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Useful predictors of progression-free survival for Japanese patients with LATITUDE-high-risk metastatic castration-sensitive prostate cancer who received upfront abiraterone acetate.

Int J Urol 2021 Dec 4. Epub 2021 Dec 4.

Department of Urology, School of Medicine, Fujita Health University, Toyoake, Japan.

Objective: Recently, hormonal therapy using abiraterone acetate, a second-generation androgen receptor axis-targeted agent, was reported to improve overall survival and progression-free survival in men with LATITUDE-high-risk metastatic castration-sensitive prostate cancer. This observational multicenter study aimed to assess the efficacy of upfront abiraterone acetate in Japanese patients with LATITUDE-high-risk metastatic castration-sensitive prostate cancer.

Methods: The present study included 112 Japanese patients with LATITUDE-high-risk metastatic castration-sensitive prostate cancer who received upfront abiraterone acetate at four institutions belonging to the Tokai Urologic Oncology Research Seminar group, between January 2018 and September 2020. Read More

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December 2021

Digital dermoscopy monitoring of melanocytic lesions: Two novel calculators combining static and dynamic features to identify melanoma.

J Eur Acad Dermatol Venereol 2021 Dec 4. Epub 2021 Dec 4.

Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy.

Background: Early diagnosis is the most effective intervention to improve the prognosis of cutaneous melanoma. Even though the introduction of dermoscopy has improved the diagnostic accuracy, it can still be difficult to distinguish some melanomas from benign melanocytic lesions. Digital dermoscopy monitoring can identify dynamic changes of melanocytic lesions: to date, some algorithms where proposed, but a universally accepted one still lacks. Read More

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December 2021

Instantaneous wave-free ratio for guiding treatment of nonculprit lesions in patients with acute coronary syndrome: A retrospective study.

Catheter Cardiovasc Interv 2021 Dec 4. Epub 2021 Dec 4.

Reina Sofía Hospital, Department of Cardiology, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain.

Background: The aim of this study was to analyze the feasibility of a physiological coronary evaluation with the instantaneous wave-free ratio (iFR) of nonculprit lesions in patients with acute coronary syndrome (ACS) successfully revascularized.

Methods: A multicenter registry including patients of four high-volume PCI centers with ACS and underwent successful revascularization of the culprit vessel and had other nonculprit lesions that were physiologically evaluated with the iFR between January 2017 and December 2019. The primary endpoint was a composite of cardiac death, nonfatal myocardial infarction, probable or definitive stent thrombosis and new revascularization (MACEs). Read More

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December 2021

"Do I still have epilepsy?" Epilepsy identity 15-20 years after anterior temporal lobectomy.

Epilepsia 2021 Dec 4. Epub 2021 Dec 4.

Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Vic., Australia.

Objective: Identity is a multifaceted construct, comprising personal identity (sense of being a unique individual) and social identity (the sense-of-self derived from membership of social groups). Social identity involves explicit identification with a group ("I am …") and implicit behaviors or attitudes associated with group membership. Following successful treatment with surgery, patients with epilepsy can undergo a complex and lasting change in personal identity. Read More

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December 2021

Shear-Wave Elastography of Patellar Ligament and Achilles Tendon in Semiprofessional Athletes: Comparing With the Nonexercising Individuals.

J Ultrasound Med 2021 Dec 3. Epub 2021 Dec 3.

Department of Radiology, Istanbul Haseki Training and Research Hospital, Istanbul, Turkey.

Objectives: To compare semiprofessional athletes and nonexercising individuals in terms of p-SWE properties of the patellar ligament and the Achilles tendon.

Methods: This case-control study was conducted in University of Health Sciences, Haseki Education and Research Hospital. A total of 58 individuals, with 29 in each group (according to power analysis), were included in the study. Read More

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December 2021

Clinic and ambulatory blood pressure in relation to the interaction between plasma advanced glycation end products and sodium dietary intake and renal handling.

Hypertens Res 2021 Dec 3. Epub 2021 Dec 3.

Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Advanced glycation end product (AGE) clearance may cause renal tubular injuries, such as changes in sodium reabsorption. We hypothesize that AGEs interact with sodium metabolism to influence blood pressure (BP). The study participants were outpatients who were suspected of having hypertension but had not been treated with antihypertensive medication. Read More

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December 2021

Management of Peripheral T-Cell Lymphoma in Children and Adolescents Including STAT 3 Mutation Hyper-IgE Syndrome: One Size Does Not Fit All.

J Pediatr Hematol Oncol 2021 Dec 3. Epub 2021 Dec 3.

Departments of Pediatric Hematology, Oncology, Blood and Marrow Transplantation Pediatric Critical Care, Apollo Hospitals, Chennai, Tamil Nadu, India.

Peripheral T-cell lymphoma (PTCL) is a rare form of lymphoma in children with limited published data on treatment and lack of a uniformly accepted treatment algorithm. We retrospectively analyzed the data in children up to 18 years of age diagnosed to have PTCL from January 2016 to June 2020. The study included six children with a median age of 10 years, the youngest being a 7-month-old girl. Read More

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December 2021

The Suboptimal Pediatric HIV Viral Load Cascade: Multidistrict Cohort Study Among Children Taking Antiretroviral Therapy in Lesotho, Southern Africa.

Pediatr Infect Dis J 2021 Nov 30. Epub 2021 Nov 30.

From the SolidarMed, Partnerships for Health, Maseru, Lesotho Institute of Global Health, University of Geneva, Geneva, Switzerland Department of Medicine, Swiss Tropical & Public Health Institute, Basel, Switzerland Molecular Virology, Department of Biomedicine, University of Basel, Basel, Switzerland University of Basel, Basel, Switzerland Ministry of Health of Lesotho, Maseru, Lesotho Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.

Background: Children living with HIV and taking antiretroviral therapy (ART) are a priority group for routine viral load (VL) monitoring. As per Lesotho guidelines, a VL ≥1000 copies/mL ("unsuppressed") should trigger adherence counseling and a follow-up VL; 2 consecutive unsuppressed VLs ("virologic failure") qualify for switching to second-line ART, with some exceptions. Here, we describe the pediatric VL cascade in Lesotho. Read More

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November 2021

Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANES.

Diabetes Care 2021 Dec 3. Epub 2021 Dec 3.

Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China

Objective: Despite that periodical monitoring of cobalamin (vitamin B12) in metformin-treated patients with diabetes is recommended, cobalamin-associated mortality benefits or risks remain unclear. We investigated the association between cobalamin intake and related biomarkers and mortality risk in adults with diabetes using metformin or not.

Research Design And Methods: This study included 3,277 adults with type 2 diabetes from The National Health and Nutrition Examination Survey (NHANES) and followed up until 31 December 2015. Read More

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December 2021

Safety, activity, and long-term outcomes of pomalidomide in the treatment of Kaposi sarcoma among individuals with or without HIV infection.

Clin Cancer Res 2021 Dec 3. Epub 2021 Dec 3.

HIV and AIDS Malignancy branch, CCR/NCI/NIH.

Purpose: Kaposi sarcoma (KS) is caused by Kaposi sarcoma herpesvirus ((KSHV), also known as human herpesvirus 8 (HHV-8)). KS, which develops most frequently among people with HIV, is generally treated with chemotherapy, but these drugs have acute and cumulative toxicities. We previously described initial results of a trial of pomalidomide, an oral immunomodulatory derivative of thalidomide, in patients with KS. Read More

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December 2021

Transumbilical laparoscopy-assisted Malone procedure for fecal incontinence in children.

Pediatr Neonatol 2021 Nov 3. Epub 2021 Nov 3.

Division of Pediatric Surgery, Department of Surgery, Shuang Ho Hospital, New Taipei City, Taiwan; Department of Surgery, School of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background: Transumbilical laparoscopy-assisted Malone procedure (TULAM) is a single-incision laparoscopic procedure in which the appendicostomy is made at umbilicus. The aim of this study is to evaluate the outcomes of TULAM.

Methods: With IRB approval, the medical records of the patients who underwent TULAM were retrospectively reviewed between July 2013 and December 2018. Read More

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November 2021

Localized cystic disease of the kidney in pediatric patients: Clinical and imaging findings with long term follow up.

J Pediatr Urol 2021 Nov 12. Epub 2021 Nov 12.

Department of Radiology and Research Institute of Radiological Science, Severance Children's Hospital, Yonsei University College of Medicine, South Korea.

Introduction: This study aimed to describe the clinical and imaging findings, including ultrasonography (US) findings, and long-term follow-up results in pediatric patients with localized cystic disease of the kidney (LCDK).

Material And Methods: Retrospective review of pediatric patients diagnosed with LCDK based on imaging findings showing multiple localized renal cysts with intervening normal renal parenchyma from January 2002 to August 2020. Clinical presentations and US features of the affected and contralateral kidneys were reviewed and compared with computed tomography or magnetic resonance imaging findings, if available. Read More

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November 2021

Impact of sarcopenia on outcomes of patients treated with trimodal therapy for muscle invasive bladder cancer.

Urol Oncol 2021 Nov 30. Epub 2021 Nov 30.

Division of Urology, McGill University Health Centre, Montreal, Canada. Electronic address:

Objective: We sought to investigate the incidence of sarcopenia and its impact on main oncological outcomes in patients with muscle invasive bladder cancer (MIBC) treated with trimodal therapy (TMT).

Patients And Methods: This was a retrospective analysis of 141 MIBC patients treated with TMT in the period 2002 to 2018. Sarcopenia was identified through pretreatment computed tomography scans and defined as a skeletal muscle index of <55 cm/m for men and <39 cm/m for women. Read More

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November 2021

Real-world use of mycophenolate mofetil in inflammatory bowel disease: Results from the ENEIDA registry.

Dig Liver Dis 2021 Nov 30. Epub 2021 Nov 30.

Hospital Universitario de Canarias, Gastroenterology Dept., La Laguna, Spain.

Background: Studies to evaluate the use of mycophenolate mofetil (MMF) in inflammatory bowel disease (IBD) are limited after the appearance of biological treatments.

Aims: Our primary objective was to evaluate the effectiveness and safety of MMF in IBD.

Methods: IBD patients who had received MMF were retrieved from the ENEIDA registry. Read More

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November 2021

A Clinical Decision Aid to Support Personalized Treatment Selection for Patients with Clinical T1 Renal Masses: Results from a Multi-institutional Competing-risks Analysis.

Eur Urol 2021 Nov 30. Epub 2021 Nov 30.

Department of Urology, Mayo Clinic, Rochester, MN, USA.

Background: Personalized treatment for clinical T1 renal cortical masses (RCMs) should take into account competing risks related to tumor and patient characteristics.

Objective: To develop treatment-specific prediction models for cancer-specific mortality (CSM), other-cause mortality (OCM), and 90-d Clavien grade ≥3 complications across radical nephrectomy (RN), partial nephrectomy (PN), thermal ablation (TA), and active surveillance (AS).

Design, Setting, And Participants: Pretreatment clinical and radiological features were collected for consecutive adult patients treated with initial RN, PN, TA, or AS for RCMs at four high-volume referral centers (2000-2019). Read More

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November 2021

Preliminary Functional Outcome Following Robotic Intracorporeal Orthotopic Ileal Neobladder Suspension with Round Ligaments in Women with Bladder Cancer.

Eur Urol 2021 Nov 30. Epub 2021 Nov 30.

Department of Urology, Urology Institute of PLA, Southwest Hospital, Third Military Medical University, Chongqing, China.

Background: Chronic urinary retention (CUR) is a frequent complication after orthotopic neobladder (ONB) reconstruction in women. To decrease CUR, several open surgical modifications to provide back support to the ONB have been established on the basis of pelvic anatomical differences between females and males.

Objective: To illustrate our technique for robotic intracorporeal reconfiguration of ONB as integrated into our open surgical approach to provide back support to the ONB with round ligaments in women. Read More

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November 2021

Immediate restoration of fixed full-arch prostheses placed on implants in both fresh and healed sockets using the flat one-bridge technique: a 7-year retrospective study.

BMC Oral Health 2021 Dec 3;21(1):617. Epub 2021 Dec 3.

, Turin, Italy.

Background: The aim of this retrospective study was to document the long-term clinical efficacy of a surgical-prosthetic technique (the flat one-bridge technique) involving the immediate restoration of both postextraction and nonpostextraction implants supporting full-arch restorations.

Methods: Implants were placed by adapting the axis to the available bone. Flat definitive abutments were connected during surgery and never disconnected to compensate for eventual implant disparallelism. Read More

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December 2021

Evaluation of parallel endplate osteotomy for severe rigid spinal deformities: a retrospective analysis of 36 cases with a minimum 2-year follow-up.

BMC Musculoskelet Disord 2021 Dec 3;22(1):1011. Epub 2021 Dec 3.

Department of Orthopedics, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen, 518000, PR, China.

Background: To report on the technique and results of parallel endplate osteotomy (PEO) for severe rigid spinal deformity.

Methods: We retrospectively reviewed the clinical data of 36 patients with severe rigid spinal deformities who underwent PEO between July 2016 and December 2018 and who were followed up for at least 24 months.

Results: Following PEO, the kyphosis and scoliosis correction rates reached 77. Read More

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December 2021

Efficacy and safety of percutaneous nephrolithotomy in patients with chronic kidney disease: Outcomes from a tertiary care center.

J Endourol 2021 Dec 3. Epub 2021 Dec 3.

All India Institute of Medical Sciences - Rishikesh, 442339, Urology, Rishikesh, Uttarakhand, India;

Background: The management of renal stone disease in the presence of chronic kidney disease is a challenging scenario, both in terms of surgical safety as well as perioperative outcomes. The aim of the present study is to study the efficacy, safety, and outcomes of percutaneous nephrolithotomy in patients with chronic kidney disease.

Materials And Methods: A prospective study was conducted including adult patients with renal stone disease and a creatinine clearance of <90ml/min (Stage 2 CKD or more) who underwent percutaneous nephrolithotomy. Read More

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December 2021

Factors associated with retention and adherence in a comprehensive, diverse HIV Pre-Exposure Prophylaxis (PrEP) clinic.

AIDS Res Hum Retroviruses 2021 Dec 3. Epub 2021 Dec 3.

University of Colorado Denver School of Medicine, 12225, Internal Medicine, 12700 E. 19th Avenue Box B168, Aurora, Colorado, United States, 80045-2581;

Introduction: Retention in HIV pre-exposure prophylaxis (PrEP) care and adherence to PrEP has been suboptimal in some populations, despite evidence that high adherence dramatically enhances PrEP efficacy. A comprehensive PrEP Clinic with a retention specialist and clinical pharmacist could impact patient's retention and adherence in PrEP care.

Methods: A retrospective electronic medical record review of patients attending an academic PrEP Clinic was conducted between 6/2018 to 6/2019 (at least one visit attended for PrEP was required). Read More

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December 2021

Long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with COVID-19: A cohort study with 4 months median follow-up.

J Infect Public Health 2021 Nov 18;15(1):21-28. Epub 2021 Nov 18.

Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Prince Abdullah Ben Khaled Celiac Disease Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Post-acute COVID-19 syndrome (PACS) is an emerging healthcare burden. We therefore aimed to determine predictors of different functional outcomes after hospital discharge in patients with COVID-19.

Methods: An ambidirectional cohort study was conducted between May and July 2020, in which PCR-confirmed COVID-19 patients underwent a standardized telephone assessment between 6 weeks and 6 months post discharge. Read More

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November 2021

Clinical Outcomes and Safety Profile in the Treatment of Synchronous Non-Metastatic Lung Tumors with Stereotactic Body Radiotherapy.

Pract Radiat Oncol 2021 Nov 30. Epub 2021 Nov 30.

Yale School of Medicine, Department of Therapeutic Radiology. Electronic address:

Purpose/objectives: Stereotactic body radiotherapy (SBRT) has increasingly been used to treat early-stage primary lung cancers, but its effectiveness and safety in patients with multiple synchronous primary lung tumors (SPLC) is not as well-established. Our aim was to evaluate clinical outcomes, patterns of recurrence, and toxicities for these patients.

Methods/materials: We queried an institutional database of patients treated with SBRT for primary lung tumors from 2007 to 2019. Read More

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November 2021

Improving of long-term follow-up after cystocele repair.

J Gynecol Obstet Hum Reprod 2021 Nov 30:102278. Epub 2021 Nov 30.

Department of Obstetrics, Gynecology and Pediatrics, Moscow Medical University REAVIZ, Moscow, Russian Federation.

Introduction: The anterior vaginal wall is the most common site of repair compared with apex and posterior vaginal wall, and is also the site with the highest recurrence rate after surgery. The aim of this study was to evaluate the anatomical location of apex in patients with cystocele staged 2-3 (POP-Q), to correct all anatomical defects and to improve cystocele repair results.

Materials And Methods: This was a single-center prospective study of women with cystocele of stage 2-3 with and without apical prolapse who underwent combined surgical treatment. Read More

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November 2021

Margin marking before colorectal endoscopic mucosal resection and its impact on neoplasia recurrence (with video).

Gastrointest Endosc 2021 Nov 30. Epub 2021 Nov 30.

Department of Gastroenterology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; Department of Gastroenterology, Veterans Administration Medical Center, White River Junction, Vermont.

Background And Aims: Ablation of resection margins after endoscopic mucosal resection (EMR) of large nonpedunculated colorectal polyps decreases recurrence. Margin marking before EMR (EMR-MM) may represent an alternative method to achieve a healthy resection margin. We aimed to determine the efficacy of EMR-MM in reducing neoplasia recurrence. Read More

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November 2021

Factors Associated With Lung Cancer Screening Adherence Among Patients With Negative Baseline CT Results in a Community Health Care Setting.

J Am Coll Radiol 2021 Nov 30. Epub 2021 Nov 30.

Department of Radiology, Northwell Health, Manhasset, New York; Feinstein Institutes for Medical Research, Manhasset, New York; Department of Pulmonary Medicine, Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Manhasset, New York.

Purpose: Lung cancer screening (LCS) decreases lung cancer mortality; however, that reduction depends upon screening adherence. The purpose of this study was to determine factors associated with adherence rate for LCS among patients with negative baseline CT results in a multi-integrated health care network.

Methods: A retrospective analysis was conducted among patients with negative baseline CT results in a multi-integrated health care network LCS program between January 2015 and January 2020. Read More

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November 2021

Initiation of Anti-Hypertensive Drugs and Outcomes in Patients with Heart Failure with Reduced Ejection Fraction.

Am J Med 2021 Nov 30. Epub 2021 Nov 30.

Veterans Affairs Medical Center, Washington, DC; Georgetown University, Washington, DC; George Washington University, Washington, DC. Electronic address:

Background: In patients with heart failure with reduced ejection fraction (HFrEF) and hypertension, systolic blood pressure is recommended to be maintained below 130 mmHg, although this has not been shown to be associated with improved outcomes. We examined the association of anti-hypertensive drug initiation and outcomes in patients with HFrEF.

Methods: In the Medicare-linked OPTIMIZE-HF, 7966 patients with HFrEF (ejection fraction ≤40%) without renal failure were not receiving anti-hypertensive drugs before hospitalization, of whom 692 received discharge prescriptions for those drugs (thiazides and calcium channel blockers). Read More

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November 2021

Pulmonary Specialist Involvement in Critical Asthma in the Pediatric Intensive Care Unit: a Retrospective Review.

Pediatr Pulmonol 2021 Dec 2. Epub 2021 Dec 2.

Department of Pediatrics, Section of Pulmonary Medicine, Baylor College of Medicine, Houston, TX.

Introduction: Asthma is one of the most common chronic diseases of childhood. There is a scarcity of published literature on critical asthma, considered acute asthma requiring pediatric intensive care unit (PICU) admission. The goal of this study was to describe the clinical care of children with critical asthma admitted to a single center PICU and to determine whether pulmonary medicine consultation during admission impacted outcomes. Read More

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December 2021

Development of a Prognostic Model for Predicting Multiple Sclerosis After Optic Neuritis: A Secondary Analysis of Data From the Optic Neuritis Treatment Trial.

J Neuroophthalmol 2021 Oct 22. Epub 2021 Oct 22.

Department of Neurology (WL), the First Affiliated Hospital of Guangxi Medical University, Nanning, China; Department of Environmental Health Sciences (XD), University at Albany, State University of New York, Rensselaer, New York; State Key Laboratory of Ophthalmology (XX), Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; Department of Ophthalmology (RS, ML, YD), the First Affiliated Hospital of Guangxi Medical University, Nanning, China; Byers Eye Institute (HEM), Stanford University, Palo Alto, California; and Department of Neurology and Neurological Sciences (HEM), Stanford University, Stanford, California.

Background: Optic neuritis can be the initial manifestation of multiple sclerosis (MS). The purpose of this study was to develop a prognostic model for predicting the risk of MS development among patients with optic neuritis.

Methods: The data from 388 patients with optic neuritis were retrieved from the Optic Neuritis Treatment Trial (ONTT). Read More

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October 2021

Urinary cadmium and incident heart failure: A case-cohort analysis among never-smokers in Denmark.

Epidemiology 2021 Dec 1. Epub 2021 Dec 1.

Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA Christina Lee Brown Envirome Institute, Division of Environmental Medicine, Department of Medicine, University of Louisville, Louisville, KY, USA Danish Cancer Society Research Center, Copenhagen, Denmark Department of Environmental Science, Aarhus University, Roskilde, Denmark Center for Analytical Science, Research Triangle Institute, Research Triangle Park, NC, USA Department of Family Medicine, University of Colorado Denver, Denver, CO, USA Department of Public Health, Aarhus University, Aarhus, Denmark Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark Department of Public Health, University of Copenhagen, Copenhagen, Denmark Program in Public Health, Department of Family, Population, & Preventive Medicine, Stony Brook University, NY, USA Department of Environmental Health, Boston University, Boston, MA, USA.

Background: Epidemiologic studies suggest cadmium exposure is associated with cardiovascular disease risk, including heart failure. However, prior findings may be influenced by tobacco smoking, a dominant source of cadmium exposure and risk factor for heart failure. The present study leverages up to 20 years of follow-up in the Danish Diet, Cancer and Health cohort to examine the relationship between urinary cadmium and incident heart failure among people who never smoked. Read More

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December 2021

Accuracy of Pathologic Diagnosis in Patients With Lymphoma and Survival: A Prospective Analysis From Botswana.

JCO Glob Oncol 2021 Sep;7:1620-1632

Department of Pathology, Massachusetts General Hospital, Boston, MA.

Purpose: With intense HIV epidemics, southern African countries have a high burden of classic Hodgkin lymphoma (CHL) and non-Hodgkin lymphoma (NHL). However, suboptimal access to pathology resources limits subtype classification. We sought to assess the diagnostic accuracy of specimens classified as lymphoma and to determine association between discordant pathologic diagnosis and overall survival. Read More

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September 2021