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Effect of different structural flaxseed lignans on the stability of flaxseed oil-in-water emulsion: An interfacial perspective.

Food Chem 2021 Apr 8;357:129522. Epub 2021 Apr 8.

Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Hubei Key Laboratory of Lipid Chemistry and Nutrition, and Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Wuhan 430062, China. Electronic address:

The influences of the different structural flaxseed lignans on flaxseed oil (FO) emulsions during storage and digestion were investigated, focusing on their interfacial behavior. From perspective of interface, more than 60% of secoisolariciresinol (SECO) and the acidic hydrolysates of flaxseed lignan macromolecule (FLEH) were located on the interface of FO emulsions. It improved the stability of FO emulsions both during storage and digestion by inhibiting of free radical penetration and improving their targeted antioxidative activity. Read More

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Unilateral prefrontal lobotomy for epilepsy: technique and surgical anatomy.

Neurosurg Focus 2020 04;48(4):E10

1Department of Neurosurgery, University Hospital of Lausanne.

Objective: Surgery for frontal lobe epilepsy remains a challenge because of the variable seizure outcomes after surgery. Disconnective procedures are increasingly applied to isolate the epileptogenic focus and avoid complications related to extensive brain resection. Previously, the authors described the anterior quadrant disconnection procedure to treat large frontal lobe lesions extending up to but not involving the primary motor cortex. Read More

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Altered local spontaneous activity in frontal lobe epilepsy: a resting-state functional magnetic resonance imaging study.

Brain Behav 2016 11 21;6(11):e00555. Epub 2016 Sep 21.

Key Laboratory for NeuroInformation of Ministry of Education Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China.

Purpose: The purpose of this study was to investigate the local spatiotemporal consistency of spontaneous brain activity in patients with frontal lobe epilepsy (FLE).

Method: Eyes closed resting-state functional magnetic resonance imaging (fMRI) data were collected from 19 FLE patients and 19 age- and gender-matched healthy controls. A novel measure, named FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) was used to assess the spatiotemporal consistency of local spontaneous activity (emphasizing both local temporal homogeneity and regional stability of brain activity states). Read More

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November 2016

Altered basal ganglia-cortical functional connections in frontal lobe epilepsy: A resting-state fMRI study.

Epilepsy Res 2016 12 24;128:12-20. Epub 2016 Oct 24.

Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.

Objectives: The purpose of this study was to investigate alterations of basal ganglia-cortical functional connections in patients with frontal lobe epilepsy (FLE).

Method: Resting-state functional magnetic resonance imaging (fMRI) data were gathered from 19 FLE patients and 19 age- and gender-matched healthy controls. Functional connectivity (FC) analysis was used to assess the functional connections between basal ganglia and cerebral cortex. Read More

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December 2016

Patient-specific connectivity pattern of epileptic network in frontal lobe epilepsy.

Neuroimage Clin 2014 16;4:668-75. Epub 2014 Apr 16.

Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

There is evidence that focal epilepsy may involve the dysfunction of a brain network in addition to the focal region. To delineate the characteristics of this epileptic network, we collected EEG/fMRI data from 23 patients with frontal lobe epilepsy. For each patient, EEG/fMRI analysis was first performed to determine the BOLD response to epileptic spikes. Read More

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October 2015

Pediatric frontal lobe epilepsy: white matter abnormalities and cognitive impairment.

Acta Neurol Scand 2014 Apr 20;129(4):252-62. Epub 2013 Sep 20.

Department of Neurology, Maastricht University Medical Centre, Maastricht, the Netherlands; Research School for Mental Health & Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands; Department of Research and Development, Epilepsy Centre Kempenhaeghe, Heeze, the Netherlands.

Objectives: Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE). Its etiology remains unknown. With diffusion tensor imaging, we have studied cerebral white matter properties and associations with cognitive functioning in children with FLE and healthy controls. Read More

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The applications of time-frequency analyses to ictal magnetoencephalography in neocortical epilepsy.

Epilepsy Res 2010 Aug 1;90(3):199-206. Epub 2010 Jun 1.

Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

Purpose: Ictal magenetoencephalographic (MEG) discharges convey significant information about ictal onset and propagation, but there is no established method for analyzing ictal MEG. This study sought to clarify the usefulness of time-frequency analyses using short-time Fourier transform (STFT) for ictal onset and propagation of ictal MEG activity in patients with neocortical epilepsy.

Methods: Four ictal MEG discharges in two patients with perirolandic epilepsy and one with frontal lobe epilepsy (FLE) were evaluated by time-frequency analyses using STFT. Read More

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Magnetoencephalographic study of rhythmic mid-temporal discharges in non-epileptic and epileptic patients.

Seizure 2003 Jun;12(4):220-5

Integrated Brain Research Unit, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei 112, Taiwan, ROC.

To evaluate the source location and clinical significance of rhythmic mid-temporal theta discharges (RMTD) by MEG in non-epileptic and epileptic patients, we conducted simultaneous MEG and EEG recordings with a whole-scalp 306-channel neuromagnetometer in three patients: one with right temporal lobe epilepsy (TLE), one with right frontal lobe epilepsy (FLE), and one with tension headache. We visually detected the RMTD activity and interictal spikes, and then localised their generators by MEG source modelling. We repeated MEG measurement 3 months after right anterior temporal lobectomy (ATL) in the TLE patient; 3 months after anticonvulsant medication in the FLE patient. Read More

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PET-MR image fusion in soft tissue sarcoma: accuracy, reliability and practicality of interactive point-based and automated mutual information techniques.

Eur J Nucl Med Mol Imaging 2003 Jan 11;30(1):54-62. Epub 2002 Oct 11.

The Clinical PET Centre, Lower Ground Floor, Lambeth Wing, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.

The fusion of functional positron emission tomography (PET) data with anatomical magnetic resonance (MR) or computed tomography images, using a variety of interactive and automated techniques, is becoming commonplace, with the technique of choice dependent on the specific application. The case of PET-MR image fusion in soft tissue is complicated by a lack of conspicuous anatomical features and deviation from the rigid-body model. Here we compare a point-based external marker technique with an automated mutual information algorithm and discuss the practicality, reliability and accuracy of each when applied to the study of soft tissue sarcoma. Read More

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January 2003

Clinical usefulness of the dipole tracing method for localizing interictal spikes in partial epilepsy.

Epilepsia 1998 Apr;39(4):371-9

Department of Brain Pathophysiology, Kyoto University School of Medicine, Japan.

Purpose: To clarify the clinical usefulness of the dipole tracing method in evaluation of interictal EEG spikes in patients with partial epilepsy.

Methods: Eight patients with partial epilepsy were studied. We compared the generator source of interictal spikes detected by the dipole tracing method with the results of magnetic resonance imaging (MRI), interictal/ictal measurement of cerebral blood flow (CBF) by single photon emission computed tomography (SPECT), interictal measurement of glucose metabolism by positron emission tomography (PET) and invasive electrocorticogram (ECoG). Read More

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The effects of stimulation of substantia innominata and sensory receiving areas of the forebrain upon the activity of neurons within the amygdala of the anesthetized cat.

Brain Res 1983 Jun;269(1):119-32

The present study investigated the response characteristics of individual neurons in the amygdala following stimulation of the substantia innominata (SI), and compared these responses with those elicited by stimulation of insular and temporal polar cortices and the lateral olfactory tract (LOT). Recordings were made from single units within the medial, central, basal, and lateral amygdaloid nuclei of anesthetized, male cats. Stimulating electrodes were located in the SI, LOT, and sylvian cortex (SG). Read More

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