Nutr Neurosci 2019 Feb 10;22(2):132-144. Epub 2017 Aug 10.
c Scientific Institute, IRCCS Eugenio Medea , Via Don Luigi Monza, 20-23842 Bosisio Parini , LC , Italy.
Gene-environment interaction is an emerging hypothesis to expound not only the autism pathogenesis but also the increased incidence of neurodevelopmental disorders (such as autistic spectrum disorder, attention-deficit, hyperactivity disorder). Among xenobiotics, mycotoxins are worldwide contaminants of food that provoke toxicological effects, crucially resembling several symptoms associated with autism such as oxidative stress, intestinal permeability, and inflammation. Here, we focused on a group of mycotoxins to test their role in the manifestation of autism, try to explain their mechanism of action, and discuss possible preventive and therapeutic interventions. Read More