Free Radic Biol Med 2021 Mar 26;168:1-5. Epub 2021 Mar 26.
Mediterranea Cardiocentro, Napoli, Italy; Department of Clinical, Internal, Anaesthesiologic, and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy. Electronic address:
Type 2 diabetes mellitus (T2DM) is associated with oxidative stress but the underlying mechanisms promoting oxidative stress as well as its relationship with cardiovascular events is still unclear. In 375 T2DM patients who were followed-up for approximately 5 years we measured the serum levels of soluble NOX2-derived peptide (sNOX2-dp), a marker of Nox2 activation, and albumin, a powerful antioxidant protein. In the entire cohort soluble Nox2 and serum albumin were significantly correlated (r = -0. Read More