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Screening of tick-borne pathogens in argasid ticks in Zambia: Expansion of the geographic distribution of Rickettsia lusitaniae and Rickettsia hoogstraalii and detection of putative novel Anaplasma species.

Ticks Tick Borne Dis 2021 Apr 5;12(4):101720. Epub 2021 Apr 5.

Laboratory of Parasitology, Graduate School of Infectious Diseases, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan. Electronic address:

Ticks (Ixodidae and Argasidae) are important arthropod vectors of various pathogens that cause human and animal infectious diseases. Many previously published studies on tick-borne pathogens focused on those transmitted by ixodid ticks. Although there are increasing reports of viral pathogens associated with argasid ticks, information on bacterial pathogens they transmit is scarce. Read More

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Seeking sustainable development policies at the municipal level based on the triad of city, economy and environment: evidence from Hunan province, China.

J Environ Manage 2021 Apr 15;290:112554. Epub 2021 Apr 15.

State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing and Digital Earth of Chinese Academy of Sciences, Beijing, 100875, China; Beijing Engineering Research Center for Global Land Remote Sensing Products, Institute of Remote Sensing Science and Engineering, Faculty of Geographical Science, Beijing Normal University, Beijing, 100875, China.

Keeping urbanization, economy and eco-environment in harmony is a core issue for attaining Sustainable Development Goals (SDGs) in any complex geographical regions. Previous studies mainly focused on seeking the balance between urban expansion levels, eco-environment quality and socioeconomic degree. But the challenges still exist in solving the negative influence of urban expansion that affects eco-environmental and economic development. Read More

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Implementing practices focused on workplace health and psychological wellbeing: A systematic review.

Soc Sci Med 2021 Apr 1;277:113888. Epub 2021 Apr 1.

Employment Systems and Institutions Group, Norwich Business School, University of East Anglia, NR4 7TJ, United Kingdom.

Rationale: Workplace health and wellbeing practices (WHWPs) often fail to improve psychological health or wellbeing because of implementation failure. Thus, implementation should be evaluated to improve the effectiveness of WHWPs.

Objective: We conducted a systematic review to identify critical success factors for WHWP implementation and gaps in the evidence. Read More

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Nomophobia and the influence of time to REST among nursing students. A descriptive, correlational and predictive research.

Nurse Educ Pract 2021 Mar 19;52:103025. Epub 2021 Mar 19.

University of Granada. Faculty of Education and Sport, Melilla, Spain. Electronic address:

The inclusion of the smartphone in society has brought many advantages, but also disadvantages, such as nomophobia, considered as a digital disease generated by the excessive use of the smartphone. The general objective of the research is to know and analyse the prevalence of nomophobia among nursing students and knowing the influence of time to rest. The research design is descriptive, correlational, transversal and predictive with a quantitative research methodology. Read More

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Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease.

Neuroimage Clin 2021 Apr 5;30:102658. Epub 2021 Apr 5.

Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Maindy Road, Cardiff, CF 24 4HQ, UK.

White matter (WM) alterations have been identified as a relevant pathological feature of Huntington's disease (HD). Increasing evidence suggests that WM changes in this disorder are due to alterations in myelin-associated biological processes. Multi-compartmental analysis of the complex gradient-echo MRI signal evolution in WM has been shown to quantify myelin in vivo, therefore pointing to the potential of this technique for the study of WM myelin changes in health and disease. Read More

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MOL-PCR and xMAP technology - a multiplex system for fast detection of food- and water-borne viruses.

J Mol Diagn 2021 Apr 14. Epub 2021 Apr 14.

Department of Animal Origin Food and Gastronomic Sciences, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Palackeho tr. 1946/1, CZ61242 Brno, Czech Republic.

Viruses are common causes of food- and water-borne diseases worldwide. Conventional identification of these agents is based on cultivation, antigen detection, electron microscopy or real-time polymerase chain reaction. Since recent technological advancements in detection methods are focused on fast and robust analysis, a rapid multiplexing technology, which can detect a broad spectrum of pathogenic viruses connected to food or water contamination, was utilized. Read More

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The Asthma Toolkit Bootcamp to Improve Rural Primary Care for Pediatric Asthma.

J Allergy Clin Immunol Pract 2021 Apr 14. Epub 2021 Apr 14.

Breathing Institute, Section of Pediatric Pulmonary & Sleep Medicine, Children's Hospital Colorado, National Jewish Health, University of Colorado School of Medicine.

Background: Children with asthma living in rural areas receive most of their care from primary care providers (PCPs) who have variable knowledge of evidence-based guideline management.

Objective: To test the capacity of The Asthma Toolkit Bootcamp (ATB) program to improve PCP guidelines adherence and reduce healthcare utilization in rural children with asthma.

Methods: The ATB program provided intensive training in NHLBI guidelines-based asthma care, evaluated within a RE-AIM implementation science framework. Read More

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Risk Factors for Perioperative Morbidity in Adults Undergoing Cardiac Surgery at Children's Hospitals.

Ann Thorac Surg 2021 Apr 14. Epub 2021 Apr 14.

Division of Cardiothoracic Surgery, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.

Background: Increasing numbers of adult with congenital heart disease (ACHD) undergo cardiac surgery in children's hospitals, yet surgical outcomes data are limited. We sought to better understand the impact of preoperative risk factors on postoperative complications and cardiac intensive care unit (CICU) length of stay (LOS).

Methods: Surgical CICU admissions for patients > 18 years in the Pediatric Cardiac Critical Care Consortium registry (8/2014-1/2019; 34 hospitals) were included. Read More

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Intraoperative methylprednisolone and neurodevelopmental outcomes in infants after cardiac surgery.

Ann Thorac Surg 2021 Apr 14. Epub 2021 Apr 14.

Department of Pediatrics, Medical University of South Carolina, Charleston, SC.

Background: Neurodevelopmental impairment is a significant consequence for survivors of surgery for critical congenital heart disease. This study sought to determine if intraoperative methylprednisolone during neonatal cardiac surgery is associated with neurodevelopmental outcomes at 12 months of age and to identify early prognostic variables associated with neurodevelopmental outcomes.

Methods: A planned secondary analysis of a two-center, double-blind, randomized, placebo-controlled trial of intraoperative methylprednisolone in neonates undergoing cardiac surgery was performed. Read More

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Heart-lung interactions in COVID-19: prognostic impact and usefulness of bedside echocardiography for monitoring of the right ventricle involvement.

Authors:
Michael Dandel

Heart Fail Rev 2021 Apr 17. Epub 2021 Apr 17.

German Centre for Heart and Circulatory Research (DZHK) Partner Site, Berlin, Berlin, Germany.

Due to the SARS-CoV-2 infection-related severe pulmonary tissue damages associated with a relative specific widespread thrombotic microangiopathy, the pathophysiologic role of heart-lung interactions becomes crucial for the development and progression of right ventricular (RV) dysfunction. The high resistance in the pulmonary circulation, as a result of small vessel thrombosis and hypoxemia, is the major cause of right heart failure associated with a particularly high mortality in severe COVID-19. Timely identification of patients at high risk for RV failure, optimization of mechanical ventilation to limit its adverse effects on RV preload and afterload, avoidance of medication-related increase in the pulmonary vascular resistance, and the use of extracorporeal membrane oxygenation in refractory respiratory failure with hemodynamic instability, before RV failure develops, can improve patient survival. Read More

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Implementation of peer recovery coach services for opioid overdose patients in emergency departments in Indiana: findings from an informal learning collaborative of stakeholders.

Transl Behav Med 2021 Apr 17. Epub 2021 Apr 17.

Center for Dissemination and Implementation Science, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

The Recovery Coach and Peer Support Initiative (RCPSI) in Indiana focused on implementing peer recovery coaches (PRCs) to engage opioid overdose patients in emergency department (ED) settings and promote entry into recovery services. State workers and researchers organized an informal learning collaborative primarily through teleconference meetings with representatives of 11 health service vendors to support implementation. This study presents qualitative analysis of the teleconference meeting discussions that guided RCPSI implementation to display how the informal learning collaborative functioned to support implementation. Read More

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Implementation of the Good Life with osteoArthritis in Denmark (GLA:D) Program across Canada for the Management of Hip and Knee Osteoarthritis.

Healthc Q 2021 Apr;24(1):54-59

A physiotherapist and the executive director of Bone and Joint Canada in Toronto, ON, where she leads system-improvement projects in orthopedics and arthritis. She is the clinical lead for the implementation of the GLA:D program across Canada. She can be contacted at

Good Life with osteoArthritis in Denmark (GLA:D®) is a program for the management of patients with hip and knee osteoarthritis (OA). Adapted for the Canadian population, the GLA:DTM Canada program implements evidence-based strategies to support the prevention, early diagnosis and effective management of hip and knee OA. GLA:D assists local communities in implementing OA strategies across the spectrum of disease severity. Read More

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Neural Correlates of Alcohol Use Disorder Severity among Non-Treatment Seeking Heavy Drinkers: An Examination of the Incentive Salience and Negative Emotionality Domains of the Alcohol and Addiction Research Domain Criteria.

Alcohol Clin Exp Res 2021 Apr 17. Epub 2021 Apr 17.

The Mind Research Network, Albuquerque, NM, USA.

Background: The Alcohol and Addiction Research Domain Criteria (AARDoC) proposes that alcohol use disorder is associated with neural dysfunction in three primary domains: incentive salience, negative emotionality, and executive function. Prior studies in heavy drinking samples have examined brain activation changes associated with alcohol and negative affect cues, representing the incentive salience and negative emotionality domains, respectively; yet studies examining such cue-induced changes in functional connectivity are relatively sparse.

Methods: Non-treatment seeking heavy drinking adults (N=149, 56. Read More

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A scoping review of workplace wellness audit tools assessing physical activity and sedentary behavior.

Health Promot J Austr 2021 Apr 16. Epub 2021 Apr 16.

Knowledge Resource Service, Alberta Health Services, Tom Baker Cancer Centre, Canada.

Background: Regular physical inactivity and excessive sedentary behaviour are public and population health concerns. The workplace is an ideal health promotion intervention setting to support employees, particularly office workers. Workplace assessments are a critical component of workplace health promotion programming. Read More

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Students as Leaders in Supporting Campus Wellbeing: Peer-to-Peer Health Promotion in Higher Education.

Health Promot J Austr 2021 Apr 16. Epub 2021 Apr 16.

Student Experience Office, Western Sydney University, Australia.

Issue Addressed: This study aimed to analyse the relationship between peer-delivered health promotion programs and student wellbeing, and to expand the limited body of research examining peer-to-peer mental health promotion as experienced by student leaders.

Methods: The study was cross-sectional and focused on the experience of participants of a Sydney-based University Mental Health Day event, including student leaders, student participants, university staff and industry partners. It adopted a mixed-method approach to data collection, including a quantitative and a qualitative phase. Read More

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Progress and challenges of helical-shaped geothermal heat exchangers.

Environ Sci Pollut Res Int 2021 Apr 16. Epub 2021 Apr 16.

Faculty of Mechanical Engineering, Semnan University, Semnan, Iran.

Among various types of renewable energy, geothermal energy is recognized as an effective method for supplying thermal energy. Ground heat exchangers, as the main part of a geothermal energy system, are utilized for the extraction of the heat from the ground. Helical-shaped geothermal heat exchangers are very popular in this field as they need less land space compared to the other traditional straight ones. Read More

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Back to the future: optimised microwell culture of individual human preimplantation stage embryos.

J Assist Reprod Genet 2021 Apr 16. Epub 2021 Apr 16.

Altravita IVF Clinic, Moscow, Russia.

Although in vitro culture of human embryos is a crucial step in assisted reproduction, the lack of focused research hampers worldwide standardisation and consistent outcomes. Only 1.2% of research papers published in five leading journals in human reproduction in 2019 focused on in vitro culture conditions, creating the impression that the optimisation process has approached its limits. Read More

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On evidence fiascos and judgments in COVID-19 policy.

Hist Philos Life Sci 2021 Apr 16;43(2):61. Epub 2021 Apr 16.

Department of Electronics, Information and Bioengineering, Politecnico Di Milano, Milan, Italy.

Calls for evidence-based approaches to COVID-19 have sparked up discussions on the use of evidence for policy. In this note, we expand these discussions: while the debate has mostly focused on the types of evidence to be used for policy, we argue that the assessment of judgments involved in data practices and evidence production should play a central role in evaluating policy. Read More

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Young adults' coping strategies against loneliness during the COVID-19-related quarantine in Greece.

Health Promot Int 2021 Apr 17. Epub 2021 Apr 17.

1st Department of Psychiatry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, General Hospital "Papageorgiou", Ring Road Thessaloniki, N. Efkarpia, 54603 Thessaloniki, Greece.

COVID-19 and the related quarantine disrupted young adults' academic and professional life, daily routine and socio-emotional well-being. This cross-sectional study focused on the emotional and behavioural responses of a young adult population during the COVID-19-related quarantine in April 2020, in Greece. The study was conducted through an online survey. Read More

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Conserved long-range base pairings are associated with pre-mRNA processing of human genes.

Nat Commun 2021 Apr 16;12(1):2300. Epub 2021 Apr 16.

Skolkovo Institute of Science and Technology, Moscow, Russia.

The ability of nucleic acids to form double-stranded structures is essential for all living systems on Earth. Current knowledge on functional RNA structures is focused on locally-occurring base pairs. However, crosslinking and proximity ligation experiments demonstrated that long-range RNA structures are highly abundant. Read More

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Association of diabetes with frequency and cost of hospital admissions: a retrospective cohort study.

CMAJ Open 2021 Apr-Jun;9(2):E406-E412. Epub 2021 Apr 16.

Department of Medicine (Choi), University of Toronto; Li Ka Shing Knowledge Institute (Booth, Jung, Verma, Razak) and Department of Medicine, Division of Endocrinology (Booth), St. Michael's Hospital; Division of General Internal Medicine (Lapointe-Shaw, Rawal), University Health Network; Program of Medicine and Institute for Better Health (Tang), Trillium Health Partners; Division of General Internal Medicine (Kwan), Mount Sinai Hospital; Division of General Internal Medicine (Weinerman), Sunnybrook Health Sciences Centre; Division of General Internal Medicine (Verma, Razak), St. Michael's Hospital, Toronto, Ont.

Background: Acute inpatient hospital admissions account for more than half of all health care costs related to diabetes. We sought to identify the most common and costly conditions leading to hospital admission among patients with diabetes compared with patients without diabetes.

Methods: We used data from the General Internal Medicine Inpatient Initiative (GEMINI) study, a retrospective cohort study, of all patients admitted to a general internal medicine service at 7 Toronto hospitals between 2010 and 2015. Read More

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Implementation conditions leading to the scale-up of an innovation involving the optimal use of antipsychotics in long-term care centers: The Optimizing Practices, use, Care and Services-Antipsychotics (OPUS-AP) program.

Res Social Adm Pharm 2021 Apr 12. Epub 2021 Apr 12.

University of Sherbrooke, Canada; Research Center on Aging of CIUSSS de L'Estrie-CHUS, Canada. Electronic address:

Background: Antipsychotics are often used for the first-line management of behavioral and psychological symptoms of dementia despite their limited efficacy and the risk of serious adverse drug events, compounded with disregard for guidelines recommending prioritizing non-pharmacological interventions. Some innovative interventions promote the deprescription of antipsychotics in long term care (LTC) settings.

Objective: The objective of this article is to present the conditions leading to the scale-up of an innovative program on the appropriate use of antipsychotics in LTC centers. Read More

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A delicate redox balance between iron and heme oxygenase-1 as an essential biological feature of endometriosis.

Arch Med Res 2021 Apr 13. Epub 2021 Apr 13.

Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, 634-8522, Nara, Japan; Ms.Clinic MayOne, Kashihara, 634-0813, Nara, Japan. Electronic address:

Background: Recent studies have focused on the role of oxidative stress, which may be implicated in the development, progression, and pathophysiology of endometriosis.

Aim Of The Study: The aim of this study is to investigate the redox balance of endometriosis by simultaneously measuring iron-related compounds (total iron, heme iron, free iron, oxyhemoglobin [oxyHb], methemoglobin [metHb] and 8-hydroxy-2-deoxy guanosine [8-OHdG]) and antioxidants (bilirubin, heme oxygenase-1 [HO-1] and total antioxidant capacity [TAC]).

Methods: This study includes 236 histopathologically confirmed cases (178 cases of endometriosis and 58 cases of non-endometriosis). Read More

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Pediatric hematolymphoid pathology in the gastrointestinal tract.

Semin Diagn Pathol 2021 Mar 26. Epub 2021 Mar 26.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.

Hematolymphoid processes involving the gastrointestinal tract in the pediatric and adolescent young adult (AYA) populations include processes occurring primarily within the gastrointestinal tract as well as systemic diseases with predilection for gastrointestinal involvement. Here, we present a focused review of reactive and neoplastic entities occurring in the pediatric and AYA age groups. Read More

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A case of delayed cyst formation post brain AVM stereotactic radiosurgery for arteriovenous malformation: Case report.

J Clin Neurosci 2021 May 4;87:17-19. Epub 2021 Mar 4.

Royal Brisbane and Women Hospital, Queensland, Australia. Electronic address:

Arteriovenous malformations (AVMs) are a rare cause of cerebrovascular abnormality with incidence of about 1 in 100,000 people per year and point prevalence of about 0.2%. AVMs are associated with serious complications such as intracranial haemorrhage (2-4% a year, 16% and 29% at 10 and 20 years after diagnosis), seizures (10-30%), focal neurologic deficits, and headaches. Read More

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[Contribution of electronic cigarettes in smoking patients with psychotic disorders. A literature review].

Encephale 2021 Apr 13. Epub 2021 Apr 13.

Unité de recherche clinique Pierre-Deniker, centre hospitalier Henri-Laborit, université de Poitiers, 370, avenue Jacques-Cœur, CS 10587, 86021 Poitiers cedex, France.

Objectives: This systematic literature review focused on patients suffering from schizophrenia (SZ), psychotic disorders or mental illness (MI) including SZ. It was interested in data on prevalence of electronic cigarette (EC) use, patient perceptions and expectations, as well as caregivers' attitudes towards the EC and its benefit in helping to stop or reduce smoking.

Method: The research was carried out on Medline for the period 2000-2020. Read More

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Short- and long-term dynamics of the physiological and behavioral response to heat stress and thymol supplementation in Japanese quail.

J Therm Biol 2021 Apr 18;97:102876. Epub 2021 Feb 18.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Investigaciones Biológicas y Tecnológicas (IIByT), Av. Vélez Sarsfield 1611, CP 5016, Córdoba, Argentina; Universidad Nacional de Córdoba, Facultad de Ciencias Exactas, Físicas y Naturales, Instituto de Ciencia y Tecnología de Los Alimentos (ICTA), Av. Vélez Sarsfield 1611, CP 5016, Córdoba, Argentina; Universidad Nacional de Córdoba, Facultad de Ciencias Exactas, Físicas y Naturales, Cátedra de Química Biológica, Av. Vélez Sarsfield 1611, CP 5016, Córdoba, Argentina. Electronic address:

Organisms have evolved endogenous timing systems that enable them to predict temporal changes and to coordinate complex internal processes. However, temporal dynamics of biological responses are most often ignored in fields such as dietary supplementation of farm animals exposed to artificial environmental challenges. Herein, we hypothesized that the potential for thymol (2-isopropyl-5-methylphenol) to alleviate physiological and behavioral consequences of heat stress is time-dependent on both long-term (i. Read More

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The COVID-19 pandemic and eating disorders in children, adolescents, and emerging adults: virtual care recommendations from the Canadian consensus panel during COVID-19 and beyond.

J Eat Disord 2021 Apr 16;9(1):46. Epub 2021 Apr 16.

McMaster University, Hamilton, ON, Canada.

Objective: The COVID-19 pandemic has had detrimental effects on mental health. Literature on the impact on individuals with eating disorders is slowly emerging. While outpatient eating disorder services in Canada have attempted to transition to virtual care, guidelines related to optimal virtual care in this field are lacking. Read More

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Individual quality of life and the environment - towards a concept of livable areas for persons with disabilities in Poland.

BMC Public Health 2021 Apr 17;21(1):740. Epub 2021 Apr 17.

SGH Warsaw School of Economics, Institute of Statistics and Demography, Warsaw, Poland.

Background: The United Nations Convention on the Rights of Persons with Disabilities [1] highlights the need to create proper socioeconomic and political conditions for persons with disabilities, with a special focus on their immediate living conditions. According to the Convention, these conditions should be built to ensure that persons with disabilities have the potential to enjoy a high quality of life (QoL), and this principle is reflected in the notion of livable areas. The crucial aspect of this framework is the relationship between the individual QoL and the environment, broadly understood as the socioeconomic as well as the technical conditions in which persons with disabilities function. Read More

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Antiphase synchronization in multiplex networks with attractive and repulsive interactions.

Phys Rev E 2021 Mar;103(3-1):032310

Physics and Applied Mathematics Unit, Indian Statistical Institute, 203 B. T. Road, Kolkata-700108, India.

A series of recent publications, within the framework of network science, have focused on the coexistence of mixed attractive and repulsive (excitatory and inhibitory) interactions among the units within the same system, motivated by the analogies with spin glasses as well as to neural networks, or ecological systems. However, most of these investigations have been restricted to single layer networks, requiring further analysis of the complex dynamics and particular equilibrium states that emerge in multilayer configurations. This article investigates the synchronization properties of dynamical systems connected through multiplex architectures in the presence of attractive intralayer and repulsive interlayer connections. Read More

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