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Epilepsy surgery in stroke-related epilepsy?

Seizure 2021 Apr 5;88:116-124. Epub 2021 Apr 5.

Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario, Canada, N6A 5A5; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario, Canada, N6A 5A5; Neuro-Epidemiology Unit, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario, Canada, N6A 5A5. Electronic address:

Purpose: To provide a descriptive analysis on the presurgical evaluation and surgical management of a cohort of patients with stroke related epilepsy (SRE).

Methods: We retrospectively examined the clinical characteristics, results of non-invasive and invasive presurgical evaluation, surgical management and outcome of consecutive patients with drug-resistant SRE in our institution from January 1, 2013 to January 1, 2020.

Results: Twenty-one of 420 patients (5%) who underwent intracranial EEG (iEEG), resective epilepsy surgery and/or vagus nerve stimulation (VNS) placement, had SRE. Read More

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The effect of plaque control in the treatment of Oral Lichen Planus with gingival manifestations: a Systematic Review.

Community Dent Health 2021 Apr 9. Epub 2021 Apr 9.

Centre for Host Microbiome Interactions, Kings College, London.

Background: Oral lichen planus (OLP) is a chronic autoimmune disease that frequently affects the oral mucosa. Patients with OLP tend to present with plaque accumulation which may further exacerbate the lichenoid lesion, thus plaque control may improve the quality of life of patients. The aim of this review was to test the effect of plaque control on OLP with gingival manifestations. Read More

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Nonconvulsive status epilepticus manifesting as rapidly progressive dementia and infarction in the splenium of the corpus callosum: A case report.

Medicine (Baltimore) 2021 Apr;100(15):e25263

Department of Neurology, Neuroscience Center.

Rationale: Nonconvulsive status epilepticus (NCSE) is a heterogeneous disease with multiple subtypes. NCSE poses great diagnostic and therapeutic challenges due to the lack of typical symptoms. Here, we report a case of NCSE manifesting as rapidly progressive dementia (RPD) and infarction in the splenium of the corpus callosum. Read More

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Long-term Effect of Individualized Titanium Mesh in Orbital Floor Reconstruction After Maxillectomy.

Laryngoscope 2021 Apr 13. Epub 2021 Apr 13.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.

Objective: The aim of this study was to determine the clinical outcomes and long-term stability of individualized titanium mesh combined with free flap for orbital floor reconstruction after maxillectomy and to identify the risk factors for titanium mesh exposure.

Material And Methods: The data of 66 patients who underwent maxillectomy and orbital floor defect reconstruction by individualized titanium mesh in Peking University School and Hospital of Stomatology between 2011 and 2019 were retrospectively reviewed. Postoperative ophthalmic function and success of aesthetic restoration were assessed. Read More

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A rare case of ectopic ACTH syndrome caused by primary renal neuroendocrine tumor.

Endocrinol Diabetes Metab Case Rep 2021 Apr 12;2021. Epub 2021 Apr 12.

Division of Endocrinology and Metabolism, Department of Medicine.

Summary: Ectopic adrenocorticotropic hormone (ACTH) secretion is responsible for 5-15% of Cushing's syndrome (CS). Neuroendocrine tumor (NET) is a common cause of ectopic ACTH syndrome (EAS). However, primary renal NET is exceedingly rare. Read More

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Diagnostic accuracy of breast MRI for patients with suspicious nipple discharge and negative mammography and ultrasound: a prospective study.

Eur Radiol 2021 Apr 13. Epub 2021 Apr 13.

Department of Radiology, Institut Bergonié, Comprehensive Cancer Centre, F-33076, Bordeaux, France.

Objectives: To evaluate the diagnostic accuracy of breast MRI in identifying lesions requiring excision for patients with suspicious nipple discharge but normal mammograms and ultrasounds.

Methods: Between September 2013 and May 2019, 106 female participants (mean age 57.9 years) were consecutively included in this prospective multicenter study; 102 were retained for analysis. Read More

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Hidradenoma papilliferum of the hymen: a case report.

J Med Case Rep 2021 Apr 13;15(1):162. Epub 2021 Apr 13.

Department of Gynaecology and Obstetrics, Akdeniz University Hospital, Antalya, Turkey.

Background: Hidradenoma papilliferum is a rare benign neoplasm arising from apocrine glands. It occurs commonly on the anogenital region of middle-aged women. It usually presents as a slow growing, solitary asymptomatic, skin colored or red nodule less than 1 cm in diameter. Read More

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[Application and value of excimer laser ablation in the treatment of lower limb atherosclerotic obliterans].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(14):1026-1030

Department of Vascular Surgery, Zhongshan Hospital, Fudan University,Shanghai 200032, China.

To evaluate the results of excimer laser ablation (ELA) in the treatment of lower limb atherosclerotic obliterans (ASO). From June 2019 to March 2020, patients who underwent ELA combined with drug-coated balloon (DCB) for lower limb atherosclerotic obliterans (ASO) were enrolled. Demographics, lesion characteristics, procedure-related outcomes and complications were collected and analyzed. Read More

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Radiomics analysis of chest CT to predict the overall survival for the severe patients of COVID-19 pneumonia.

Phys Med Biol 2021 Apr 12. Epub 2021 Apr 12.

Department of Radiology, Wuhan University Zhongnan Hospital, Wuhan, Hubei, CHINA.

Personalized assessment and treatment of severe patients with COVID-19 pneumonia have greatly affected the prognosis and survival of these patients. This study aimed to develop the radiomics models as the potential biomarkers to estimate the overall survival (OS) for the COVID-19 severe patients. A total of 74 COVID-19 severe patients were enrolled in this study, and 30 of them died during the follow-up period. Read More

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[Prognostic value of interim PET/CT in non-hodgkin lymphoma].

Rev Med Chil 2020 Nov;148(11):1558-1567

Departamento de Hemato-oncología y Jefe de Banco de Sangre, Clínica Las Condes, Santiago, Chile.

Background: The prognosis of Non-Hodgkin Lymphoma (NHL) depends on the type of lymphoma, the extension of the disease and the response to therapy.

Aim: To evaluate the prognostic value of pretreatment and interim PET/CT compared to classic prognosis factors and body composition measurement (sarcopenia, adipopenia) in patients with recently diagnosed NHL.

Material And Methods: Patients with recently diagnosed NHL who had staging 18F-FDG PET/CT performed between December 2008 and August 2018 were selected. Read More

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November 2020

Efficacy and safety of bioresorbable scaffolds in patients with coronary bifurcation lesions: A systematic review and meta-analysis.

Cardiol J 2021 Apr 12. Epub 2021 Apr 12.

Department of Cardiology, The First Hospital of Lanzhou University, No. 1, West Road, Donggang, Cheng guan District, 730000 Lanzhou, China.

Background: Bioresorbable scaffolds (BRS) were considered to be beneficial for coronary bifurcation lesions regarding the avoidance of lateral branch opening incarceration after complete absorption. However, data is limited in this setting. The aim of this meta-analysis was to evaluate the short (6-month) and medium-term (1-year) outcomes of BRS in patients with coronary bifurcation lesions. Read More

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Promotion of Cervical Screening among Long-term Non-attendees by Human Papillomavirus Self-sampling.

J Cancer Prev 2021 Mar;26(1):25-31

Department of Obstetrics and Gynecology, Skåne University Hospital, Lund University, Lund, Sweden.

Cervical cancer is preventable through gynecological screening. To promote participation among non-attending women, self-collected vaginal samples for detection of high-risk human papillomavirus (hr-HPV) is an option. The aims of this study were to investigate the response of self-collected vaginal samples for hr-HPV testing among long-term non-attendees, to explore the attendance at follow-up among HPV-positive women, and to analyze the prevalence of hr-HPV and severe cervical dysplasia or cancer among the responders. Read More

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Tuberculosis Septic Arthritis of the Elbow: A Case Report and Literature Review.

Cureus 2021 Mar 8;13(3):e13765. Epub 2021 Mar 8.

Department of Orthopedics, Prince of Songkhla University, Songkhla, THA.

Tuberculosis (TB) infections of the musculoskeletal system are rare. A 77-year-old female with chronic left elbow pain for five months was treated by irrigation and debridement of the elbow for a presumed diagnosis of septic arthritis. Her pain and wound condition did not improve, and she was referred to our institution. Read More

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Contribution of Clinically Indicated Repeat Renal Biopsy in Indian Patients with Lupus Nephritis.

Indian J Nephrol 2020 Nov-Dec;30(6):377-381. Epub 2020 Feb 11.

Department of Histopathology, PGIMER, Chandigarh, India.

Background: Repeat renal biopsy is usually done for lupus nephritis (LN) flare or resistant disease. We analyzed the changes between first and repeat biopsy and the contribution of repeat biopsy on renal outcome in LN patients.

Methods: This was a retrospective study carried out at a tertiary care center in India. Read More

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February 2020

A multi-institutional analysis of fractionated versus single-fraction stereotactic body radiotherapy (SBRT) in the treatment of primary lung tumors: a comparison between two antipodal fractionations.

Clin Transl Oncol 2021 Apr 10. Epub 2021 Apr 10.

Department of Radiation Oncology, Sant'Andrea Hospital, "Sapienza" University of Rome, Rome, Italy.

Objectives: Stereotactic body radiotherapy (SBRT) is a consolidate treatment for inoperable early-stage lung tumors, usually delivered in single or multi-fraction regimens. We aimed to compare these two approaches in terms of local effectiveness, safety and survival.

Materials And Methods: Patients affected by medically inoperable early-stage lung tumor were treated at two Institutions with two different schedules: 70 Gy in ten fractions (TF) (BED10: 119 Gy) or 30 Gy in single fraction (SF) (BED10: 120 Gy). Read More

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Long-term outcomes of oligometastatic breast cancer patients treated with curative intent: an updated report.

Breast Cancer 2021 Apr 11. Epub 2021 Apr 11.

Division of Clinical Oncology and Hematology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, Japan.

Background: Oligometastatic breast cancer (OMBC) is characterized by limited metastatic tumor numbers and sites. We have reported a 20-year overall survival (OS) rate and relapse-free rate (RFR) of 34.1% and 27. Read More

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Gastric Adenoma: A High Incidence Rate of Developing Carcinoma and Risk of Metachronous Gastric Cancer according to Long-Term Follow-Up.

Digestion 2021 Apr 9:1-9. Epub 2021 Apr 9.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Introduction: Gastric adenomas are histologically defined as benign epithelial tumors. While some of them remain adenomas for a long time, others progress to carcinomas. However, long-term outcomes of such cases are not entirely clear. Read More

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Risk factors of local recurrence following implant-based breast reconstruction in breast cancer patients.

BMC Womens Health 2021 Apr 10;21(1):147. Epub 2021 Apr 10.

Department of Breast Surgery, Hiroshima City Hospital, 7-33 Moto-machi, Naka-ku, Hiroshima, 730-8518, Japan.

Background: The number of patients desiring implant-based breast reconstruction has been increasing. While local recurrence is observed in patients with breast reconstruction, only a few reports have focused on the risk factors for local recurrence and the prognosis after developing local recurrence.

Methods: We analyzed 387 patients who underwent implant-based breast reconstruction during the period from 2004 to 2017 in Hiroshima City Hospital. Read More

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Dynamic analysis of CSF1R-related leukoencephalopathy on magnetic resonance imaging: a case report.

BMC Neurol 2021 Apr 10;21(1):156. Epub 2021 Apr 10.

Department of Neurology, Liuzhou People's Hospital, Liuzhou, China.

Background: Colony-stimulating factor 1 receptor (CSF1R)-related leukoencephalopathy is a rare and rapidly progressive leukoencephalopathy characterized by cognitive, motor, and neuropsychiatric symptoms, which is often misdiagnosed. Magnetic resonance imaging (MRI) signs and follow-up MRI of CSF1R-related leukoencephalopathy could help in establishing a diagnosis, but these features are not widely known by general neurologists.

Case Presentation: A 34-year-old man was admitted for progressive weakness of the right limbs over 8 months. Read More

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Clinical and radiological activity of secondary progressive multiple sclerosis in a population-based cohort.

Eur J Neurol 2021 Apr 10. Epub 2021 Apr 10.

Université de Lorraine, EA 4360 Apemac, F-54500, Vandoeuvre-Lès-Nancy, France.

Background: Patients with secondary progressive multiple sclerosis (SP MS) and clinical and/or radiological activity could be the more likely to benefit from disease modifying treatments. To evaluate the proportions each year after progression onset, we studied patients with SP MS onset between 2002 and 2012 from a population-based multiple sclerosis registry in North-Eastern France.

Methods: Progression onset was first identified by the neurologist's diagnosis (N cohort), then by using an automated data-driven definition (D cohort). Read More

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Correlations among disability, anti-AQP4 antibody status and prognosis in the spinal cord involved patients with NMOSD.

BMC Neurol 2021 Apr 9;21(1):153. Epub 2021 Apr 9.

Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang-Gung University, Linkou, Taoyuan, Taiwan.

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a rare neuroinflammatory disorder of the central nervous system that typically involves the optic nerve, the spinal cord and other specific brain regions. In relapse of the disease, factors associated with clinical features and lesion severity are important for clinicians to predict disease-related disability.

Methods: We retrospectively analyzed 22 female patients with NMOSD who had spinal cord lesions. Read More

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GLOS and HARM in patients with transient neurovascular symptoms with and without ischemic infarction.

J Neuroradiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.

Background And Purpose: Gadolinium leakage in ocular structures (GLOS) on fluid attenuated inversion recovery images (FLAIR) is a novel imaging marker in acute ischemic stroke and other neurological disorders.

Methods: In patients with transient neurovascular symptoms who underwent repeated MRI with intravenous contrast agent administration, the presence of acute ischemic lesions on diffusion-weighted images (DWI) as well as the frequency and pattern of blood-brain barrier and blood-retina barrier impairment as demonstrated by the hyperintense acute reperfusion marker (HARM) and GLOS respectively on postcontrast FLAIR were evaluated.

Results: Overall 28 patients with transient neurovascular symptoms (median age 70. Read More

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Laparoscopic anterior hepatic transection for resecting lesions originating in the paracaval portion of the caudate lobe (with videos).

Surg Endosc 2021 Apr 9. Epub 2021 Apr 9.

Institute of Hepatobiliary Surgery, First Affiliated Hospital, Army Medical University, 30 Gaotanyan Main Street, Shapingba District, Chongqing, 400038, China.

Background: The paracaval portion of the caudate lobe is located in the core of the liver. Lesions originating in the paracaval portion often cling to or even invade major hepatic vascular structures. The traditional open anterior hepatic transection approach has been adopted to treat paracaval-originating lesions. Read More

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Born in the Purple: An Exceptional Case of Cutis Marmorata Telangiectatica Congenita.

Acta Dermatovenerol Croat 2020 Dec;28(4):247-248

Department of Dermatology, University General Hospital of Patras, Rion, Greece, Greece;

A full-term, 2-day-old female neonate with a congenital non-tender reticular patch that did not disappear with local warming was referred to our department for consultation. The family history as well as the antenatal course and delivery were unremarkable. On examination, we evidenced a fixed, marbled, bluish to deep purple lesion with a fishnet appearance extending over the right side of her body, face, and scalp. Read More

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December 2020

Unusual Clinical Presentation of Giant Extragenital Condyloma.

Acta Dermatovenerol Croat 2020 Dec;28(7):240-241

Andrija Jovic, MD, Clinical Center of Nis, Clinic of Dermatovenereology , Bulevar Zorana Djindjica 48, Nis, Serbia;

Dear editor, Condylomata accuminatum (CA) is a human papillomavirus (HPV) related sexually transmitted infection (STI), clinically characterized by solitary or even clustered dark red or pink lesions solely affecting the anogenital area (1). CA involving the extragenital, non-mucosal skin has been sporadically reported (2-4). Diagnosis of CA is usually straightforward when the lesions are located on the anogenital area. Read More

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December 2020

Safety of topical interventions for the treatment of actinic keratosis.

Expert Opin Drug Saf 2021 Apr 9. Epub 2021 Apr 9.

Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

: Actinic keratosis (AK) are proliferations of atypical keratinocytes that may eventually progress to cutaneous squamous cell carcinoma. Therefore, AK requires consequent and early treatment.: A variety of effective approaches is currently available for the clearance of AK. Read More

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TLM Outcomes in Elderly Patients with Glottic Pre-Malignancy and Early Malignancy; A 12-Year Retrospective Study.

Ann Otol Rhinol Laryngol 2021 Apr 9:34894211007819. Epub 2021 Apr 9.

Castle Hill Hospital, Cottingham, Hull, UK.

Introduction: UK population ageing and associated cancer risk predicts an increase in the prevalence of laryngeal cancer in elderly patients. Whilst trans-oral laser microsurgery (TLM) has been demonstrated to achieve excellent control of early disease with few complications, data specifically related to its safety and efficacy in older patients is lacking. We report the largest series to date. Read More

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Long term renal function following selective angioembolization for iatrogenic vascular lesions after partial nephrectomy: A matched case-control study.

Investig Clin Urol 2021 Mar 25. Epub 2021 Mar 25.

Section of Urology, Department of Surgery, The University of Chicago Medicine, Chicago, IL, USA.

Purpose: Partial nephrectomy is associated with a 1%-2% risk of renal iatrogenic vascular lesion (IVL) that are commonly treated with selective angioembolization (SAE). The theoretical advantage of SAE is preservation of renal parenchyma by targeting only the bleeding portion of the kidney. Our study aims to assess the long-term effect of SAE on renal function, especially that this intervention requires potentially nephrotoxic contrast load injection. Read More

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Outcomes of Surgical Excision and High-Dose-Rate Brachytherapy for Earlobe Keloids.

World J Plast Surg 2021 Jan;10(1):78-84

Plastic and Reconstructive Surgery Department, Hospital Universitario de Caracas, Universidad Central de Venezuela, Los Chaguaramos, Distrito Capital, Venezuela.

Background: Radiotherapy as an adjuvant therapy to surgical resection has shown variable rates of recurrence treating earlobe keloids. The purpose of this study was to describe our experience with surgical excision followed by high-dose-rate brachytherapy and present our outcomes after 24 months of follow-up.

Methods: Retrospective chart of 14 patients with 14 earlobe keloids treated with surgical excision followed by high-dose-rate brachytherapy, between January 2015 and May 2016 were enrolled. Read More

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January 2021

A Dose-Response Relationship to Radiotherapy for Cutaneous Lesions of Langerhans Cell Histiocytosis.

Case Rep Oncol Med 2021 24;2021:6680635. Epub 2021 Mar 24.

Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, USA.

Langerhans cell histiocytosis (LCH) is a rare disease, afflicting approximately 4.6 and 1-2 per 1 million children and adults, respectively. While LCH can involve numerous organ systems such as the lung or bone, it is uncommon for the disease to be limited to the skin. Read More

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