15,550 results match your criteria focal lesion


Lesion loci of impaired affective prosody: A systematic review of evidence from stroke.

Brain Cogn 2021 Jun 9;152:105759. Epub 2021 Jun 9.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Cognitive Science, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, United States.

Affective prosody, or the changes in rate, rhythm, pitch, and loudness that convey emotion, has long been implicated as a function of the right hemisphere (RH), yet there is a dearth of literature identifying the specific neural regions associated with its processing. The current systematic review aimed to evaluate the evidence on affective prosody localization in the RH. One hundred and ninety articles from 1970 to February 2020 investigating affective prosody comprehension and production in patients with focal brain damage were identified via database searches. Read More

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Meningioangiomatosis: an uncommon cause of focal epilepsy with characteristic neuroimaging and neuropathology.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Neuropathology, Greater Manchester Neurosciences Centre, Salford, UK.

A 3-year-old boy presented with acute onset of prolonged right sided focal seizures with secondary generalisation. The investigation findings were suggestive of a neoplastic process more than an inflammatory process. Decision to perform brain biopsy from the lesion to establish the precise nature of lesion was undertaken. Read More

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Autologous Matrix-Induced Chondrogenesis (AMIC) for Isolated Retropatellar Cartilage Lesions: Outcome after a Follow-Up of Minimum 2 Years.

Cartilage 2021 Jun 11:19476035211021908. Epub 2021 Jun 11.

Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Purpose: To evaluate autologous matrix-induced chondrogenesis (AMIC) for isolated focal retropatellar cartilage lesions and the influence of patellofemoral (PF) anatomy on clinical outcomes at a minimum of 2-year follow-up.

Methods: Twenty-nine consecutive patients (31 knees) who underwent retropatellar AMIC with a mean age of 27.9 ± 11. Read More

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The evaluation of a multiphasic 3D-bioplotted scaffold seeded with adipose derived stem cells to repair osteochondral defects in a porcine model.

J Biomed Mater Res B Appl Biomater 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopaedics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

There is a need for the development of effective treatments for focal articular cartilage injuries. We previously developed a multiphasic 3D-bioplotted osteochondral scaffold design that can drive site-specific tissue formation when seeded with adipose-derived stem cells (ASC). The objective of this study was to evaluate this scaffold in a large animal model. Read More

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WFUMB position paper. Incidental findings of the salivary glands.

Med Ultrason 2021 Jun 8. Epub 2021 Jun 8.

Department Allgemeine Innere Medizin (DAIM) Kliniken Hirslanden Beau Site, Salem und Permanence, Bern, Switzerland.

A salivary incidentaloma (SI) stands for any focal salivary lesion, independent of size, discovered by any imaging method including ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), multimodal positron emis-sion tomography (PET) combined with CT or MRI, or X-ray imaging, performed for another reason, in the absence of known salivary glands' disease. The article presents a detailed analysis of salivary gland diseases with the emphasis on neoplasms. It describes frequency of SIs found on imaging, their prevalence, epidemiology and clinical significance. Read More

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An analysis of distinct navigational domains and topographical disorientation syndromes in ABI: A meta-analysis.

J Clin Exp Neuropsychol 2021 Jun 9:1-20. Epub 2021 Jun 9.

Department of Psychology and Counselling, School of Psychology and Public Health, La Trobe University, Bundoora, Australia.

Topographical disorientation is the impairment or inability to successfully navigate in three-dimensional space. Differing topographical disorientation syndromes have been associated with distinct lesion sites in the acquired brain injury (ABI) literature. This meta-analysis attempted to investigate the relationship between lesion location and dysfunctions in specific navigational abilities resulting in topographical disorientation in individuals with ABI, as measured by their performance on experimental and neuropsychological tests. Read More

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Blastic plasmacytoid dendritic cell neoplasm of the breast: A case report and review of the literature.

Medicine (Baltimore) 2021 May;100(19):e25699

Department of Radiology.

Rationale: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an uncommon and aggressive hematologic malignancy that arises from plasmacytoid dendritic cells. BPDCN typically presents with skin lesions with or without involvement of lymph nodes, peripheral blood, or bone marrow. However, breast involvement of BPDCN is rare and there has been no report describing the radiologic features of BPDCN within breast parenchyma. Read More

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Concomitant Presence of Hydatid Cyst and Colorectal Liver Metastasis

Turkiye Parazitol Derg 2021 06;45(2):146-148

University Hospital Centre Zagreb Faculty of Medicine, Department of Surgery, Zagreb, Croatia

A 65-year-old man, with signs of acute colon obstruction, was diagnosed with rectal tumour and liver hydatid cyst. Additionally, a focal liver lesion in segment 1 was detected. Moreover, physical examination revealed hepatomegaly and abdominal distension. Read More

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Detecting lumbar lesions in Tc-MDP SPECT by deep learning: comparison with physicians.

Med Phys 2021 Jun 8. Epub 2021 Jun 8.

Gordon Center of Medical Imaging, Massachusetts General Hospital, Boston, MA, USA.

Purpose: Tc-MDP SPECT is an established tool for diagnosing lumbar stress, a common cause of low back pain (LBP) in pediatric patients. However, detection of small stress lesions is complicated by the low quality of SPECT, leading to significant inter-reader variability. The study objectives were to develop an approach based on a deep convolutional neural network (CNN) for detecting lumbar lesions in Tc-MDP scans and to compare its performance to that of physicians in a localization receiver operating characteristic (LROC) study. Read More

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Biochemical and structural basis of the passive mechanical properties of whole skeletal muscle.

J Physiol 2021 Jun 7. Epub 2021 Jun 7.

Department of Physical Therapy and Rehabilitation Sciences and School of Biomedical Engineering, Sciences and Health Systems, Drexel University, Philadelphia, PA, USA.

Passive skeletal muscle mechanical properties of whole muscle are not as well understood as muscle's active mechanical properties. Both the structural basis for passive mechanical properties and the properties themselves are challenging to determine because it is not clear which structures within skeletal muscle actually bear passive loads and there are not established standards by which to make mechanical measurements. Evidence suggests that titin bears the majority of the passive load within the single muscle cell. Read More

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Frequency and phenotype of thalamic aphasia.

J Neurol 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.

Background: Aphasia is a recognized presenting symptom of thalamic lesions. Little is known regarding its frequency and phenotype. We examined the frequency of thalamic aphasia following Isolated Acute unilateral ischemic Lesions in the Thalamus (IALT) with respect to lesion location. Read More

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Hidradenocarcinoma of the Abdominal Wall Treated With Wide Surgical Excision and Adjuvant Radiotherapy.

Cureus 2021 Apr 27;13(4):e14724. Epub 2021 Apr 27.

Department of Radiation Oncology, Beaumont Health, Royal Oak, USA.

Hidradenocarcinomas are rare malignant sweat gland tumors that typically arise in the head and neck area. To the best of our knowledge, this is the only reported instance of hidradenocarcinoma of the abdominal wall as well as the first case arising from a region of prior trauma. A 72-year-old female presented with a left abdominal wall lesion, which she had first noticed after an injury to the area. Read More

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The Effect of Focal Damage to the Right Medial Posterior Cerebellum on Word and Sentence Comprehension and Production.

Front Hum Neurosci 2021 20;15:664650. Epub 2021 May 20.

Wellcome Centre for Human Neuroimaging, University College London, London, United Kingdom.

Functional imaging studies of neurologically intact adults have demonstrated that the right posterior cerebellum is activated during verb generation, semantic processing, sentence processing, and verbal fluency. Studies of patients with cerebellar damage converge to show that the cerebellum supports sentence processing and verbal fluency. However, to date there are no patient studies that investigated the specific importance of the right posterior cerebellum in language processing, because: (i) case studies presented patients with lesions affecting the anterior cerebellum (with or without damage to the posterior cerebellum), and (ii) group studies combined patients with lesions to different cerebellar regions, without specifically reporting the effects of right posterior cerebellar damage. Read More

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Granuloma Faciale Involving the Tarsoconjunctival Surface of the Eyelid.

Ophthalmic Plast Reconstr Surg 2021 Jun 4. Epub 2021 Jun 4.

South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia Division of Sonic Healthcare Limited, Clinpath Pathology, Mile End, South Australia, Australia Flinders Eye Centre, Bedford Park, South Australia, Australia.

We present the case of a Caucasian woman with a histology-confirmed granuloma faciale of the tarsoconjunctival surface of the eyelid. A 66-year-old female patient presented with a 1-week history of painless left upper eyelid mass without history of allergy, trauma, or ocular surgery. There was an elevated well-demarcated flesh-colored lesion within the tarsus. Read More

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Incidental Finding of a Parotid Basal Cell Adenoma With High Tracer Uptake on 68Ga-DOTATOC PET/CT.

Clin Nucl Med 2021 Jul;46(7):e381-e383

Oto-Rhino-Laryngology Department, University Hospital Morvan.

Abstract: A 67-year-old man was referred to our department to undergo a 68Ga-DOTATOC PET/CT during the systematic follow-up of a small intestine neuroendocrine tumor. PET revealed an incidental focal increased uptake of 68Ga-DOTATOC matching with a left intraparotid lesion on the combined contrast-enhanced CT, suggestive of a benign salivary tumor. An MRI was performed to characterize this lesion, and finally, the patient underwent surgery. Read More

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Sotos syndrome: a pitfall in the presurgical workup of temporal lobe epilepsy.

Epileptic Disord 2021 Jun 1. Epub 2021 Jun 1.

Department of Neuropediatrics, University Children's Hospital Zurich, Switzerland, University of Zurich, Switzerland, Children's Research Centre, University Children's Hospital Zurich, Switzerland.

Tumour-associated epilepsy accounts for a quarter of paediatric patients undergoing epilepsy surgery with the vast majority achieving long-term seizure and drug freedom. We report the case of an eight-year-old patient who presented with developmental delay and overgrowth, followed by temporal lobe seizures that were attributed to a mesio-temporal brain tumour, and who was eventually treated with epilepsy surgery. Histopathology revealed a diffuse astrocytoma but its gross total resection surprisingly failed to control the temporal lobe seizures. Read More

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Outcomes after high-dose radiation in the management of neuroendocrine neoplasms.

PLoS One 2021 2;16(6):e0252574. Epub 2021 Jun 2.

Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, United States of America.

Background: Neuroendocrine neoplasms (NENs) comprise a rare and heterogenous group of cancers, for which the role of radiation therapy continues to evolve. The purpose of this study is to analyze oncologic outcomes after the use of high-dose radiation in management of NENs at a tertiary hospital.

Materials And Methods: We performed a retrospective review of patients who received high-dose radiation with intent to cure or provide durable local control (defined as biologically effective dose (BED) ≥40, α/β = 10) for a localized or metastatic NEN from 2006 to 2019. Read More

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Dual contrast liver MRI: a pictorial illustration.

Abdom Radiol (NY) 2021 Jun 2. Epub 2021 Jun 2.

Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Liver magnetic resonance imaging (MRI) is a commonly performed imaging technique with multiple indications and applications. There are two general groups of contrast agents used when imaging the liver, extracellular contrast agents (ECA) and hepatobiliary agents (HBA), each of which has its own advantages and limitations. Liver MRI with ECA provides excellent information on abdominal vasculature and better quality multi-phasic studies for characterization of focal liver lesions. Read More

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Multichannel three-dimensional fully convolutional residual network-based focal liver lesion detection and classification in Gd-EOB-DTPA-enhanced MRI.

Int J Comput Assist Radiol Surg 2021 Jun 1. Epub 2021 Jun 1.

Department of Radiology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) has high diagnostic accuracy in the detection of liver lesions. There is a demand for computer-aided detection/diagnosis software for Gd-EOB-DTPA-enhanced MRI. We propose a deep learning-based method using one three-dimensional fully convolutional residual network (3D FC-ResNet) for liver segmentation and another 3D FC-ResNet for simultaneous detection and classification of a focal liver lesion in Gd-EOB-DTPA-enhanced MRI. Read More

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A Semiquantitative Scoring System for Histopathological and Immunohistochemical Assessment of Lesions and Tissue Tropism in Avian Influenza.

Viruses 2021 05 9;13(5). Epub 2021 May 9.

Institute of Veterinary Pathology, Leipzig University, 04103 Leipzig, Germany.

The main findings of the post-mortem examination of poultry infected with highly pathogenic avian influenza viruses (HPAIV) include necrotizing inflammation and viral antigen in multiple organs. The lesion profile displays marked variability, depending on viral subtype, strain, and host species. Therefore, in this study, a semiquantitative scoring system was developed to compare histopathological findings across a wide range of study conditions. Read More

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Whole Body Low Dose Computed Tomography (WBLDCT) Can Be Comparable to Whole-Body Magnetic Resonance Imaging (WBMRI) in the Assessment of Multiple Myeloma.

Diagnostics (Basel) 2021 May 11;11(5). Epub 2021 May 11.

School of Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, MB, Italy.

Aim of the study is to compare the agreement between whole-body low-dose computed tomography (WBLDCT) and magnetic resonance imaging (WBMRI) in the evaluation of bone marrow involvement in patients with multiple myeloma (MM). Patients with biopsy-proven MM, who underwent both WBLDCT and WBMRI were retrospectively enrolled. After identifying the presence of focal bone involvement (focal infiltration pattern), the whole skeleton was divided into five anatomic districts (skull, spine, sternum and ribs, pelvis, and limbs). Read More

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A novel approach to evaluate the effects of artificial bone focal lesion on the three-dimensional strain distributions within the vertebral body.

PLoS One 2021 1;16(6):e0251873. Epub 2021 Jun 1.

Dept of Oncology and Metabolism and INSIGNEO Institute for in silico Medicine, The University of Sheffield, Sheffield, United Kingdom.

The spine is the first site for incidence of bone metastasis. Thus, the vertebrae have a high potential risk of being weakened by metastatic tissues. The evaluation of strength of the bone affected by the presence of metastases is fundamental to assess the fracture risk. Read More

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Magnetic source imaging in presurgical evaluation of paediatric focal drug-resistant epilepsy and its predictive value of surgical outcome in lesional cases: A single-centre experience from South India.

Seizure 2021 May 24;91:22-28. Epub 2021 May 24.

MEG research Centre, NIMHANS, Hosur Road, Bangalore, India; Department of Neurology, NIMHANS, Hosur Road, Bangalore, India. Electronic address:

Objective: This study aims to evaluate the utility of magnetoencephalography in presurgical planning and in predicting post-surgical seizure outcome.

Methods: This study included a cohort of 231 children (1-18 years) with focal drug-resistant epilepsy who underwent MEG as a part of their presurgical workup. Characteristics of MEG observations were described in all children. Read More

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Quantitative MRI susceptibility mapping reveals cortical signatures of changes in iron, calcium and zinc in malformations of cortical development in children with drug-resistant epilepsy.

Neuroimage 2021 May 29;238:118102. Epub 2021 May 29.

Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London, London, UK; Wellcome EPSRC Centre for Medical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, UK. Electronic address:

Objective: Malformations of cortical development (MCD), including focal cortical dysplasia (FCD), are the most common cause of drug-resistant focal epilepsy in children. Histopathological lesion characterisation demonstrates abnormal cell types and lamination, alterations in myelin (typically co-localised with iron), and sometimes calcification. Quantitative susceptibility mapping (QSM) is an emerging MRI technique that measures tissue magnetic susceptibility (χ) reflecting it's mineral composition. Read More

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Pathology-selective antiepileptic effects in the focal freeze-lesion rat model of malformation of cortical development.

Exp Neurol 2021 May 29;343:113776. Epub 2021 May 29.

Charité - Universitätsmedizin Berlin, Clinical and Experimental Epileptology, Department of Neurology, Charitéplatz 1, 10117 Berlin, Germany; Epilepsy-Center Berlin-Brandenburg, Institute for Diagnostics of Epilepsy, Berlin, Germany; Berlin Institute of Health at Charité -Universitätsmedizin Berlin, NeuroCure Clinical Research Center, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

Malformations of cortical development (MCD) represent a group of rare diseases with severe clinical presentation as epileptic and pharmacoresistant encephalopathies. Morphological studies in tissue from MCD patients have revealed reduced GABAergic efficacy and increased intracellular chloride concentration in neuronal cells as important pathophysiological mechanisms in MCD. Also, in various animal models, alterations of GABAergic inhibition have been postulated as a predominant factor contributing to perilesional hyperexcitability. Read More

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Electrophysiological Monitoring of Focal and Entire Retinal Function during Treatment with Intravitreal Methotrexate for Intraocular Lymphoma.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):277-282. Epub 2021 Apr 30.

Department of Ophthalmology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.

We describe the electroretinographic findings of a case of primary intraocular lymphoma (PIOL) wherein the patient received intravitreal injections of methotrexate (ivMTX). A 62-year-old man developed blurred vision and complained of decreased visual acuity (VA) in his right eye. Fundus examination showed vitreous opacity and multiple subretinal yellowish lesions. Read More

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Targeted Blood Brain Barrier Opening With Focused Ultrasound Induces Focal Macrophage/Microglial Activation in Experimental Autoimmune Encephalomyelitis.

Front Neurosci 2021 12;15:665722. Epub 2021 May 12.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Experimental autoimmune encephalomyelitis (EAE) is a model of multiple sclerosis (MS). EAE reflects important histopathological hallmarks, dissemination, and diversity of the disease, but has only moderate reproducibility of clinical and histopathological features. Focal lesions are less frequently observed in EAE than in MS, and can neither be constrained to specific locations nor timed to occur at a pre-specified moment. Read More

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A case of a large solitary fibrous tumor in the thigh, displaying NAB2ex4-STAT6ex2 gene fusion.

Skeletal Radiol 2021 May 29. Epub 2021 May 29.

Department of Surgical Oncology (Bone and Soft Tissues), Disease Management Group, Tata Memorial Hospital (TMH), Homi Bhabha National Institute (HBNI) University, Parel, Mumbai, India.

A solitary fibrous tumor (SFT) is documented in several body sites. However, there are few reports on the radiological and corresponding histopathological, including immunohistochemical, features of SFT in the lower extremities. A 58-year-old male presented with a lump in his right thigh of 6 months duration. Read More

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Transitional pattern as a potential marker of epileptogenic zone in focal epilepsy - Clinical observations from intracerebral recordings.

Epilepsy Res 2021 Aug 21;174:106676. Epub 2021 May 21.

Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China. Electronic address:

Objectives: To investigate the characteristics of transition from interictal to ictal phase in intracranial recordings and further to determine the potential marker of epileptogenic zone.

Methods: Eighteen patients with drug-refractory epilepsy who underwent stereo-electroencephalography (SEEG) evaluation and subsequent resective surgery were included. All patients were seizure-free post-operatively. Read More

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Interference of commissural connections through the genu of the corpus callosum specifically impairs sensorimotor gating.

Behav Brain Res 2021 May 25;411:113383. Epub 2021 May 25.

Key Lab of Organ Development and Regeneration of Zhejiang Province, Institute of Life Sciences, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 311121, China. Electronic address:

White matter abnormalities in schizophrenic patients are characterized as regional tract-specific. Myelin loss at the genu of the corpus callosum (GCC) is one of the most consistent findings in schizophrenic patients across the different populations. We characterized the axons that pass through the GCC by stereotactically injecting an anterograde axonal tracing viral vector into the forceps minor of the corpus callosum in one hemisphere, and identified the homotopic brain structures that have commissural connections in the two hemispheres of the prefrontal cortex, including the anterior cingulate area, the prelimbic area, the secondary motor area, and the dorsal part of the agranular insular area, along with commissural connections with the primary motor area, caudoputamen, and claustrum. Read More

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