191 results match your criteria flow slippage

Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage.

Int J Mol Sci 2021 May 27;22(11). Epub 2021 May 27.

Department of Biochemistry & Molecular Biology, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.

Insulin-like growth factor 1 receptor (IGF1R), a receptor-type tyrosine kinase, transduces signals related to cell proliferation, survival, and differentiation. We recently reported that OSI-906, an IGF1R inhibitor, in combination with the Aurora B inhibitor ZM447439 suppresses cell proliferation. However, the mechanism underlying this suppressive effect is yet to be elucidated. Read More

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Steric and Slippage Effects on Mass Transport by Using an Oscillatory Electroosmotic Flow of Power-Law Fluids.

Micromachines (Basel) 2021 May 10;12(5). Epub 2021 May 10.

Departamento de Termofluidos, Facultad de Ingeniería, UNAM, Ciudad de México 04510, Mexico.

In this paper, the combined effect of the fluid rheology, finite-sized ions, and slippage toward augmenting a non-reacting solute's mass transport due to an oscillatory electroosmotic flow (OEOF) is determined. Bikerman's model is used to include the finite-sized ions (steric effects) in the original Poisson-Boltzmann (PB) equation. The volume fraction of ions quantifies the steric effects in the modified Poisson-Boltzmann (MPB) equation to predict the electrical potential and the ion concentration close to the charged microchannel walls. Read More

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STRs: Ancient Architectures of the Genome beyond the Sequence.

J Mol Neurosci 2021 May 30. Epub 2021 May 30.

Division of Medical Genetics, Tabriz Childrens Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

Short tandem repeats (STRs) are commonly defined as short runs of repetitive nucleotides, consisting of tandemly repeating 2-6- bp motif units, which are ubiquitously distributed throughout genomes. Functional STRs are polymorphic in the population, and their variations influence gene expression, which subsequently may result in pathogenic phenotypes. To understand STR phenotypic effects and their functional roles, we describe four different mutational mechanisms including the unequal crossing-over model, gene conversion, retrotransposition mechanism and replication slippage. Read More

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The role of the potential field on occurrence and flow of octane in quartz nanopores.

Phys Chem Chem Phys 2021 May;23(19):11507-11514

College of Science, China University of Petroleum (East China), Qingdao 266580, P. R. China.

Occurrence and flow of hydrocarbons in nanopores are two important issues in the effective exploitation of shale oil reservoirs. In this study, molecular dynamics simulations are employed to investigate the mechanisms about occurrence and flow of octane in slit-shaped quartz nanopores. We show that the occurrence state of octane and, therefore, its flow behavior are profoundly affected by the potential field from quartz walls and adsorption layers if the nanopore width w becomes less than 50 Å. Read More

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Modeling and Simulation of Shale Fracture Attitude.

ACS Omega 2021 Mar 8;6(11):7312-7333. Epub 2021 Mar 8.

Departments of Chemical and Petroleum Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada.

A large number of natural fractures are distributed in shale gas reservoirs. In-depth studying of the attitude of fractures is of great significance for the efficient development of shale gas. In previous studies, the complex three-dimensional discrete fracture networks (DFNs) and transport mechanisms were often not fully considered. Read More

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Evaporation in nano/molecular materials.

Adv Colloid Interface Sci 2021 Apr 23;290:102385. Epub 2021 Feb 23.

Department of Mechanical Engineering, University of Houston, 4726 Calhoun Rd, Houston, TX 77204, USA. Electronic address:

Evaporation is a physical phenomenon with fundamental significance to both nature and technology ranging from plant transpiration to DNA engineering. Various analytical and empirical relationships have been proposed to characterize evaporation kinetics at macroscopic scales. However, theoretical models to describe the kinetics of evaporation from nano and sub-nanometer (molecular) confinements are absent. Read More

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Comparison of a nonpneumatic device to four currently available intermittent pneumatic compression devices on common femoral blood flow dynamics.

J Vasc Surg Venous Lymphat Disord 2021 Feb 1. Epub 2021 Feb 1.

Northshore University Health System, Evanston, Ill.

Objective: The purpose of the present study was to compare common femoral vein blood flow enhancement during external mechanical compression using the novel, nonpneumatic Recovery Force Health Movement and Compressions (MAC) System (Recovery Force USA, Fishers, Ind), and four currently available intermittent pneumatic compression devices.

Methods: The MAC device was compared with the Kendall SCD 700 (Cardinal Health, Dublin, Ohio), Arjo Huntleigh Flowtron ACS900 (Arjo, Malmö, Sweden), ActiveCare+S.F. Read More

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February 2021

Reassessing water slippage in hydrophobic nanostructures.

J Chem Phys 2020 Nov;153(19):191101

State Key Laboratory of Geomechanics and Geotechnical Engineering, Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, Wuhan 430071, China.

Reported data of measured slip lengths in nanostructures span several orders of magnitude, from a few nanometers to tens of micrometers. Small roughness on surfaces caused by structural defects or thermal fluctuations dramatically reduces slippage. Tiny bubbles entrapped on rough surfaces can also affect slippage. Read More

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November 2020

Salinity Independent Flow Measurement of Vertical Upward Gas-Liquid Flows in a Small Pipe Using Conductance Method.

Sensors (Basel) 2020 Sep 15;20(18). Epub 2020 Sep 15.

School of Electrical and Information Engineering, Tianjin University, Tianjin 300072, China.

Flow measurement in gas-liquid two-phase flow is always a challenging work, because of the non-uniform phase distribution, severe slippage effect between phases, and different flow structures. Furthermore, the variation of salinity changes the water conductivity, which brings more difficulties to multiphase flow measurement. In this study, a methodology for flow measurement using the conductance method in gas-liquid two-phase flow with salinity change is proposed. Read More

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September 2020

Restoring arteriovenous access: Pilot study using a scoring balloon in 50 patients.

J R Ross

J Vasc Access 2020 Sep 16:1129729820949403. Epub 2020 Sep 16.

Dialysis Access Institute, Orangeburg, SC, USA.

Background: Arteriovenous access failure is most often due to the development of neointimal hyperplastic stenoses. Balloon angioplasty remains standard of care for endovascular treatment of stenoses obstructing blood flow in hemodialysis fistulas and grafts. Scoring balloon technologies have been developed to disrupt the atheromatous plaque and have shown to be safe and effective for treating stenosis in the hemodialysis access circuit. Read More

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September 2020

Cyclin E2 Promotes Whole Genome Doubling in Breast Cancer.

Cancers (Basel) 2020 Aug 13;12(8). Epub 2020 Aug 13.

The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.

Genome doubling is an underlying cause of cancer cell aneuploidy and genomic instability, but few drivers have been identified for this process. Due to their physiological roles in the genome reduplication of normal cells, we hypothesised that the oncogenes cyclins E1 and E2 may be drivers of genome doubling in cancer. We show that both cyclin E1 () and cyclin E2 () mRNA are significantly associated with high genome ploidy in breast cancers. Read More

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Mesoscopic method to study water flow in nanochannels with different wettability.

Phys Rev E 2020 Jul;102(1-1):013306

MOE Key Laboratory of Thermo-Fluid Science and Engineering, School of Energy and Power Engineering, Xi'an Jiaotong University, Xi'an 710049, China.

Molecular dynamics (MD) simulations is currently the most popular and credible tool to model water flow in nanoscale where the conventional continuum equations break down due to the dominance of fluid-surface interactions. However, current MD simulations are computationally challenging for the water flow in complex tube geometries or a network of nanopores, e.g. Read More

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Visual Field Artifacts From Face Mask Use.

J Glaucoma 2020 10;29(10):989-991

Princess Alexandra Eye Pavilion, NHS Lothian.

Purpose: The coronavirus (COVID-19) pandemic has had a profound impact on how glaucoma care is delivered, necessitating reduced clinic flow, social distancing, and use of face coverings by patients and staff. This case highlights the need to be aware of improperly fitted face masks as a cause of artifact on standard automated perimetry (SAP).

Clinical Presentation: A 32-year-old female underwent SAP with the 24-2 SITA Fast test of the Humphrey Field Analyzer wearing an ear-loop surgical face mask. Read More

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October 2020

Middle Cerebral Artery-to-Middle Cerebral Artery Bypass with Superficial Temporal Artery Interposition Graft for the Treatment of Recurrent Thrombosed Middle Cerebral Artery Aneurysm.

World Neurosurg 2020 11 11;143:17. Epub 2020 Jul 11.

Department of Neurosurgery, Medical College of the University of Ulsan, Asan Medical Center, Seoul, Korea. Electronic address:

Microsurgical treatment of thrombosed middle cerebral artery (MCA) aneurysm is very complicated, especially in recurrent cases. A 48-year-old man presented with a recurrent thrombosed right MCA aneurysm. We performed MCA-to-MCA bypass using a superficial temporal artery (STA) interposition graft and proximal trapping. Read More

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November 2020

Impact of methodological artifact on digested sludge flow curve measurement.

MethodsX 2020 20;7:100972. Epub 2020 Jun 20.

Chemical and Environmental Engineering, School of Engineering, RMIT University, VIC 3000, Australia.

Inconsistent experimental procedures have been used to characterize sludge rheology in literature. This often has resulted in proposing different rheological models for sludge as well as non-comparable data. Any collected rheological data needs to be interpreted considering the methodology used for its collection because otherwise they cannot be used by engineers for design and troubleshooting. Read More

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Effect of slip on the contact-line instability of a thin liquid film flowing down a cylinder.

Phys Rev E 2020 May;101(5-1):053108

College of Pipeline and Civil Engineering, China University of Petroleum (East China), Qingdao 266580, China.

Liquid coating films on solid surfaces exist widely in a plethora of industrial processes. In this study, we focus on the falling of a liquid film on the side surface of a vertical cylinder, where the surface is viewed as slippery, such as a liquid-infused surface. The evolution profiles and flow instability of the advancing contact line are comprehensively analyzed. Read More

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Ab initio nanofluidics: disentangling the role of the energy landscape and of density correlations on liquid/solid friction.

Nanoscale 2020 May;12(20):10994-11000

Department of Chemistry, Universität Zürich, 8057 Zürich, Switzerland.

Despite relevance to water purification and renewable energy conversion membranes, the molecular mechanisms underlying water slip are poorly understood. We disentangle the static and dynamical origin of water slippage on graphene, hBN and MoS2 by means of large-scale ab initio molecular dynamics. Accounting for the role of the electronic structure of the interface is essential to determine that water slips five and eleven times faster on graphene compared to hBN and to MoS2, respectively. Read More

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Preferential Killing of Tetraploid Colon Cancer Cells by Targeting the Mitotic Kinase PLK1.

Cell Physiol Biochem 2020 Apr;54(2):303-320

Department of Laboratory Medicine, Translational Cancer Research, Faculty of Medicine, Lund University, Lund, Sweden,

Background/aims: Chromosomal instability is a well-known factor in the progression of different types of cancer, including colorectal cancer. Chromosomal instability results in severely rearranged karyotypes and aneuploidy. Tetraploidy constitutes an intermediate phase during the polyploidy/aneuploidy cascade in oncogenesis, and tetraploid cells are particularly resistant to chemotherapy. Read More

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A novel physical mechanism of liquid flow slippage on a solid surface.

Sci Adv 2020 Mar 27;6(13):eaaz0504. Epub 2020 Mar 27.

Department of Fundamental Engineering, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.

Viscous liquids often exhibit flow slippage on solid walls. The occurrence of flow slippage has a large impact on the liquid transport and the resulting energy dissipation, which are crucial for many applications. It is natural to expect that slippage takes place to reduce the dissipation. Read More

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Roughness-Induced Friction on Liquid Foams.

Phys Rev Lett 2020 Mar;124(11):118003

Université Paris-Saclay, CNRS, Laboratoire de Physique des Solides, 91405 Orsay, France.

Complex liquids flow is known to be drastically affected by the roughness condition at the interfaces. We combined stresses measurements and observations of the flow during the motion of different rough surfaces in dry liquid foams. We visually show that three distinct friction regimes exist: slippage, stick-slip motion, and anchored soap films. Read More

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Wettability effect on wave propagation in saturated porous medium.

J Acoust Soc Am 2020 Feb;147(2):911

Department of Seismology, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Carretera Ensenada-Tijuana No. 3918, Zona Playitas, Ensenada, BC, 22860, Mexico.

Micro-fluid mechanics studies have revealed that fluid slip on the boundary of a flow channel is a quite common phenomenon. In the context of a fluid-saturated porous medium, this implies that the fluid slippage increases with the increase of the hydrophobicity, which is the non-wetting degree. Previous studies find that wettability of the pore surface is strongly related to the slippage, which is characterized by slip length. Read More

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February 2020

Relative Permeability Characteristics During Carbon Capture and Sequestration Process in Low-Permeable Reservoirs.

Materials (Basel) 2020 Feb 22;13(4). Epub 2020 Feb 22.

China University of Petroleum (Beijing), Beijing 102249, China.

The injection of carbon dioxide (CO) in low-permeable reservoirs can not only mitigate the greenhouse effect on the environment, but also enhance oil and gas recovery (EOR). For numerical simulation work of this process, relative permeability can help predict the capacity for the flow of CO throughout the life of the reservoir, and reflect the changes induced by the injected CO. In this paper, the experimental methods and empirical correlations to determine relative permeability are reviewed and discussed. Read More

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February 2020

Exploring Anomalous Fluid Behavior at the Nanoscale: Direct Visualization and Quantification via Nanofluidic Devices.

Acc Chem Res 2020 02 10;53(2):347-357. Epub 2020 Jan 10.

Department of Mechanical and Industrial Engineering , University of Toronto , Toronto , Ontario M5S 3G8 , Canada.

Nanofluidics is the study of fluids under nanoscale confinement, where small-scale effects dictate fluid physics and continuum assumptions are no longer fully valid. At this scale, because of large surface-area-to-volume ratios, the fluid interaction with boundaries becomes more pronounced, and both short-range steric/hydration forces and long-range van der Waals forces and electrostatic forces dictate fluid behavior. These forces lead to a spectrum of anomalous transport and thermodynamic phenomena such as ultrafast water flow, enhanced ion transport, extreme phase transition temperatures, and slow biomolecule diffusion, which have been the subject of extensive computational studies. Read More

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February 2020

Electrotunable Lubrication with Ionic Liquids: the Effects of Cation Chain Length and Substrate Polarity.

ACS Appl Mater Interfaces 2020 Jan 8;12(3):4105-4113. Epub 2020 Jan 8.

Department of Chemistry, Molecular Sciences Research Hub , Imperial College , W12 0BZ London , U.K.

Electrotunable lubrication with ionic liquids (ILs) provides dynamic control of friction with the prospect to achieve superlubrication. We investigate the dependence of the frictional and structural forces with 1-,2-methyl-imidazolium tetrafluoroborate [CMIM][BF] ( = 2, 4, 6) ILs as a lubricant on the molecular structure of the liquid, normal load, and polarity of the electrodes. Using non-equilibrium molecular dynamics simulations and coarse-grained force-fields, we show that the friction force depends significantly on the chain length of the cation. Read More

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January 2020

Direct Simulation Monte Carlo investigation of fluid characteristics and gas transport in porous microchannels.

Sci Rep 2019 Nov 20;9(1):17183. Epub 2019 Nov 20.

Department of Mechanical Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, P.O. Box 91775-1111, Mashhad, Iran.

The impetus of the current research is to use the direct simulation Monte Carlo (DSMC) algorithm to investigate fluid behaviour and gas transport in porous microchannels. Here, we demonstrate DSMC's capability to simulate porous media up to 40% porosity. In this study, the porous geometry is generated by a random distribution of circular obstacles through the microchannel with no interpenetration between the obstacles. Read More

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November 2019

Flow Measurement of Oil-Water Two-Phase Flow at Low Flow Rate Using the Plug-in Conductance Sensor Array.

Sensors (Basel) 2019 Oct 25;19(21). Epub 2019 Oct 25.

School of Electrical and Information Engineering, Tianjin University, Tianjin 300072, China.

In order to improve the flow measurement accuracy of oil-water two-phase flow at low flow rate, this paper presents a plug-in conductance sensor array (PICSA) for the measurement of water holdup and cross-correlation velocity. Due to the existence of the insert body in PICSA, the effect of slippage and the non-uniform distribution of dispersed phase on the measurement of oil-water two-phase flow at low flow rate can be reduced. The finite element method is used to analyze the electric field distribution characteristics of the plug-in conductance sensor, and the sensor geometry is optimized. Read More

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October 2019

Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer.

Onco Targets Ther 2019 24;12:7877-7886. Epub 2019 Sep 24.

Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, People's Republic of China.

Purpose: To explore if bexarotene (BEX) synergistically enhances docetaxel (DTX) cytotoxicity in castration-resistant prostate cancer cell lines.

Materials And Methods: MTT assay was used to measure the cytotoxic effect of DTX and BEX on castration-resistant prostate cancer (CRPC) cell proliferation and the combination index (CI) values calculated to analyze the interaction between DTX and BEX. Flow cytometry and Western blot analysis identified the underlying mechanism for the synergistic effect of BEX and DTX. Read More

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September 2019

Topology and stochasticity of turbulent magnetic fields.

Phys Rev E 2019 Jul;100(1-1):013201

Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218, USA.

We present a mathematical formalism for the topology and stochasticity of vector fields based on renormalization group methodology. The concept of a scale-split energy density, ψ_{l,L}=B_{l}·B_{L}/2 for vector field B(x,t) renormalized at scales l and L, is introduced in order to quantify the notion of the field topological deformation, topology change, and stochasticity level. In particular, for magnetic fields, it is shown that the evolution of the field topology is directly related to the field-fluid slippage, which has already been linked to magnetic reconnection in previous work. Read More

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Large slippage and depletion layer at the polyelectrolyte/solid interface.

Soft Matter 2019 Aug 25;15(31):6308-6317. Epub 2019 Jul 25.

Univ. Grenoble Alpes, CNRS, LIPhy, 38000 Grenoble, France.

The slippage of polymer solutions on solid surfaces is often attributed to a depletion layer whose origin, thickness, and interaction with the flow are poorly understood. Using a Dynamic Surface Force Apparatus we report a structural and nanorheological study of the interface between hydrolyzed poly-acrylamide solutions and platinum surfaces. Polyelectrolyte chains adsorb on the surfaces in a thin charged layer, acting as a nonattractive wall for the bulk solution. Read More

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Analysis of dual solution for MHD flow of Williamson fluid with slippage.

Heliyon 2019 Mar 18;5(3):e01345. Epub 2019 Mar 18.

Faculty of Mathematics and Statistics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam.

This study investigates the numerical solutions of MHD boundary layer and heat transfer of the Williamson fluid flow on the exponentially vertical shrinking sheet, having variable thickness and thermal conductivity under effects of the velocity and thermal slip parameters. It is also assumed that shrinking/stretching velocity, as well as the wall temperature, has the exponential function form. In this study, the continuity, momentum and energy equations with buoyancy parameter and Hartmann number are incorporated especially in the Williamson fluid flow case. Read More

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