549 results match your criteria flaxseed lignan


Oral Pharmacokinetics of Enriched Secoisolariciresinol Diglucoside and Its Polymer in Rats.

J Nat Prod 2021 May 27. Epub 2021 May 27.

Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada.

Secoisolariciresinol diglucoside (SDG) is the principal lignan of flaxseed and precursor of its aglycone, secoisolariciresinol (SECO), and the mammalian lignans enterolactone (EL) and enterodiol (ED), the putative bioactive forms of oral administration of SDG. SDG is present in the seed hull as an ester-linked polymer. Although extraction and purification of SDG monomer is costly, the use of naturally occurring SDG in polymer form may offer a more economical approach for delivery of this precursor. Read More

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A comprehensive review on different classes of polyphenolic compounds present in edible oils.

Authors:
Alam Zeb

Food Res Int 2021 May 16;143:110312. Epub 2021 Mar 16.

Department of Biochemistry, University of Malakand, Khyber Pakhtunkhwa, Pakistan. Electronic address:

Edible oils are used as a frying medium and in the preparation of several food products. They are mainly constituting triacylglycerols as major components, while other compounds are classified as minor constituents, which include polyphenols. This class of compounds plays an important role in the thermal stability and quality attributes of the finished industrial food products. Read More

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Short-term exposure to synthetic flaxseed lignan LGM2605 alters gut microbiota in mice.

Microbiologyopen 2021 Mar;10(2):e1185

Department of Biological Sciences, Idaho State University, Pocatello, ID, USA.

LGM2605 is a synthetic version of the naturally occurring flaxseed lignan secoisolariciresinol diglucoside (SDG), with known anti-inflammatory and antioxidant properties; however, its effects on gut microbial composition have not previously been evaluated. In the present study, we sought to determine how the 10-day oral administration of LGM2605 alters the gut microbiota of mice. Eight-week-old female C57BL/6 mice were treated with either LGM2605 or saline, administered daily via oral gavage over a 10-day treatment period. Read More

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Disposition of Dietary Polyphenols in Breast Cancer Patients' Tumors, and Their Associated Anticancer Activity: The Particular Case of Curcumin.

Mol Nutr Food Res 2021 May 3:e2100163. Epub 2021 May 3.

Laboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, Campus de Espinardo, Murcia, 30100, Spain.

Scope: Some polyphenol-derived metabolites reach human breast cancer (BC) tissues at concentrations that induce cell senescence. However, this is unknown for isoflavones, curcuminoids, and lignans. Here, their metabolic profiling in normal (NT) and malignant (MT) mammary tissues of newly-diagnosed BC patients and the tissue-occurring metabolites' anticancer activity are evaluated. Read More

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The legitimacy of using dietary supplement diglycoside secoisolariciresinol (SDG) from flaxseed in cancer.

Rocz Panstw Zakl Hig 2021 ;72(1):9-20

Wroclaw Medical University, Department of Dietetic, Wroclaw, Poland.

Linseed, commonly known as flaxseed, is a fibre-rich food product. According to the recent study prepared by the American Institute for Cancer Research (AICR), an adequate intake of dietary fiber contributes to reducing the risk of colorectal cancer. In addition, the flaxseed and the oil extracted from it are considered to be food products with a high content of anti-inflammatory, unsaturated α-linolenic acid (ALA). Read More

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January 2021

Effect of different structural flaxseed lignans on the stability of flaxseed oil-in-water emulsion: An interfacial perspective.

Food Chem 2021 Apr 8;357:129522. Epub 2021 Apr 8.

Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Hubei Key Laboratory of Lipid Chemistry and Nutrition, and Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Wuhan 430062, China. Electronic address:

The influences of the different structural flaxseed lignans on flaxseed oil (FO) emulsions during storage and digestion were investigated, focusing on their interfacial behavior. From perspective of interface, more than 60% of secoisolariciresinol (SECO) and the acidic hydrolysates of flaxseed lignan macromolecule (FLEH) were located on the interface of FO emulsions. It improved the stability of FO emulsions both during storage and digestion by inhibiting of free radical penetration and improving their targeted antioxidative activity. Read More

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Enterolignan Production in a Flaxseed Intervention Study in Postmenopausal US Women of African Ancestry and European Ancestry.

Nutrients 2021 Mar 12;13(3). Epub 2021 Mar 12.

Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Lignans are phytochemicals studied extensively as dietary factors in chronic disease etiology. Our goal was to examine associations between the gut microbiota and lignan metabolism and whether these associations differ by ethnicity. We conducted a flaxseed (FS) dietary intervention in 252 healthy, postmenopausal women of African ancestry (AA) and European ancestry (EA). Read More

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New Insight into Justicidin B Pathway and Production in .

Int J Mol Sci 2021 Mar 2;22(5). Epub 2021 Mar 2.

Institute of Agricultural Biology and Biotechnology, National Research Council, Via Bassini 15, 20133 Milan, Italy.

Lignans are the main secondary metabolites synthetized by species as plant defense compounds but they are also valuable for human health, in particular, for novel therapeutics. In this work, in vitro cultures, cells (Cc), adventitious roots (ARc) and hairy roots (HRc) were developed for the production of justicidin B through elicitation with methyl jasmonate (MeJA) and coronatine (COR). The performances of the cultures were evaluated for their stability, total phenols content and antioxidant ability. Read More

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Secoisolariciresinol diglucoside induces caspase-3-mediated apoptosis in monolayer and spheroid cultures of human colon carcinoma cells.

J Food Biochem 2021 May 29;45(5):e13719. Epub 2021 Mar 29.

Department of Medical Biology, School of Medicine, Süleyman Demirel Universtiy, Isparta, Turkey.

Apoptotic effects of secoisolariciresinol diglucoside (SDG) in 2D and 3D cultures of SW480 cells were investigated. 40-200 μM SDG was used and IC50 values were determined for three different time intervals as 24, 48, or 72 hr for further experiments. BrdU, TUNEL, AIF, and caspase-3 stainings were used. Read More

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Effects of a Cereal Bar with a Combination of Phytoestrogens on the Climacteric Symptoms: A Placebo-Controlled, Randomized Trial.

J Am Coll Nutr 2021 Mar 18:1-8. Epub 2021 Mar 18.

Post Graduate Program in Food Science and Technology, Federal University of Fronteira Sul, Laranjeiras do Sul, Brazil.

Objective: This study evaluated whether the consumption of a cereal bar combining different phytoestrogens could contribute to the reduction of climacteric symptoms in women.

Methods: This is a clinical, prospective, randomized, simple-blind trial. Forty-eight women, aged 40-65 years, with climacteric symptoms, from a city in southwestern Paraná, Brazil. Read More

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NMR and LC-MS-Based Metabolomics to Study Osmotic Stress in Lignan-Deficient Flax.

Molecules 2021 Feb 2;26(3). Epub 2021 Feb 2.

UMRT INRAE 1158 BioEcoAgro, Laboratoire BIOPI, University of Picardie Jules Verne, 80000 Amiens, France.

Lignans, phenolic plant secondary metabolites, are derived from the phenylpropanoid biosynthetic pathway. Although, being investigated for their health benefits in terms of antioxidant, antitumor, anti-inflammatory and antiviral properties, the role of these molecules in plants remains incompletely elucidated; a potential role in stress response mechanisms has been, however, proposed. In this study, a non-targeted metabolomic analysis of the roots, stems, and leaves of wild-type and PLR1-RNAi transgenic flax, devoid of (+) secoisolariciresinol diglucoside ((+) SDG)-the main flaxseed lignan, was performed using H-NMR and LC-MS, in order to obtain further insight into the involvement of lignan in the response of plant to osmotic stress. Read More

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February 2021

A comprehensive review on Linum usitatissimum medicinal plant: Its phytochemistry, pharmacology and ethnomedicinal uses.

Mini Rev Med Chem 2021 Feb 3. Epub 2021 Feb 3.

Molecular Modeling Drug-design and Discovery Laboratory, Pharmacology Research Division, BCSIR Laboratories Chattogram, Bangladesh Council of Scientific and Industrial Research, Chattogram. Bangladesh.

Background: Linum usitatissimum or flax has been broadly utilized in numerous milieus world-wide as a primeval medicinal plant because of its health benefits in diverse types of diseases.

Objective: The objective of this review is to assemble the latest information on the botanical description, distribution, conventional uses, and biochemical constituents, along with the pharmacological activities and toxicity of flax .

Method: For this purpose, data on Linum was accumulated from scientific journals, books, and worldwide acknowledged scientific databases via a library and electronic search. Read More

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February 2021

Flaxseed and Camelina Meals as Potential Sources of Health-Beneficial Compounds.

Plants (Basel) 2021 Jan 14;10(1). Epub 2021 Jan 14.

Department of Agricultural, Food and Environment, University of Pisa, 56124 Pisa, Italy.

Seed meals and cakes, deriving from minor oilseed crops, represent interesting co-products for the presence of a high content of proteins and bioactive compounds that could be successfully explored as valuable plant-derived feedstocks for food and non-food purposes. In this contest, flaxseed ( L.) and camelina ( (L. Read More

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January 2021

Flaxseed Lignans and Polyphenols Enhanced Activity in Streptozotocin-Induced Diabetic Rats.

Biology (Basel) 2021 Jan 11;10(1). Epub 2021 Jan 11.

Faculty of Chemical Engineering and Environmental Protection, Gheorghe Asachi Technical University of Iasi, 700050 Iasi, Romania.

Flaxseeds play an important role in human health due to their chemical composition and recognized beneficial outcomes. This study investigated the antidiabetic effects of present lignans and polyphenols found in the flaxseed extract on streptozotocin (STZ)-induced diabetic rats. The flaxseed administration produced favorable changes in body weight, food and water intake, and glycosylated hemoglobin and blood glucose quantities in the treated diabetic rats. Read More

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January 2021

Serumal Lipidomics Reveals the Anti-inflammatory Effect of Flax Lignans and Sinapic Acid in High-Fat-Diet-Fed Mice.

J Agric Food Chem 2021 Jan 11. Epub 2021 Jan 11.

Key Laboratory of Oilseeds Processing of Ministry of Agriculture, Key Laboratory of Biology and Genetic Improvement of Oil Crops of Ministry of Agriculture, and Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuchang, Wuhan, Hubei 430062, People's Republic of China.

Flax lignans (SDG) and sinapic acid (SA) both have the function of antioxidation and anti-inflammation. However, previous studies have focused mainly on biochemical measurements, gene expression analysis, and clinical assessments. There are limited studies that systematically reveal the underlying mechanism of the anti-inflammation effect of SDG or SA from the lipidomic point of view. Read More

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January 2021

Flaxseed oil stimulates gynecomastia.

BMJ Case Rep 2020 Dec 10;13(12). Epub 2020 Dec 10.

Department of Medicine and Surgery, Kokusai Iryo Fukushi Daigaku Daigakuin-Tokyo Aoyama Campus, Minato-ku, Tokyo, Japan.

Flaxseed oil contains lignans, which exhibit anti-inflammatory and antiatherogenic activities. A 70-year-old male patient presented to our office due to hyperlipidaemia and started to take a tablespoon of flaxseed oil daily. Three months later, he reported left breast swelling and pain. Read More

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December 2020

Flaxseed and Its Components in Treatment of Hyperlipidemia and Cardiovascular Disease.

Int J Angiol 2020 Dec 14;29(4):216-222. Epub 2020 Apr 14.

Department of Physiology (APP), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

This paper describes the effects of flaxseed and its components (flax oil, secoisolariciresinoldiglucoside[SDG], flax lignan complex [FLC], and flax fibers] on serum lipids (total cholesterol [TC], low-density lipoprotein-cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglycerides [TG]) in animals and humans. Ordinary flaxseed reduces TG, TC, LDL-C, and TC/HDL-C levels in a dose-dependent manner in animals. In humans, it reduces serum lipids in hypercholesterolemicpatients but has no effects in normocholesterolemicpatients. Read More

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December 2020

Technical note: Quantification of lignans in the urine, milk, and plasma of flaxseed cake-fed dairy sheep.

J Dairy Sci 2021 Jan 12;104(1):391-396. Epub 2020 Nov 12.

State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, P. R. China 010070; Key Laboratory of Forage and Endemic Crop Biotechnology of Ministry of Education, School of Life Sciences, Inner Mongolia University, Hohhot, P. R. China 010070. Electronic address:

Mammalian lignans are phytoestrogens with important bioactivities, and their concentrations in livestock milk may influence the health of consumers. This research aimed to establish a method to quantify multiple mammalian lignans in the biofluids of dairy sheep using ultra-HPLC-triple quadropole mass spectrometry with multiple-reaction monitoring. Secoisolariciresinol, 2-[(4-hydroxy-3-methoxyphenyl)methyl]-3-[(3-hydroxyphenyl)methyl]-1,4-butanediol, enterodiol (ED), enterolactone (EL), ED-sulfate (ED-S), and EL-sulfate (EL-S) were purified from the urine of flaxseed cake-fed dairy sheep. Read More

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January 2021

Nuclear Magnetic Resonance and Calorimetric Investigations of Extraction Mode on Flaxseed Gum Composition.

Polymers (Basel) 2020 Nov 11;12(11). Epub 2020 Nov 11.

Littoral Côte d'Opale University, UR 4492, UCEIV, Unité de Chimie Environnementale et Interactions sur le Vivant, SFR Condorcet FR CNRS 3417, 145 Avenue Maurice Schumann, 59140 Dunkerque, France.

We discussed about the influence of extraction mode on the flaxseed gums composition and their thermal stabilities. In order to do so, flaxseed gum was extracted by both classical magnetic stirring method and ultrasonic-assisted extraction (UAE). As a function of time, protein content, gum yield, pH values were evaluated and samples were characterized by H and C nuclear magnetic resonance (NMR) experiments as well as scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). Read More

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November 2020

The anti-cancer effect of flaxseed lignan derivatives on different acute myeloid leukemia cancer cells.

Biomed Pharmacother 2020 Dec 17;132:110884. Epub 2020 Oct 17.

Department of Natural Sciences, Lebanese American University, Byblos, Lebanon. Electronic address:

Flaxseeds have been known for their anti-cancerous effects due to the high abundance of lignans released upon ingestion. The most abundant lignan, secoisolariciresinol diglucoside (SDG), is ingested during the dietary intake of flax, and is then metabolized in the gut into two mammalian lignan derivatives, Enterodiol (END) and Enterolactone (ENL). These lignans were previously reported to possess anti-tumor effects against breast, colon, and lung cancer. Read More

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December 2020

UPLC-HRMS Analysis Revealed the Differential Accumulation of Antioxidant and Anti-Aging Lignans and Neolignans in Cultures of L.

Front Plant Sci 2020 23;11:508658. Epub 2020 Sep 23.

EA2106 Biomolécules et Biotechnologies Végétales, Université de Tours, Tours, France.

Over the last few decades, methods relating to plant tissue culture have become prevalent within the cosmetic industry. Forecasts predict the cosmetic industry to grow to an annual turnover of around a few hundred billion US dollars. Here we focused on L. Read More

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September 2020

Characterization of Flaxseed Oil Bimodal Emulsions Prepared with Flaxseed Oil Cake Extract Applied as a Natural Emulsifying Agent.

Polymers (Basel) 2020 Sep 26;12(10). Epub 2020 Sep 26.

Center of Bioimmobilisation and Innovative Packaging Materials, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology Szczecin, Janickiego 35, 71-270 Szczecin, Poland.

Currently, a majority of oilseeds plants are converted into byproducts and waste materials during processing. Press cakes are rich in valuable biopolymers, such as proteins and polysaccharides (fiber, lignans, etc.). Read More

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September 2020

Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression.

Biomolecules 2020 09 8;10(9). Epub 2020 Sep 8.

Department of Physiology and Pathophysiology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 09J, Canada.

MicroRNAs (miRNAs/miRs) such as miR-1, miR-133a, miR-133b, miR-135a, and miR-29b play a key role in many cardiac pathological remodeling processes, including apoptosis, fibrosis, and arrhythmias, after a myocardial infarction (MI). Dietary flaxseed has demonstrated a protective effect against an MI. The present study was carried out to test the hypothesis that dietary flaxseed supplementation before and after an MI regulates the expression of above-mentioned miRNAs to produce its cardioprotective effect. Read More

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September 2020

Effect of a Flaxseed Lignan Intervention on Circulating Bile Acids in a Placebo-Controlled Randomized, Crossover Trial.

Nutrients 2020 Jun 19;12(6). Epub 2020 Jun 19.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Plant lignans and their microbial metabolites, e.g., enterolactone (ENL), may affect bile acid (BA) metabolism through interaction with hepatic receptors. Read More

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In silico and in vitro identification of secoisolariciresinol as a re-sensitizer of P-glycoprotein-dependent doxorubicin-resistance NCI/ADR-RES cancer cells.

PeerJ 2020 10;8:e9163. Epub 2020 Jun 10.

Department of Biomedical Sciences/College of Veterinary Medicine, King Faisal University, Al-Ahsa, Eastern Region, Saudi Arabia.

P-glycoprotein (P-gp) is one of the highly expressed cancer cell efflux transporters that cause the failure of chemotherapy. To reverse P-gp induced multidrug resistance, we employed a flaxseed-derived lignan; secoisolariciresinol (SECO) that acts as an inhibitor of breast cancer resistance protein; another efflux transporter that shares some substrate/inhibitor specificity with P-gp. Molecular dynamics (MD) simulation identified SECO as a possible P-gp inhibitor. Read More

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Effects of Biogenic Zinc Oxide Nanoparticles on Growth and Oxidative Stress Response in Flax Seedlings vs. In Vitro Cultures: A Comparative Analysis.

Biomolecules 2020 06 17;10(6). Epub 2020 Jun 17.

Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan.

biosynthesizes lignans and neolignans that are diet and medicinally valuable metabolites. In recent years, zinc oxide nanoparticles (ZnONPs) have emerged as potential elicitors for the enhanced biosynthesis of commercial secondary metabolites. Herein, we investigated the influence of biogenic ZnONPs on both seedlings and stem-derived callus of . Read More

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Micropropagation and Production of Health Promoting Lignans in .

Plants (Basel) 2020 Jun 9;9(6). Epub 2020 Jun 9.

Botany and Microbiology Department, College of Science, King Saud University, Riyadh 11362, Saudi Arabia.

commonly known as flax or linseed is an important medicinal plant, produces medicinally potent lignans, used in the treatment of several human diseases. Lignans limited production in the natural plants does not meet the increasing market demand. This study was conducted to establish an easy and rapid method for the in vitro micropropagation and production of potent lignans and antioxidant secondary metabolites in linseed. Read More

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Secoisolariciresinol diglucoside protects against cadmium-induced oxidative stress-mediated renal toxicity in rats.

J Trace Elem Med Biol 2020 May 18;61:126552. Epub 2020 May 18.

Department of Biochemistry, Yuvaraja's College, University of Mysore, Mysuru, 570005, Karnataka, India; Department of Biotechnology, Yuvaraja's College, University of Mysore, Mysuru, 570005, Karnataka, India. Electronic address:

Background: Cadmium is a well known environmental pollutant and strong toxic heavy metal, that causes oxidative damage to various organs of the body, including the kidney. Cadmium (II) chloride (CdCl) is a water-soluble crystalline form, which exhibits a higher affinity with chlorides at the target site. The current study examined the protective effects of Secoisolariciresinol diglucoside (SDG), a principal lignan extracted from flaxseeds against CdCl-induced renal toxicity in rats. Read More

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Flaxseed for Health and Disease: Review of Clinical Trials.

Comb Chem High Throughput Screen 2020 ;23(8):699-722

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Background: Flaxseed (Linum usitatissimum) is an oil-based seed that contains high amounts of alpha-linolenic acid, linoleic acid, lignans, fiber and many other bioactive components which is suggested for a healthier life. Nowadays, flaxseed is known as a remarkable functional food with different health benefits for humans and protects against cardiovascular disease, diabetes, dyslipidemia, obesity and altogether metabolic syndrome.

Methods: To review the bioactive components of flaxseed and their potential health effects, PubMed and Scopus were searched from commencement to July 2019. Read More

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January 2020

Randomized Phase IIB Trial of the Lignan Secoisolariciresinol Diglucoside in Premenopausal Women at Increased Risk for Development of Breast Cancer.

Cancer Prev Res (Phila) 2020 07 20;13(7):623-634. Epub 2020 Apr 20.

Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas.

We conducted a multiinstitutional, placebo-controlled phase IIB trial of the lignan secoisolariciresinol diglucoside (SDG) found in flaxseed. Benign breast tissue was acquired by random periareolar fine needle aspiration (RPFNA) from premenopausal women at increased risk for breast cancer. Those with hyperplasia and ≥2% Ki-67 positive cells were eligible for randomization 2:1 to 50 mg SDG/day (Brevail) versus placebo for 12 months with repeat bio-specimen acquisition. Read More

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