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Differential Diagnosis of Acute and Chronic Gouty Arthritis by Multijoint Ultrasound.

Ultrasound Med Biol 2021 Jul 26. Epub 2021 Jul 26.

Department of Ultrasound, First Affiliated Hospital of Chengdu Medical College, Chengdu, China.

To investigate whether multi-joint ultrasound (US) findings in patients with gouty arthritis could be used to distinguish between acute and chronic stages, we performed a retrospective study with 129 enrolled patients from the Rheumatology Department of the First Affiliated Hospital of Chengdu Medical College from September 1, 2018 to June 12, 2019. Patients with acute or non-acute gout were categorized using clinical data, and US imaging findings of the knees, ankles and first metatarsophalangeal joints were analyzed and compared between groups. Notably, we found that the most prevalent sign detected by US was the hyperechoic spot in the synovium, followed by arthrosynovitis, aggregates, double contour signs and tophi; meanwhile, bone erosions were the least common. Read More

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The impact of spontaneous echo contrast on tunneled dialysis catheter patency.

J Vasc Access 2021 Jul 29:11297298211035599. Epub 2021 Jul 29.

Department of Anesthesiology and Reanimation, Hitit University Faculty of Medicine, Çorum, Turkey.

Background: Spontaneous echo contrast (SEC) is an ultrasonographic image of swirling blood flow resembling a dynamic, cigarette smoke-like image. It is mostly observed during the insertion of tunneled dialysis catheters (TDC) into internal jugular veins with ultrasound guidance, often different levels of SEC can be seen. The aim of this study is to investigate the impact of SEC detected during TDC insertion on the patency of the catheter. Read More

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Mechanochromic, Structurally Colored, and Edible Hydrogels Prepared from Hydroxypropyl Cellulose and Gelatin.

Adv Mater 2021 Jul 29:e2102112. Epub 2021 Jul 29.

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

Hydroxypropyl cellulose (HPC) is an edible, cost-effective and widely used derivative of cellulose. Under lyotropic conditions in water, HPC forms a photonic, liquid crystalline mesophase with an exceptional mechanochromic response. However, due to insufficient physical cross-linking photonic HPC can flow freely as a viscous liquid, preventing the exploitation of this mechanochromic material in the absence of any external encapsulation or structural confinement. Read More

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Accuracy of Post-thrombolysis ST-segment Reduction as an Adequate Reperfusion Predictor in the Pharmaco-Invasive Approach.

Arq Bras Cardiol 2021 Jul;117(1):15-25

Universidade Federal de Sao Paulo, São Paulo, SP - Brasil.

Background: Primary percutaneous coronary intervention is considered the "gold standard" for coronary reperfusion. However, when not available, the drug-invasive strategy is an alternative method and the electrocardiogram (ECG) has been used to identify reperfusion success.

Objectives: Our study aimed to assess ST-Segment changes in post-thrombolysis and their power to predict recanalization and using the angiographic scores TIMI-flow and Myocardial Blush Grade (MBG) as an ideal reperfusion criterion. Read More

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Ivermectin for preventing and treating COVID-19.

Cochrane Database Syst Rev 2021 Jul 28;7:CD015017. Epub 2021 Jul 28.

Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Wuerzburg, Germany.

Background: Ivermectin, an antiparasitic agent used to treat parasitic infestations, inhibits the replication of viruses in vitro. The molecular hypothesis of ivermectin's antiviral mode of action suggests an inhibitory effect on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the early stages of infection. Currently, evidence on efficacy and safety of ivermectin for prevention of SARS-CoV-2 infection and COVID-19 treatment is conflicting. Read More

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Investigation of carbonaceous materials electrosorption attributes and its performance for capacitive deionization process within the presence of humic acid.

Environ Sci Pollut Res Int 2021 Jul 28. Epub 2021 Jul 28.

Water Research Laboratory, Water Institute, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu, 614 114, India.

This present investigation emphasizes on pros and cons of humic acid (HA) on electrosorption behaviour and performance efficiency of capacitive deionization (CDI) process. Electrosorptive removal of HA was examined by lab scale CDI flow cell under 100 ppm NaSO as a supporting electrolyte. In addition, the electrosorption capacitance and desalination performances were also evaluated through cyclic voltammetry studies. Read More

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Basilar artery trunk aneurysm: clinical and angiographic outcomes of endovascular treatment.

J Neurointerv Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Neurosurgery, Ajou University School of Medicine and Graduate School of Medicine, Suwon, Gyeonggi-do, Korea (the Republic of)

Background: Basilar artery (BA) trunk aneurysms are rare, and the clinical characteristics and outcomes of endovascular treatment (EVT) remain unclear. The purpose of this study was to report clinical and angiographic outcomes of BA trunk aneurysm treated with EVT and to analyze risk factors for unfavorable outcomes.

Methods: From October 2004 to December 2020, a total of 40 patients with BA trunk aneurysms underwent EVT. Read More

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uPAR controls vasculogenic mimicry ability expressed by drug-resistant melanoma cells.

Oncol Res 2021 Jul 27. Epub 2021 Jul 27.

Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134, Florence, Italy.

Malignant melanoma is a highly aggressive skin cancer characterized by an elevated grade of tumor cell plasticity. Such plasticity allows melanoma cells adaptation to different hostile conditions and guarantees tumor survival and disease progression, including aggressive features such as drug resistance. Indeed, almost 50% of melanoma rapidly develop resistance to the BRAFV600E inhibitor vemurafenib, with fast tumor dissemination, a devastating consequence for patients' outcomes. Read More

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Urodynamic effects of prostatic urethral lift procedure for male voiding LUTS.

J Endourol 2021 Jul 27. Epub 2021 Jul 27.

Radboudumc, 6034, Urology, Nijmegen, Gelderland, Netherlands;

Aims: Primary objective is to investigate whether prostatic urethral lift (PUL) results in an improvement of urodynamic parameters that define bladder outlet obstruction (urethral resistance algorithm [URA], Schäfer grade, PdetQmax, PdetOpen).

Methods: 20 patients (main inclusion criteria: ≥ 50 years of age, BPO, IPSS ≥ 13, prostate volume ≤ 60 mL, no middle prostate lobe) were enrolled in the study and a PUL was performed. Patients underwent urodynamic investigation and filled out the IPSS and QoL before and after PUL. Read More

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A dynamic, convenient and accurate method for assessing the flood risk of people and vehicle.

Sci Total Environ 2021 Jul 18;797:149036. Epub 2021 Jul 18.

Beijing Capital Co Ltd, Beijing 100028, China.

With the increase of extreme rainstorm caused by climate change, and the development of urbanization and the improvement of people's living standard, there is an urgent need to draw a dynamic, convenient and accurate flood risk map for different disaster bearing bodies, so as to protect people's lives and properties, as well as improve people's risk awareness and facilitate people's lives. This study mainly researched a method of drawing a dynamic, convenient and accurate flood risk map for people and vehicle. In this study, the surface runoff is simulated by GPU (Graphics Processing Unit) Accelerated Surface Water Flow and Transport model (GAST model), meanwhile, the flood risk of people and vehicle is graded base on the incipient velocity formulas, the most unfavorable principle and grading method, finally, the method is applied in two application cases. Read More

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The Recanalization After Thrombolysis as Surrogate for Clinical Outcomes in Patients with ST-segment Elevation Acute Myocardial Infarction: A Systematic Review and Meta-Regression Analysis of Data from Randomized Controlled Trials.

Br J Clin Pharmacol 2021 Jul 26. Epub 2021 Jul 26.

Peking University Clinical Research Institute, Peking University First Hospital, Beijing, China.

Aim: Thrombolytic therapy has been known to be effective in reducing clinical outcomes and increasing recanalization rate among patients with ST-segment elevation acute myocardial infarction (STEMI). However, whether post-thrombolysis recanalization could be used as a surrogate for clinical outcomes is unknown.

Methods: We systematically searched PubMed, EMBASE and the Cochrane Library database to identify randomized controlled trials (RCT) that examined effects of thrombolytic agents in STEMI. Read More

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Renal Dysfunction as a Predictor of Slow-Flow/No-Reflow Phenomenon and Impaired ST Segment Resolution After Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction With Initial Thrombolysis in Myocardial Infarction Grade 0.

Circ J 2021 Jul 20. Epub 2021 Jul 20.

Department of Cardiology, Fujieda Municipal General Hospital.

Background: The slow-flow/no-reflow phenomenon and impaired ST segment resolution (STR) following primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) predict unfavorable prognosis and are characterized by obstruction of the coronary microvascular. Several predictors of slow-flow/no-reflow have been revealed, but few studies have investigated predictors of slow-flow/no-reflow and STR exclusively in acute myocardial infarction patients with initial Thrombolysis in Myocardial Infarction (TIMI) Grade 0.Methods and Results:In all, 279 STEMI patients with initial TIMI Grade 0 were enrolled in the study. Read More

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Hybrid repair versus conventional open repair for aortic arch dissection.

Cochrane Database Syst Rev 2021 Jul 25;7:CD012920. Epub 2021 Jul 25.

Department of Vascular and Endovascular Surgery, The Galway Clinic, Galway, Ireland.

Background: A dissection of the aorta is a separation or tear of the intima from the media. This tear allows blood to flow not only through the original aortic flow channel (known as the true lumen), but also through a second channel between the intima and media (known as the false lumen). Aortic dissection is a life-threatening condition which can be rapidly fatal. Read More

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Pre-transplant minimal residual disease assessment and transplant-related factors predict the outcome of AML patients undergoing allogeneic stem cell transplantation.

Eur J Haematol 2021 Jul 23. Epub 2021 Jul 23.

IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

We studied pre-transplant minimal residual disease (MRD) in 224 patients (median age 44 years; range 17-65) with acute myeloid leukemia (AML) undergoing allogeneic stem cell transplant (HSCT) in complete remission. MRD was evaluated on marrow samples using multicolor flow cytometry (MFC) and assessment of WT1 gene expression. Both methods showed a strong prognostic value and their combination allowed the identification of 3 groups of patients with different risk of relapse. Read More

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Priming of Sorafenib Prior to Radiofrequency Ablation Does Not Increase Treatment Effect in Hepatocellular Carcinoma.

Dig Dis Sci 2021 Jul 23. Epub 2021 Jul 23.

Boston Medical Center, Boston University, Boston, MA, USA.

Background: Preclinical studies have shown that modulation of the tumor microvasculature with anti-angiogenic agents decreases tumor perfusion and may increase the efficacy of radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC). Retrospective studies suggest that sorafenib given prior to RFA promotes an increase in the ablation zone, but prospective randomized data are lacking.

Aims: We conducted a randomized, double-blind, placebo-controlled phase II trial to evaluate the efficacy of a short-course of sorafenib prior to RFA for HCC tumors sized 3. Read More

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Retinal emboli after cervicopetrous junction internal carotid artery pseudoaneurysm stenting.

Am J Ophthalmol Case Rep 2021 Sep 9;23:101164. Epub 2021 Jul 9.

Department of Ophthalmology, Wayne and Gladys Valley Center for Vision, University of California San Francisco, 490 Illinois Street, 5th Floor, San Francisco, CA, 94143, USA.

Purpose: To describe acute and chronic retinal ischemic changes following an internal carotid artery pseudoaneurysm stenting procedure, and to review current evidence for risk factors and management of post-procedural retinal ischemic events.

Observation: A 50-year-old man presented with a 3-month history of pulsatile tinnitus, headache, and intermittent blurry vision. A CT angiogram of head and neck showed bilateral cervicopetrous internal carotid artery (ICA) pseudoaneurysms. Read More

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September 2021

Two-Stage Versus One-Stage Nipple-Sparing Mastectomy: Timing of Surgery Prevents Nipple Loss.

Ann Surg Oncol 2021 Jul 21. Epub 2021 Jul 21.

Section of Surgical Oncology, Department of Surgery, Stanford University School of Medicine Stanford, Stanford, CA, USA.

Background: Devascularization of the nipple-areola complex (NAC) before nipple-sparing mastectomy (NSM) enhances blood flow to the skin. This study analyzed the effect of the interval between stages in two-stage (2S) operations and compared the ischemic events with those of one-stage (1S) NSM.

Methods: Ischemic complications were defined as partial/reversible (PR) or full-thickness/irreversible (FI) skin necrosis of the NAC or flap. Read More

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Correlation of brachycephaly grade with level of exophthalmos, reduced airway passages and degree of dental malalignment' in Persian cats.

PLoS One 2021 21;16(7):e0254420. Epub 2021 Jul 21.

Department of Veterinary Clinical Sciences, Clinic for Small Animals, Neurosurgery, Neuroradiology and Clinical Neurology, Justus-Liebig University-Giessen, Giessen, Germany.

For many years, there has been a trend to breed cats with an increasing degree of brachycephalic head features, which are known to have a severe impact on the animals' health and welfare. The direct relation between different grades of brachycephaly and their negative implications have not been researched in this species. The aim of this study was therefore to establish correlations between the different grades of brachycephaly and reduced upper respiratory airways, exophthalmos of the eye globes and malalignment of the teeth in Persian cats. Read More

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Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β -AR/MACC1 axis.

Cancer Commun (Lond) 2021 Jul 20. Epub 2021 Jul 20.

Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China.

Background: Depression is a common, easily ignored, accompanied disease of gastric cancer (GC) patients and is often observed with elevated plasma catecholamine levels. Depression frequently promotes GC progression and leads to poor clinical outcomes; however, the molecular mechanisms underlying depression-induced GC progression remain poorly understood. We aimed to study the effects of depression on GC progression and explore possible mechanisms mediating the action of depression-associated catecholamines on GC. Read More

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Blunt renal trauma-induced hypertension in pediatric patients: a single-center experience.

J Pediatr Urol 2021 Jun 30. Epub 2021 Jun 30.

Clinic of Urology and Pediatric Urology, University Hospital Erlangen, Germany. Electronic address:

Purpose: Children have a greater chance of sustaining a renal injury than adults and higher odds of having a high-grade renal injury. Hypertension is a rare complication of blunt renal trauma, with risk being higher in cases of major renal trauma. We reviewed the cases of pediatric blunt renal trauma-induced hypertension in our tertiary referral center in an attempt to better understand this rare condition. Read More

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Impact of photobiomodulation in a patient-derived xenograft model of oral squamous cell carcinoma.

Oral Dis 2021 Jul 17. Epub 2021 Jul 17.

Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Campinas, Brazil.

Background: Photobiomodulation therapy (PBMT) is an effective method for the prevention of oral mucositis. However, the effects of PBMT on oral squamous cell carcinoma (OSCC) have not yet been fully elucidated. This study aimed to evaluate the impact of PBMT in an OSCC-patient-derived xenograft (OSCC-PDX) model. Read More

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Importance of complex blood flow in the assessment of aortic regurgitation severity using phase contrast magnetic resonance imaging.

Int J Cardiovasc Imaging 2021 Jul 17. Epub 2021 Jul 17.

Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, 413 45, Gothenburg, Sweden.

This study aimed to investigate if and how complex flow influences the assessment of aortic regurgitation (AR) using phase contrast MRI in patients with chronic AR. Patients with moderate (n = 15) and severe (n = 28) chronic AR were categorized into non-complex flow (NCF) or complex flow (CF) based on the presence of systolic backward flow volume. Phase contrast MRI was performed repeatedly at the level of the sinotubular junction (Ao1) and 1 cm distal to the sinotubular junction (Ao2). Read More

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Radiomics-Based Machine Learning Classification for Glioma Grading Using Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging.

J Comput Assist Tomogr 2021 Jul 13. Epub 2021 Jul 13.

From the Department of Medical Technology, Osaka University Hospital Department of Medical Physics and Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Objective: The aim of this study was to evaluate various radiomics-based machine learning classification models using the apparent diffusion coefficient (ADC) and cerebral blood flow (CBF) maps for differentiating between low-grade gliomas (LGGs) and high-grade gliomas (HGGs).

Methods: Fifty-two glioma patients, including 18 LGGs (grade II) and 34 HGGs (grade III/IV), were examined using a 3.0-T magnetic resonance scanner. Read More

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Degenerative Cervical Spondylosis: A Cause of Vertigo?

Global Spine J 2021 Jul 16:21925682211027840. Epub 2021 Jul 16.

Department of Orthopedics, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Study Design: Prospective observational study.

Objectives: Studying the effect of degenerative cervical spondylosis(CS) on blood flow velocity of vertebral artery (VA) during cervical spine rotation in different head positions and its association with vertigo.

Introduction: Vertigo is one of the most common complaints seen in an out-patient clinic. Read More

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Does Mesenchymal Stromal Cell Count in Pre-autologous Hematopoietic Stem Cell Transplant Peripheral Blood and Apheresis Product Predict for Infectious Complications in the Post-transplant Period?

Indian J Hematol Blood Transfus 2021 Jul 28;37(3):484-488. Epub 2021 Feb 28.

Department of Internal Medicine, PGIMER, Chandigarh, India.

Mesenchymal stromal cells (MSC) have gained attention in the recent past considering their multipotentiality and organ-healing properties. Exogenous administration of MSC in the pre-hematopoietic stem cell transplant (HSCT) setting has been reported to enhance engraftment, heal graft-vs-host disease and increase infections in the post-HSCT period. In this study, we aimed to determine the effect of endogenous pre-HSCT MSC on the post-HSCT infectious complications in patients undergoing autologous-HSCT. Read More

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Left Ventricular Flow Dynamics with the HeartMate3 Left Ventricular Assist Device: Effect of Inflow Cannula Position and Speed Modulation.

ASAIO J 2021 Jul 8. Epub 2021 Jul 8.

From the Bioengineering Program, Department of Mechanical Engineering, San Diego State University, San Diego, California.

Improper left ventricular assist device (LVAD) inflow cannula (IC) positioning creates areas of stasis and low pulsatility that predispose thromboembolism, but may be mitigated with LVAD speed modulation. A mock loop study was performed to assess the sensitivity of left ventricle (LV) flow architecture to IC position and speed modulation during HeartMate3 support. System pressure, flow, and the time-resolved velocity field were measured within a transparent silicone LV for three IC angles and three IC insertion depths at matched levels of cardiac function and LVAD speed. Read More

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Natural History and Prognosis of Patients with Unrepaired Tricuspid Regurgitation Undergoing Implantation of Left Ventricular Assist Device.

ASAIO J 2021 Jul 8. Epub 2021 Jul 8.

From the Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Department of Cardio-Thoracic Surgery, Rabin Medical Center, Petah Tikva, Israel Department of Anesthesia, Rabin Medical Center, Petah Tikva, Israel.

We aimed to describe the natural history of left ventricular assist device (LVAD)-supported patients with preimplantation significant tricuspid regurgitation (TR) in a single-center retrospective analysis of LVAD-implanted patients (2008-2019). TR severity was assessed semiqualitatively using color-Doppler flow: insignificant TR (iTR) was defined as none/mild TR and significant TR (sTR) as ≥moderate TR. Included were 121 LVAD-supported patients of which 53% (n = 64) demonstrated sTR preimplantation. Read More

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Flexible oxygen concentrators for medical applications.

Sci Rep 2021 07 12;11(1):14317. Epub 2021 Jul 12.

Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, 77843-3122, USA.

Medical oxygen concentrators (MOCs) are used for supplying medical grade oxygen to prevent hypoxemia-related complications related to COVID-19, chronic obstructive pulmonary disease (COPD), chronic bronchitis and pneumonia. MOCs often use a technology called pressure swing adsorption (PSA), which relies on nitrogen-selective adsorbents for producing oxygen from ambient air. MOCs are often designed for fixed product specifications, thereby limiting their use in meeting varying product specifications caused by a change in patient's medical condition or activity. Read More

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Modified Cavoportal Hemitransposition for Severe Portal Vein Thrombosis Contributed to Long-term Survival After Deceased Donor Liver Transplantation-Insight Into Portal Modulation for Improving Survival: A Case Report.

Transplant Proc 2021 Jul 9. Epub 2021 Jul 9.

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.

Background: Severe/massive portal vein thrombosis (PVT) deteriorates peri-liver transplantation outcomes. Cavoportal hemitransposition (CPHT) is a rescue procedure for severe PVT, and short-term outcomes have been well studied. However, CPHT is associated with some long-term issues caused by portal flow modulation via extraordinary reconstruction. Read More

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