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CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway.

J Exp Clin Cancer Res 2022 Aug 13;41(1):246. Epub 2022 Aug 13.

Department of Dermatology, Xiangya Hospital, Central South University; Hunan Key Laboratory of Skin Cancer and Psoriasis and Hunan Engineering Research Center of Skin Health and Disease; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Xiangya Road #87, Changsha, 410008, Hunan, China.

Background: Malignant transformation of the epidermis is an essential process in the pathogenesis of cutaneous squamous-cell carcinoma (cSCC). Although evidence has demonstrated that CD147 plays key roles in various tumors, the role of CD147 in epidermal malignant transformation in vivo remains unclear.

Methods: Epidermal CD147-overexpression or knockout (Epi or Epi) transgenic mouse models were generated for in vivo study. Read More

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A high-throughput microfluidic device based on controlled incremental filtration to enable centrifugation-free, low extracorporeal volume leukapheresis.

Sci Rep 2022 Aug 13;12(1):13798. Epub 2022 Aug 13.

Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd, Houston, TX, 77204-5060, USA.

Leukapheresis, the extracorporeal separation of white blood cells (WBCs) from red blood cells (RBCs) and platelets (PLTs), is a life-saving procedure used for treating patients with cancer and other conditions, and as the initial step in the manufacturing of cellular and gene-based therapies. Well-tolerated by adults, leukapheresis poses a significant risk to neonates and low-weight infants because the extracorporeal volume (ECV) of standard centrifugation-based machines represents a particularly large fraction of these patients' total blood volume. Here we describe a novel high-throughput microfluidic device (with a void volume of 0. Read More

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WO/Ag/ZnO S-scheme heterostructure thin film spinning disc photoreactor for intensified photodegradation of cephalexin antibiotic.

Chemosphere 2022 Aug 10:135812. Epub 2022 Aug 10.

Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.

The presence of antibiotics in wastes and drinking water has led to serious environmental and health concerns, further necessitating the development of an advanced sustainable strategy to eliminate antibiotics from aquatic media. In this context, the present research reports the successful fabrication of a spinning disc photoreactor (SDPR) supported ZnO/Ag/WO S-scheme visible-light-driven thin-film photocatalyst to study the degradation of cephalexin (CPX) as a target pollutant under blue light irradiation. The optical, electrochemical and physicochemical characterization of the as-prepared thin-film samples were carried out by XRD, top-view FE-SEM, EDS-mapping, UV-Vis-DRS, contact angle, EIS, transient photocurrent, mott Schottky and AFM techniques. Read More

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Glutathione S-transferase Mu 3 is associated to in vivo fertility, but not sperm quality, in bovine.

Animal 2022 Aug 10;16(9):100609. Epub 2022 Aug 10.

Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, ES-17003 Girona, Spain; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, ES-17003 Girona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), ES-08010 Barcelona, Spain. Electronic address:

In the dairy breeding industry, pregnancy of dairy cows is essential to initiate milk production, so that high fertility rates are required to increase their productivity. In this regard, sperm proteins that are indicative of sperm quality and/or fertility have become an important target of study. Glutathione S-transferase Mu 3 (GSTM3) has been established as a fertility and sperm quality parameter in humans and pigs and, consequently, it might be a potential biomarker in cattle. Read More

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Effect of high-flow nasal cannula on mechanical ventilator duration in bronchiolitis patients.

Respir Med 2022 Aug 5;201:106946. Epub 2022 Aug 5.

Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: High-flow nasal cannula (HFNC) therapy is a widely used non-invasive respiratory support that may decrease invasive mechanical ventilation. This study evaluated the real-world effect of HFNC on the duration of mechanical ventilation among acute bronchiolitis patients on a nationwide level.

Methods: We retrospectively analyzed bronchiolitis patients (28 days-3 years old) who were admitted to tertiary hospitals for respiratory support from 2012 to 2019 using the Korean National Health Insurance database. Read More

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Coronary microembolization sheep model by adjusting the number of microspheres based on coronary blood flow.

Artif Organs 2022 Aug 12. Epub 2022 Aug 12.

The University of Tokyo, Department of Cardiac Surgery, 7-3-1, Hongo, Bunkyo, Tokyo, Japan.

Background: A heart failure model using coronary microembolization in large animals is indispensable for medical research. However, the heterogeneity of myocardial response to microembolization is a limitation. We hypothesized that adjusting the number of injected microspheres according to coronary blood flow could stabilize the severity of heart failure. Read More

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Enhanced thermal effectiveness for electroosmosis modulated peristaltic flow of modified hybrid nanofluid with chemical reactions.

Sci Rep 2022 Aug 12;12(1):13756. Epub 2022 Aug 12.

Department of Mathematics, COMSATS University Islamabad, Islamabad, Pakistan.

In this analysis, the thermal and flow properties of modified hybrid nanofluids (MNFs) have been investigated under the effects of electroosmosis and homogeneous-heterogeneous chemical reactions. Three types of nanoparticles of Cu, CuO, and AlO are utilized to monitor the performance of the MNFs with water as a working liquid. The determination of the heating phenomenon is explored by incorporating the effects of NPs shape, temperature reliant viscosity, Joule heating, heat generation/absorption and viscous dissipation. Read More

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Immediate Effects of Manipulating Footwear or Cadence on the Lower Limb Biomechanics of Female Masters Runners.

J Appl Biomech 2022 Aug 11:1-8. Epub 2022 Aug 11.

Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, BC,Canada.

The objective of this study was to compare the immediate effects of modifications to footwear or cadence on lower limb biomechanics of female Masters runners. After analyzing habitual treadmill running biomechanics in 20 female runners (52.4 [8. Read More

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Degradation of micropollutants in flow-through UV/chlorine reactors: Kinetics, mechanism, energy requirement and toxicity evaluation.

Chemosphere 2022 Aug 9:135890. Epub 2022 Aug 9.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China.

The degradation of three micropollutants (i.e., atrazine (ATZ), sulfamethoxazole (SMX) and metoprolol (MET)) was comprehensively investigated in flow-through UV/chlorine reactors. Read More

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Optimising profitability and productivity of pasture-based dairy farms with automatic milking systems.

Animal 2022 Aug 9;16(9):100605. Epub 2022 Aug 9.

Dairy Science Group, School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camden, NSW 2567, Australia.

There is a large variability in profitability and productivity between farms operating with automatic milking systems (AMS). The objectives of this study were to identify the physical factors associated with profitability and productivity of pasture-based AMS and quantify how changes in these factors would affect farm productivity. We utilised two different datasets collected between 2015 and 2019 with information from commercial pasture-based AMS farms. Read More

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Tomato growth promotion by the fungal endophytes Serendipita indica and Serendipita herbamans is associated with sucrose de-novo synthesis in roots and differential local and systemic effects on carbohydrate metabolisms and gene expression.

J Plant Physiol 2022 Jul 8;276:153755. Epub 2022 Jul 8.

Department of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Adaptive Biotechnologies, Global Change Research Institute, Czech Academy of Sciences, Brno, Czech Republic. Electronic address:

Plant growth-promoting and stress resilience-inducing root endophytic fungi represent an additional carbohydrate sink. This study aims to test if such root endophytes affect the sugar metabolism of the host plant to divert the flow of resources for their purposes. Fresh and dry weights of roots and shoots of tomato (Solanum lycopersicum) colonised by the closely related Serendipita indica and Serendipita herbamans were recorded. Read More

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Removal of antibiotics from milk via ozonation in a vortex reactor.

J Hazard Mater 2022 Jul 20;440:129642. Epub 2022 Jul 20.

Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, Turin 10125, Italy. Electronic address:

Antibiotics (ABX) residues occur frequently in milk, causing considerable wastage of medicated milk and serious economic losses, and making the issue a burden for the dairy industry. Improper disposal of medicated milk harms dairy production, animal welfare, and the environment. This work studies the use of ozonation in a vortex reactor for removing ceftiofur hydrochloride (CEF), sulfamonomethoxine sodium (SMM), marbofloxacin (MAR) and oxytetracycline (OTC) from milk. Read More

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Biofabrication and characterization of multispecies electroactive biofilms in stratified paper-based scaffolds.

Analyst 2022 Aug 12. Epub 2022 Aug 12.

Bioelectronics & Microsystems Laboratory, Department of Electrical & Computer Engineering, State University of New York at Binghamton, Binghamton, New York, 13902, USA.

Bioelectrochemical technologies have attracted significant scientific interest because the effective bacterial electron exchange with external electrodes can provide a sustainable solution that joins environmental remediation and energy recovery. Multispecies electroactive bacterial biofilms are catalysts that will drive the operation of bioelectrochemical devices. Unfortunately, there is a lack of understanding of key mechanisms determining their electron-generating capabilities and syntrophic relations within microbial communities in biofilms. Read More

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Graphene-Coated PVDF/PAni Fiber Mats and Their Applications in Sensing and Nanogeneration.

ACS Appl Mater Interfaces 2022 Aug 12. Epub 2022 Aug 12.

Department of Mechanical Engineering, University of Texas Rio Grande Valley, Edinburg, Texas78539, United States.

Forcespinning is a powerful technique to produce fiber systems with suitable properties for a vast array of applications. This study investigates the sensing and energy generation performance of PVDF/PAni fiber mat systems made by the forcespinning method with and without graphene coating. The developed fiber mats were coated with graphene nanoflakes by drop-casting. Read More

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Head and thorax elevation prevents the rise of intracranial pressure during extracorporeal resuscitation in swine.

Shock 2022 Aug 9. Epub 2022 Aug 9.

Université de Paris, Necker University Hospital, Assistance Publique-Hôpitaux de Paris, SAMU de Paris-ICU, F-75015, Paris France.

Aim: Head and thorax elevation during cardio-pulmonary resuscitation improves cerebral hemodynamics and ultimate neurological outcome after cardiac arrest. Its effect during extracorporeal cardiopulmonary resuscitation (E-CPR) is unknown. We tested whether this procedure could improve hemodynamics in swine treated by E-CPR. Read More

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Spray drying and nano spray drying as manufacturing methods of drug-loaded polymeric particles.

Polim Med 2022 Aug 12. Epub 2022 Aug 12.

Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Kraków, Poland.

In this review, benefits and drawbacks of the process of spray drying and nano spray drying with regard to the manufacturing of polymeric particles for pharmaceutical applications are discussed. Spray drying has been used for many years in the food, chemical and pharmaceutical industries for converting liquids into solids, in order to form products of uniform appearance. The construction of spray dryer enables to atomize the liquid into small droplets, which ensures a large surface area for heat and mass transfer, and significantly shortens the processing. Read More

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Investigation of the synergistic effect of melt-extension and nanofiller on the crystal-crystal phase transition from form II to I of isotactic polybutene-1.

Soft Matter 2022 Aug 12. Epub 2022 Aug 12.

National Engineering Research Center for Advanced Polymer Processing Technology, The Key Laboratory of Material Processing and Mold of Ministry of Education, College of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450002, P. R. China.

New questions and conjectures are raised on the crystal-crystal phase transition of isotactic polybutene-1 (iPB-1) containing nanofiller in the flow field. In this work, we investigate the phase transition from flow-induced oriented form II to I in iPB-1 blends with multi-walled carbon nanotubes (MWCNTs) with a homemade two-drum extensional rheometer combined with wide-angle X-ray diffraction (WAXD) measurements. The MWCNTs show a limited promoting effect on the phase transition kinetics under quiescent conditions, while the phase transition kinetic is highly accelerated with the impose of melt-extension. Read More

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Human lung vascular endothelium may limit viral replication and recover in time upon the infection with rhinovirus HRV16.

APMIS 2022 Aug 11. Epub 2022 Aug 11.

Department of Immunology and Allergy, Chair of Pulmonology, Rheumatology and Clinical Immunology, Medical University of Lodz, Poland;Pomorska 251, 92-213 Lodz, Poland.

Vascular endothelium is a semi-permeable barrier that regulates the flow of nutrients, ions, cytokines, and immune cells between blood and tissues. Barrier properties of endothelium, its ability to regenerate, and the potential for secretion of inflammatory mediators play a crucial role in maintaining local tissue homeostasis. The lung vascular endothelial cells was shown to be infected by human rhinovirus and generate antiviral, inflammatory and cytopathic responses. Read More

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Oil Emulsion Promotes Autophagy in Ovarian Cancer Cells Through the miR-8485/LAMTOR3/mTOR/ATG13 Signaling Axis.

Front Pharmacol 2022 25;13:935155. Epub 2022 Jul 25.

The First Affiliated Hospital of Hainan Medical University, Haikou, China.

Ovarian cancer is a common malignant tumor of the female reproductive tract, with the highest mortality rate. At present, no effective approaches to improve the survival rate exist. Oil Emulsion (BJOE), an extract from [Simaroubaceae], exhibits antitumor effects and can increase the sensitivity of radiotherapy and chemotherapy in many types of cancers. Read More

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Effects of CDT on Hemodynamics and Quality of Life in a Subgroup of Patients with Lower Limb Deep Vein Thrombosis Carel: A Case-Control Study.

Comput Math Methods Med 2022 2;2022:6607240. Epub 2022 Aug 2.

Vascular Surgery, The Affiliated People's Hospital of Ningbo University, Ningbo City Zhejiang Province 315000, China.

Objective: To explore the effects of combined catheter-directed thrombolysis (CDT) on hemodynamics and quality of life in a subgroup of patients with lower limb deep vein thrombosis carel by using a case-control study.

Methods: Eighty-four patients with deep venous thrombosis (DVT: acute DVT and chronic DVT) of lower extremities treated in our hospital from April 2017 to June 2021 were randomly assigned into the control group ( = 42) and the research group ( = 42). The control group only received routine nursing combined with CDT; the research group was treated with cluster nursing l combined with CDT. Read More

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Comparison of the Effects of Hysteroscopic Cold Broad Sword Play Combined with Estrogen and Progestin Sequential Therapy and Drospirenone and Ethinylestradiol Tablets in Patients with Severe Intrauterine Adhesion.

Emerg Med Int 2022 31;2022:9898228. Epub 2022 Jul 31.

Department Obsterics and Gynecology, Zhuji Maternal and Child Health Hospital, Zhuji, Zhejiang 311800, China.

Objective: To compare the effects of hysteroscopic cold broad sword play combined with estrogen and progestin sequential therapy and drospirenone and ethinylestradiol tablets in patients with severe intrauterine adhesion.

Methods: One hundred and eight patients with severe IUA admitted to our hospital from May 2019 to October 2021 were selected for the study. Patients were divided according to their treatment regimen into group A ( = 54) treated with hysteroscopic cold broad sword play + drospirenone and ethinylestradiol tablets and group B ( = 54) treated with hysteroscopic cold broad sword play + estrogen and progestin sequential therapy. Read More

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Enhanced Inhibitory Effect of DC-CIK Cells on Lung Adenocarcinoma via Anti-Tim-3 Antibody and Antiprogrammed Cell Death-1 Antibody and Possible Mechanism.

Evid Based Complement Alternat Med 2022 31;2022:4097576. Epub 2022 Jul 31.

The Second Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China.

Objective: To investigate the effect and mechanism of blocking the signaling pathways of the T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) and programmed death protein 1 (PD-1) in dendritic cell-cytokine induced killer (DC-CIK) cells on human lung adenocarcinoma A549 cells.

Methods: Peripheral blood mononuclear cells (PBMCs) were isolated and induced into mature DC-CIK cells by cytokines . After blocking the Tim-3 and PD-1 signaling transduction pathways with anti-Tim-3 and anti-PD-1 antibodies, DC-CIK cells were coincubated with A549 cells. Read More

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MiRNA-148a inhibits cell growth and drug resistance by regulating expression in renal cell carcinoma.

Transl Androl Urol 2022 Jul;11(7):996-1006

Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Background: We aimed to explore miR-148a exerts a tumor suppressor effect and arsenic trioxide (AsO) sensitivity on renal cell carcinoma (RCC).

Methods: We performed polymerase chain reaction (PCR) on 42 pairs of tumor and paracancerous samples collected from RCC patients to investigate the miR-148a expression; meanwhile, we analyzed the interplay between clinical indicators and miR-148a expression of RCC. Then, the influence of miR-148a overexpression on the functions of RCC cells were analyze using transwell migration assay, Cell Counting Kit-8 (CCK-8), and cell wound healing assay. Read More

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Value of Artificial Neural Network Ultrasound in Improving Breast Cancer Diagnosis.

Comput Intell Neurosci 2022 31;2022:1779337. Epub 2022 Jul 31.

Department of Medical, Hunan Polytechnic of Environment and Biology, Hengyang 421000, Hunan, China.

Ultrasound-guided needle biopsy based on artificial neural network, as a safe, effective, and simple preoperative pathological diagnosis technique, has been widely used in clinical practice. Ultrasound-guided needle biopsy based on artificial neural networks for suspicious breast lesions found in conventional ultrasound examinations is an effective method for preoperative diagnosis. The purpose of this article is to study the value of artificial neural network ultrasound in improving breast cancer diagnosis. Read More

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Effects of arterial blood supply on the survival of reverse-flow island flaps: an experimental study.

Am J Transl Res 2022 15;14(7):5068-5076. Epub 2022 Jul 15.

Department of Hand and Foot Surgery, The Second Affiliated Hospital of Soochow University Suzhou 215004, Jiangsu, China.

Objectives: This study aimed to investigate the effect of arterial blood supply on the survival area of retrograde island flap.

Methods: The vein and saphenous artery in rabbits were selected to design the reverse-flow island flap experimental model. Forty rabbits were randomly divided into four groups: control group (group A), partial anastomosis of the saphenous artery group (group B), partial anastomosis of the vein group (group C), and no superficial vein group (group D). Read More

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Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma.

Dis Markers 2022 27;2022:8159537. Epub 2022 Jul 27.

Department of Biliary-Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Pancreatic ductal adenocarcinoma (PDAC) is one of the highest-grade malignancies in the world. More effective biomarkers and treatment plans are necessary to improve the diagnosis rate and clinical outcome. The oncogenesis of PDAC is influenced by several factors, including chronic pancreatitis (CP). Read More

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Generation of miniploid cells and improved natural transformation procedure for a model cyanobacterium PCC 7942.

Front Microbiol 2022 26;13:959043. Epub 2022 Jul 26.

School of Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen, China.

The biotechnologically important and naturally transformable cyanobacterium, PCC 7942, possesses multiple genome copies irrespective of its growth rate or condition. Hence, segregating mutations across all genome copies typically takes several weeks. In this study, 7942 cultivation on a solid growth medium was optimised using different concentrations of agar, the addition of antioxidants, and overexpression of the catalase gene to facilitate the rapid acquisition of colonies and fully segregated lines. Read More

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Genetic Structure of the Endangered Coral Cladocora caespitosa Matches the Main Bioregions of the Mediterranean Sea.

Front Genet 2022 26;13:889672. Epub 2022 Jul 26.

Department Biodiversidad y Biología Evolutiva, Museo Nacional de Ciencias Naturales, MNCN (CSIC), Madrid, Spain.

Population connectivity studies are a useful tool for species management and conservation planning, particular of highly threatened or endangered species. Here, we evaluated the genetic structure and connectivity pattern of the endangered coral across its entire distribution range in the Mediterranean Sea. Additionally, we examined the relative importance of sexual and asexual reproduction in the studied populations and their genetic diversity. Read More

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Characterizing the respiratory-induced mechanical stimulation at the maxillary sinus floor following sinus augmentation by computational fluid dynamics.

Front Bioeng Biotechnol 2022 26;10:885130. Epub 2022 Jul 26.

Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, United States.

The relationship between maxillary sinus pneumatization and respiratory-induced fluid mechanics remains unclear. The purpose of this study was to simulate and measure the respiratory-induced mechanical stimulation at the sinus floor under different respiratory conditions and to investigate its potential effect on the elevated sinus following sinus-lifting procedures. The nasal airway together with the bilateral maxillary sinuses of the selected patient was segmented and digitally modeled from a computed tomographic image. Read More

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Innovative experimental animal models for real-time comparison of antithrombogenicity between two oxygenators using dual extracorporeal circulation circuits and indocyanine green fluorescence imaging.

Artif Organs 2022 Aug 11. Epub 2022 Aug 11.

Department of Cardiovascular Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.

Background: Antithrombogenicity of extracorporeal membrane oxygenation (ECMO) devices, particularly oxygenators, is a current problem, with numerous studies and developments underway. However, there has been limited progress in developing methods to accurately compare the antithrombogenicity of oxygenators. Animal experiments are commonly conducted to evaluate the antithrombogenicity of devices; however, it is challenging to maintain a steady experimental environment. Read More

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