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The Art of Rhinoplasty: Researching Technical and Cultural Foundations of Western World Rhinosurgery, from the Middle Ages to the Renaissance.

Aesthetic Plast Surg 2021 Apr 19. Epub 2021 Apr 19.

Department of Plastic and Reconstructive Surgery, Medical School, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy.

The analysis of the written sources allowed to follow the gradual development of every new technique in the field of rhinoplasty but also to understand the value of this surgery in those ancient times, highlighting a deep connection between traumatologic surgery of the nose and the development of modern "aesthetic and reconstructive" Rhinosurgery. Specifically, we analyzed the techniques described by less known surgeons to emphasize their cultural and surgical value. As a matter of fact, the descriptions offered by these authors clearly show the importance of rhinoplasty as a cardinal and autonomous practice since Antiquity, also clarifying the persistence and development of specific techniques for this surgical practice in the History of medicine. Read More

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Addressing Hospital-Acquired Hypoglycemia.

Am J Nurs 2021 May;121(5):56-61

Lucille Hughes is director of diabetes education and Maura Caragher is inpatient diabetes education coordinator at Mount Sinai South Nassau, Oceanside, NY. Contact author: Lucille Hughes, The authors have disclosed no potential conflicts of interest, financial or otherwise.

Background: Hospitalized patients who have diabetes often experience hospital-acquired hypoglycemia, a potentially serious adverse event; as a result, management of this condition has become an important quality of care indicator in the inpatient environment. A growing body of research and evidence-based clinical guidelines support proper timing of point of care (POC) blood glucose (BG) measurements, mealtime insulin administration, and meal delivery to reduce the incidence of both hypoglycemic and hyperglycemic events. Monitoring and improving the timing of these three patient care interventions are recognized as a crucial step in the safe and effective care of patients with diabetes. Read More

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Comparison of Endoscopic Techniques in the Management of Type I Gastric Neuroendocrine Neoplasia: A Systematic Review.

Gastroenterol Res Pract 2021 30;2021:6679397. Epub 2021 Mar 30.

Digestive Disease Unit, Sant'Andrea University Hospital, ENETS Center of Excellence, Rome, Italy.

Background: Endoscopic resection is considered the treatment of choice for type I gastric neuroendocrine neoplasia (gNEN) given its indolent behaviour; however, the favoured endoscopic technique to remove these tumours is not well established.

Aims: This systematic review is aimed at investigating the best endoscopic management for type I gNEN.

Methods: PubMed Central/Medline and Scopus were systematically searched for records up to August 31, 2020. Read More

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Postsurgical Prosthetic Rehabilitation after Mandibular Ameloblastoma Resection: A 7-Year Follow-Up Case Report.

Case Rep Dent 2021 28;2021:5593973. Epub 2021 Mar 28.

Department of Odontostomatology, Faculty of Medicine and Health Sciences (Dentistry), University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.

Ameloblastomas are benign but locally invasive odontogenic tumors most frequently located in the mandible. The gold standard of treatment is the surgical resection of the tumor with safety margins. Postsurgical defects generate a significant morbidity that needs reconstruction and oral rehabilitation to restore the oral functions. Read More

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Two Cases of Spontaneous Isolated Dissection of Superior Mesenteric Artery in One Night: Report of a (Noninvasive) Double Challenge.

Am J Case Rep 2021 Apr 13;22:e929538. Epub 2021 Apr 13.

Department of Medical Surgical Sciences and Advanced Technologies "GF Ingrassia" - Radiology Unit I, University Hospital "Policlinico-San Marco", Catania, Italy.

BACKGROUND Spontaneous isolated dissection of the superior mesenteric artery (SID-SMA) is a rare but potentially fatal condition. Although many cases of SID-SMA have been reported in the literature in recent years because of the increased use of contrast-enhanced computed tomography (CT) scanning, optimal management has not yet been firmly established. CASE REPORT We report 2 cases of SID-SMA that were managed with stenting and angioplasty via transfemoral access. Read More

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Long-Term Cognitive Outcomes and Sleep in Adults After Extracorporeal Life Support.

Crit Care Explor 2021 Apr 2;3(4):e0390. Epub 2021 Apr 2.

Department of Medicine (Critical Care Medicine), University Health Network, Toronto, ON, Canada.

Objectives: To assess differences in cognitive outcomes and sleep in adult survivors of critical illness, managed with venovenous extracorporeal membrane oxygenation as compared to conventional mechanical ventilation only.

Design: Retrospective cohort study linked with data from the COGnitive outcomes and WELLness study.

Setting: A multisite study from five adult medical/surgical ICUs in Toronto. Read More

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Automated Near Real-Time Ventilator Data Feedback Reduces Incidence of Ventilator-Associated Events: A Retrospective Observational Study.

Crit Care Explor 2021 Apr 2;3(4):e0379. Epub 2021 Apr 2.

Department of Anesthesiology, Southern New Hampshire Medical Center, Nashua, NH.

Objectives: Critical care teams are encouraged to follow best practice protocols to help wean mechanically ventilated patients from the ventilator to reduce ventilator-associated events including ventilator-associated conditions, probable ventilator-associated pneumonias, and infection-related ventilator-associated conditions. Providers monitor for alerts suggestive of possible ventilator-associated events and advise when patients should undergo spontaneous breathing trials. Compliance with protocols in most units is suboptimal. Read More

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Culture-Negative Mycotic Aortic Aneurysms Probably Have a Less Severe Clinical Nature Than Culture-Positive Counterparts.

Ann Vasc Surg 2021 Apr 5. Epub 2021 Apr 5.

Division of Vascular Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea, 06351. Electronic address:

Background: Mycotic aortic aneurysm constitutes a potentially devastating disease that necessitates prompt suspicion and diagnosis. There is no exact consensus for treatment, but removal of infected tissues and prolonged use of antimicrobials based on the identified causative microorganisms seem widely acceptable and have been similarly practiced worldwide. However, some patients still show no identified microorganisms. Read More

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Do the patient education program and nurse-led telephone follow-up improve treatment adherence in hemodialysis patients? A randomized controlled trial.

BMC Nephrol 2021 Apr 7;22(1):119. Epub 2021 Apr 7.

Patient Safety Research Center, Clinical Research Institute, Nursing & Midwifery School, Urmia University of Medical Sciences, Urmia, Iran.

Background: End-Stage Renal Disease (ESRD) is the final and permanent stage of Chronic Kidney Disease (CKD). Hemodialysis (HD) is the most common treatment for CKD. To have desirable therapeutic outcomes, patients have to adhere to a specific therapeutic regimen that reduces the hospitalization rate and side-effects of HD. Read More

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Capillaroscopy: a useful tool in the early diagnosis of connective tissue disease and nonscleroderma spectrum disorders.

Minerva Cardiol Angiol 2021 Apr 7. Epub 2021 Apr 7.

Centro Studi Malattie Vascolari J.F. Merlen, Frosinone, Italy.

Background: Detection of early capillaroscopic alterations in the preclinical phase may prove useful in patients with non-scleroderma connective tissue disease (CTD). We aimed to verify whether certain capillaroscopic alterations, alone or in combination, might be predictive of CTD.

Methods: We retrospectively collected data on patients with Raynaud's phenomenon who underwent capillaroscopy conducted by highly expert examiners with a degree in vascular medicine at our institutions. Read More

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Effect of Empowerment Program with and without Telenursing on Self-efficacy and Glycosylated Hemoglobin Index of Patients with Type-2 Diabetes: A Randomized Clinical Trial.

J Caring Sci 2021 Mar 1;10(1):22-28. Epub 2021 Mar 1.

Endocrine and Diabetes Center,Sina Medical Research & Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

Developing new training methods for improving the health of diabetic patients has always been a concern for nurses. The present study aims to investigate the effects of empowerment-based interventions with or without telenursing on self-efficacy and HbA1c level in diabetic patients. In this randomized clinical trial, 156 patients with type-2 diabetes were randomly assigned into two intervention groups (empowerment with/without telenursing) and one control group. Read More

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Effect of self-administration of medication programme on cardiovascular inpatients' medication adherence and nurses' satisfaction: A randomized clinical trial.

Nurs Open 2021 Apr 3. Epub 2021 Apr 3.

Department of Community Health Sciences, UCLA Fielding School of Public Health, American Public Health Association, Los Angeles, CA, USA.

Aim: To investigate the effect of self-administration of medication programme on medication adherence in cardiovascular inpatients and nurse's satisfaction.

Design: Randomized clinical trial with parallel-group design guided by the CONSORT checklist.

Methods: In this study, sixty cardiovascular inpatients were selected through convenience sampling and then randomly assigned to control and intervention groups, in 2018, Iran. Read More

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The Effects of Sterilization Procedures on the Cutting Efficiency of Endodontic Instruments: A Systematic Review and Network Meta-Analysis.

Materials (Basel) 2021 Mar 22;14(6). Epub 2021 Mar 22.

Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy.

Sterilization processes guarantee the sterility of dental instruments but can negatively affect instrument features by altering their physical and mechanical properties. The endodontic instrumentation can undergo a series of alterations, ranging from corrosion to variation in the cutting angle and then changes in the torsional properties and torsional fatigue resistance. This systematic literature review and meta-analysis aims to investigate alterations to the cutting efficiency of endodontic instruments that are induced by procedures for their disinfection and sterilization. Read More

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Effects of a Cognitive Rehabilitation Programme on the Independence Performing Activities of Daily Living of Persons with Dementia-A Pilot Randomized Controlled Trial.

Brain Sci 2021 Mar 3;11(3). Epub 2021 Mar 3.

ADOLOR Research Group, Department of Medical-Surgical Therapy, Medicine Faculty, Extremadura University, 06006 Badajoz, Spain.

Background: In all types of dementia, cognitive abilities are affected, behaviour is altered and functional capacity is progressively lost. This cognitive deterioration manifests in the decrease of abilities required to perform the activities of daily living (ADL). The objective of this pilot study was to assess the effect of an Occupational Therapy programme based on the training of ADL through cognitive stimulation on the independence of ADL of persons with dementia. Read More

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Association between Radiotherapy and Risk of Cancer Associated Venous Thromboembolism: A Sub-Analysis of the COMPASS-CAT Study.

Cancers (Basel) 2021 Mar 2;13(5). Epub 2021 Mar 2.

Department of Internal Medicine, Division of Hematology/Oncology, American University of Beirut, Beirut 1107 2020, Lebanon.

Background: The role and effect of radiotherapy in the development of VTE has not been extensively explored; Methods: This is a post-hoc analysis from the COMPASS-CAT trial. Patients with breast, lung, colon or ovarian cancer, with early, locally advanced or metastatic disease and receiving chemotherapy were included. Primary endpoint was documented symptomatic VTE; Results: A total of 1355 patients were enrolled between November 2013 and November 2015. Read More

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Isolated intestinal Ganglioneuromatosis: case report and literature review.

Ital J Pediatr 2021 Mar 30;47(1):80. Epub 2021 Mar 30.

NESMOS Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.

Background: Intestinal Ganglioneuromatosis (IG) is a rare disorder of the enteric nervous system. In pediatric age it is often associated with genetic syndromes such as Neurofibromatosis 1 (NF1), multiple endocrine neoplasia type 2B (MEN2B) and Cowden syndrome (PTEN mutation), and ganglioneuromas (GNs) may be sometimes the first sign of the disease. Isolated GNs are rare and sporadic. Read More

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A non-alcohol-related case of Madelung's disease: Challenging patient with progressive jugular vein distension.

Radiol Case Rep 2021 May 19;16(5):1183-1187. Epub 2021 Mar 19.

Department of Medical Surgical Sciences and Advanced Technologies, Radiology I Unit, University of Catania, Via Santa Sofia 78, 92123 Catania, Italy.

Madelung's disease or multiple symmetric lipomatosis (MSL) is a rare benign disease characterized by abnormal, multiple and symmetric fat depositions in the subcutaneous layer, involving head, neck, back, trunk and also upper and lower limbs. MSL may be related to alcohol abuse or metabolic disorders; it may be both silent or clinically manifest. We describe a case of a 48-yo man with β-thalassemia admitted to medicine department for neck swelling without fever or respiratory symptoms. Read More

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Nox2 up-regulation and hypoalbuminemia in patients with type 2 diabetes mellitus.

Free Radic Biol Med 2021 Mar 26;168:1-5. Epub 2021 Mar 26.

Mediterranea Cardiocentro, Napoli, Italy; Department of Clinical, Internal, Anaesthesiologic, and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy. Electronic address:

Type 2 diabetes mellitus (T2DM) is associated with oxidative stress but the underlying mechanisms promoting oxidative stress as well as its relationship with cardiovascular events is still unclear. In 375 T2DM patients who were followed-up for approximately 5 years we measured the serum levels of soluble NOX2-derived peptide (sNOX2-dp), a marker of Nox2 activation, and albumin, a powerful antioxidant protein. In the entire cohort soluble Nox2 and serum albumin were significantly correlated (r = -0. Read More

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Compliance with American College of Chest Physicians (ACCP) recommendations for thromboembolic prophylaxis in the intensive care unit: a level I trauma center experience.

Patient Saf Surg 2021 Mar 25;15(1):13. Epub 2021 Mar 25.

Trauma Research Department, Research Medical Center, Kansas City, MO, USA.

Background: Recommendations are for nearly universal venous thromboembolism (VTE) prophylaxis in critically ill hospitalized patients because of their well-recognized risks. In those intensive care units (ICUs) where patient care is more uniformly directed, it may be expected that VTE prophylaxis would more closely follow this standard over units that are less uniform, such as open-model ICUs.

Methods: This was a retrospective cohort study on all patients aged 18+ admitted to an open ICU between 6/1/2017 and 5/31/2018. Read More

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Effects of the COVID-19 lockdown on glycaemic control in subjects with type 2 diabetes: the glycalock study.

Diabetes Obes Metab 2021 Mar 25. Epub 2021 Mar 25.

Experimental Medicine Department, Sapienza University of Rome, Latina, Italy.

Aim: To assess the effect of the coronavirus disease 2019 (COVID-19) lockdown on glycaemic control in subjects with type 2 diabetes (T2D).

Materials And Methods: In this observational, multicentre, retrospective study conducted in the Lazio region, Italy, we compared the differences in the HbA1c levels of 141 subjects with T2D exposed to lockdown with 123 matched controls with T2D who attended the study centres 1 year before. Basal data were collected from 9 December to 9 March and follow-up data from 3 June to 10 July in 2020 for the lockdown group, and during the same timeframes in 2019 for the control groups. Read More

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Daratumumab as Single Agent in Relapsed/Refractory Myeloma Patients: A Retrospective Real-Life Survey.

Front Oncol 2021 5;11:624405. Epub 2021 Mar 5.

Division of Hematology, University Hospital Policlinico Vittorio Emanuele, Catania, Italy.

Background: The anti-CD38 monoclonal antibody daratumumab is approved as a single agent for the treatment of patients with relapsed/refractory multiple myeloma (RRMM) who received at least three prior lines of therapy, including proteasome inhibitor and immunomodulatory agent. A retrospective multicentric study was designed to evaluate feasibility, tolerability, and efficacy of daratumumab in monotherapy in RRMM.

Methods: This study included 44 consecutive RRMM patients that underwent daratumumab monotherapy after a median number of four prior therapies (range 2-9). Read More

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Epigenetic regulation of DAT gene promoter modulates the risk of externalizing and internalizing behaviors on a normative population: An explorative study.

Behav Brain Res 2021 May 18;406:113246. Epub 2021 Mar 18.

Center for Behavioral Science and Mental Health - Istituto Superiore di Sanità, Rome, Italy; Faculty of Psychology - Uninettuno University, Rome, Italy. Electronic address:

Accumulating research addressed epigenetic modifications and their role on behavioral phenotypes. We recently proposed to study methylation dynamics of two CpG motifs within the 5'-UTR of dopamine transporter (DAT) gene. Starting from a normative population sample of young adults, we selected three sub-groups based on their prevalent symptoms: subjects were assigned to Internalizing, Externalizing and Low-risk sub-groups according to elevated scores in specific phenotypic scales. Read More

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Risk assessment and management among frontline nurses in the context of the COVID-19 virus in the northern region of the Kingdom of Saudi Arabia.

Appl Nurs Res 2021 04 11;58:151410. Epub 2021 Feb 11.

Deparment of Medical-Surgical, College of Nursing, University of Hail, Applied Health Sciences Building, Building 9, Altqutta, Alqutta Road, Hail City, Saudi Arabia.

Objective: This study aimed to assess the post-contact risk of nurses who provide care for patients diagnosed with COVID-19.

Methods: This investigation employed a quantitative-descriptive design. The study sample was comprised of the frontline nurses in the COVID-19 center hospitals in the northern part of Saudi Arabia. Read More

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Exploring Strategies to Build Resiliency in Nurses During Work Hours.

J Nurs Adm 2021 Apr;51(4):185-191

Author Affiliations: Associate Professor (Drs Mintz-Binder and Andersen), School of Nursing, Texas Tech University Health Sciences Center, Lubbock; Director of Magnet Program and Centralized Nursing (Ms Sweatt), Methodist Mansfield Medical Center, Mansfield; and Health Science Center Senior Research Associate (Dr Song), School of Nursing, Texas Tech University Health Sciences Center, Lubbock.

Objective: This pilot study investigated increasing nurse resiliency utilizing a toolkit of stress-reducing interventions on medical-surgical units at 4 hospitals.

Background: Resiliency-building activities are time consuming and undertaken outside work hours. Although the activities show a positive impact on resilience, researchers investigated whether similar results could be achieved where nurses experience work stress. Read More

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Exploring the consequences of patient commitment to cardiac rehabilitation program: A qualitative study.

J Educ Health Promot 2021 28;10:30. Epub 2021 Jan 28.

Department of Nursing, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Background: Commitment to implementing cardiac rehabilitation (CR) plays an important role in managing the problems caused by heart diseases. Commitment to the treatment plan implementation is accompanied by numerous positive consequences. This study was carried out to explain the consequences of commitment to CR. Read More

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January 2021

Vaccination Status of Mothers and Children from the 'Mamma & Bambino' Cohort.

Vaccines (Basel) 2021 Feb 17;9(2). Epub 2021 Feb 17.

Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.

According to the evidence demonstrating vaccines' safety and effectiveness in anticipation of and during pregnancy, several countries have established immunization programs during the periconceptional period. Here, we evaluated vaccination status among 220 mother-child pairs, using data from the 'Mamma & Bambino' cohort. The self-reported data were evaluated at delivery, and with planned follow-ups at 1-2 years after delivery. Read More

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February 2021

Oncological Results of Laparoscopically Assisted Radical Vaginal Hysterectomy in Early-Stage Cervical Cancer: Should We Really Abandon Minimally Invasive Surgery?

Cancers (Basel) 2021 Feb 17;13(4). Epub 2021 Feb 17.

Gynecologic Oncology Unit, Clínic Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clínic Barcelona, 08036 Barcelona, Spain.

Background: Recent evidence indicates that some minimally invasive surgery approaches, such as laparoscopic and robotic-assisted radical hysterectomy, offer lower survival rates to patients with early-stage cervical cancer than open radical hysterectomy. We evaluated the oncological results of a different minimally invasive surgery approach, that of laparoscopically assisted radical vaginal hysterectomy (LARVH) in this setting.

Methods: From January 2001 to December 2018, patients with early-stage cervical cancer were treated by LARVH. Read More

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February 2021

Depression and frailty in older adults: A population-based cohort study.

PLoS One 2021 4;16(3):e0247766. Epub 2021 Mar 4.

Faculty of Medicine, University of Brasilia, Brasilia, Federal District, Brazil.

Background: Studies have shown an association between depression and frailty, even though the literature has not reached a consensus regarding how these syndromes interact. Although prospective cohort studies on this topic are still scarce, they could contribute to understanding this relationship. We aimed to observe whether depressive symptoms are risk factors for the onset of frailty among older adults living in São Paulo, Brazil. Read More

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Chromosome 15q BP4-BP5 Deletion in a Girl with Nocturnal Frontal Lobe Epilepsy, Migraine, Circumscribed Hypertrichosis, and Language Impairment.

J Epilepsy Res 2020 Dec 31;10(2):84-91. Epub 2020 Dec 31.

Unit of Neonatology University Hospital "Policlinico-Vittorio Emanuele", Catania, Italy.

The 15q13.3 microdeletion (microdel15q13.3) syndrome (OMIM 612001) has been reported in healthy subjects as well as in individuals with a wide spectrum of clinical manifestations ranging from mild to severe neurological disorders, including developmental delay/intellectual disability, autism spectrum disorder, schizophrenia, epilepsy, behavioral problems and speech dysfunction. Read More

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December 2020

The effect of rehabilitation education through social media on the quality of life in burn patients: a randomized, controlled, clinical trial.

BMC Med Inform Decis Mak 2021 Feb 22;21(1):70. Epub 2021 Feb 22.

Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Burn is one of the most brutal harms to the human body and mind and its wide-ranging complications have many adverse effects on the patients' quality of life. The present study was conducted to investigate the effect of rehabilitation education through social media on burn patients' quality of life.

Methods: The present randomized, controlled, clinical trial was conducted on 60 patients admitted to Imam Reza Hospital Burn Center in the city of Mashhad, Iran, who were randomly assigned to either the intervention or control groups (n = 30 per group). Read More

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February 2021