Chemistry 2022 Jan 18. Epub 2022 Jan 18.
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Key Laboratory of Organofluorine Chemistry, 345 Ling-Ling Road, Xu-Hui District, 200032, Shanghai, CHINA.
S -(Trifluoromethyl) benzothioate (TFBT) is developed as an inexpensive, bench-stable and user-friendly trifluoromethylthiolation reagent, which can be easily synthesized using KF as the only fluorine source. By using TFBT, trifluoromethylthiolates with various counterions can be readily obtained. The synthetic application of TFBT is demonstrated by trifluoromethylthiolation-halogenation of arynes, bis(trifluoromethylthiolation)-halogenation of 1,2-benzdiynes, nucleophilic substitution of alkyl halides, deoxytrifluoromethylthiolation of alcohols, and cross-coupling with aryl and vinyl boronic acids. Read More