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The Suboptimal Pediatric HIV Viral Load Cascade: Multidistrict Cohort Study Among Children Taking Antiretroviral Therapy in Lesotho, Southern Africa.

Pediatr Infect Dis J 2021 Nov 30. Epub 2021 Nov 30.

From the SolidarMed, Partnerships for Health, Maseru, Lesotho Institute of Global Health, University of Geneva, Geneva, Switzerland Department of Medicine, Swiss Tropical & Public Health Institute, Basel, Switzerland Molecular Virology, Department of Biomedicine, University of Basel, Basel, Switzerland University of Basel, Basel, Switzerland Ministry of Health of Lesotho, Maseru, Lesotho Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.

Background: Children living with HIV and taking antiretroviral therapy (ART) are a priority group for routine viral load (VL) monitoring. As per Lesotho guidelines, a VL ≥1000 copies/mL ("unsuppressed") should trigger adherence counseling and a follow-up VL; 2 consecutive unsuppressed VLs ("virologic failure") qualify for switching to second-line ART, with some exceptions. Here, we describe the pediatric VL cascade in Lesotho. Read More

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November 2021

Increased risk of Graves´ophthalmopathy in patients with increasing TRAb after radioiodine treatment and the impact of CTLA4 on TRAb titres.

Endocrine 2021 Dec 2. Epub 2021 Dec 2.

Department of Endocrinology, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö and Lund, Sweden.

Introduction: Treatment of Graves´ disease (GD) with radioiodine increases the risk of developing Graves´ ophthalmopathy (GO), and the link between thyroid and orbital tissue may be the presence of TSH-receptors. Radioiodine increases the titers of TRAb and the aim was to investigate the relationship between GO and TRAb titers after treatment with radioiodine and to define the impact of risk genes.

Methods: GD patients without ophthalmopathy or previous treatment with radioiodine were prospectively included at treatment with radioiodine for hyperthyroidism. Read More

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December 2021

Clinical Outcome and Drug Expenses of Intravitreal Therapy for Diabetic Macular Edema: A Retrospective Study in Sardinia, Italy.

J Clin Med 2021 Nov 16;10(22). Epub 2021 Nov 16.

Ophthalmology Unit, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy.

Background: Diabetic macular edema (DME) is a leading cause of visual loss in working-age adults. The purpose of this retrospective study was to perform an epidemiological analysis on DME patients treated with intravitreal drugs in a tertiary hospital. The clinical outcome, adverse drug reactions (ADRs), and intravitreal drug expenses were assessed. Read More

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November 2021

Laser Ablation Treatment of Recurrent Lymph Node Metastases from Papillary Thyroid Carcinoma.

J Clin Med 2021 Nov 14;10(22). Epub 2021 Nov 14.

Department of Endocrine and Ultrasound-Guided Surgery, Ospedale del Mare, 80147 Naples, Italy.

(1) Background: The incidence of papillary thyroid cancers is increasing. Papillary neoplasm metastasizes to the central and lateral lymph nodes of the neck. The recurrence rate is less than 30%. Read More

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November 2021

Functional and Cost Audit of Primary Total Knee Arthroplasty in Public vs Private Hospitals: A Retrospective Cohort Study.

Indian J Orthop 2021 Oct 20;55(5):1306-1316. Epub 2021 Mar 20.

Department of Orthopaedics, HBT Medical College and Dr. R.N. Cooper Municipal General Hospital, Mumbai, Maharashtra India.

Background: Government funded hospitals are believed to be stigmatised with 'substandard care' and constant fear of infection. The aim of this study is to compare the results and direct expenditure incurred for total knee arthroplasty (TKA) done at a government funded public teaching hospital with an economy packaged private hospital in India.

Materials And Methods: A review of electronic and physical records of the patients operated by the senior author for primary TKA at a government funded hospital and a private hospital spanning 2007 to 2019 was done. Read More

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October 2021

Effects of home medication review on drug-related problems and health-related quality of life among community-dwelling older adults in China.

J Am Pharm Assoc (2003) 2021 Oct 26. Epub 2021 Oct 26.

Background: There is a lack of research on the nature of drug-related problems (DRPs) in older adult communities in China and the impact of home medication review on DRP reduction and health-related quality-of-life (HRQoL) improvement.

Objectives: To identify and categorize DRPs in older adults in China and to assess the impact of home medication review.

Methods: The prospective study was conducted in 2 community health service centers in Shanghai, China from December 2018 to December 2019. Read More

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October 2021

[Efficacy and safety of percutaneous closure of ventricular septal rupture after acute myocardial infarction: a clinical study of 69 cases].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Nov;49(11):1094-1101

Department of Cardiology, Central China Fuwai Hospital (Central China Fuwai Hospital of Zhengzhou University), Heart Center of Henan Provincial People's Hospital, Henan Key Laboratory of Coronary Heart Disease Control, Henan Research Center for Cardiovascular Epidemiology, Zhengzhou 450003, China.

To investigate the efficacy and safety of percutaneous closure of ventricular septal rupture (VSR) after acute myocardial infarction (AMI) and the risk factors of all-cause mortality at 30 days after operation. This is a retrospective case series study. A total of 69 patients with post-AMI VSR, underwent percutaneous closure of VSR from October 2013 to May 2020 in Department of Cardiology of Henan Provincial People's Hospital and Department of Cardiology of Central China Fuwai Hospital, were included. Read More

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November 2021

Single pharmacy governed denosumab home administration: optimal adherence by means of a fracture liaison service (FLS) and home care collaboration.

Osteoporos Int 2021 Nov 13. Epub 2021 Nov 13.

Department of Internal Medicine and Endocrinology, Reinier the Graaf Gasthuis, Delft, The Netherlands.

Low adherence for denosumab (Dmab, Prolia®) is of major concern. Dutch pharmacies deliveries were calculated recently being 76.5% for a total of 3 injections. Read More

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November 2021

The Effect of Switching to Long-Acting Injection (LAI) Antipsychotic Therapy on Patients with Schizophrenia.

Curr Health Sci J 2021 Apr-Jun;47(2):237-248. Epub 2021 Jun 30.

Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.

Material And Method: We analyzed 362 patients with schizophrenia admitted during 2016 in an acute psychiatric ward and in a chronic psychiatric ward, diagnosed with paranoid or other schizophrenia, according to DSM-IV-TR, which, after remission of the symptoms of the acute episode, they benefited from antipsychotic therapy only in oral formulation. For some of these patients we instituted maintenance therapy with depot formulas. Patients were followed for up to two years. Read More

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Lasting symptoms and long-term health-related quality of life after totally minimally invasive, hybrid and open Ivor Lewis esophagectomy.

Eur J Surg Oncol 2021 Nov 3. Epub 2021 Nov 3.

Department of Surgery, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

Aim: Compared to open esophagectomy (OE), both totally minimally invasive (TMIE) and laparoscopy-assisted hybrid minimally invasive (HMIE) reduce postoperative morbidity and improve short-term health-related quality of life (HRQoL). We aimed to compare lasting symptoms and long-term HRQoL in an international population-based setting between patients who underwent Ivor Lewis TMIE, HMIE or OE.

Methods: Patients who were relapse-free at least one year after TMIE, HMIE or OE for esophageal or junctional carcinoma between January 2010 and June 2016 were included. Read More

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November 2021

Coagulation parameters in the newborn and infant - the Copenhagen Baby Heart and COMPARE studies.

Clin Chem Lab Med 2021 Nov 9. Epub 2021 Nov 9.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.

Objectives: The coagulation system is not fully developed at birth and matures during the first months of infancy, complicating clinical decision making within hemostasis. This study evaluates coagulation parameters at birth and two months after birth, and tests whether cord blood can be used as a proxy for neonatal venous blood measurements.

Methods: The Copenhagen Baby Heart Study (CBHS) and the COMPARE study comprise 13,237 cord blood samples and 444 parallel neonatal venous blood samples, with a two month follow-up in 362 children. Read More

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November 2021

Admission free-fatty acid level is a predictor of the mid-term worsening renal function in patients with ST-segment elevation myocardial infarction.

Heart Vessels 2021 Nov 5. Epub 2021 Nov 5.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

Whether free fatty acids (FFAs), which are generators of reactive oxygen species and substrates of cytotoxic lipid peroxidation products in proximal tubules of the kidney, can be a predictor of worsening renal function (WRF) is not fully elucidated. A total of 110 patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention within 24 h after symptom onset were included. The exclusion criteria were out-of-hospital cardiac arrest, vasospastic angina, hemodialysis, and/or lack of data. Read More

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November 2021

[Comparison of the Outcomes of Revision Anterior Cruciate Ligament Reconstruction Using Cadaverous BTB Graft with the Outcomes of Primary ACL Reconstruction with Filtering out the Effects of Age and Sex].

Acta Chir Orthop Traumatol Cech 2021 ;88(5):362-368

Ortopedická klinika Lékařské fakulty Masarykovy univerzity Brno a Fakultní nemocnice Brno.

PURPOSE OF THE STUDY Evaluation of the success rate of revision ACL reconstruction using the cadaverous BTB allogeneic graft and comparison of the outcomes achieved with the data of patients after the primary ACL reconstruction using the autologous BTB graft with filtering out the potential effect of diversity of the groups of patients as concerns sex and age. MATERIAL AND METHODS The evaluated outcomes of 34 patients operated in the period 2004-2017, i.e. Read More

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November 2021

The accuracy of robot-assisted S2 alar-iliac screw placement at two different healthcare centers.

J Spine Surg 2021 Sep;7(3):326-334

Department of Orthopaedics, Columbia University Medical Center, The Och Spine Hospital at New York-Presbyterian, New York, NY, USA.

Background: Current literature on robot-assisted S2 alar-iliac (S2AI) screw placement shows favorable outcomes and screw accuracy; however, the data is limited by a few retrospective, single-surgeon studies. To the author's knowledge, this is the first multicenter study which evaluates the accuracy of robot-assisted S2AI screws.

Methods: Adult (≥18 years old) patients who underwent robot-assisted S2AI screw placement from 2017-2019 were reviewed. Read More

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September 2021

Comparison of mini-open repair system and percutaneous repair for acute Achilles tendon rupture.

BMC Musculoskelet Disord 2021 Oct 30;22(1):914. Epub 2021 Oct 30.

Department of Orthopedics Surgery, The 6th Medical Center of Chinese PLA General Hospital, No. 6, Fucheng Road, Haidian District, Beijing, 100048, People's Republic of China.

Background: To reduce incision complications, minimally invasive operative approaches for treatment with acute Achilles tendon rupture have been developed, such as Mini-open repair and percutaneous repair. Which technique is the better surgical option? In the present study, we compared the two surgical procedures- modified Mini-open repair versus percutaneous repair-in the treatment of acute Achilles tendon rupture.

Methods: From January 2016 to November 2018, 68 matched patients with acute Achilles tendon rupture were divided into treatment group (Mini-open with modified Ma-Griffith technique) and control group (the Ma-Griffith technique). Read More

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October 2021

Effect of Elective Internal Mammary Node Irradiation on Disease-Free Survival in Women With Node-Positive Breast Cancer: A Randomized Phase 3 Clinical Trial.

JAMA Oncol 2021 Oct 25. Epub 2021 Oct 25.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

Importance: The benefit of internal mammary node irradiation (IMNI) for treatment outcomes in node-positive breast cancer is unknown.

Objective: To investigate whether the inclusion of IMNI in regional nodal irradiation improves disease-free survival (DFS) in women with node-positive breast cancer.

Design, Setting, And Participants: This multicenter, phase 3 randomized clinical trial was conducted from June 1, 2008, to February 29, 2020, at 13 hospitals in South Korea. Read More

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October 2021

Life's Simple 7 and the risk of stroke in Finnish men: A prospective cohort study.

Prev Med 2021 Dec 20;153:106858. Epub 2021 Oct 20.

Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Central Finland Health Care District, Department of Internal Medicine, Jyvaskyla, Finland.

Background: Population-wide preventive measures constitute important approaches towards reducing stroke risk and its associated burden. We sought to examine the association between American Heart Association's (AHA) Life's Simple7 (LS7) score and the risk of stroke in men.

Methods: The study is based on the prospective population-based Kuopio Ischaemic Heart Disease cohort comprising men (42-60 years) without pre-existing history of stroke at baseline (1984-1989). Read More

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December 2021

Real-World Incidence of Immune-Related Adverse Events Associated with Nivolumab Plus Ipilimumab in Patients with Advanced Renal Cell Carcinoma: A Retrospective Observational Study.

J Clin Med 2021 Oct 18;10(20). Epub 2021 Oct 18.

Department of Urology, Saitama Medical Center Saitama Medical University, Kawagoe 350-8550, Japan.

Real-world incidence of immune-related adverse events (irAEs) associated with nivolumab plus ipilimumab in patients with renal cell carcinoma (RCC) has been rarely demonstrated. The present study aims to report the safety outcomes of this combination therapy in the real-life population. We conducted a multi-institutional retrospective observational study that assessed the incidence and severity of irAEs associated with nivolumab plus ipilimumab in 41 Japanese patients with metastatic and/or locally advanced RCC. Read More

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October 2021

The Added Value of Combined Timed Up and Go Test, Walking Speed, and Grip Strength on Predicting Recurrent Falls in Chinese Community-dwelling Elderly.

Clin Interv Aging 2021 5;16:1801-1812. Epub 2021 Oct 5.

Department of Rehabilitation, School of Medical Technology, Tianjin Medical University, Tianjin, People's Republic of China.

Purpose: To determine whether combined performance-based models could exert better predictive values toward discriminating community-dwelling elderly with high risk of any-falls or recurrent-falls.

Participants And Methods: This prospective cohort study included a total of 875 elderly participants (mean age: 67.10±5. Read More

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November 2021

The longer-term effects of access to HIV self-tests on HIV testing frequency in high-risk gay and bisexual men: follow-up data from a randomised controlled trial.

Lancet Reg Health West Pac 2021 Sep 15;14:100214. Epub 2021 Jul 15.

Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.

Background: A wait-list randomised controlled trial in Australia (FORTH) in high-risk gay and bisexual men (GBM) showed access to free HIV self-tests (HIVSTs) doubled the frequency of HIV testing in year 1 to reach guideline recommended levels of 4 tests per year, compared to two tests per year in the standard-care arm (facility-based testing). In year 2, men in both arms had access to HIVSTs. We assessed if the effect was maintained for a further 12 months. Read More

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September 2021

Predictors of clinical outcome after rotational atherectomy-facilitated percutaneous coronary intervention in hemodialysis patients.

Ann Palliat Med 2021 Oct 11. Epub 2021 Oct 11.

Sapporo Heart Center, Sapporo Cardio Vascular Clinic, Sapporo, Japan.

Background: Percutaneous coronary intervention (PCI) in hemodialysis patients with severely calcified and diffused lesions is associated with extremely high rates of major adverse cardiovascular events (MACE), even when facilitated by rotational atherectomy (ROTA). Potential risk factors for MACE with ROTAfacilitated PCI in hemodialysis patients should be identified.

Methods: We retrospectively analyzed a consecutive cohort of patients from the Sapporo Cardiovascular Clinic database, who were on maintenance hemodialysis with severe calcified lesions and treated with ROTAfacilitated PCI. Read More

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October 2021

Effectiveness of a Psychosocial Care Quality Improvement Strategy to Address Quality of Life in Patients With Cancer: The HuCare2 Stepped-Wedge Cluster Randomized Trial.

JAMA Netw Open 2021 Oct 1;4(10):e2128667. Epub 2021 Oct 1.

Medical Oncology Division, Department of Oncology, ASST of Cremona, Cremona, Italy.

Importance: Many patients with cancer who would benefit from psychosocial care do not receive it. Implementation strategies may favor the integration of psychosocial care into practice and improve patient outcomes.

Objective: To evaluate the effectiveness of the Humanization in Cancer Care (HuCare) Quality Improvement Strategy vs standard care as improvement of at least 1 of 2 domains (emotional or social function) of patient health-related quality of life at baseline and 3 months. Read More

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October 2021

The treatment zone size and its decentration influence axial elongation in children with orthokeratology treatment.

BMC Ophthalmol 2021 Oct 12;21(1):362. Epub 2021 Oct 12.

Eye Institute and School of Optometry, Tianjin, China.

Background: To investigate whether the treatment zone size (TZS) and treatment zone decentration (TZD) will affect the axial elongation in myopic children undergoing orthokeratology treatment.

Methods: A self-controlled retrospective study was conducted on 352 children who met the inclusion criteria. Axial length was measured before and at 12 months after the initial lens wear. Read More

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October 2021

Long-term outcomes of transvaginal mesh surgery for pelvic organ prolapse: a retrospective cohort study.

BMC Womens Health 2021 10 11;21(1):362. Epub 2021 Oct 11.

Department of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, 128 Shenyang Road, Shanghai, China.

Background: The objective of this study was to evaluate the overall outcomes and complications of transvaginal mesh (TVM) placement for the management of pelvic organ prolapse (POP) with different meshes with a greater than 10-years of follow-up.

Methods: We performed a retrospective review of patients with POP who underwent prolapse repair surgery with placement of transvaginal mesh (Prolift kit or self-cut Gynemesh) between January 2005 and December 2010. Baseline of patient characteristics were collected from the patients' medical records. Read More

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October 2021

Formation, Growth, or Rupture of De Novo Intracranial Aneurysms: Long-Term Follow-up Study of Subarachnoid Hemorrhage Survivors.

Neurosurgery 2021 Nov;89(6):1104-1111

Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: The survival rate of aneurysmal subarachnoid hemorrhage (aSAH) has gradually increased, leading to more clinical cases of de novo intracranial aneurysms (DNIAs).

Objective: To identify the characteristics of patients with DNIA growth or rupture.

Methods: We included 1601 patients with aSAH treated by clipping from January 1993 to May 2010. Read More

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November 2021

Laparoscopic transgastric necrosectomy in treatment of walled-off pancreatic necrosis with sinistral portal hypertension.

BMC Surg 2021 Oct 10;21(1):362. Epub 2021 Oct 10.

Department of General Surgery, Xuanwu Hospital, Capital Medical University, No. 45, Xicheng, Beijing, 100053, People's Republic of China.

Background: Laparoscopic transgastric necrosectomy (LTGN) has been used in treatment of walled-off pancreatic necrosis (WON) for more than a decade. However, the safety and effectiveness of LTGN for WON with sinistral portal hypertension was still unclear.

Methods: WON patients with sinistral portal hypertension treated in our department between January 2011 and December 2018 were included and retrospectively analyzed in this study. Read More

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October 2021

Visual acuity outcomes after cataract surgery in type 2 diabetes: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study.

Br J Ophthalmol 2021 Jun 18. Epub 2021 Jun 18.

Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland, USA

Aims: To evaluate visual acuity (VA) outcomes of cataract surgery, and factors associated with good visual outcomes, among a population with diabetes.

Methods: Participants with type 2 diabetes enrolled in The Action to Control Cardiovascular Risk in Diabetes (ACCORD) study and ACCORD-eye substudy. 1136 eyes of 784 ACCORD participants receiving cataract surgery during follow-up (2001-2014) were included. Read More

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C-reactive protein is associated with postoperative outcomes in patients with intestinal Behçet's disease.

BMC Gastroenterol 2021 Oct 7;21(1):362. Epub 2021 Oct 7.

Gastroenterology and Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: Patients with intestinal Behçet's disease (BD) frequently undergo intestinal resections, which significantly affects postoperative morbidity and mortality. The aim of this study was to identify the association between C-reactive protein (CRP) levels and postoperative outcomes in patients with intestinal BD who underwent surgical bowel resection.

Methods: Patients who were diagnosed with intestinal BD and underwent intestinal surgery due to BD at Severance Hospital between November 2005 and April 2018 were retrospectively investigated. Read More

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October 2021

Comparative analysis of macular microstructure in eyes treated with human amniotic membrane plug or internal limiting membrane transplant for Failed Macular Hole.

Acta Ophthalmol 2021 Sep 25. Epub 2021 Sep 25.

Department of Ophthalmology, Catholic University of Sacred-Heart Foundation "Policlinico Universitario A. Gemelli" IRCCS, Rome, Italy.

Objective: To document comparative analysis of macular microstructures of eyes treated with autologous internal limiting membrane (ILM) transplant and human Amniotic Membrane (hAM) plug transplant for failed macular holes (FMH).

Materials And Methods: Six patients who underwent successful surgeries for FMH were evaluated. The first three patients had undergone autologous ILM transplant, the others had undergone hAM plug transplant. Read More

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September 2021

Changes in serum lactate dehydrogenase levels as markers of pathological response and prognosis in colorectal liver metastases patients receiving neoadjuvant chemotherapy followed by resection.

Ann Palliat Med 2021 10 17;10(10):10276-10292. Epub 2021 Sep 17.

Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: This study sought to evaluate the effects of pre-neoadjuvant chemotherapy lactate dehydrogenase (pre-NAC LDH) levels, preoperative LDH levels, and changes in LDH levels on the pathological response and outcomes of colorectal liver metastases (CRLM) patients treated with liver resection after NAC.

Methods: This study included 152 colorectal CRLM patients, who underwent NAC followed by liver resection. Patients were excluded if they were diagnosed with other malignancies or lacked follow-up and clinical data. Read More

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October 2021