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Contralateral Axillary Nodal Metastases: Stage IV Disease or a Manifestation of Progressive Locally Advanced Breast Cancer?

Ann Surg Oncol 2021 Jul 21. Epub 2021 Jul 21.

Department of Surgery, Duke University Medical Center, Durham, NC, USA.

Background: Contralateral axillary nodal metastases (CAM) is classified as stage IV disease, although many centers treat CAM with curative intent. We hypothesized that patients with CAM, treated with multimodality therapy, would have improved overall survival (OS) versus patients with distant metastatic disease (M1) and similar OS to those with locally advanced breast cancer (LABC).

Methods: Using the NCDB (2004-2016), we categorized adult patients with node-positive breast cancer into three study groups: LABC, CAM, and M1. Read More

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The Spectrum of C4d Deposition in Renal Biopsies of Lupus Nephritis Patients.

Front Immunol 2021 1;12:654652. Epub 2021 Jul 1.

Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.

Objectives: This study aimed to determine the prevalence and localization of complement factor C4d in renal biopsies from patients with lupus nephritis (LN), as well as its associations with the disease's clinico-pathological features. The correlation between arteriolar C4d deposition and renal microvascular lesions (RVLs) was further analyzed.

Methods: A total of 325 biopsy-proven LN patients were enrolled, and their clinico-pathological data were collected. Read More

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Neurocognitive assessments are more important among adolescents than adults for predicting psychosis in clinical high risk.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 Jul 15. Epub 2021 Jul 15.

Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China; CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, PR China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China.

Background: Few studies have examined the effects of age on neurocognition to predict conversion to psychosis in individuals with clinical high-risk(CHRs). This study aimed to compare the extent and predictive performance of cognitive deficits between adolescents and adults with CHR.

Methods: A comprehensive neuropsychological battery was performed on 325 CHRs and 365 healthy controls(HCs). Read More

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Association Between Graft Choice and 6-Year Outcomes of Revision Anterior Cruciate Ligament Reconstruction in the MARS Cohort.

Am J Sports Med 2021 Jul 14:3635465211027170. Epub 2021 Jul 14.

University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background: Although graft choice may be limited in the revision setting based on previously used grafts, most surgeons believe that graft choice for anterior cruciate ligament (ACL) reconstruction is an important factor related to outcome.

Hypothesis: In the ACL revision setting, there would be no difference between autograft and allograft in rerupture rate and patient-reported outcomes (PROs) at 6-year follow-up.

Study Design: Cohort study; Level of evidence, 2. Read More

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[Effect of autoflation on the prognosis of otitis media with effusion in children].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jun;56(6):573-578

Department of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Institute of Otology, School of Medicine, Shanghai Jiaotong University, Shanghai Key Laboratory of Ear and Nose Disease Transformation, Shanghai 200092, China.

To investigate the effect of autoinflation on the prognosis of OME in children. Total of 325 pediatric patients, age ranged from 3 to 8 years, with OME(486 ears)diagnosed in our department from January 2019 to January 2020 were collected. Among them, 177 were males, 148 were females. Read More

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Contrast-enhanced ultrasound guided pleural biopsy improves diagnostic confidence for pleural based lesions: a 3-year prospective study.

BMC Pulm Med 2021 Jul 12;21(1):224. Epub 2021 Jul 12.

Department of Tuberculosis and Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.

Objective: To evaluate the accuracy and safety of contrast-enhanced ultrasound (CEUS) guided biopsy in the diagnosis of radiologically determined pleural based lesions.

Method: A prospective study was conducted on patients with radiologically determined pleural based lesions. Patients who met the inclusion criteria received pleural biopsy guided by CEUS to obtain specimens, followed by histomathological and microbiological examinations. Read More

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[Comparable study of alternative-level and all-level Arch mini-plate fixation for unilateral open-door laminoplasty].

Zhonghua Yi Xue Za Zhi 2021 Jul;101(25):1978-1984

Department of Orthopedics, Peking University International Hospital, Beijing 102206, China.

To compare the clinical effect of alternative-level and all-level Arch mini-plate fixation in patients undergoing unilateral open-door laminoplasty. Clinical data of 134 patients administrated in the Peking University International Hospital for multistage cervical spondylotic myelopathy from March 2015 to March 2019 were reviewed retrospectively. There were 63 males and 71 females with an average age of (62±8) years and a mean disease course of (18±7) months (3-37 months). Read More

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Resection of congenital hemivertebra in pediatric scoliosis: the experience of a two-specialty surgical team.

J Neurosurg Pediatr 2021 Jul 2:1-10. Epub 2021 Jul 2.

1Department of Orthopedics, Columbia University Irving Medical Center, New York, New York.

Objective: Institutions investigating value and quality emphasize utilization of two attending surgeons with different areas of technical expertise to treat complex surgical cases and to minimize complications. Here, the authors chronicle the 12-year experience of using a two-attending surgeon, two-specialty model to perform hemivertebra resection in the pediatric population.

Methods: Retrospective cohort data from 2008 to 2019 were obtained from the NewYork-Presbyterian Morgan Stanley Children's Hospital operative database. Read More

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Very low rate of residual neoplasia after non-curative endoscopic submucosal dissection: a western single-center experience.

Eur J Gastroenterol Hepatol 2021 Jan 14. Epub 2021 Jan 14.

aGastroenterology Department, Faculty of Medicine, Centro Hospitalar S. João bIpatimup/i3S (Instituto de Investigação e Inovação em Saúde da Universidade do Porto) cPathology Department, Faculty of Medicine, Centro Hospitalar S. João, Porto, Portugal.

Background: Short and long outcomes of endoscopic submucosal dissection (ESD) are now well described. However, the outcome of non-curative ESDs is scarcely reported.

Objective: To describe our experience with non-curative ESDs, assessing the presence of residual lesion in the endoscopic follow-up or surgery. Read More

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January 2021

Effect of Preoperative Modifiable Psychological and Behavioural Factors on Early Outcome Following Total Knee Arthroplasty in an Indian Population.

Indian J Orthop 2021 Aug 19;55(4):939-947. Epub 2021 Jan 19.

Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.

Background: Non-surgical factors have been found to have significant impact on outcome following Total Knee Arthroplasty (TKA). The study was conducted to know the independent effect of each of the four interacting psychological factors: anxiety, depression, pain catastrophizing and kinesiophobia on early outcome following TKA in an Indian population.

Materials And Methods: 104 consecutive patients undergoing TKA were included in the study and followed up at 6 weeks, 6 months and one year. Read More

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Healthcare Resource Utilization and Costs in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration.

Clin Ophthalmol 2021 23;15:2643-2651. Epub 2021 Jun 23.

The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, Department of Pharmacy and The Department of Health Services and Economics, University of Washington, Seattle, WA, USA.

Purpose: Geographic atrophy (GA) is an advanced form of nonexudative age-related macular degeneration (AMD) that lacks treatment options. With considerable interpatient variability in the rate of GA progression due to lesion characteristics, information characterizing the disease burden is limited. The aim of this study was to describe the healthcare resource utilization (HCRU) and costs associated with increasing severity levels of GA. Read More

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Bevacizumab biosimilar LY01008 compared with bevacizumab (Avastin) as first-line treatment for Chinese patients with unresectable, metastatic, or recurrent non-squamous non-small-cell lung cancer: A multicenter, randomized, double-blinded, phase III trial.

Cancer Commun (Lond) 2021 Jun 29. Epub 2021 Jun 29.

Respiratory Department, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang, 317000, P. R. China.

Background: Previous studies have demonstrated the preclinical pharmacological and toxicological consistency, and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab (Avastin). This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC).

Methods: Stage IIIB-IV NSCLC patients with evaluable lesions, good physical status, and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin (combined treatment) for 4-6 cycles, followed by maintenance monotherapy with LY01008 until disease progression, intolerable toxicity, or death. Read More

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Is 24/7 remote patient management in heart failure necessary? Results of the telemedical emergency service used in the TIM-HF and in the TIM-HF2 trials.

ESC Heart Fail 2021 Jun 28. Epub 2021 Jun 28.

Medical Department, Division of Cardiology and Angiology, Centre for cardiovascular Telemedicine, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin, D-10117, Germany.

Aims: Telemedical emergency services for heart failure (HF) patients are usually provided during business hours. However, many emergencies occur outside of business hours. This study evaluates if a 24/7 telemedical emergency service is needed for the remote management of high-risk HF patients. Read More

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Impact of smoking on survival in nasopharyngeal carcinoma: A cohort study with 23,325 patients diagnosed from 1990 to 2016.

Radiother Oncol 2021 Jun 25;162:7-17. Epub 2021 Jun 25.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, PR China; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address:

Background: We aimed to compare the survival outcomes of patients with nasopharyngeal carcinoma (NPC) who had different smoking behaviors and were treated with two- or three-dimensional radiotherapy (2D/3DRT) or intensity-modulated radiotherapy (IMRT) with a long-term follow up.

Methods: From 1990 to 2016, 23,325 patients with NPC were included. The primary endpoint of this study was overall survival (OS). Read More

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Is immediate treatment necessary for diabetic macular edema after pars plana vitrectomy for tractional complications of proliferative diabetic retinopathy?

Int Ophthalmol 2021 Jun 25. Epub 2021 Jun 25.

Retina Vitreous Service, L V Prasad Eye Institute, Vishakhapatnam, India.

Purpose: To assess the treatment benefit of eyes with diabetic macular edema (DME) in vitrectomized eyes for tractional complications of proliferative diabetic retinopathy (PDR).

Methods: In a retrospective multicentre observational study in India, the clinical outcomes of eyes with center-involving DME in vitrectomized eyes for tractional complications of PDR in people with type 2 diabetes with at least 12 months follow-up data were assessed. The DME status and visual acuity outcomes were compared between those who received treatment versus those observed. Read More

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The College of American Pathologists Foundation's See, Test & Treat Program®: an Evaluation of a One-Day Cancer Screening Program Implemented in Mississippi.

J Cancer Educ 2021 Jun 23. Epub 2021 Jun 23.

Department of Pathology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.

Women in Mississippi experience significant barriers to healthcare that results in high incidence rates of late-stage breast, cervical, and oropharyngeal cancer. We implemented See, Test, & Treat, a cancer screening and education program, that was aimed at increasing access to cancer screening for underserved women in the Jackson Metropolitan Area. During the event, 103 women between the ages of 21 and 69 years old received breast, cervical, and/or oral cancer screenings. Read More

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[Analysis of factors related to the prognostic benefit of neoadjuvant chemotherapy followed by interval debulking surgery in patients with advanced ovarian cancer].

Zhonghua Fu Chan Ke Za Zhi 2021 Jun;56(6):385-392

Gynecologic Oncology Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.

To explore the prognostic factors of patients with advanced epithelial ovarian cancer (EOC) who received neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). The clinical and pathological data of patients with stage Ⅲc-Ⅳ EOC underwent surgical treatment in Sichuan Cancer Center from January 1st, 2014 to December 31th, 2018 were retrospectively analyzed, and the prognosis was followed up. (1) A total of 216 EOC patients were included in the study, whose age was (52. Read More

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The top 100 highly cited articles on anterior cruciate ligament from 2000 to 2019: A bibliometric and visualized analysis.

Orthop Traumatol Surg Res 2021 Jun 17:102988. Epub 2021 Jun 17.

Rehabilitation Medicine Department, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China; Department of Rehabilitation Medicine, Southwest Medical University, Luzhou, Sichuan, China. Electronic address:

Introduction: Bibliometrics can trace the overall research trend in a specific field. To our knowledge, there has been no comprehensive bibliometric analysis of all anterior cruciate ligament (ACL) research from 2000-2019. We provided a bibliometric and visualized analysis of the top 100 highly-cited articles on ACL indexed by the Web of Science (WoS) to provide researchers with the present research status and the potential direction of ACL research. Read More

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Life expectancy estimations and determinants of return to work among cancer survivors over a 7-year period.

Sci Rep 2021 Jun 18;11(1):12858. Epub 2021 Jun 18.

Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Due to advances in medical science and technology, the number of cancer survivors continues to increase. The workplace needs and employment difficulties cancer survivors face after treatment need to be addressed to protect these individuals' right to work and to maintain the overall labor force of the country. We conducted a retrospective cohort study with a follow-up period from 2004 to 2010. Read More

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Reconstruction of Large Area of Deep Wound in the Foot and Ankle with Chimeric Anterolateral Thigh Perforator Flap.

Orthop Surg 2021 Jun 17. Epub 2021 Jun 17.

Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: To evaluate the clinical application and surgical efficacy of the chimeric perforator flap pedicled with the descending branch of the lateral circumflex femoral artery and the lateral thigh muscle flap for the reconstruction of the large area of deep wound in foot and ankle.

Methods: Clinical data of 32 cases who underwent chimeric anterolateral thigh perforator flap to repair the large area of deep wound of the foot and ankle from January 2015 to December 2018 were retrospectively analyzed. The sizes of the defects ranged from 18 cm × 10 cm to 35 cm × 20 cm, with exposed tendon and bone and/or partial defects and necrosis, contaminations, accompanied by different degrees of infection. Read More

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Factors Associated with Benzodiazepines Prolonged-Term Use in Post-Stroke Subjective Sleep Disturbance: A Single-Centre Retrospective Study from China.

Drug Des Devel Ther 2021 9;15:2469-2481. Epub 2021 Jun 9.

Department of Neurology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, Hainan Province, 572013, People's Republic of China.

Purpose: To investigate the prevalence of short- and long-term benzodiazepine and z-drugs (BZD) for the treatment of post-stroke subjective sleep disturbance (SSD) and to evaluate the risk factors associated with prolonged BZD treatment in this patient body.

Patients And Methods: Between 1st January 2018 and 1st December 2018, we identified 542 inpatients suffering from acute stroke in Heyuan People's Hospital. Of these, 290 inpatients were included in our final analysis. Read More

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Serum uric acid, disease severity and outcomes in COVID-19.

Crit Care 2021 06 14;25(1):212. Epub 2021 Jun 14.

Division of Nephrology, Cliniques universitaires Saint-Luc, 1200, Brussels, Belgium.

Background: The severity of coronavirus disease 2019 (COVID-19) is highly variable between individuals, ranging from asymptomatic infection to critical disease with acute respiratory distress syndrome requiring mechanical ventilation. Such variability stresses the need for novel biomarkers associated with disease outcome. As SARS-CoV-2 infection causes a kidney proximal tubule dysfunction with urinary loss of uric acid, we hypothesized that low serum levels of uric acid (hypouricemia) may be associated with severity and outcome of COVID-19. Read More

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The use of Ologen Collagen Matrix implants to treat ocular hypotony developing after trabeculectomy: A case series.

Eur J Ophthalmol 2021 Jun 12:11206721211023314. Epub 2021 Jun 12.

HCLOE Oftalmologia Especializada, São Paulo, São Paulo, Brazil.

Purpose: Late hypotony is an undesirable and challenging complication of glaucoma surgery. We describe our use of the Ologen Collagen Matrix to treat late hypotony developing after trabeculectomy.

Study Design: A retrospective study performed at three eye surgery centers in Brazil. Read More

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Influential factors of subacromial impingement syndrome after hook plate fixation for acromioclavicular joint dislocation: A retrospective study.

Medicine (Baltimore) 2021 Jun;100(23):e26333

Department of Orthopedic Trauma Surgery, Ningbo No.6 Hospital.

Abstract: Subacromial impingement syndrome (SIS) after hook plate fixation for acromioclavicular joint (AC) dislocation was the most common complication. However, the researches on its' influential factors were rare. The purpose of this study was to identify the risk factors by analyzing the influencing factors of postoperative SIS and minimize the incidence of SIS in clinical surgery. Read More

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Association of Maternal Influenza Vaccination During Pregnancy With Early Childhood Health Outcomes.

JAMA 2021 06;325(22):2285-2293

ICES, Toronto, Ontario, Canada.

Importance: Seasonal influenza vaccination in pregnancy can reduce influenza illness among pregnant women and newborns. Evidence is limited on whether seasonal influenza vaccination in pregnancy is associated with adverse childhood health outcomes.

Objective: To assess the association between maternal influenza vaccination during pregnancy and early childhood health outcomes. Read More

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General Health Checks in Adult Primary Care: A Review.

JAMA 2021 06;325(22):2294-2306

Division of General Internal Medicine and Geriatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Importance: General health checks, also known as general medical examinations, periodic health evaluations, checkups, routine visits, or wellness visits, are commonly performed in adult primary care to identify and prevent disease. Although general health checks are often expected and advocated by patients, clinicians, insurers, and health systems, others question their value.

Observations: Randomized trials and observational studies with control groups reported in prior systematic reviews and an updated literature review through March 2021 were included. Read More

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The balance of giving versus receiving social support and all-cause mortality in a US national sample.

Proc Natl Acad Sci U S A 2021 Jun;118(24)

Institute for Policy Research, Northwestern University, Evanston, IL 60208.

While numerous studies exist on the benefits of social support (both receiving and giving), little research exists on how the balance between the support that individuals regularly give versus that which they receive from others relates to physical health. In a US national sample of 6,325 adults from the National Survey of Midlife Development in the United States, participants were assessed at baseline on hours of social support given and received on a monthly basis, with all-cause mortality data collected from the National Death Index over a 23-y follow-up period. Participants who were relatively balanced in the support they gave compared to what they received had a lower risk of all-cause mortality than those who either disproportionately received support from others (e. Read More

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Opioid Prescribing Habits for Common Arthroscopic Procedures in Opioid Naïve Patients.

Orthop J Sports Med 2021 May 21;9(5):23259671211009263. Epub 2021 May 21.

Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Background: With the opioid epidemic and the increasing number of opioid-related deaths, there is growing awareness in the medical community regarding the dangers of opioid overprescription. As a result, there is a willingness among physicians to abandon old norms and adopt new data-driven prescribing practices.

Purpose: To demonstrate patient-reported consumption data of opioid medications after anterior cruciate ligament (ACL) reconstructions (ACLRs), knee arthroscopies, and rotator cuff repairs to provide data-driven guidelines for prescribing opioids after these procedures. Read More

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Long-term stability of computational parameters during approach-avoidance conflict in a transdiagnostic psychiatric patient sample.

Sci Rep 2021 Jun 3;11(1):11783. Epub 2021 Jun 3.

Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK, 74136, USA.

Maladaptive behavior during approach-avoidance conflict (AAC) is common to multiple psychiatric disorders. Using computational modeling, we previously reported that individuals with depression, anxiety, and substance use disorders (DEP/ANX; SUDs) exhibited differences in decision uncertainty and sensitivity to negative outcomes versus reward (emotional conflict) relative to healthy controls (HCs). However, it remains unknown whether these computational parameters and group differences are stable over time. Read More

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Single institution experience with telemedicine for pediatric urology outpatient visits: Adapting to COVID-19 restrictions, patient satisfaction, and future utilization.

J Pediatr Urol 2021 May 20. Epub 2021 May 20.

Division of Urology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA. Electronic address:

Introduction: Widespread utilization of telemedicine in our practice to date has been limited to the evaluation of certain post-surgical patients. The COVID-19 pandemic acutely stressed our established system and required us to enhance our utilization of telemedicine. We hypothesized that expansion of telemedicine to new and follow up patient visits for pediatric urology could be done effectively in a way that satisfied patient and parental expectations. Read More

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