102 results match your criteria focus loc


Cortical Responses to Vowel Sequences in Awake and Anesthetized States: A Human Intracranial Electrophysiology Study.

Cereb Cortex 2021 Jun 12. Epub 2021 Jun 12.

Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.

Elucidating neural signatures of sensory processing across consciousness states is a major focus in neuroscience. Noninvasive human studies using the general anesthetic propofol reveal differential effects on auditory cortical activity, with a greater impact on nonprimary and auditory-related areas than primary auditory cortex. This study used intracranial electroencephalography to examine cortical responses to vowel sequences during induction of general anesthesia with propofol. Read More

View Article and Full-Text PDF

Gut hormones, adipokines, and pro- and anti-inflammatory cytokines/markers in loss of control eating: A scoping review.

Appetite 2021 Jun 7:105442. Epub 2021 Jun 7.

School of Nursing, University of Rochester, 601 Elmwood Avenue, Rochester, NY, 14642, USA. Electronic address:

Loss of control (LOC) eating is the defining feature of binge-eating disorder, and it has particular relevance for bariatric patients. The biomarkers of LOC eating are unclear; however, gut hormones (i.e. Read More

View Article and Full-Text PDF

Experimental liver models: From cell culture techniques to microfluidic organs-on-chip.

Liver Int 2021 May 9. Epub 2021 May 9.

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy.

The liver is one of the most studied organs of the human body owing to its central role in xenobiotic and drug metabolism. In recent decades, extensive research has aimed at developing in vitro liver models able to mimic liver functions to study pathophysiological clues in high-throughput and reproducible environments. Two-dimensional (2D) models have been widely used in screening potential toxic compounds but have failed to accurately reproduce the three-dimensionality (3D) of the liver milieu. Read More

View Article and Full-Text PDF

Ultra-high-frequency (UHF) surface-acoustic-wave (SAW) microfluidics and biosensors.

Nanotechnology 2021 May 10;32(31). Epub 2021 May 10.

INTA srl, Intelligent Acoustics Systems, Via Nino Pisano 14, I-56122 Pisa, Italy.

Surface acoustic waves (SAWs) have the potential to become the basis for a wide gamut of lab-on-a-chips (LoCs). These mechanical waves are among the most promising physics that can be exploited for fulfilling all the requirements of commercially appealing devices that aim to replace-or help-laboratory facilities. These requirements are low processing cost of the devices, scalable production, controllable physics, large flexibility of tasks to perform, easy device miniaturization. Read More

View Article and Full-Text PDF

Relationship between religiosity, spirituality and physical and mental outcomes in fibromyalgia patients.

Clin Exp Rheumatol 2021 Apr 9. Epub 2021 Apr 9.

Sackler School of Medicine, Tel Aviv University, and Internal Medicine H, Tel Aviv Sourasky Medical Centre, Israel.

Objectives: The coping mechanisms utilised by patients with the fibromyalgia syndrome (FM) pose a crucial focus of treatment. Previous research points to the positive effects of religiosity and spirituality (R/S) as tools for coping with illness. The role of these factors in coping with chronic pain in FMS has not previously been studied. Read More

View Article and Full-Text PDF

Demographic-Dependent Risk of Developing Severe Novel Psychiatric Disorders after Concussion.

J Neurotrauma 2021 Apr 26. Epub 2021 Apr 26.

Department of Neurosurgery, and Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Current guidelines for patients experiencing a concussion or mild traumatic brain injury (mTBI) often focus on conservative care and observation. However, mTBI may increase the risk of severe novel psychiatric disorders (NPDs) within 180 days, and long-term management of mTBI should include psychiatric evaluation in patient populations. Retrospective cohort analysis was conducted using 8 years of the Nationwide Readmission Database. Read More

View Article and Full-Text PDF

Design of micromagnetic arrays for on-chip separation of superparamagnetic bead aggregates and detection of a model protein and double-stranded DNA analytes.

Sci Rep 2021 Mar 5;11(1):5302. Epub 2021 Mar 5.

School of Chemistry, University College Dublin, Belfield, Dublin, Ireland.

Magnetically actuated lab-on-a-chip (LOC) technologies have enabled rapid, highly efficient separation of specific biomarkers and cells from complex biological samples. Nonlinear magnetophoresis (NLM) is a technique that uses a microfabricated magnet array (MMA) and a time varying external magnetic field to precisely control the transport of superparamagnetic (SPM) beads on the surface of a chip based on their size and magnetization. We analyze the transport and separation behavior of SPM monomers and dimers on four MMA geometries, i. Read More

View Article and Full-Text PDF

Rapid Manufacturing of Multilayered Microfluidic Devices for Organ on a Chip Applications.

Sensors (Basel) 2021 Feb 16;21(4). Epub 2021 Feb 16.

Nanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), 12 Baldiri Reixac 15-21, 08028 Barcelona, Spain.

Microfabrication and Polydimethylsiloxane (PDMS) soft-lithography techniques became popular for microfluidic prototyping at the lab, but even after protocol optimization, fabrication is yet a long, laborious process and partly user-dependent. Furthermore, the time and money required for the master fabrication process, necessary at any design upgrade, is still elevated. Digital Manufacturing (DM) and Rapid-Prototyping (RP) for microfluidics applications arise as a solution to this and other limitations of photo and soft-lithography fabrication techniques. Read More

View Article and Full-Text PDF
February 2021

Are the early childhood antecedents of men's external locus of control similar to those of their female partners?

Wellcome Open Res 2018 2;3:28. Epub 2021 Feb 2.

Department of Psychology, Emory University, Atlanta, GA, GA30322, USA.

The concept of locus of control of reinforcement was introduced by Julian Rotter and has been the focus of intense research for nearly half a century.  Surprisingly little research has been directed at clarifying antecedents of locus of control (LOC) orientations in adult men apart from a few small studies. We previously identified a number of independent antecedents associated with women's LOC, including features of their parents and early childhood. Read More

View Article and Full-Text PDF
February 2021

Aspects of Point-of-Care Diagnostics for Personalized Health Wellness.

Int J Nanomedicine 2021 14;16:383-402. Epub 2021 Jan 14.

Department of Civil & Environmental Engineering, Hanyang University, Seoul 04763, Republic of Korea.

Advancements in analytical diagnostic systems for point-of-care (POC) application have gained considerable attention because of their rapid operation at the site required to manage severe diseases, even in a personalized manner. The POC diagnostic devices offer easy operation, fast analytical outcome, and affordable cost, which promote their advanced research and versatile adoptability. Keeping advantages in view, considerable efforts are being made to design and develop smart sensing components such as miniaturized transduction, interdigitated electrodes-based sensing chips, selective detection at low level, portable packaging, and sustainable durability to promote POC diagnostics according to the needs of patient care. Read More

View Article and Full-Text PDF
January 2021

Gradient Waveguide Thickness Guided-Mode Resonance Biosensor.

Sensors (Basel) 2021 Jan 7;21(2). Epub 2021 Jan 7.

Department of Mechanical Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan.

Portable systems for detecting biomolecules have attracted considerable attention, owing to the demand for point-of-care testing applications. This has led to the development of lab-on-a-chip (LOC) devices. However, most LOCs are developed with a focus on automation and preprocessing of samples; fluorescence measurement, which requires additional off-chip detection instruments, remains the main detection method in conventional assays. Read More

View Article and Full-Text PDF
January 2021

Emerging on-chip surface acoustic wave technology for small biomaterials manipulation and characterization.

Biomater Sci 2021 Mar;9(5):1574-1582

Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO 80309, USA. and Biomedical Engineering Program, University of Colorado Boulder, Boulder, CO 80309, USA.

A surface acoustic wave (SAW) is a sound wave travelling on the surface of an elastic material. SAW offers a robust control of the acoustic energy leading to an unparalleled versatility. As an actuator, SAW can exert acoustic forces on particles and fluids thus enabling dexterous micro/nanoscale manipulations. Read More

View Article and Full-Text PDF

Financial Socialization, Childhood Experiences and Financial Well-Being: The Mediating Role of Locus of Control.

Front Psychol 2020 29;11:2162. Epub 2020 Sep 29.

School of Finance and Economics, Jiangsu University, Zhenjiang, China.

The present study evaluates an empirical model of financial well-being (FWB) based on early childhood consumer experiences (ECCE) and financial socialization (FS). FWB is the overall satisfaction with one's current financial situation, and that plays a vital role in the overall success and helps to overcome psychological health issues among adults. The results of the study suggested that ECCE has a significant direct effect on the FWB among adults. Read More

View Article and Full-Text PDF
September 2020

Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip.

Micromachines (Basel) 2020 Jun 18;11(6). Epub 2020 Jun 18.

Institut de Génie Biomédical, Polytechnique Montréal, Montreal, QC H3C 3A7, Canada.

Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged in recent years and microengineered cell culture platforms have been created. These micro-devices, known as organ-on-a-chip (OOC) platforms mimic the in vivo like microenvironment of living organs and offer more physiologically relevant in vitro models of human organs. Consequently, the concept of OOC has gained great attention from researchers in the field worldwide to offer powerful tools for biomedical researches including disease modeling, drug development, etc. Read More

View Article and Full-Text PDF

Cassava breeding and agronomy in Asia: 50 years of history and future directions.

Breed Sci 2020 Apr 5;70(2):145-166. Epub 2020 Mar 5.

International Laboratory for Cassava Molecular Breeding, National Key Laboratory for Plant Cell Biotechnology, Agricultural Genetics Institute, Pham Van Dong Rd, Bac Tu Liem District, Hanoi, Vietnam.

In Asia, cassava () is cultivated by more than 8 million farmers, driving the rural economy of many countries. The International Center for Tropical Agriculture (CIAT), in partnership with national agricultural research institutes (NARIs), instigated breeding and agronomic research in Asia, 1983. The breeding program has successfully released high-yielding cultivars resulting in an average yield increase from 13. Read More

View Article and Full-Text PDF

Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics.

Adv Biochem Eng Biotechnol 2020 May 21. Epub 2020 May 21.

Department of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa, Israel.

The recent coronavirus (COVID-19) pandemic has underscored the need to move from traditional lab-centralized diagnostics to point-of-care (PoC) settings. Lab-on-a-chip (LoC) platforms facilitate the translation to PoC settings via the miniaturization, portability, integration, and automation of multiple assay functions onto a single chip. For this purpose, paper-based assays and microfluidic platforms are currently being extensively studied, and much focus is being directed towards simplifying their design while simultaneously improving multiplexing and automation capabilities. Read More

View Article and Full-Text PDF

Contagious Bovine Pleuropneumonia: A Comprehensive Overview.

Vet Pathol 2020 07 11;57(4):476-489. Epub 2020 May 11.

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise "G. Caporale," OIE Reference Laboratory for Contagious Bovine Pleuropneumonia, Campo Boario, Teramo, Italy.

Contagious bovine pleuropneumonia (CBPP) is a respiratory disease of cattle that is listed as notifiable by the World Organization for Animal Health. It is endemic in sub-Saharan Africa and causes important productivity losses due to the high mortality and morbidity rates. CBPP is caused by subsp. Read More

View Article and Full-Text PDF

Expert opinion-management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors.

Leukemia 2020 06 4;34(6):1495-1502. Epub 2020 May 4.

Hammersmith Hospital, Imperial College London, London, UK.

Regardless of line of therapy, treatment goals in chronic phase chronic myeloid leukemia (CML) are: avoid progression to accelerated phase or blast crisis CML such that patients achieve a life expectancy comparable with that of the general population; avoid adverse events (AEs); and restore and maintain quality of life. The most important prognostic factor for achieving these goals is response to tyrosine kinase inhibitors (TKIs) at key milestones. For patients failing a TKI, a treatment change is mandatory to limit the risk of progression and death. Read More

View Article and Full-Text PDF

Spatial variability and influence of biological parameters on microplastic ingestion by Boops boops (L.) along the Italian coasts (Western Mediterranean Sea).

Environ Pollut 2020 Aug 22;263(Pt A):114429. Epub 2020 Mar 22.

ISPRA, Italian National Institute for Environmental Protection and Research, Via di Castel Romano 100, 00144, Rome, RM, Italy. Electronic address:

Recently, many studies focus on the ingestion of microplastics by marine biota. Fish exploit almost every kind of marine environment, occupy many ecological niches and are an important food source for human populations worldwide. For these reasons, they seem to represent very appropriate biological indicators of microplastic ingestion. Read More

View Article and Full-Text PDF

Identification and integrated analysis of glyphosate stress-responsive microRNAs, lncRNAs, and mRNAs in rice using genome-wide high-throughput sequencing.

BMC Genomics 2020 Mar 17;21(1):238. Epub 2020 Mar 17.

Institute of Crop and Nuclear Technology Utilization, Zhejiang Academy of Agricultural Sciences, 198, Shiqiao Road, Hangzhou, 310021, Zhejiang, China.

Background: Glyphosate has become the most widely used herbicide in the world. Therefore, the development of new varieties of glyphosate-tolerant crops is a research focus of seed companies and researchers. The glyphosate stress-responsive genes were used for the development of genetically modified crops, while only the EPSPS gene has been used currently in the study on glyphosate-tolerance in rice. Read More

View Article and Full-Text PDF

Decidualized juvenile cystic adenomyoma mimicking a cornual pregnancy.

Fertil Steril 2020 02;113(2):463-465

Department of Obstetrics and Gynecology, Bahceci Woman Health Center Reproductive Endocrinology and Infertility, Istanbul, Turkey.

Objective: To demonstrate the laparoscopic excision technique of a juvenile cystic adenomyoma and show how the decidualization of ectopic endometrial tissue can lead to the misdiagnosis of a focus of ectopic pregnancy.

Design: Description and step-by-step demonstration of the surgical procedure using a video recording (Canadian Task Force Classification 3).

Setting: Teaching and research hospital. Read More

View Article and Full-Text PDF
February 2020

Lab-on-a-Chip Systems for Aptamer-Based Biosensing.

Micromachines (Basel) 2020 Feb 20;11(2). Epub 2020 Feb 20.

Department of Electrical and Computer Engineering, University of New Hampshire, Durham, NH 03824, USA.

Aptamers are oligonucleotides or peptides that are selected from a pool of random sequences that exhibit high affinity toward a specific biomolecular species of interest. Therefore, they are ideal for use as recognition elements and ligands for binding to the target. In recent years, aptamers have gained a great deal of attention in the field of biosensing as the next-generation target receptors that could potentially replace the functions of antibodies. Read More

View Article and Full-Text PDF
February 2020

Sex differences in symptom presentation and functional outcomes: a pilot study in a matched sample of veterans with mild TBI.

Brain Inj 2020 03 17;34(4):535-547. Epub 2020 Feb 17.

Defense and Veterans Brain Injury Center (DVBIC), VA Palo Alto Health Care System (VAPAHCS), Palo Alto, CA, USA.

: Research focused on mild traumatic brain injury in active military and veteran populations details the psychological, neurological and functional outcomes of mTBI, in a primarily male (~95%) cohort. This may misrepresent female symptoms and outcomes. Here we assess for genuine sex differences in symptom presentation and functional outcomes. Read More

View Article and Full-Text PDF

On the Evolution and Functional Diversity of Terpene Synthases in the Pinus Species: A Review.

J Mol Evol 2020 04 8;88(3):253-283. Epub 2020 Feb 8.

Dipartimento per la Innovazione nei Sistemi Biologici, Agroalimentari e Forestali, Università Della Tuscia, Via S. Camillo De Lellis, s.n.c, 01100, Viterbo, Italy.

In the biosynthesis of terpenoids, the ample catalytic versatility of terpene synthases (TPS) allows the formation of thousands of different molecules. A steadily increasing number of sequenced plant genomes invariably show that the TPS gene family is medium to large in size, comprising from 30 to 100 functional members. In conifers, TPSs belonging to the gymnosperm-specific TPS-d subfamily produce a complex mixture of mono-, sesqui-, and diterpenoid specialized metabolites, which are found in volatile emissions and oleoresin secretions. Read More

View Article and Full-Text PDF

Cortical lesions causing loss of consciousness are anticorrelated with the dorsal brainstem.

Hum Brain Mapp 2020 04 6;41(6):1520-1531. Epub 2020 Jan 6.

Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Brain lesions can provide unique insight into the neuroanatomical substrate of human consciousness. For example, brainstem lesions causing coma map to a specific region of the tegmentum. Whether specific lesion locations outside the brainstem are associated with loss of consciousness (LOC) remains unclear. Read More

View Article and Full-Text PDF

3D-Printed Lab-on-a-Chip Diagnostic Systems-Developing a Safe-by-Design Manufacturing Approach.

Micromachines (Basel) 2019 Nov 28;10(12). Epub 2019 Nov 28.

Innovation in Research & Engineering Solutions (IRES), Boulevard Edmond Machtens 79/22, 1080 Brussels, Belgium.

The aim of this study is to provide a detailed strategy for Safe-by-Design (SbD) 3D-printed lab-on-a-chip (LOC) device manufacturing, using Fused Filament Fabrication (FFF) technology. First, the applicability of FFF in lab-on-a-chip device development is briefly discussed. Subsequently, a methodology to categorize, identify and implement SbD measures for FFF is suggested. Read More

View Article and Full-Text PDF
November 2019

Stem Cells: The Game Changers of Human Cardiac Disease Modelling and Regenerative Medicine.

Int J Mol Sci 2019 Nov 16;20(22). Epub 2019 Nov 16.

Department of Experimental and Clinical Medicine, Research Center for Advanced Biochemistry and Molecular Biology, University "Magna Graecia" of Catanzaro, 88100 Loc., Germaneto, Catanzaro, Italy.

A comprehensive understanding of the molecular basis and mechanisms underlying cardiac diseases is mandatory for the development of new and effective therapeutic strategies. The lack of appropriate cell models that faithfully mirror the human disease phenotypes has hampered the understanding of molecular insights responsible of heart injury and disease development. Over the past decade, important scientific advances have revolutionized the field of stem cell biology through the remarkable discovery of reprogramming somatic cells into induced pluripotent stem cells (iPSCs). Read More

View Article and Full-Text PDF
November 2019

SinoPedia-A Linked Data Services platform for decentralized knowledge base.

PLoS One 2019 2;14(8):e0219992. Epub 2019 Aug 2.

Shanghai Library/Institute of Scientific & Technical Information of Shanghai, Shanghai, China.

Knowledge bases are largely developed and utilized in academic and industrial fields, such as DBPedia, VIAF, LoC, Getty, and which are published in the Linked Data format. However, if you want to view different resources on these knowledge bases, you have to switch between different web pages from these resources. Therefore, we proposed a decentralized data hub named SinoPedia, which consists of several linked data services and can re-publish these RDF data in one platform. Read More

View Article and Full-Text PDF
February 2020

Mild traumatic brain injury characteristics do not negatively influence cognitive processing therapy attendance or outcomes.

J Psychiatr Res 2019 09 24;116:7-13. Epub 2019 May 24.

Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, USA; Psychology Service, VA San Diego Healthcare System, USA; Department of Psychiatry, University of California, San Diego, USA.

Some providers have expressed hesitation about the appropriateness of PTSD treatment for veterans with a history of mild traumatic brain injury (mTBI), given concerns that TBI-related sequelae may negatively affect PTSD treatment and/or should be the focus of treatment instead. However, research suggests that those with a history of mTBI can benefit from evidence-based PTSD treatment. To extend these findings, we examined whether specific mTBI injury markers were associated with PTSD treatment attendance and response. Read More

View Article and Full-Text PDF
September 2019