168,645 results match your criteria focusing

Quantitative Removal of Pyrrolizidine Alkaloids from Essential Oils by the Hydrodistillation Step in Their Manufacturing Process.

Planta Med 2021 Jul 22. Epub 2021 Jul 22.

G. Pohl-Boskamp GmbH & Co. KG, Hohenlockstedt, Germany.

Pyrrolizidine alkaloids are naturally occurring toxins produced by certain weeds that can, if accidentally co-harvested, contaminate plant-based food, feed, and herbal medicinal products. Focusing on herbal medicinal products, the presence of pyrrolizidine alkaloids is restricted by regulatory prescribed thresholds to assure patient safety. Among the multitude of different herbal active substances utilized in herbal medicinal products, the class of pharmaceutically effective essential oils is considered to exhibit a negligible contribution to pyrrolizidine alkaloid contamination. Read More

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Experimental evaluation of the near-field and far-field heating of focused ultrasound using the thermal dose concept.

Ultrasonics 2021 Jul 15;116:106513. Epub 2021 Jul 15.

Department of Electrical Engineering, Computer Engineering, and Informatics, Cyprus University of Technology, Limassol, Cyprus. Electronic address:

Background: Conventional motion algorithms utilized during High Intensity Focused Ultrasound (HIFU) procedures usually sonicate successive tissue cells, thereby inducing excess deposition of thermal dose in the pre-focal region. Long delays (~60 s) are used to reduce the heating around the focal region. In the present study the experimental evaluation of six motion algorithms so as to examine the required delay and algorithm for which the pre-focal (near-field) and post-focal (far-field) heating can be reduced using thermal dose estimations is presented. Read More

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Higher order aberrations and retinal image quality during short-term accommodation in children.

Vision Res 2021 Jul 19;188:74-84. Epub 2021 Jul 19.

Queensland University of Technology, Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Centre for Vision and Eye Research, Brisbane, Queensland, Australia.

Changes in higher order aberrations (HOA's) and retinal image quality during accommodation have not previously been examined in children. This study measured ocular HOA's in ninety non-myopic, school-aged children during short-term accommodation tasks at 0, 3, 6, and 9 D demands presented via a Badal optometer mounted to a Hartmann-Shack wavefront aberrometer (COAS-HD, Wavefront Sciences). Eighty-four participants who exhibited active accommodation were included in the analyses. Read More

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Therapeutic Potential of Endothelial Progenitor Cells in Pulmonary Diseases.

Am J Respir Cell Mol Biol 2021 Jul 22. Epub 2021 Jul 22.

Cincinnati Children's Hospital Medical Center, Pediatrics, Division of Pulmonary Biology, Cincinnati, Ohio, United States;

Compromised alveolar development and pulmonary vascular remodeling are hallmarks of pediatric lung diseases such as bronchopulmonary dysplasia (BPD) and alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). Although advances in surfactant therapy, corticosteroids, and anti-inflammatory drugs have improved clinical management of preterm infants, still those who suffer with severe vascular complications lack viable treatment options. Paucity of the alveolar capillary network in ACDMPV causes respiratory distress and leads to mortality in a vast majority of ACDMPV infants. Read More

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Efficacy of temporally intensified exposure for anxiety disorders: A multicenter randomized clinical trial.

Depress Anxiety 2021 Jul 22. Epub 2021 Jul 22.

Institute of Clinical Psychology & Psychotherapy, Technische Universität Dresden, Dresden, Germany.

Background: The need to optimize exposure treatments for anxiety disorders may be addressed by temporally intensified exposure sessions. Effects on symptom reduction and public health benefits should be examined across different anxiety disorders with comorbid conditions.

Methods: This multicenter randomized controlled trial compared two variants of prediction error-based exposure therapy (PeEx) in various anxiety disorders (both 12 sessions + 2 booster sessions, 100 min/session): temporally intensified exposure (PeEx-I) with exposure sessions condensed to 2 weeks (n = 358) and standard nonintensified exposure (PeEx-S) with weekly exposure sessions (n = 368). Read More

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Renovation priorities for old residential districts based on resident satisfaction: An application of asymmetric impact-performance analysis in Xi'an, China.

PLoS One 2021 22;16(7):e0254372. Epub 2021 Jul 22.

School of Management, Xi'an University of Architecture and Technology, Xi'an, China.

China is currently designing a regional economic layout for high-quality urban development, shifting its focus from the primary stage of beautifying cities to the next stage of profound urbanization aiming at strengthening industry. This is of high importance given that the urbanization rate of permanent residents by the end of 2019 was 60.60%, according to the National Bureau of Statistics of China. Read More

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Trauma-focused treatments for depression. A systematic review and meta-analysis.

PLoS One 2021 22;16(7):e0254778. Epub 2021 Jul 22.

School of Psychology and Exercise Science, Murdoch University, Murdoch, WA, Australia.

Background: Trauma-focused treatments (TFTs) have demonstrated efficacy at decreasing depressive symptoms in individuals with PTSD. This systematic review and meta-analysis evaluated the effectiveness of TFTs for individuals with depression as their primary concern.

Methods: A systematic search was conducted for RCTs published before October 2019 in Cochrane CENTRAL, Pubmed, EMBASE, PsycInfo, and additional sources. Read More

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Addressing antimicrobial resistance by improving access and quality of care-A review of the literature from East Africa.

PLoS Negl Trop Dis 2021 Jul 22;15(7):e0009529. Epub 2021 Jul 22.

The Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Universal access to healthcare, including quality medicines, is a fundamental human right but is still out of reach for many in low- and middle-income countries (LMICs). An existing framework capturing variability of access to healthcare in low-resource settings includes the 5 dimensions: availability, accessibility, affordability, adequacy, and acceptability. This framework encompasses key components, including health infrastructure and means to access it as well as service organisation, costs, and factors that influence users' satisfaction. Read More

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Fact-Checking of Health Information: The Effect of Media Literacy, Metacognition and Health Information Exposure.

J Health Commun 2021 Jul 22:1-10. Epub 2021 Jul 22.

Department of Educational Psychology, College of Education, Washington State University, Pullman, Washington, USA.

With the rampant circulation of health information, concerns for the information quality are growing. Thereby, scholars are calling for media literacy as an educative means to cultivate fact-checking behavior among information consumers. Focusing on the critical role of metacognition for education effectiveness, this study examined the underlying mechanism that is conducive to the success of media literacy in the context of health information consumption. Read More

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Migration-related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policy.

Dev Psychobiol 2021 Jul 22. Epub 2021 Jul 22.

Department of Psychology, Yale University, New Haven, Connecticut, USA.

Children make up over half of the world's migrants and refugees and face a multitude of traumatic experiences prior to, during, and following migration. Here, we focus on migrant children emigrating from Mexico and Central America to the United States and review trauma related to migration, as well as its implications for the mental health of migrant and refugee children. We then draw upon the early adversity literature to highlight potential behavioral and neurobiological sequalae of migration-related trauma exposure, focusing on attachment, emotion regulation, and fear learning and extinction as transdiagnostic mechanisms underlying the development of internalizing and externalizing symptomatology following early-life adversity. Read More

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Investigational Treatments for Epidermolysis Bullosa.

Am J Clin Dermatol 2021 Jul 22. Epub 2021 Jul 22.

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan, Taiwan.

Epidermolysis bullosa (EB) is a heterogeneous group of rare inherited blistering skin disorders characterized by skin fragility following minor trauma, usually present since birth. EB can be categorized into four classical subtypes, EB simplex, junctional EB, dystrophic EB and Kindler EB, distinguished on clinical features, plane of blister formation in the skin, and molecular pathology. Treatment for EB is mostly supportive, focusing on wound care and patient symptoms such as itch or pain. Read More

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Landscape of EBV-positive gastric cancer.

Gastric Cancer 2021 Jul 22. Epub 2021 Jul 22.

Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1, Hikarigaoka, Fukushima, 960-1295, Japan.

Epstein-Barr virus-positive gastric cancer [EBV (+) GC] is associated with EBV infection and is one of the GC subtypes defined by the Cancer Genome Atlas. EBV (+) GC has several distinct genomic or epigenomic features and clinicopathological characteristics compared with other molecular subtypes of GC. Here, we summarize the unique features of EBV (+) GC including the clinical and histopathological features, and discuss associated genetic and epigenetic aberrations. Read More

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Ultrasound in legal medicine-a missed opportunity or simply too late? A narrative review of ultrasonic applications in forensic contexts.

Int J Legal Med 2021 Jul 22. Epub 2021 Jul 22.

Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objectives: Conventional autopsies remain the gold standard of postmortem healthcare quality assurance and help gathering extended knowledge on diseases. In answer to constantly declining autopsy rates non- or minimally invasive autopsy methods were introduced. Ultrasound is a well-established tool for imaging commonly used in clinical practice. Read More

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Ti-Decorated B/N-doped graphene as a high-capacity hydrogen storage material: a DFT study.

Dalton Trans 2021 Jul 22. Epub 2021 Jul 22.

Center for Organic Electronic and Alternative Energy, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.

The adsorption properties of the hydrogen atom on our newly designed materials were investigated using density functional theory (DFT) calculations, focusing on the role of dopants in modulating the binding properties of the metal. We proposed decorating Ti4 on pristine, B- and N-doped graphene surfaces for preparing a large-capacity hydrogen-storage device. Computational results indicate that the doping of B on graphene enhances the interaction between the metal cluster and the supporting substrate with a very strong binding energy of -6. Read More

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COVID-19 lockdown: Impact on college students' lives.

J Am Coll Health 2021 Jul 22:1-15. Epub 2021 Jul 22.

University of Utah School of Medicine, Salt Lake City, Utah, USA.

In light of COVID-19, leaders issued stay-at-home orders, including closure of higher-education schools. Most students left campus, likely impacting their employment and social network. Leaders are making decisions about opening universities and modality of instruction. Read More

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"Older adults consider others' intentions less but allocentric outcomes more than young adults during an ultimatum game": Correction to Cho et al. (2020).

Psychol Aging 2021 Jul 22. Epub 2021 Jul 22.

Department of Psychology, Pusan National University.

Reports an error in "Older adults consider others' intentions less but allocentric outcomes more than young adults during an ultimatum game" by Isu Cho, Hyun-joo Song, Hackjin Kim and Sunhae Sul (, 2020[Nov], Vol 35[7], 974-980). In the original article, there was a typographical error in the grant number awarded to Hyun-joo Song. The correct grant number is NRF-2018S1A3A2075114. Read More

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Pathology and systemic therapy of non-clear cell renal cell carcinoma: an overview.

Expert Rev Anticancer Ther 2021 Jul 22. Epub 2021 Jul 22.

Medical Clinic II, J.W. Goethe University, Frankfurt, Germany.

Introduction: Non-clear cell renal cell carcinoma (nccRCC) represents a highly heterogenous group of kidney cancer entities. As most clinical trials predominantly include patients with clear cell RCC (ccRCC), nccRCC treatment guidelines are mainly extrapolated from recommendations in ccRCC. Here, we review and elucidate current data on the pathologic classification and treatment of nccRCC. Read More

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Genetic counseling, virtual visits, and equity in the era of COVID-19 and beyond.

J Genet Couns 2021 Jul 21. Epub 2021 Jul 21.

Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts, USA.

Overnight, as a result of the COVID-19 pandemic, telehealth rapidly transitioned from limited application to widespread implementation. The field of genetic counseling was well positioned to make this transition to virtual care since there is generally less of a need for patients to be seen in-person for physical exams or urgent care. Going forward, virtual visits will presumably become a mainstay in the provision of genetic services and it is anticipated that clinics will adopt "hybrid" models with both in-person and virtual visit options. Read More

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Developing bioorthogonal probes to span a spectrum of reactivities.

Nat Rev Chem 2020 21;4:476-489. Epub 2020 Jul 21.

Departments of Chemistry, University of California, Irvine, California 92697, United States.

Bioorthogonal chemistries enable researchers to interrogate biomolecules in living systems. These reactions are highly selective and biocompatible and can be performed in many complex environments. However, like any organic transformation, there is no perfect bioorthogonal reaction. Read More

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Graft Versus Host Disease After Intestinal Transplantation: A Single-center Experience.

Transplant Direct 2021 Aug 19;7(8):e731. Epub 2021 Jul 19.

MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC.

Background: Graft versus host disease (GVHD) is an uncommon but highly morbid complication of intestinal transplantation (ITx). In this study, we reviewed our 17-y experience with GVHD focusing on factors predicting GVHD occurrence and survival.

Methods: Retrospective review of 271 patients who received 1 or more ITx since program inception in 2003 with survival analysis using Cox proportional hazard modeling. Read More

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Mitochondrial dysfunction: A hidden trigger of autism?

Genes Dis 2021 Sep 16;8(5):629-639. Epub 2020 Jul 16.

Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu 641043, India.

Autism is a heterogeneous neurodevelopmental and neuropsychiatric disorder with no precise etiology. Deficits in cognitive functions uncover at early stages and are known to have an environmental and genetic basis. Since autism is multifaceted and also linked with other comorbidities associated with various organs, there is a possibility that there may be a fundamental cellular process responsible for this. Read More

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September 2021

Keeping Balance Between Genetic Stability and Plasticity at the Telomere and Subtelomere of .

Bibo Li

Front Cell Dev Biol 2021 5;9:699639. Epub 2021 Jul 5.

Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, United States.

Telomeres, the nucleoprotein complexes at chromosome ends, are well-known for their essential roles in genome integrity and chromosome stability. Yet, telomeres and subtelomeres are frequently less stable than chromosome internal regions. Many subtelomeric genes are important for responding to environmental cues, and subtelomeric instability can facilitate organismal adaptation to extracellular changes, which is a common theme in a number of microbial pathogens. Read More

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Does Chronic Obstructive Pulmonary Disease Affect Workers' Health?

Li-Peng Yao Ran Tao

Front Public Health 2021 5;9:711629. Epub 2021 Jul 5.

Qingdao Municipal Center for Disease Control and Preventation, Qingdao, China.

During recent decades, the elevation of workers' health has become the utmost point of concern since it is considered among the primary indicators of economies. The economies, especially the emerging ones, are primarily focusing on every indicator to uplift their businesses. Along with the other aspects, it is also required to assess the impact of Chronic Obstructive Pulmonary Disease (COPD) on workers' health conditions in small- and medium-scale enterprises (SMEs). Read More

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Role of Threat and Coping Appraisal in Protection Motivation for Adoption of Preventive Behavior During COVID-19 Pandemic.

Front Public Health 2021;9:678566. Epub 2021 Jul 5.

World Health Organization RNTCP Technical Support Network, Swasthya Bhawan, Kolkata, India.

With more than 100 million cases and over 2 million deaths globally, the COVID-19 pandemic continues to remain a major threat. Identifying the behavioral factors influencing preventive behaviors for COVID-19 are crucial in devising public health policies to promote essential strategies to combat the pandemic in an efficient manner. The current study was therefore conducted to estimate the prevalence of COVID-19 preventive behaviors and measure their association with behavioral constructs like threat perception, response efficacy, and self-efficacy, as per socio-demographic background. Read More

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Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review.

Front Endocrinol (Lausanne) 2021 29;12:681649. Epub 2021 Jun 29.

Endocrine and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

Background: Obesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be partially accountable for the observed phenotypic variability. Read More

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The Emergence of Creative Leaders Within Social Networks: The Case of Andy Warhol in the Art World of New York.

Front Psychol 2021 5;12:635678. Epub 2021 Jul 5.

Kent Business School, University of Kent, Canterbury, United Kingdom.

The creative leadership literature has identified personality traits, skills, states, and behaviours which are effective within creative contexts and organisations, but it is yet to address how creative leaders emerge from social networks. This conceptual paper delineates the processes of creative leader emergence within the context of contemporary visual arts. Using a relational view of creative leader emergence, this paper incorporates the leader emergence processes of achievement and ascription, and then adjusts them to the context of the art world. Read More

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The Metallome as a Link Between the "Omes" in Autism Spectrum Disorders.

Front Mol Neurosci 2021 5;14:695873. Epub 2021 Jul 5.

Department of Biological Sciences, University of Limerick, Limerick, Ireland.

Metal dyshomeostasis plays a significant role in various neurological diseases such as Alzheimer's disease, Parkinson's disease, Autism Spectrum Disorders (ASD), and many more. Like studies investigating the proteome, transcriptome, epigenome, microbiome, etc., for years, metallomics studies have focused on data from their domain, i. Read More

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Angiotensin receptor-neprilysin inhibitors: Comprehensive review and implications in hypertension treatment.

Hypertens Res 2021 Jul 21. Epub 2021 Jul 21.

The Department of Geriatric and General Medicine, Osaka university Graduate School of Medicine, Suita, Osaka, Japan.

Angiotensin receptor-neprilysin inhibitors (ARNIs) are a new class of cardiovascular agents characterized by their dual action on the major regulators of the cardiovascular system, including the renin-angiotensin system (RAS) and the natriuretic peptide (NP) system. The apparent clinical benefit of one ARNI, sacubitril/valsartan, as shown in clinical trials, has positioned the drug class as a first-line therapy in patients with heart failure, particularly with reduced ejection fraction. Accumulating evidence also suggests that sacubitril/valsartan is superior to conventional RAS blockers in lowering blood pressure in patients with hypertension. Read More

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Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism.

Mol Psychiatry 2021 Jul 21. Epub 2021 Jul 21.

Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1249, Institut de Neurobiologie de la Méditerranée (INMED), Institut Marseille Maladies Rares (MarMaRa), Aix-Marseille Université, Marseille, France.

Oxytocin is an important regulator of the social brain. In some animal models of autism, notably in Magel2-deficient mice, peripheral administration of oxytocin in infancy improves social behaviors until adulthood. However, neither the mechanisms responsible for social deficits nor the mechanisms by which such oxytocin administration has long-term effects are known. Read More

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CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1.

Sci Rep 2021 Jul 21;11(1):14849. Epub 2021 Jul 21.

Cancer Immunology and Immune Modulation, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany.

More than 70% of colorectal, prostate, ovarian, pancreatic and breast cancer specimens show expression of CD276 (B7-H3), a potential immune checkpoint family member. Several studies have shown that high CD276 expression in cancer cells correlates with a poor clinical prognosis. This has been associated with the presence of lower tumor infiltrating leukocytes. Read More

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