Arterioscler Thromb Vasc Biol 2021 Jul 15:ATVBAHA121316539. Epub 2021 Jul 15.
School of Physiology, Pharmacology & Neuroscience, Faculty of Biomedical Sciences, University of Bristol, United Kingdom. (A.S., M.B., C.T., J.L., D.P., R.J.R.).
Objective: Extracellular vesicles (EVs) facilitate molecular transport across extracellular space, allowing local and systemic signaling during homeostasis and in disease. Extensive studies have described functional roles for EV populations, including during cardiovascular disease, but the in vivo characterization of endogenously produced EVs is still in its infancy. Because of their genetic tractability and live imaging amenability, zebrafish represent an ideal but under-used model to investigate endogenous EVs. Read More