous coronary intervention (PCI).

Methods: A total of 2397 consecutive patients with ACS but no HF treated by PCI were retrospectively recruited from January 2010 to June 2017. Read More

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PET/CT helps to determine treatment duration in patients with resected as well as inoperable alveolar echinococcosis.

Parasitol Int 2021 Apr 16:102356. Epub 2021 Apr 16.

Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Switzerland.

Purpose: The aim of the study was to determine the role of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) at the end of benzimidazole therapy in alveolar echinococcosis.

Methods: A total of 22 patients undergoing PET/CT at the end of benzimidazole therapy were retrospectively registered. Maximum standardized uptake values (SUV) were measured in remaining echinococcus manifestations and compared to normal liver tissue. Read More

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Recipient Obesity and Kidney Transplant Outcomes: A Mate-Kidney Analysis.

Am J Kidney Dis 2021 Apr 16. Epub 2021 Apr 16.

Section of Nephrology, Department of Medicine, University of Chicago, IL. Electronic address:

Rationale & Objective: The impact of extreme recipient obesity on long-term kidney transplant outcomes has been controversial. This study sought to evaluate the association of various levels of recipient obesity on kidney transplantation outcomes by comparing mate-kidney recipient pairs to address possible confounding effects of donor characteristics on post-transplant outcomes.

Design: Nationwide observational cohort study, using mate-kidney models. Read More

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Virtue male sling outcomes and application to a contemporary nomogram.

Can J Urol 2021 Apr;28(2):10625-10630

Department of Surgery, Division of Urology, City of Hope Medical Center, Duarte, California, USA.

INTRODUCTION To report outcomes of our Virtue male sling series and evaluate predictors of surgical success and failure. We also retrofit the Male Stress Incontinence Grading Scale (MSIGS) refined nomogram, including the standing cough test (SCT), to assess its application to our cohort.

Materials And Methods: A retrospective review was completed at a single institution over a 4 year period of all Virtue male slings implanted for stress urinary incontinence (SUI). Read More

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Feasibility Study of Transanal Irrigation Using a Colostomy Irrigation System in Patients with Low Anterior Resection Syndrome.

Dis Colon Rectum 2021 Apr 13. Epub 2021 Apr 13.

Colorectal Surgery Division, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil. Wound, Ostomy and Continence Outpatient Care, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Background: Low anterior resection syndrome has a negative impact on quality of life. Intestinal irrigation is a method of lavage consisting of a scheduled evacuation.

Objective: To evaluate functional and quality of life outcomes in patients with low anterior resection syndrome post transanal irrigation using a colostomy irrigation system. Read More

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Multisystem Inflammatory Syndrome in Infants <12 months of Age, United States, May 2020-January 2021.

Pediatr Infect Dis J 2021 Apr 16. Epub 2021 Apr 16.

From the CDC COVID-19 Response Team, Atlanta, Georgia New York City Department of Health and Mental Hygiene, Long Island City, New York; California Department of Health, Richmond; Los Angeles County Department of Public Health, Los Angeles, California; Louisiana Department of Health, New Orleans, Los Angeles; Pennsylvania Department of Health, Harrisburg, Pennsylvania; Epidemic Intelligence Service, Atlanta, Georgia; Minnesota Department of Health, St. Paul, Minnesota; Wisconsin Department of Health Services, Madison, Wisconsin; Tennessee Department of Health, Nashville, Tennessee; Connecticut Department of Public Health, Hartford, Connecticut; Maryland Department of Health, Baltimore, Maryland; and Nevada Department of Health and Human Services, Reno, Nevada.

Background: Multisystem inflammatory syndrome in children (MIS-C), temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified in infants <12 months old. Clinical characteristics and follow-up data of MIS-C in infants have not been well described. We sought to describe the clinical course, laboratory findings, therapeutics and outcomes among infants diagnosed with MIS-C. Read More

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Clinical Characteristics and Management of Cerebral Venous Sinus Thrombosis in Patients With Antiphospholipid Syndrome: A Single-Center Retrospective Study.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:1076029621999104

Department of Neurology, Xuanwu Hospital, 12517Capital Medical University, Beijing, China.

Antiphospholipid syndrome (APS) with cerebral venous sinus thrombosis (CVST) is a relatively rare phenomenon, and this observational study aimed to investigate the clinical characteristics of APS patients complicated with CVST. We retrospectively investigated the clinical characteristics of CVST events in APS and compared differential characteristics and associated factors between APS patients with and without CVST. Twenty-one CVST patients with APS were enrolled including 14 females (9. Read More

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Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50.

J Clin Oncol 2021 Apr 19:JCO2100174. Epub 2021 Apr 19.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.

Purpose: We report the first 5-year follow-up of any first-line phase III immunotherapy trial for non-small-cell lung cancer (NSCLC). KEYNOTE-024 (ClinicalTrials.gov identifier: NCT02142738) is an open-label, randomized controlled trial of pembrolizumab compared with platinum-based chemotherapy in patients with previously untreated NSCLC with a programmed death ligand-1 (PD-L1) tumor proportion score of at least 50% and no sensitizing or alterations. Read More

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Spermatic Cord Block Series as a Minimally Invasive Therapy for Chronic Scrotal Content Pain.

J Urol 2021 Apr 19:101097JU0000000000001777. Epub 2021 Apr 19.

Rush University Medical Center, Chicago, Illinois.

Purpose: The primary aim of our study was to evaluate relief of chronic scrotal content pain after a series of spermatic cord blocks with a combination of local anesthetic and a steroid. Secondary aims were to assess factors associated with a positive response and complications.

Materials And Methods: We performed a retrospective chart review of patients who underwent spermatic cord block series for chronic scrotal content pain at our practice between 2012 and 2019. Read More

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Contemporary Rates of Gynecologic Organ Involvement in Females With Muscle Invasive Bladder Cancer: A Retrospective Review of Women Undergoing Radical Cystectomy Following Neoadjuvant Chemotherapy.

J Urol 2021 Apr 19:101097JU0000000000001784. Epub 2021 Apr 19.

Department of Urology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: According to the AUA/ASCO/ASTRO/SUO Guideline on treatment of nonmetastatic muscle-invasive bladder cancer (MIBC), females requiring radical cystectomy (RC) should undergo concomitant anterior pelvic exenteration despite low rates of malignant involvement of gynecologic organs. We present the clinicopathological characteristics of patients with MIBC treated with neoadjuvant chemotherapy (NAC) and evaluate the impact of NAC on gynecologic organ involvement (GOI).

Materials And Methods: An IRB approved review of patients with cT2-T3 MIBC treated with RC at our institution between 2005-2018 was performed. Read More

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Veno-occlusive disease risk in pediatric patients with acute myeloid leukemia treated with gemtuzumab ozogamicin before allogeneic hematopoietic cell transplantation.

Pediatr Blood Cancer 2021 Apr 19:e29067. Epub 2021 Apr 19.

CIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Background: Gemtuzumab ozogamicin (GO) administered before allogeneic hematopoietic cell transplantation (alloHCT) has been linked to an increased risk of hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS).

Procedure: This retrospective analysis examined VOD/SOS risk and clinical outcomes in pediatric patients with acute myeloid leukemia who received myeloablative alloHCT in 2008-2011 with (n = 148) and without (n = 348; controls) prior GO exposure and were reported to the Center for International Blood and Marrow Transplant Research.

Results: Cumulative incidences (95% confidence interval [CI]) of VOD/SOS and severe VOD/SOS, respectively, at 100 days were 16% (11-23%) and 8% (4-13%) for GO-exposed patients and 10% (7-13%) and 3% (2-5%) for controls. Read More

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The Impact of Coronavirus (COVID-19) Related Public-Health Measures on Training Behaviours of Individuals Previously Participating in Resistance Training: A Cross-Sectional Survey Study.

Sports Med 2021 Apr 19. Epub 2021 Apr 19.

Solent University, Southampton, UK.

Introduction: Understanding the impact of lockdown upon resistance training (RT), and how people adapted their RT behaviours, has implications for strategies to maintain engagement in similar positive health behaviours. Further, doing so will provide a baseline for investigation of the long-term effects of these public health measures upon behaviours and perceptions, and facilitate future follow-up study.

Objectives: To determine how the onset of coronavirus (COVID-19), and associated 'lockdown', affected RT behaviours, in addition to motivation, perceived effectiveness, enjoyment, and intent to continue, in those who regularly performed RT prior to the pandemic. Read More

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Gastric and Small Intestine Gist: Results of 156 Cases in 20 Years.

J Gastrointest Cancer 2021 Apr 19. Epub 2021 Apr 19.

Esofagogastric Unit, Bellvitge University Hospital, de La Feixa Llarga, s/n L´Hospitalet de Llobregat, Barcelona, Spain.

Purpose: Gastric and small intestine are the most common gastrointestinal stromal tumors (GISTs). There are few studies of patients who underwent surgical treatment with disparate findings. We aimed to evaluate the differences between groups and the risk factors for recurrence and mortality. Read More

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Duration of response after DEB-TACE compared to lipiodol-TACE in HCC-naïve patients: a propensity score matching analysis.

Eur Radiol 2021 Apr 19. Epub 2021 Apr 19.

Department of Interventional Radiology, Pisa University Hospital, Via Paradisa 2, 56126, Pisa, Italy.

Objectives: To retrospectively compare long-term outcomes of first-line drug-eluting particle (DEB)- transarterial chemoembolization (TACE) and lipiodol-TACE, in patients with unresectable hepatocellular (HCC).

Methods: We retrospectively reviewed our database to identify adult patients with treatment-naïve unresectable HCC, who underwent TACE from 2006 to 2013. Patients were excluded in the absence of complete medical records relative to first TACE, 1-month follow-up, and/or sufficient follow-up data. Read More

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Real-world experience of olaparib as maintenance therapy in BRCA-mutated recurrent ovarian cancer.

Arch Gynecol Obstet 2021 Apr 19. Epub 2021 Apr 19.

Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Purpose: The primary objective of our study was to investigate the effectiveness and safety of olaparib maintenance therapy in patients with BRCA-mutated recurrent ovarian cancer in daily practice. The secondary objective of this study was to identify prognostic factors associated with prolonged progression-free survival (PFS) in such patients.

Methods: We conducted a retrospective analysis of 40 patients who received olaparib maintenance treatment. Read More

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Three Decades of Follow-up After Surgical Closure of Subarterial Ventricular Septal Defect.

Pediatr Cardiol 2021 Apr 19. Epub 2021 Apr 19.

Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, 102, Pokfulam Road, Hong Kong, China.

We determined the occurrence of aortic regurgitation (AR), AR progression and risk factors in patients followed up for up to three decades after closure of subarterial VSD. We reviewed the outcomes of 86 patients categorized into three groups: group I comprised 37 patients without AR and had VSD closure alone, group II comprised 40 patients with AR and had VSD closure without aortic valvoplasty, and group III comprised 9 patients with AR and required both VSD closure and aortic valvoplasty. Patients were followed up for 18. Read More

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Propensity score-based analysis of long-term follow-up in patients supported with durable centrifugal left ventricular assist devices: the EUROMACS analysis.

Eur J Cardiothorac Surg 2021 Apr 19. Epub 2021 Apr 19.

Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Objectives: The HeartWare HVAD (HW) and the HeartMate3 (HM3) are presently the most commonly used continuous-flow left ventricular assist devices worldwide. We compared the outcomes of patients supported with either of these 2 devices based on data from the EUROMACS (European Registry for Patients with Mechanical Circulatory Support).

Methods: A retrospective analysis of the survival and complications profile in propensity score-matched adult patients enrolled in the EUROMACS between 01 January 2016 and 01 September 2020 and supported with either an HW or HM3. Read More

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Pure red cell aplasia in systemic lupus erythematosus, a nationwide retrospective cohort and review of the literature.

Rheumatology (Oxford) 2021 Apr 19. Epub 2021 Apr 19.

Service de Médecine Interne, Centre National de Référence des Cytopénies Auto-Immunes de l'Adulte, Centre Hospitalier Universitaire Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris Est Créteil, Créteil, France.

Objectives: To characterize the clinical and biological course, management and response to treatment in Systemic Lupus Erythematosus (SLE)-associated Pure Red Cell Aplasia (PRCA).

Methods: Nationwide multicentre retrospective cohort study. From 2006 to 2018, we included adults with a diagnosis of PRCA supported by bone-marrow examination and SLE or biologic manifestations of SLE after ruling out parvovirus B19 infection. Read More

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Postdiagnostic dairy products intake and colorectal cancer survival in US males and females.

Am J Clin Nutr 2021 Apr 19. Epub 2021 Apr 19.

Department of Nutrition, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.

Background: To evaluate the association between postdiagnostic dairy intake and survival among patients with colorectal cancer (CRC).

Methods: This study analyzed data from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Postdiagnostic dairy intake and other dietary and lifestyle factors were obtained from validated questionnaires. Read More

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Diets benefiting health and climate relate to longevity in northern Sweden.

Am J Clin Nutr 2021 Apr 19. Epub 2021 Apr 19.

Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Diets combining adequate nutritional quality and low climate impact are highly needed for human and planet health.

Objectives: We aimed to 1) evaluate nutrient density indexes' ability to predict mortality, and 2) assess the effects of diets varying in nutrient density and climate impact on total mortality.

Methods: Dietary data from 49,124 women and 47,651 men aged 35-65 y in the population-based prospective study Västerbotten Intervention Programme (Sweden) were used. Read More

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Chronic kidney disease in acute coronary syndromes: real world data of long-term outcomes.

Future Cardiol 2021 Apr 19. Epub 2021 Apr 19.

Serviço de Cardiologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Patients with chronic kidney disease (CKD) are at increased cardiovascular risk. Patients with acute coronary syndrome were retrospectively allocated to three groups (stage 3A, stage 3B or stage 4) based on the Kidney Disease Improving Global Outcomes classification formulas: the CKD Epidemiology Collaboration (CKD-EPI; N = 401) and the modification of diet in renal disease (n = 355). The primary end point was all-cause mortality (median follow-up time, 32 months [15-70]). Read More

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Do we need skin toxicity? Association of immune checkpoint inhibitor and tyrosine kinase inhibitor-related cutaneous adverse events with outcomes in metastatic renal cell carcinoma.

Int J Dermatol 2021 Apr 19. Epub 2021 Apr 19.

Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Introduction: Skin toxicity is a common, expected side effect of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) used for metastatic renal cell carcinoma (mRCC). We evaluated the association between skin toxicity and clinical efficacy outcomes of these agents in mRCC patients.

Methods And Materials: Data were obtained from patients with mRCC treated with TKIs and/or ICIs from 2016-2019 at a referral hospital in Mexico City. Read More

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The "Eyelet Sign" as an MRI Clue for Inflammatory Brown Syndrome.

J Neuroophthalmol 2021 Apr 14. Epub 2021 Apr 14.

Department of Ophthalmology (FCF, KL, KPW, CG-K), University Hospital Zurich and University of Zurich, Zurich, Switzerland; Department of Diagnostic Radiology (RK), University Children's Hospital Zurich and University of Zurich, Zurich, Switzerland; Institute of Neuroradiology (WW), University Hospital Zurich and University of Zurich, Zurich, Switzerland; Department of Ophthalmology (VS), Cantonal Hospital St. Gallen, St. Gallen, Switzerland; and Department of Neurology (KPW), University Hospital Zurich and University of Zurich, Zurich, Switzerland.

Background: Brown syndrome is characterized by a restrictive elevation deficit of the affected eye in adduction. Besides the well-known congenital form, different acquired etiologies including inflammation, trauma, and surgery may prevent the superior oblique (SO) tendon from gliding freely through the trochlea on attempted upgaze. We present MRI findings in pediatric and adult patients with inflammatory acquired Brown syndrome. Read More

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Antiresorptive treatment and talar collapse after displaced fractures of the talar neck: a long-term follow-up of 19 patients.

Acta Orthop 2021 Apr 18:1-6. Epub 2021 Apr 18.

Department of Orthopedics and Department of Biomedical and Clinical Sciences, Faculty of Health Science, Linköping University, Linköping.

Background and purpose - Displaced fractures of the talar neck are associated with a high risk of structural collapse. In this observational analysis we hypothesized that pharmacological inhibition of osteoclast function might reduce the risk of structural collapse through a reduction in bone resorption during revascularization of the injured bone.Patients and methods - Between 2002 and 2014 we treated 19 patients with displaced fractures of the talar neck with open reduction and internal fixation. Read More

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Postoperative Hallux Varus Treatment by Reverse Scarf Osteotomy.

Foot Ankle Int 2021 Apr 19:10711007211001027. Epub 2021 Apr 19.

Clinique Victor Hugo, Paris, France.

Background: Postoperative hallux varus is often accompanied by an abnormal decrease in the first-second (M1M2) intermetatarsal angle, which we have sought to correct by a reverse scarf-type osteotomy.

Methods: A series of 36 hallux varus operated on by reverse scarf osteotomy, including 14 with prior osteotomies, was reviewed with an average follow-up of 56 months. The measurements were clinical: American Orthopaedic Foot & Ankle Society (AOFAS) score, visual analog scale (VAS) pain score, subjective satisfaction index, joint mobility, and radiologic angles: M1M2 and first metatarsophalangeal angle. Read More

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Association of Carotid Intima-Media Thickness and Other Carotid Ultrasound Features With Incident Dementia in the ARIC-NCS.

J Am Heart Assoc 2021 Apr 17:e020489. Epub 2021 Apr 17.

Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN.

Background Increased carotid intima-media thickness, interadventitial diameter, presence of carotid plaque, and lower distensibility are predictors for cardiovascular disease. These indices likely relate to cerebrovascular disease, and thus may constitute a form of vascular contributions to dementia and Alzheimer disease-related dementia. Therefore, we assessed the relationship of carotid measurements and arterial stiffness with incident dementia in the ARIC (Atherosclerosis Risk in Communities) study. Read More

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Risk Factors and Outcomes of Recurrent Drug-Eluting Stent Thrombosis: Insights From the REAL-ST Registry.

J Am Heart Assoc 2021 Apr 17:e018972. Epub 2021 Apr 17.

Department of Cardiovascular Medicine Graduate School of Medicine Kyoto University Kyoto Japan.

Background Stent thrombosis (ST) after drug-eluting stent (DES) implantation remains a life-threatening complication. Recurrent ST (RST) is not a rare phenomenon, potentially contributing to high mortality after the index ST events. However, little evidence is available about the incidence, risk factors, and clinical outcomes of definite RST after DES thrombosis. Read More

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All-Cause Mortality Risk and Attributable Deaths Associated with Long-Term Exposure to Ambient PM in Chinese Adults.

Authors:
Yunquan Zhang

Environ Sci Technol 2021 Apr 19. Epub 2021 Apr 19.

Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China.

Several recent studies in China have associated raised mortality risks with chronic exposure to ambient PM. However, cohort evidence covering general populations and more homogeneous regions is extensively scarce. We conceived a nationwide perspective cohort study from 2010 through 2018, by enrolling 30 946 adult men and women aged 16-110 years from 25 provincial regions in mainland China. Read More

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