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Primary biliary cholangitis presenting with Fanconi syndrome: an important phenotype.

BMJ Case Rep 2022 Aug 16;15(8). Epub 2022 Aug 16.

Renal Medicine, Freeman Hospital, Newcastle-upon-Tyne, UK.

A woman in her 50s was referred to nephrology clinic due to progressive chronic kidney disease. She exhibited features of proximal renal tubulopathy, namely Fanconi syndrome, including normoglycaemic glycosuria, normal anion gap metabolic acidosis, and intermittent hypouricaemia and hypophosphataemia. Kidney biopsy showed tubulointerstitial inflammation and focal chronic damage. Read More

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Elevated neopterin in tuberculosis and co-infection with HIV and the effect of treatment: A systematic review, meta-analysis, and meta-regression.

Int Immunopharmacol 2022 Aug 13;111:109147. Epub 2022 Aug 13.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:

Background: Neopterin (NEO) is a marker of immune stimulation. Increased NEO levels have been associated with autoimmune diseases, infections, and malignancies. Studies of NEO alterations in tuberculosis (TB) with or without HIV co-infection show inconsistent results. Read More

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Amyloid-β levels and cognitive trajectories in non-demented pTau181-positive subjects without amyloidopathy.

Brain 2022 Aug 16. Epub 2022 Aug 16.

Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Phosphorylated Tau181 (pTau181) in cerebrospinal fluid (CSF) and recently in plasma has been associated with Alzheimer's disease. In the absence of amyloidopathy, individuals with increased total Tau levels and/or temporal lobe atrophy experience no or only mild cognitive decline compared with biomarker-negative controls, leading to the proposal to categorize this constellation as Suspected non-Alzheimer disease pathophysiology (SNAP). We investigated whether the characteristics of SNAP also applied to individuals with increased CSF-pTau181 without amyloidopathy. Read More

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Chronic Pediatric Retinal Detachment with Multiple Macrocysts.

Retin Cases Brief Rep 2022 Aug 16. Epub 2022 Aug 16.

Department of Ophthalmology, Henry Ford Health System, Detroit, Michigan, USA.

Purpose: To describe a case of chronic pediatric retinal detachment with multiple macrocysts, its surgical management, and a review of the literature.

Methods: Case report with fundus photography and optical coherence tomography.

Results: We describe a case of an asymptomatic, 11-year-old male with a chronic rhegmatogenous retinal detachment with multiple peripheral macrocysts. Read More

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Vitreous Seeding of Renal Cell Carcinoma in a Patient Receiving Checkpoint Inhibitors.

Retin Cases Brief Rep 2022 Aug 16. Epub 2022 Aug 16.

Department of Ophthalmology, Rush University Medical Center, Chicago, IL.

Purpose: To describe a case of vitreous seeding with tractional retinal detachment due to metastatic renal cell carcinoma (RCC) in a patient on systemic checkpoint inhibitors.

Methods: Case Report.

Results: A 44-year-old Hispanic woman with a history of RCC with metastases to the lungs, adrenal glands, hilar lymph nodes, and peritoneum presented with a complaint of severe floaters and blurry vision of the right eye for two months. Read More

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A + T ± status across MCI and dementia due to AD: a clinic-based, retrospective study.

Neurol Sci 2022 Aug 16. Epub 2022 Aug 16.

Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy.

Background: This study aimed at comparing, within the 2018 NIA-AA amyloidosis/tauopathy/neurodegeneration (ATN) framework, the distribution of T ± profiles across A + patients with MCI and dementia in a retrospective, single-center, clinic-based cohort.

Methods: We retrospectively collected data on N = 168 A + patients with either MCI due to AD (N = 50) or probable AD dementia (ADD; N = 118). ATN status was assigned, according to the 2018 NIA-AA framework, based on cerebrospinal fluid (CSF) biomarker concentrations. Read More

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Leptomeningeal Metastasis from Non-Small Cell Lung Cancer and Current Landscape of Treatments.

Clin Cancer Res 2022 Aug 16. Epub 2022 Aug 16.

St. Francis Hospital, Hartford, CT, United States.

Leptomeningeal metastasis (LM), also known as leptomeningeal carcinomatosis (LC), is a devastating complication of metastatic cancer that occurs when neoplastic cells invade the meningeal space. Diagnosis of LM remains challenging given the heterogeneous signs and symptoms at presentation and requires thorough neurological examination, cerebrospinal fluid (CSF) analysis, and magnetic resonance imaging (MRI) of the brain and spine with gadolinium. Detecting neoplastic cells in the cerebrospinal fluid is the gold standard for diagnosing leptomeningeal metastases; however, it has low sensitivity and may require multiple CSF samples. Read More

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[Rapidly progressive dementia as the initial presentation of human immunodeficiency virus infection].

An Sist Sanit Navar 2022 Aug 16;45(2). Epub 2022 Aug 16.

Servicio de Neurología. Hospital Clínico Universitario Lozano Blesa. Zaragoza. España..

Dementia associated with human immunodeficiency virus (HIV) is currently a rare cause of rapidly progressive dementia. Its appearance is not only limited to the late phases of the disease, but can sometimes be the presenting symptom. We present the case of a patient who debuted with anxious-depressive symptoms and rapid cognitive deteri-oration with early repercussions on his daily functionality. Read More

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Leptomeningeal Carcinomatosis: A Case Report and Literature Review.

Cureus 2022 Jul 12;14(7):e26790. Epub 2022 Jul 12.

Internal Medicine, Freeman Health, Joplin, USA.

Leptomeningeal carcinomatosis (LC) is a rare complication of malignant tumors that involves metastasis to the meninges surrounding the brain and/or spinal cord. The incidence of LC appears to be increasing, which has been attributed to increased survival times of cancer patients and increased diagnostic sensitivity. In this case, we discuss a patient with a history of colon cancer and lung cancer who was admitted with multiple cranial nerve palsies and sensory deficits. Read More

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[Factors analysis of worsening renal function in patients with acute right ventricular myocardial infarction during hospitalization].

Zhonghua Yi Xue Za Zhi 2022 Aug;102(30):2368-2373

Heart Failure Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.

To analyze the related factors of worsening renal function (WRF) in patients with acute right ventricular myocardial infarction (RVMI) during hospitalization. A total of 98 patients with acute RVMI admitted to the emergency comprehensive ward of Beijing Anzhen Hospital from August 2011 to January 2020 were enrolled in this cross-sectional study. According to the situation of WRF, the patients were divided into non-WRF group (76 cases) and WRF group (22 cases). Read More

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Development of Pulmonary Alveolar Proteinosis in a Patient With Adult-Onset Still Disease Treated With Tocilizumab.

J Rheumatol 2022 Aug 15. Epub 2022 Aug 15.

Center for Rheumatic Diseases; Department of Pulmonary and Critical Care Medicine, Mie University Hospital, Tsu, Japan. Address correspondence to Dr. Y. Ito, Center for Rheumatic Diseases, Mie University Hospital 2-174 Edobashi, Tsu, Mie 514-8507, Japan. Email: ac.jp. The authors declare no conflicts of interest relevant to this article. The Institutional Review Board of Mie University Hospital has deemed that an ethical review is not required for case reports. We obtained written consent to report the case described in this paper.

We report a patient with systemic adult-onset Still disease (AOSD) who developed anti-granulocyte-macrophage colony-stimulating factor (GM-CSF)-positive pulmonary alveolar proteinosis (PAP) while using tocilizumab (TCZ), diagnosed by milky white bronchoalveolar lavage fluid (BALF; Figure 1). To our knowledge, this is the first case of PAP in AOSD. Read More

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Thoracic empyema caused by Alloscardovia omnicolens and Bifidobacteriumdentium.

J Infect Chemother 2022 Aug 12. Epub 2022 Aug 12.

Department of Laboratory Medicine, Chiba Aoba Municipal Hospital, Japan. Electronic address:

A 62-year-old man was admitted to our emergency department with the complaint of worsening dyspnea after initiating anti-tuberculous therapy (isoniazid [300 mg/day], rifampicin [600 mg/day], ethambutol [750 mg/day], and pyrazinamide [1,500 mg/day]) for tuberculous pleuritis. His oral hygiene status was poor. The patient had no significant past medical history. Read More

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The Effect of Tranexamic Acid for Visualization on pump pressure and visualization during Arthroscopic Rotator Cuff Repair: a blinded, randomized controlled trial.

J Shoulder Elbow Surg 2022 Aug 12. Epub 2022 Aug 12.

Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

Introduction: Tranexamic acid (TXA) has been used surgically to decrease blood loss. The ability of TXA to improve arthroscopic visualization and allow for reduction in pump pressure is unknown. The purpose of this study was to determine the effect of intravenous TXA on change in pump pressure and visualization during arthroscopic rotator cuff repair. Read More

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Predicting Visual Outcomes in Choroidal Osteoma Treated with Anti-vascular Endothelial Growth Factor.

Am J Ophthalmol 2022 Aug 12. Epub 2022 Aug 12.

Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Eonjuro 211, Gangnam-gu, Seoul, Republic of Korea. Electronic address:

Purpose: To determine potential factors associated with the long-term visual prognoses in patients with choroidal osteoma undergoing anti-vascular endothelial growth factor (VEGF) treatment.

Design: Retrospective case series METHODS: Patients diagnosed at tertiary high-volume hospitals between January 2000 and December 2020 were evaluated. The primary outcome measure was visual acuity at 5 years' follow-up. Read More

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MRI of a middle ear cholesteatoma in a cat.

Vet Radiol Ultrasound 2022 Aug 15. Epub 2022 Aug 15.

Pieper Memorial Veterinary Center, Middletown, Connecticut, USA.

A 9-year-old Maine coon cat presented with right-sided Horner and facial nerve paralysis. Magnetic resonance imaging (MRI) showed a heterogeneously contrast-enhancing mass occupying the right dorsolateral compartment of the tympanic cavity and extending into the ventromedial compartment, which was expanded and fluid filled. A ventral bulla osteotomy was performed to debulk the soft tissue mass. Read More

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Rapid brain MRI protocols result in comparable differential diagnoses versus a full brain protocol in most canine and feline cases.

Vet Radiol Ultrasound 2022 Aug 15. Epub 2022 Aug 15.

Department of Quantitative Health Sciences, University of Massachusetts Medical School, 368 Plantation St, Worcester, Massachusetts, USA.

Evaluation of brain disease in veterinary patients uses a wide variety of MRI sequences. A shortened protocol that maintains consistency of interpretation would reduce radiologist reporting time, patient anesthetic time, and client cost. The aims of this retrospective, methods comparison, observer agreement study were to evaluate whether abbreviated MRI protocols alter differential diagnoses and recommendations compared to our institution's standard protocol; evaluate interobserver agreement on standard brain MRIs; and assess whether differential diagnoses change after postcontrast images. Read More

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Mantle cell lymphoma with aseptic meningitis mimicking hydrocephalus on brain imaging.

Nagoya J Med Sci 2022 May;84(2):470-476

Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.

An 83-year-old man underwent head computed tomography (CT) to investigate cognitive decline and gait disturbance and was admitted to undergo a cerebrospinal fluid (CSF) tap test for suspected idiopathic normal-pressure hydrocephalus. He had a history of chemotherapy for mantle cell lymphoma (MCL), but CT on admission showed no evidence of recurrence. After admission, his level of consciousness rapidly deteriorated and CSF examination suggested infiltration of MCL into the central nervous system (CNS). Read More

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Coexistence of anti-SOX1 and anti-GABAB receptor antibodies with paraneoplastic limbic encephalitis presenting with seizures and memory impairment in small cell lung cancer: A case report.

Front Immunol 2022 28;13:955170. Epub 2022 Jul 28.

Department of Neurology, First Affiliated Hospital of Jilin University, Changchun, China.

Purpose: Paraneoplastic neurological syndromes associated with autoantibodies are rare diseases that cause abnormal manifestations of the nervous system. Early diagnosis of paraneoplastic neurological syndromes paves the way for prompt and efficient therapy.

Case Report: we reported a 56-year-old man presenting with seizures and rapidly progressive cognitive impairment diagnosed as paraneoplastic limbic encephalitis (PLE) with anti-SRY-like high-mobility group box-1 (SOX-1) and anti-γ-aminobutyric acid B (GABAB) receptor antibodies and finally confirmed by biopsy as small cell lung cancer (SCLC). Read More

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Finite Element Model to Simulate Two-Phase Fluid Flow in Naturally Fractured Oil Reservoirs: Part I.

Reda Abdel Azim

ACS Omega 2022 Aug 25;7(31):27278-27290. Epub 2022 Jul 25.

American University of Kurdistan, Petroleum Engineering Department, Mustafa Barzani Building, Zakho Road, 42001 Duhok, Kurdistan, Iraq.

Naturally fractured reservoirs host more than 20% of the world's total oil and gas reserves. To produce from such reservoirs efficiently, a good understanding of the reservoir behavior at various conditions is essential. This allows us to predict the reservoir performance in advance and assess its economic feasibility. Read More

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Euglycaemic Ketoacidosis Due to Extremely Low-Calorie Intake and Dehydration After Laparoscopic Sleeve Gastrectomy in a Patient with Type 2 Diabetes.

Diabetes Metab Syndr Obes 2022 6;15:2377-2380. Epub 2022 Aug 6.

Department of Endocrinology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People's Republic of China.

Background: Bariatric surgery is an effective therapy for type 2 diabetes mellitus (T2DM) and obesity. Euglycaemic ketoacidosis (EKA) has been reported in patients taking sodium-glucose cotransporter 2 (SGLT2) inhibitors after bariatric surgery. Cases of T2DM complicated with EKA without SGLT2 inhibitors after bariatric surgery are rarely reported. Read More

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Spontaneous clival meningocele.

SAGE Open Med Case Rep 2022 6;10:2050313X221117334. Epub 2022 Aug 6.

Neuroradiology Department, Specialty Hospital of Rabat, Rabat, Morocco.

The occipital bone is an uncommon location for meningoceles protrusion. This condition occurs generally after a severe traumatism or surgical procedure. However, in some rare cases, the herniation can happen spontaneously. Read More

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Conservative treatment for cavity spilling coronary perforations.

Cardiovasc Revasc Med 2022 Aug 8. Epub 2022 Aug 8.

Klinik für Kardiologie, Medizinische Universitätsklinik, Kantonsspital Baselland, Liestal, Switzerland. Electronic address:

Coronary perforation leading to shunting to other cardiac chambers is a rare complication of percutaneous coronary intervention (PCI), and most cases reported aggressive treatment with either a covered stent, coiling, or protamine injection. We report herein two cases, one of a fairly large cavity-spilling perforation of the left anterior descending coronary artery into the right ventricle and one spilling in the coronary vein. Both iatrogenic shunts were treated conservatively, and angiographic follow-up showed spontaneous resolution, suggesting that the outcome in this type of perforation may be favorable with conservative therapy. Read More

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Meconium-Stained Amniotic Fluid: Impact on Prognosis of Neonatal Bacterial Meningitis.

J Trop Pediatr 2022 Aug;68(5)

Department of Pediatrics, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Objectives: Clinical data with respect to the impact of meconium on the prognosis of neonatal bacterial meningitis are scarce. Therefore, in this study, we aimed to determine whether meconium-stained amniotic fluid (MSAF) represents a risk factor for poor prognosis of neonatal bacterial meningitis in a confirmed case population.

Methods: This was a retrospective cohort study of 256 neonates diagnosed with bacterial meningitis hospitalized at one of three hospitals in Shantou, China, between October 2013 and September 2018. Read More

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Wiad Lek 2022 ;75(6):1796-1800


We present the case of a 10-year-old male with recurrent CSF leakage after surgery for an occipital tumor. Initial management of the CSF leak, including debridement, re-exploration, and lumbar drain insertion, failed to address the problem. The last resort was the insertion of the EVD, which managed to stop the leak. Read More

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Primary large B-cell lymphoma of the central nervous system with positive NMDAR antibody: a case report.

BMC Neurol 2022 Aug 12;22(1):298. Epub 2022 Aug 12.

Department of Pathology, Lanzhou University Second Hospital, Cuiyingmen 82, Chengguan District, 730030, Lanzhou, China.

Background: N-methyl-D-aspartate receptor (NMDAR) is an ionotropic glutamate (Glu) receptor that is widely expressed in the central nervous system (CNS), mainly in the hippocampus. We present a case in which the patient had atypical clinical manifestations and was positive for anti-NMDAR antibodies.

Case Presentation: A 40-year-old male was admitted to the hospital with "dizziness and double vision for 2 months". Read More

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Hidden appendix: A case report and literature review of perforated acute appendicitis masquerading as acute cholecystitis.

Int J Surg Case Rep 2022 Aug 8;97:107480. Epub 2022 Aug 8.

Department of General Surgery, Meenakshi Medical College Hospital and Research Institute, Enathur, Kanchipuram, Tamil Nadu 631552, India.

Introduction: Acute appendicitis of the subhepatic appendix is uncommon, and a preoperative diagnosis is difficult without a thorough understanding of the various anatomical locations. Cross-sectional imaging is indispensable for prompt diagnosis and subsequent treatment. Surgery is the standard treatment for perforated appendicitis in the subhepatic region. Read More

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Minimally Invasive Surgical Treatment of Hepatic Hydrothorax Complicated by Empyema: A Case Report.

Innovations (Phila) 2022 Aug 12:15569845221113574. Epub 2022 Aug 12.

Department of Thoracic and Cardiovascular Surgery, 65722Chonnam National University Hwasun Hospital, Chonnam National University School of Medicine, Hwasun, South Korea.

Hepatic hydrothorax complicated by empyema is difficult to manage. A 53-year-old man with liver cirrhosis was admitted for refractory right pleural effusion. He had a pleural catheter inserted 2 months prior. Read More

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[NA Rare Bacterial Pathogen in a Patient with Perihilar Cholangiocarcinoma: Erwinia persicina; First Case From Turkey].

Mikrobiyol Bul 2022 Jul;56(3):574-579

Basakşehir Cam ve Sakura City Hospital, Clinic of Hepatobiliary Surgery, Istanbul, Türkiye.

Members of the Erwiniaceae family, which can be found saprophytic in humans, have been identified several times as an infectious agent after their first identification in 1920. Erwinia persicina was first identified as a plant pathogen by being isolated from cucumber, tomato and banana in 1990, and it was shown to cause disease in many plant species in the following years. E. Read More

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Susceptibility-weighted imaging of cerebral fat embolism: A case report.

Medicine (Baltimore) 2022 Aug;101(32):e29462

Department of Neurology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.

Rationale: Cerebral fat embolism (CFE) is a rare but critical disease in a clinical setting. Considering that manifestations and CT findings of CFE tend to be atypical, this condition is very difficult to diagnose. The purpose of this article was to assess the value of susceptibility-weighted imaging (SWI) in the diagnosis of CFE. Read More

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Neuromyelitis Optica in a Young Woman With Tuberous Sclerosis: Is There an Association?

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221117808

Neurology Department, Wayne State University, Detroit, MI, USA.

Tuberous sclerosis complex (TSC) is a genetic neurocutaneous disorder that presents with multi-organ involvement, including but not limited to hamartomas in the brain, eyes, heart, lung, liver, kidney, and skin. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory, autoimmune, demyelinating, central nervous system disorder, targeting the optic nerves and spinal cord. We report a 30-year-old woman with TSC who developed tingling in the legs that gradually involved her abdomen. Read More

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