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Review and characteristics of 585 salivary gland neoplasms from a tertiary hospital registered in the Polish National Major Salivary Gland Benign Tumors Registry over a period of 5 years: a prospective study.

Otolaryngol Pol 2020 Apr;74(5):1-6

Department of Otolaryngology and Laryngological Oncology, Poznan University of Medical Sciences, Poznan, Poland.

<b>Introduction:</b> A Polish National Major Salivary Gland Benign Tumors Registry (SGR) is a report of benign salivary gland neoplasms (SGNs) from 26 different centres in Poland, introduced in 2014. The aim of this study is to analyze demographic characteristics and clinico-pathological factors of benign SGNs treated in large tertiary institutions and to determine possible correlations between selected variables. <br><b>Material and method:</b> Analysis of 585 patients recorded in SGR and operated on for SGNs in the Department of Otolaryngology and Laryngological Surgery, University of Medical Sciences, Poznań, Poland, over a 5-year period. Read More

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Diffuse large B cell lymphoma presenting as cavitary lung lesions-A misleading clinical debut diagnosed by fine-needle aspiration.

Diagn Cytopathol 2021 Sep 22. Epub 2021 Sep 22.

Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.

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September 2021

Malignancy Rates of Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS) Cases: A Tertiary Center Study.

Acta Endocrinol (Buchar) 2021 Apr-Jun;17(1):77-82

Erzurum Training and Research Hospital - Pathology, Erzurum, Turkey.

Aim: To evaluate the malignancy rates of Atypia of undetermined significance /follicular lesion of undetermined significance (AUS/FLUS) cases in the light of clinical and sonographic features.

Material And Methods: The percentage of AUS/FLUS cases, second fine needle aspiration cytology (FNAC) results, cyto-histopathological correlations and risk of malignancy were analyzed.

Results: 113 out of 1461 thyroid FNAC samples (7. Read More

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October 2021

Hyaline Vascular Type of Castleman Disease: Diagnostic Pitfalls on Cytology and Its Clinical Relevance.

Cureus 2021 Aug 14;13(8):e17174. Epub 2021 Aug 14.

Pathology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.

Castleman disease (CD) is an uncommon cause of lymphadenopathy. The role of fine-needle aspiration cytology (FNAC) as a diagnostic modality in this disease is not well established. Cytological features of CD have a considerable overlap with many reactive conditions. Read More

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Pleomorphic liposarcoma with liver metastasis diagnosed by combined fine-needle aspiration cytology and core-needle biopsy.

Diagn Cytopathol 2021 Sep 15. Epub 2021 Sep 15.

Department of Medicine and Surgery, University of Salerno, Salerno, Italy.

Pleomorphic liposarcoma (PLPS) is the rarest liposarcoma subtype, with high-local recurrence and metastasis rates. Fine-needle aspiration cytology (FNAC) is successfully used in the diagnosis of primary or metastatic soft tissue tumors, but liver metastases of PLPS diagnosed by FNAC have never been reported. The cytological diagnosis depends on the identification of lipoblasts with sharply defined cytoplasmic vacuoles indenting and distorting the nucleus in the context of a pleomorphic tumor and in a proper clinical and imaging context. Read More

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September 2021

Utility of ultrasound guided versus conventional fine needle aspiration cytology in diagnosing breast malignancies among patients with palpable breast lumps at Bugando Medical Centre, Mwanza Tanzania.

Pan Afr Med J 2021 16;39:133. Epub 2021 Jun 16.

Department of Pathology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.

Introduction: breast lump is the commonest presentation for both benign and maligant breast conditions. Both ultrasound guided and conventional fine needle aspiration cytology (FNAC) have been used for diagnosing of breast malignancy among patients with palpable breast lumps. This study compared diagnostic utility of ultrasound guided versus conventional FNAC in diagnosing breast malignancies among patients with palpable breast lumps at Bugando Medical Centre. Read More

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The Pattern of Superficial Lymphadenopathy on Fine Needle Aspiration Cytology in Clinical Practice in Islamabad.

Cureus 2021 Aug 10;13(8):e17075. Epub 2021 Aug 10.

Medical Affairs and Clinical Research, Hilton Pharma Pvt. Ltd., Karachi, PAK.

Background:  In adults, lymph nodes are not normally palpable. A number of patients with asymptomatic lymphadenopathy never visit physicians for the condition, and thus, this important sign is often missed by the medical practitioner if it is not the presenting complaint. The incidence of lymphadenopathy is suggested to be increasing. Read More

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Thyroid sarcoidosis: a rare entity in the differential diagnosis of thyroid cancer.

Endocrinol Diabetes Metab Case Rep 2021 Sep 1;2021. Epub 2021 Sep 1.

Endocrinology Department, Thessaloniki, Greece.

Summary: We present two cases of thyroid sarcoidosis that were misdiagnosed as thyroid cancer. In the first patient, fine needle aspiration cytology (FNAc) of a suspicious thyroid nodule indicated the presence of papillary thyroid cancer, and the patient underwent thyroid surgery. However, histopathology identified a sarcoid granuloma, without any sign of malignancy. Read More

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September 2021

Fine-Needle Aspiration Cytology in the Diagnosis of Breast Paraffinoma.

Acta Cytol 2021 Aug 31:1-5. Epub 2021 Aug 31.

Department of Surgery, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, Brunei Darussalam.

Introduction: Paraffin injections for breast augmentation once a popular form of mammoplasty are now considered obsolete. It had been abandoned by clinicians because of its associated serious complications. The practice is however still available and is being practiced by nonmedically qualified people. Read More

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Risk stratification by application of Milan system for reporting salivary gland cytopathology: A tertiary care experience.

Cytojournal 2021 2;18:19. Epub 2021 Aug 2.

Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Objectives: The Milan system for reporting salivary gland cytopathology (MSRSGC) classification has been proposed to improve reproducibility in the management of salivary gland lesions. Fine-needle aspiration cytology (FNAC) is a widely accepted, well-tolerated, cost-effective, minimally invasive diagnostic method for pre-operative evaluation of salivary gland lesion that aids management decisions. The present study aims to reclassify the salivary gland FNAC aspirates by applying MSRSGC and calculating the risk of neoplasm and malignancy for each diagnostic category. Read More

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Yield and costs of molecular diagnostics on thyroid cytology slides in the Netherlands, adapting the Bethesda classification.

Endocrinol Diabetes Metab 2021 Sep 2:e00293. Epub 2021 Sep 2.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Objective: To evaluate our institutional experience with molecular diagnostics (MD) on thyroid cytology smears, evaluate the costs and describe MD guided clinical management of indeterminate Bethesda III/V thyroid nodules.

Methods: We performed a retrospective review of 164 Bethesda III or V thyroid cytopathology reports subjected to MD from 2013 to 2020, that altered Bethesda classification or management. MD consisted of mutation and gene fusion analysis by next-generation sequencing (NGS) of morphologically analysed and selected cytological slides. Read More

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September 2021

Synchronous occurrence of Hurthle cell carcinoma with Hodgkin's lymphoma; the first reported case with literature review.

Ann Med Surg (Lond) 2021 Sep 24;69:102750. Epub 2021 Aug 24.

Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq.

Introduction: Hurthle cell carcinoma (HCC) is a rare type of thyroid cancer while Hodgkin's lymphoma (HL) is an uncommon cancer of the lymphocytes. The synchronous occurrence of HCC and HL in a single person has not been described in the literature. This report aims to present the first case of synchronous HCC and HL. Read More

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September 2021

Bcl-10, trypsin and synaptophysin helps recognize acinar cell and mixed acinar neuroendocrine cell carcinoma of the pancreas on both preoperative cytological samples and needle biopsy specimens.

Pathol Res Pract 2021 Aug 24;226:153593. Epub 2021 Aug 24.

Department of Pathology, ULSS9 "Scaligera", Via Valverde 42, 37100 Verona, Italy. Electronic address:

Objective: Acinar cell carcinoma (ACC) of the pancreas are known to be rare and difficult to be recognize because they mimic other unrelated tumors (neuroendocrine, solid pseudopapillary) with different clinical behavior. Especially in the setting of inoperable patients, fine needle aspiration cytology (FNAC), core needle biopsy (FNAB) and immunocyto/histochemistry (ICC/IHC) play a crucial role in the differential diagnosis. The biological material available for ICC tests obtained by minimal invasive procedures is usually limited. Read More

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Ultrasound Assessment of Regional Lymph Nodes in Melanoma Staging.

Acta Dermatovenerol Croat 2021 Jul;29(2):80-87

Marija Delaš Aždajić, MD, Department of Dermatology and Venereology , Sestre milosrdnice University Hospital Center , Vinogradska cesta 29 , 10 000 Zagreb , Croatia ;

Background: Melanoma can early metastasize to regional lymph nodes. The sentinel lymph node (SLN) is the first lymph node draining directly from the site of primary melanoma, and the pathohistological status of the SLN is the most significant prognostic factor for overall survival prevalence and prognosis in patients with melanoma. Ultrasound is a very useful for the imaging of regional lymph node metastases, combined with Doppler and cytopuncture. Read More

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Ultrasound-guided fine needle aspiration cytology of Para-aortic lymph node metastasis in uterine cervical cancer: diagnostic accuracy and impact on clinical decision making.

BMC Cancer 2021 Aug 27;21(1):964. Epub 2021 Aug 27.

Department of Ultrasound, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), No.1 East Banshan Road, Gongshu District, Hangzhou, 310022, Zhejiang Province, China.

Objective: The main aim of this study was to ascertain the effectiveness of ultrasound-guided fine needle aspiration cytology (US-FNAC) in the diagnosis of para-aortic lymph node (PALN) metastasis in uterine cervical cancer and to establish its potential impact on clinical therapeutic decision making.

Methods: We retrospectively reviewed clinical data from 92 patients diagnosed with cervical cancer with PALN enlargement between 2010 and 2018. Cytological results obtained with US-FNAC were classified by the same experienced cellular pathologists. Read More

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Water clear cell ectopic non-iatrogenic giant parathyroid adenoma in sternohyoid muscle with thyroid nodule and asymptomatic hypercalcemia due to primary hyperparathyroidism: Case report and literature review.

Int J Surg Case Rep 2021 Sep 10;86:106295. Epub 2021 Aug 10.

Department of General Surgery, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.

Background: Ectopic parathyroid gland is not uncommon, and is associated with primary hyperparathyroidism. Giant parathyroid adenoma (PA) and concurrent presence of enlarged thyroid nodule increases the probability of ectopic location. The combination of a giant PA that is ectopic (within the strap muscle) in the neck is very rare, especially in cases with no previous surgery. Read More

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September 2021

The Role of Fine Needle Aspiration Cytology in the Diagnosis of Gallbladder Cancer: A Systematic Review.

Diagnostics (Basel) 2021 Aug 6;11(8). Epub 2021 Aug 6.

3rd Surgical Department, University Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki (AUTH), 54621 Thessaloniki, Greece.

Gallbladder cancer is the most common malignancy of the biliary tract. When diagnosed in an advanced stage it has a very poor prognosis. Therefore, early diagnosis and thorough assessment of a suspicious gallbladder polyp is essential to improve survival rate. Read More

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Thyroid Nodule Characterization: How to Assess the Malignancy Risk. Update of the Literature.

Diagnostics (Basel) 2021 Jul 30;11(8). Epub 2021 Jul 30.

Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.

Ultrasound (US) is the first imaging modality for thyroid parenchyma evaluation. In the last decades, the role of ultrasound has been improved with the introduction of new US software, such as contrast-enhanced ultrasound (CEUS) and US-elastography (USE). USE is nowadays recognized as an essential part of the multiparametric ultrasound (MPUS) examination, in particular for the indeterminate thyroid nodule with possible fine-needle aspiration cytology (FNAC) number reduction; even if further and larger studies are needed to validate it. Read More

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Follicular Thyroid Carcinoma in a Developing Country: A 10-Year Retrospective Study.

Cureus 2021 Jul 23;13(7):e16594. Epub 2021 Jul 23.

Department of Medicine, Section of Endocrinology, Aga Khan University Hospital, Karachi, PAK.

Background The most common endocrine tumor is thyroid cancer. Follicular thyroid carcinoma (FTC) accounts for 5-10% of all thyroid cancers. Patients with FTC frequently present with more advanced diseases and a higher occurrence of distant metastases because of the propensity of vascular invasion. Read More

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Necessity of Fine-Needle Aspiration in Probably Benign Sonographic Appearance of Thyroid Nodules.

Iran J Otorhinolaryngol 2021 Jul;33(117):217-222

Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: The management of thyroid nodules has been proposed based on US features and information obtained from Fine-Needle Aspiration Cytology (FNAC). In this study, we checked the diagnostic value of ultrasound in comparison with FNAC in probably benign nodules of thyroid.

Materials And Methods: Patients with thyroid nodules referred to the Radiology department from 2015 to 2020, were classified into five types based on the American College of Radiology/thyroid imaging reporting and data system (TI-RADS) standards. Read More

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Review of Head and Neck Masses in the Indian Population Based on Prevalence and Etiology With an Emphasis on Primary Diagnostic Modalities.

Nilam Bhasker

Cureus 2021 Jul 7;13(7):e16249. Epub 2021 Jul 7.

Pathology, Employees' State Insurance Corporation Hospital, Lucknow, IND.

Head and neck masses are classified as sebaceous cysts (epidermoid cysts), cervical lymphadenopathy, benign lipomas, lymph nodes, thyroid swellings, or tuberculosis lymphadenitis that may be painful or painless, adherent or fluctuant. In spite of this, they have distinct prognoses and pathological features. The anatomical location of the swelling and other demographic manifestations of the patient provide valuable information about the cause and type of swelling. Read More

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The Role of FNAC in the Diagnosis and Management of Warthin Tumour: Analysis of 74 Cases.

Int Arch Otorhinolaryngol 2021 Jul 24;25(3):e379-e382. Epub 2020 Sep 24.

Alexandria Medical School, Alexandria, Egypt.

 After pleomorphic adenoma, Warthin tumor gets its popularity as the second most common benign neoplasm of the parotid gland. Fine-needle aspiration cytology (FNAC) is the most cost-effective and minimally-invasive way to determine the histological character of a parotid gland tumor.  To determine the accuracy of FNAC in the diagnosis of Warthin Tumour. Read More

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Primary ALK-Positive Large B Cell Lymphoma of Pancreas.

J Gastrointest Cancer 2021 Aug 10. Epub 2021 Aug 10.

Department of Pathology, Maulana Azad Medical College, New Delhi, India.

Introduction: Primary pancreatic B-cell lymphoma is rare with most common type being Diffuse Large B-cell lymphoma (DLBCL). Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL) represents less than 1% of all DLBCL. Extra-nodal presentation is rare with presentation as a primary pancreatic mass being exceptional. Read More

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Significance of RAS Mutations in Thyroid Benign Nodules and Non-Medullary Thyroid Cancer.

Cancers (Basel) 2021 Jul 27;13(15). Epub 2021 Jul 27.

Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy.

Thyroid nodules are detected in up to 60% of people by ultrasound examination. Most of them are benign nodules requiring only follow up, while about 4% are carcinomas and require surgery. Malignant nodules can be diagnosed by the fine-needle aspiration cytology (FNAC), which however yields an indeterminate result in about 30% of the cases. Read More

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The Value of Ultrasound-Guided Fine-Needle Aspiration Cytology Combined with Puncture Feeling in the Diagnosis of Thyroid Nodules.

Acta Cytol 2021 16;65(5):368-376. Epub 2021 Jul 16.

School of Graduate, Hebei Medical University, Shijiazhuang, China.

Introduction: There are few studies on the role of puncture feeling in thyroid nodules during ultrasound-guided fine-needle aspiration cytology (US-FNAC), although it is expected to become a new predictive technique. We aimed to analyze the importance of puncture feeling in combination with US-FNAC and investigate whether it can be used as an indicator to predict the nature of thyroid nodules.

Materials And Methods: From January 1, 2018, to October 31, 2020, a total of 623 thyroid nodules were included. Read More

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September 2021

Pregnancy-associated plasma protein A mRNA expression as a marker for differentiated thyroid cancer: results from a "surgical" and a "cytological" series.

J Endocrinol Invest 2021 Aug 4. Epub 2021 Aug 4.

Department of Medical, Surgical and Neurological Sciences, University of Siena, Viale Bracci 16, 53100, Siena, Italy.

Purpose: Pregnancy-associated plasma protein A (PAPPA) is a metalloproteinase initially described for its role during pregnancy. PAPPA regulates IGF ligands 1 (IGF1) bioavailability through the degradation of IGF-binding protein 4 (IGFBP4). After the cleavage of IGFBP4, free IGF1 is able to bind IGF1 receptors (IGF1R) triggering the downstream signaling. Read More

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Cytodiagnosis of unusual metastases in parotid gland.

J Oral Maxillofac Pathol 2021 Jan-Apr;25(1):171-176. Epub 2021 May 14.

Department of Pathology, Acharya Vinoba Bhave Rural Hospital, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India.

Documentation of metastatic lesions in the parotid gland diagnosed by fine-needle aspiration cytology (FNAC) is limited in the cytopathology literature. The metastases within the parotid masquerades clinically as primary neoplasm of parotid. The authors of present case report intent to highlight the importance of FNAC in the diagnosis of metastases in parotid. Read More

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Risk stratification of parotid neoplasms based on intraoperative frozen section and preoperative fine needle aspiration cytology.

Eur Arch Otorhinolaryngol 2021 Aug 3. Epub 2021 Aug 3.

Department of Otorhinolaryngology, Tan Tock Seng Hospital, Singapore, Singapore.

Purpose: This study aims to determine the relationship of frozen section (FS) to final histology and determine how incorporating FS may change preoperative malignancy risk estimates based on preoperative fine needle aspiration cytology (FNAC). The secondary aim is to determine if FS is useful in influencing intraoperative decision-making.

Methods: Retrospective review of 426 intraoperative FS for parotidectomies performed for primary parotid lesions. Read More

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Challenges in management of benign bone tumours complicated by pathological fracture in paediatric population.

Int J Burns Trauma 2021 15;11(3):207-219. Epub 2021 Jun 15.

Department of Orthopaedic Surgery, J. N. Medical College, Faculty of Medicine, A.M.U. Aligarh, India.

Background: Optimum treatment of pathological fractures following benign bone tumours in paediatric population is controversial. The usual difficulties encountered while dealing such cases is to establish a correct pre-operative diagnosis and to choose between conservative vs operative management. The aim of the work is to highlight the difficult aspects of diagnosis and management of pathological fractures following benign bone tumours in paediatric population. Read More

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Cytomorphological spectrum of cysticercosis: A study of 26 cases.

Cytopathology 2021 Jul 31. Epub 2021 Jul 31.

Department of Pathology, Atal Bihari Vajpayi Institute of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Background: Cysticercosis is a systemic parasitic disease caused by the larval stage of Taenia solium. It is the most common parasitic disease worldwide. Fine needle aspiration cytology can play an important role in prompt recognition of this disease. Read More

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