31,742 results match your criteria flu vaccination

Are patients with rheumatic diseases on immunosuppressive therapies protected against preventable infections? A cross-sectional cohort study.

RMD Open 2021 Apr;7(1)

Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany.

Objective: To evaluate the prevalence of infections, prevalence of hospitalisation due to infections, the vaccination status and perceived screening of infections prior to the start of biologic disease modifying antirheumatic drugs (bDMARDs) of a patient cohort with chronic inflammatory rheumatic diseases (CIRD).

Methods: Consecutive CIRD patients reporting to our specialised centre were prospectively included (n=975) in this cross-sectional study. Data on comorbidities including infections, treatment, vaccination status, screening for latent tuberculosis infection (LTBI) and hepatitis B (HepB) were collected. Read More

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The impact of influenza vaccination on cardiovascular disease.

Med Clin (Barc) 2021 Apr 5. Epub 2021 Apr 5.

Servicio de Microbiología, Hospital Universitario Río Hortega, Valladolid, España.

Influenza infection has been identified as a triggering or exacerbating factor for cardiovascular events. To analyse the effect of influenza vaccination on cardiovascular disease, a systematic search of studies published between 2009-2019 was conducted. All the studies that evaluated the effect of vaccination against influenza on cardiovascular events and their outcome were considered. Read More

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Efficacy and safety of influenza vaccination during pregnancy: realizing the potential of maternal influenza immunization.

Expert Rev Vaccines 2021 Apr 8. Epub 2021 Apr 8.

Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston TX.

Introduction: Pregnant women are at higher risk of severe complications following influenza infection compared to the general population. Influenza vaccination during pregnancy can offer direct protection to pregnant women and passive immunity to infants up to six months of age via maternal antibodies. Pregnant women are a high priority group for influenza immunization. Read More

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Annual influenza vaccination effect on the susceptibility to COVID-19 infection.

Cent Eur J Public Health 2021 Mar;29(1):14-17

Infectious Diseases Department, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Objectives: We aimed to study the effect of seasonal influenza (flu) vaccination on the susceptibility to coronavirus disease 2019 (COVID-19).

Methods: A total of 203 healthcare workers of a pandemic centre of Istanbul, Turkey, were included in this retrospective study. According to the presence or absence of flu vaccination, participants were divided into group 1 and group 2. Read More

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Investigating the procurement system for understanding seasonal influenza vaccine brand availability in Europe.

PLoS One 2021 8;16(4):e0248943. Epub 2021 Apr 8.

Seqirus, Amsterdam, The Netherlands.

Background: Timely knowledge of which influenza vaccine brands are procured and where is of interest to inform site-selection for brand-specific influenza vaccine effectiveness (VE) studies. Vaccine procurement is a key determinant of brand availability. We therefore sought to understand how the procurement for seasonal influenza vaccine in Europe is organized, how this drives brand availability and how procurement data could enable to determine brand availability pre-season. Read More

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Better, Faster, Stronger: mRNA Vaccines Show Promise for Influenza Vaccination in Older Adults.

Immunol Invest 2021 Apr 8:1-11. Epub 2021 Apr 8.

Center on Aging and Department of Immunology, University of Connecticut School of Medicine, Farmington, Connecticut, USA.

Older adults have diminished immune responses that lead to increased susceptibility and severity of infectious diseases. Influenza is a leading killer of older adults despite the availability of seasonal influenza vaccination. Influenza vaccines are strain specific, and their efficacy varies greatly year to year based on how well the vaccine virus matches the circulating strains. Read More

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SARS-CoV-2 show no infectivity at later stages in a prolonged COVID-19 patient despite positivity in RNA testing.

J Med Virol 2021 Apr 8. Epub 2021 Apr 8.

Department of Pathology, University of Missouri, Columbia, Missouri, USA.

Inpatient COVID-19 cases present enormous costs to patients and health systems in the United States. Many hospitalized patients may continue testing COVID-19 positive even after resolution of symptoms. Thus, a pressing concern for clinicians is the safety of discharging these asymptomatic patients if they have any remaining infectivity. Read More

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The Impact of Immunization and Use of Oseltamivir on Influenza-Related Hospitalizations: A Population-Based Study.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211005906

Hospital for Special Surgery, New York, NY, USA.

Background: As the COVID-19 pandemic continues into flu season, it is critical to minimize hospitalizations to maximize capacity and preserve critical care resources. We sought to identify risk factors for influenza-related hospitalization, specifically the role of immunization and oseltamivir prescriptions.

Methods: Patients with influenza diagnoses were identified from the MarketScan database (2014-2018). Read More

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The moderating effect of autonomy on promotional health messages encouraging healthcare professionals' to get the influenza vaccine.

J Exp Psychol Appl 2021 Apr 8. Epub 2021 Apr 8.

Department of Management.

Rates of flu vaccination among healthcare professionals often remain lower than recommended guidelines. We tested whether autonomy-supportive communication styles could improve the effectiveness of statements seeking to promote professionals' flu vaccination uptake. A pilot study established that statements presented in an autonomy-supportive communication style (i. Read More

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SARS-CoV-2 infection and H1N1 vaccination: does a relationship between the two factors really exist? A retrospective analysis of a territorial cohort in Ferrara, Italy.

Eur Rev Med Pharmacol Sci 2021 Mar;25(6):2795-2801

Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

Objective: SARS-CoV-2 has been compared with other strains of coronaviruses, SARS-CoV and MERS-CoV, and with the flu viruses: all of them manifest themselves with respiratory symptoms and, although their genetic patterns are similar, the spread of SARS-CoV-2 infection has quickly reached global dimensions, demonstrating that SARS-CoV-2 is a virus with greater spreading capacity, albeit less lethal. Compared with influenza viruses, coronaviruses have a longer incubation period and the patients with coronaviruses' syndromes develop more severe diseases requiring frequent hospitalizations and intensive care admissions. The aim was to explore the relationships between seasonal influenza vaccination and coronavirus infection and to understand whether this hypothetic role by the flu vaccines modifies SARS-CoV-2 infection's outcomes. Read More

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Attitudes towards COVID-19 vaccination, vaccine hesitancy and intention to take the vaccine.

Pharm Pract (Granada) 2021 Jan-Mar;19(1):2317. Epub 2021 Mar 22.

BSc.,MSc, PhD. Professor. Department of Mathematics, Faculty of Science, University of Malta. Msida (Malta).

Background: The pandemic is at a paradoxical stage, with vaccine roll out initiated but a significantly elevated level of infection and death. Hope for recovery lies in high equitable vaccine uptake.

Objective: The study aimed to: i) explore attitudes and factors influencing attitudes, towards the COVID-19 vaccine amongst people living in Malta, ii) identify the reasons as to why individuals are unsure or unwilling to take the vaccine. Read More

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Transmission and protection against re-infection in the ferret model with the SARS-CoV-2 USA-WA1/2020 reference isolate.

J Virol 2021 Apr 7. Epub 2021 Apr 7.

Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, Pennsylvania, USA.

SARS-CoV-2 has initiated a global pandemic and several vaccines have now received emergency use authorization. Using the reference strain SARS-CoV-2 USA-WA1/2020, we evaluated modes of transmission and the ability of prior infection or vaccine-induced immunity to protect against infection in ferrets. Ferrets were semi-permissive to infection with the USA-WA1/2020 isolate. Read More

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Development of a Genetically Stable Live Attenuated Influenza Vaccine Strain using an Engineered High-Fidelity Viral Polymerase.

J Virol 2021 Apr 7. Epub 2021 Apr 7.

Department of Microbiology, Kawasaki Medical School, Okayama, Japan

RNA viruses demonstrate a vast range of variants, called quasispecies, due to error-prone replication by viral RNA-dependent RNA polymerase. Although live attenuated vaccines are effective in preventing RNA virus infection, there is a risk of reversal to virulence post their administration. To test the hypothesis that high-fidelity viral polymerase reduces the diversity of influenza virus quasispecies, resulting in inhibition of reversal of the attenuated phenotype, we first screened for a high-fidelity viral polymerase using serial virus passages under selection with a guanosine analog ribavirin. Read More

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Broadly protective CD8 T cell immunity to highly conserved epitopes elicited by heat shock protein gp96-adjuvanted influenza monovalent split vaccine.

J Virol 2021 Apr 7. Epub 2021 Apr 7.

Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China

Currently, immunization with inactivated influenza virus vaccines is the most prevalent method to prevent infections. However, licensed influenza vaccines provide only strain-specific protection and need to be updated and administered yearly; thus, new vaccines that provide broad protection against multiple influenza subtypes are required. In this study, we demonstrated that intradermal immunization with gp96-adjuvanted seasonal influenza monovalent H1N1 split vaccine could induce cross-protection against both group 1 and group 2 influenza A viruses in BALB/c mice models. Read More

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Willingness to vaccinate against influenza A (H1N1)pdm09 among Brazilian civil servants: Pró-Saúde cohort study.

Rev Bras Epidemiol 2021 2;24:e210014. Epub 2021 Apr 2.

Department of Epidemiology, Institute of Social Medicine, Universidade do Estado do Rio de Janeiro - Rio de Janeiro (RJ), Brazil.

Objective: To investigate sociodemographic factors associated with the willingness to take the pandemic influenza vaccine.

Methods: This is a cross-sectional study of Brazilian civil servants participating in the fourth wave (2012-2013) of the longitudinal Pró-Saúde Study. Associations were expressed as odds ratios (OR) and 95% confidence intervals (95%CI), estimated by multivariate logistic regression models. Read More

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The effect of calcium and magnesium on activity, immunogenicity, and efficacy of a recombinant N1/N2 neuraminidase vaccine.

NPJ Vaccines 2021 Apr 6;6(1):48. Epub 2021 Apr 6.

LID Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Despite the importance of immunity against neuraminidase (NA), NA content and immunogenicity are neglected in current influenza vaccines. To address this, a recombinant N1/N2 NA vaccine (NAV) was developed. Stability assays were used to determine optimal temperature and buffer conditions for vaccine storage. Read More

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Immunisation Coverage Annual Report 2019.

Commun Dis Intell (2018) 2021 Mar 31;45. Epub 2021 Mar 31.

National Centre for Immunisation Research and Surveillance.

Abstract: Australian Immunisation Register data have been analysed for children aged < 5 years, focusing on changes in vaccination coverage at standard age milestones (12, 24 and 60 months) between 2018 and 2019. 'Fully vaccinated' coverage in 2019 increased by 0.1-0. Read More

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Simultaneous Detection and Mutation Surveillance of SARS-CoV-2 and co-infections of multiple respiratory viruses by Rapid field-deployable sequencing.

Med (N Y) 2021 Mar 31. Epub 2021 Mar 31.

Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.

Background: Strategies for monitoring the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are crucial for combating the pandemic. Detection and mutation surveillance of SARS-CoV-2 and other respiratory viruses require separate and complex workflows that rely on highly-specialized facilities, personnel, and reagents. To date, no method can rapidly diagnose multiple viral infections and determine variants in a high-throughput manner. Read More

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National Inpatient Immunization Patterns: Variation in Practice and Policy Between Vaccine Types.

Hosp Pediatr 2021 Apr 5. Epub 2021 Apr 5.

The Saban Research Institute and Southern California Clinical and Translational Science Institute Biostatistics Core, Children's Hospital Los Angeles, Los Angeles, California; and.

Background: Many hospitalized children are underimmunized, yet little is known about current systems supporting inpatient vaccination. We aim to describe national pediatric inpatient immunization practices and determine if variation exists among adolescent, childhood, and influenza vaccines.

Methods: An electronic survey regarding hospital vaccination practices was sent to physician, nurse, and pharmacy leaders via the Pediatric Research in Inpatient Settings Network in spring 2019. Read More

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Identification of the dominant non-neutralizing epitope in the haemagglutinin of H7N9 avian influenza virus.

Virus Res 2021 Apr 2;298:198409. Epub 2021 Apr 2.

Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, China; Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China. Electronic address:

H7N9 avian influenza vaccines induce high levels of non-neutralizing (nonNeu) antibodies against the haemagglutinin (HA). However, the antigenic epitopes underlying this particular antibody response are still undefined. In this study, a panel of 13 monoclonal antibodies (mAbs) against the HA protein of H7N9 virus was generated and 12 of them had no hemagglutination inhibition and virus neutralizing activities. Read More

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The Rapid Development and Early Success of Covid 19 Vaccines Have Raised Hopes for Accelerating the Cancer Treatment Mechanism.

S Amanpour

Arch Razi Inst 2021 03 1;76(1):1-6. Epub 2021 Mar 1.

Cancer Biology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

The Covid-19 pandemic has brought about rapid change in medical science. The production of new generation vaccines for this disease has surprised even their most optimistic supporters. Not only have these vaccines proven to be effective, but the importance of this disease and pandemic situation also significantly shortened the long-standing process of validating such products. Read More

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Pharmacy, workplace or primary care? Where Australian adults get their influenza vaccines.

Aust N Z J Public Health 2021 Apr 5. Epub 2021 Apr 5.

Biosecurity Program, The Kirby Institute, University of New South Wales.

Objective: To estimate the proportion of influenza vaccines administered in non-medical settings in Australia in 2019 and identify factors associated with vaccination site.

Methods: We surveyed 1,444 Australian adults online in October 2019. To identify factors associated with vaccination site, we used Pearson's chi-square test. Read More

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SARS-CoV-2 vaccine development and how Brazil is contributing.

Genet Mol Biol 2021 29;44(1 Suppl 1):e20200320. Epub 2021 Mar 29.

Instituto Butantan, Laboratório de Desenvolvimento de Vacinas, São Paulo, SP, Brazil.

The SARS-CoV-2 coronavirus pandemic calls for coordinated efforts by the scientific community for the development of vaccines. The most advanced strategies have focused on modifications of technologies that were already under development for other viruses, such as SARS, MERS, and even Influenza. Classic and new technologies, such as inactivated and attenuated viruses (non-replicative and replicative), DNA and mRNA vaccines, and nanoparticles containing SARS-CoV-2 antigens, are some of the strategies currently investigated. Read More

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Vaccination Rates and Family Barriers Among Children with Inflammatory Bowel Disease.

Crohns Colitis 360 2020 Jul 7;2(3). Epub 2020 Jul 7.

Assistant Professor of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition and Adolescent Comparative Effectiveness Research, Indiana University School of Medicine, 705 Riley Hospital Drive ROC 4210, Indianapolis, IN 46202, 317-944-3774.

Background: Many children with inflammatory bowel disease (IBD) are taking immunosuppressant medications that place them at risk for vaccine preventable diseases. Despite national guidelines, children with IBD have low vaccination rates. Adult data suggest that there is concern about the safety of vaccines. Read More

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Slowing the spread of COVID-19: Review of "Social distancing" interventions deployed by public transit in the United States and Canada.

Transp Policy (Oxf) 2021 Jun 27;106:25-36. Epub 2021 Mar 27.

The University Transportation Research Center, Region 2, The City College of New York, New York, 10031, USA.

This paper presents a review of social distancing measures deployed by transit agencies in the United States and Canada during the COVID-19 pandemic and discusses how specific operators across the two countries have implemented changes. Challenges and impacts on their operations are also provided. Social distancing is one of the community mitigation measures traditionally implemented during influenza pandemics and the novel coronavirus pandemic. Read More

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A retrospective cohort study assessing relative effectiveness of adjuvanted versus high-dose trivalent influenza vaccines among older adults in the United States during the 2018-19 influenza season.

Vaccine 2021 Mar 30. Epub 2021 Mar 30.

Seqirus Vaccines Ltd., Summit, NJ, USA.

Purpose: To evaluate the relative vaccine effectiveness (rVE) against influenza-related hospitalizations/emergency room (ER) visits, influenza-related office visits, and cardio-respiratory disease (CRD)-related hospitalizations/ER visits and compare all-cause and influenza-related costs associated with two vaccines specifically indicated for older adults (≥65 years), adjuvanted (aTIV) and high-dose trivalent influenza vaccine (TIV-HD), for the 2018-19 influenza season.

Methods: A retrospective analysis of older adults was conducted using claims and hospital data in the United States. For clinical evaluations, adjusted analyses were conducted following inverse probability of treatment weighting (IPTW) to control for selection bias. Read More

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Intranasal Immunization with the Influenza A Virus Encoding Truncated NS1 Protein Protects Mice from Heterologous Challenge by Restraining the Inflammatory Response in the Lungs.

Microorganisms 2021 Mar 26;9(4). Epub 2021 Mar 26.

Smorodintsev Research Institute of Influenza, 197022 St. Petersburg, Russia.

Influenza viruses with an impaired NS1 protein are unable to antagonize the innate immune system and, therefore, are highly immunogenic because of the self-adjuvating effect. Hence, NS1-mutated viruses are considered promising candidates for the development of live-attenuated influenza vaccines and viral vectors for intranasal administration. We investigated whether the immunogenic advantage of the virus expressing only the N-terminal half of the NS1 protein (124 a. Read More

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Achieving Influenza Vaccine Uptake Target in Canada via a Pharmacy-Led Telephone Discussion during the 2019-2020 Season.

Vaccines (Basel) 2021 Mar 26;9(4). Epub 2021 Mar 26.

Department of Obstetrics and Gynaecology, Western University Canada, London, ON N6A 5C2, Canada.

Older adults (≥65 years) are at elevated risk of influenza-related morbidity and mortality. Many developed countries do not achieve the World Health Organization influenza immunization target of 75% in people ≥65 years. We aimed to determine whether a brief pharmacy phone call could increase vaccine uptake of standard and enhanced influenza. Read More

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Factors Associated with COVID-19 Vaccine Hesitancy.

Vaccines (Basel) 2021 Mar 22;9(3). Epub 2021 Mar 22.

Comprehensive Health Research Center, Universidade NOVA de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisboa, Portugal.

It is critical to develop tailored strategies to increase acceptability of the COVID-19 vaccine and decrease hesitancy. Hence, this study aims to assess and identify factors associated with COVID-19 vaccine hesitancy in Portugal. We used data from a community-based survey, "COVID-19 Barometer: Social Opinion", which includes data regarding intention to take COVID-19 vaccines, health status, and risk perception in Portugal from September 2020 to January 2021. Read More

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Antiviral Cyanometabolites-A Review.

Biomolecules 2021 03 22;11(3). Epub 2021 Mar 22.

Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, PL-30-387 Krakow, Poland.

Global processes, such as climate change, frequent and distant travelling and population growth, increase the risk of viral infection spread. Unfortunately, the number of effective and accessible medicines for the prevention and treatment of these infections is limited. Therefore, in recent years, efforts have been intensified to develop new antiviral medicines or vaccines. Read More

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