157 results match your criteria flattening thinning

Partial corneal recovery following selective trabeculoplasty-induced keratopathy: Longitudinal analysis through scheimpflug imaging.

Am J Ophthalmol Case Rep 2021 Jun 26;22:101062. Epub 2021 Feb 26.

Glaucoma Unit, Hospital Medicina dos Olhos, 207, Salem Bechara Street, Osasco, São Paulo, 06018-180, Brazil.

Purpose: To report an uncommon case of hyperopic shift and corneal haze, flattening and thinning following a single session of selective laser trabeculoplasty (SLT), and provide longitudinal clinical data and serial analyses of corneal profile through Scheimpflug imaging. Furthermore, a careful literature review was undertaken to determine possible risk factors for this complication.

Observations: A 47-year-old woman presented with blurred vision and mild corneal edema and haze three days following routine SLT. Read More

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Comparison of Different Methods of Corneal Collagen Crosslinking: A Systematic Review.

Semin Ophthalmol 2021 Apr 22;36(3):67-74. Epub 2021 Feb 22.

Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, Spain.

: To review the scientific literature on the comparison of the efficacy of different corneal collagen crosslinking (CXL) protocols for the treatment of progressive keratoconus. Systematic review of randomized clinical trials (RCTs) on CXL outcomes. A search was carried out using the Cochrane Library, PubMed, EMBASE, Web of Science, Ovid MEDLINE, and Scopus databases. Read More

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Detection of refractive photokeratectomy traces during eye banking: impossible with organ culture but possible with an active storage machine: case report.

Cell Tissue Bank 2021 Jan 4. Epub 2021 Jan 4.

Laboratory for Corneal Graft Biology, engineering and imaging (BiiGC, EA2521), Faculty of Medicine, University Jean Monnet, Health Innovation Campus, 10 rue de la marandière, F-42055, Saint-Etienne, France.

The detection of corneas operated on for refractive surgery [LASIK or photorefractive keratectomy (PRK)] will become a major concern for eye banks in the coming years because this surgery is often forgotten during the interview with the deceased's relatives. We present here 2 corneas operated on with PKR and stored successively in organ culture (OC) and in the active storage machine (ASM) that restores intraocular pressure, restores the cornea to its original shape, respects transparency and incorporates non-invasive controls. The 2 corneas of a 49-year-old donor operated 17 years earlier by PRK for -2 and -3 diopters myopia were stored in OC for 14 days and then placed in ASM for 48 h. Read More

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January 2021

Diffuse lamellar keratitis after LASIK with low-energy femtosecond laser.

J Cataract Refract Surg 2021 02;47(2):233-237

From the Siena Eye Laser (Leccisotti, Fields), Scuola di Specializzazione in Oftalmologia, Università di Siena (Leccisotti), Siena, Italy, School of Biomedical Sciences, Ulster University (Leccisotti), Coleraine, United Kingdom.

Purpose: To evaluate the incidence, evolution, and prognosis of diffuse lamellar keratitis (DLK) in a large series of laser in situ keratomileusis (LASIK) with low-energy femtosecond laser.

Setting: Private practice, Siena, Italy.

Design: Retrospective, consecutive, noncomparative case series study. Read More

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February 2021

Modelling the effects of age-related morphological and mechanical skin changes on the stimulation of tactile mechanoreceptors.

J Mech Behav Biomed Mater 2020 12 1;112:104073. Epub 2020 Sep 1.

Department of Mechanical Engineering, Imperial College London, SW7 2AZ, London, UK.

Our sense of fine touch deteriorates as we age, a phenomenon typically associated with neurological changes to the skin. However, geometric and material changes to the skin may also play an important role on tactile perception and have not been studied in detail. Here, a finite element model is utilised to assess the extent to which age-related structural changes to the skin influence the tactile stimuli experienced by the mechanoreceptors. Read More

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December 2020

Extreme corneal flattening following collagen crosslinking for progressive keratoconus.

Eur J Ophthalmol 2020 Aug 2:1120672120947664. Epub 2020 Aug 2.

Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Purpose: To study the clinical, tomographic and densitometric features of eyes that showed >5 D of corneal flattening following collagen crosslinking (CXL) for progressive keratoconus and to identify preoperative predictive factors for such a response.

Methods: This was a retrospective case control study of 548 eyes with progressive keratoconus which had undergone epithelium-off CXL (Dresden protocol) with a follow-up of 1 to 10 years. Eyes that showed ⩾5 D corneal flattening in maximum keratometry (Kmax) following CXL (group A) were compared with one eye of the remaining patients in the same cohort (group B). Read More

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Late progressive corneal flattening, haze and visual loss after eccentric crosslinking for Pellucid marginal degeneration.

Am J Ophthalmol Case Rep 2020 Jun 22;18:100621. Epub 2020 Feb 22.

Sadalla Amin Ghanem Eye Hospital, Joinville, SC, Brazil.

Purpose: Pellucid marginal degeneration (PMD) is a rare disease that is often mistaken for keratoconus but can similarly be treated with corneal collagen crosslinking (CXL). We report a case followed though 6 years of progressive irregular corneal flattening and thinning in both eyes (OU) after eccentric CXL for PMD.

Observation: A 46-year-old man with bilateral PMD and corrected distance visual acuity (CDVA) of 20/20 (-2. Read More

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A multi-layered computational model for wrinkling of human skin predicts aging effects.

J Mech Behav Biomed Mater 2020 03 26;103:103552. Epub 2019 Nov 26.

Department of Mechanical Engineering, University of Connecticut, Storrs, CT, USA; Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA. Electronic address:

The development and progression of wrinkles from young to aged human skin relates to both structural and mechanical changes induced by aging. Here we aim to better understand the interaction of skin's layered morphology with dynamic wrinkles predicted in young and aged skin. First, we compare the predictions of wrinkling from 3-D finite element models of human skin including two to six distinct and anatomically motivated layers. Read More

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Evaluation of Ocular Complications by Using Optical Coherence Tomography in Children With Sickle Cell Disease Eye Findings in Children With Sickle Cell Disease.

J Pediatr Hematol Oncol 2020 03;42(2):92-99

Division of Pediatric Hematology, Faculty of Medicine, Mersin University, Mersin, Turkey.

Objective: The aim of this study was to compare optical coherence tomography (OCT) findings in pediatric patients with sickle cell disease (SCD) and healthy individuals and to investigate associations between these data and the patients' systemic findings.

Materials And Methods: The study included 108 eyes of 54 patients with SCD with no visual symptoms and a control group consisting of 110 eyes of 55 healthy subjects with no systemic or ocular pathology. After best-corrected visual acuity assessment, the study participants underwent a complete ophthalmologic examination including intraocular pressure. Read More

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Analysis of Compensatory Corneal Epithelial Thickness Changes in Keratoconus Using Corneal Tomography.

Cornea 2020 Mar;39(3):298-302

Department of Ophthalmology, Jamaica Hospital Medical Center, Richmond Hill, NY.

Purpose: To determine patterns of epithelial remodeling in keratoconus and to assess changes in these patterns as the disease progresses.

Methods: This is a prospective case series. Patients with keratoconus undergoing corneal collagen crosslinking underwent Scheimpflug imaging before and after epithelial debridement. Read More

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Corneal higher-order aberrations in Stevens-Johnson syndrome and toxic epidermal necrolysis.

Ocul Surf 2019 10 17;17(4):722-728. Epub 2019 Jul 17.

Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Purpose: To characterize the topography patterns and quantify corneal higher-order aberrations (HOAs) in the chronic phase of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

Methods: This retrospective, consecutive case series included 84 eyes of 49 patients in the chronic phase of SJS/TEN. HOAs of the total cornea, and of the anterior and posterior surfaces were measured using anterior segment optical coherence tomography (AS-OCT). Read More

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October 2019

Corneal crosslinking for pellucid marginal degeneration.

J Cataract Refract Surg 2019 08 2;45(8):1163-1167. Epub 2019 Jul 2.

Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Electronic address:

Purpose: To investigate the efficacy of corneal crosslinking (CXL) for pellucid marginal degeneration (PMD).

Setting: Medical University of Vienna.

Design: Retrospective study. Read More

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Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes.

Eye Contact Lens 2019 Jul;45(4):e15-e23

Sunderland Eye Infirmary (D.S.J.T., S.G.), Queen Alexandra Road, Sunderland, United Kingdom; and Academic Ophthalmology (D.S.J.T.), Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Objectives: To highlight the clinical characteristics, and visual and corneal tomographic outcomes of central toxic keratopathy (CTK) after contact lens (CL) wear and mechanical debridement.

Methods: A retrospective observational case series with literature review.

Results: Four patients (4 eyes) were included in this study; 3 (75%) females, mean age 29. Read More

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Reflectance confocal microscopy and histological features of depigmentation after local corticosteroid injection.

Skin Res Technol 2019 Nov 18;25(6):835-838. Epub 2019 Jun 18.

Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.

Background: Clinically, depigmentation after local corticosteroid injection is not rare. But there are less articles about its reflectance confocal microscopy (RCM) and histological features. This study aimed to define the RCM features and histopathologic findings of hypopigmentation after local corticosteroid injection and to analyze the correlations between the above two methods. Read More

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November 2019

Cortical thinning and flattening in schizophrenia and their unaffected parents.

Neuropsychiatr Dis Treat 2019 12;15:935-946. Epub 2019 Apr 12.

Peking University Sixth Hospital/Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, People's Republic of China.

Schizophrenia  is a neurodevelopmental disorder with high heritability. Widespread cortical thinning has been identified in schizophrenia, suggesting that it is a result of cortical development deficit. However, the findings of other cortical morphological indexes of patients are inconsistent, and the research on their relationship with genetic risk factors for schizophrenia is rare. Read More

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Immunohistochemical expression and localization of MMP-9, MMP-13, E-Cadherin and Ki-67 in road pavers' skin chronically exposed to bitumen products.

Histol Histopathol 2019 Oct 11;34(10):1141-1150. Epub 2019 Apr 11.

Department of Clinical and Experimental Medicine, Section of Occupational Medicine, University of Catania, Catania, Italy.

To investigate the matrix metalloproteinase (MMP)-9, (MMP)-13, E-Cadherin and Ki-67 expressions in road pavers' skin chronically exposed to bitumen products in order to contribute to a better understanding of the earlier tissue alteration. Skin punch biopsies from 16 daily exposed workers and a control group were studied by immunohistochemistry. Morphometric and densitometric analyses were also conducted. Read More

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October 2019

Assessment of the anterior segment of patients with primary congenital glaucoma using handheld optical coherence tomography.

Eye (Lond) 2019 08 18;33(8):1232-1239. Epub 2019 Mar 18.

Ophthalmology Group, University of Leicester, Leicester, UK.

Purpose: To investigate the potential of handheld optical coherence tomography (HH-OCT) in assessing the anterior segment of the eye in patients with primary congenital glaucoma.

Design: A prospective, case-controlled observational study.

Participants: Twenty-two patients with primary congenital glaucoma (PCG, 9 females and 13 males; mean age 4. Read More

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Corneal Scarring and Hyperopic Shift After Corneal Cross-linking for Corneal Ectasia After SMILE.

J Refract Surg 2018 Nov;34(11):779-782

Purpose: To report a case of severe corneal scarring and hyperopic shift after corneal cross-linking (CXL) for the treatment of ectasia following small incision lenticule extraction (SMILE).

Methods: Case report and literature review.

Results: A 35-year-old man was referred with severe unilateral corneal haze that developed after CXL. Read More

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November 2018

Survival Analysis of Corneal Densitometry After Collagen Cross-Linking for Progressive Keratoconus.

Cornea 2018 Nov;37(11):1449-1456

Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.

Purpose: To evaluate the history of densitometric data in patients with keratoconus undergoing corneal cross-linking.

Methods: Twenty-two eyes of 22 patients with keratoconus were included. Corneal tomography and densitometry measurements were performed before and after accelerated corneal cross-linking. Read More

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November 2018

Long-Term Shape, Curvature, and Depth Changes of the Lamina Cribrosa after Trabeculectomy.

Ophthalmology 2018 11 28;125(11):1729-1740. Epub 2018 Jun 28.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.

Purpose: To evaluate changes in lamina cribrosa (LC) shape, curvature, and depth after trabeculectomy.

Design: Prospective, observational case series.

Participants: A total of 112 patients (118 eyes) with open- or closed-angle glaucoma undergoing trabeculectomy. Read More

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November 2018

[Electroacupuncture Intervention Improved Pulmonary Function via Promoting Immunoregulation in Chronic Obstructive Pulmonary Disease Rats].

Zhen Ci Yan Jiu 2018 Apr;43(4):236-41

Department of Traditional Chinese Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

Objective: To observe the immunoregulatory effect of electroacupuncture (EA) intervention for muscular dystrophy chronic obstructive pulmonary disease (COPD) rats, so as to investigate its underlying mechanism in improving respiratory function.

Methods: Forty male SD rats were randomly divided into 5 groups: normal, model, EA, exercise, and EA+ exercise (=8 in each). The muscular dystrophy COPD model was established by placing the rats in a closed box to be exposed to cigarette smoke (3-10 cigarettes/time) for 60 min, twice daily, 6 days a week for 90 days. Read More

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Temporomandibular joint anomalies in pediatric craniofacial Gorham-Stout disease.

J Craniomaxillofac Surg 2018 Aug 9;46(8):1179-1184. Epub 2018 May 9.

Assistance Publique - Hôpitaux de Paris, Service de chirurgie maxillofaciale et plastique, Hôpital Universitaire Necker - Enfants Malades, Sorbonne Paris Cité, Université Paris Descartes, Paris, France. Electronic address:

Purpose: Gorham-Stout disease (GS) is a rare and little understood bone disease that leads to the progressive replacement of the affected bone by fibrous tissues. The mandible is the most commonly affected craniofacial bone, but there is no report to date of temporomandibular joint (TMJ) lesions in this condition. We aimed to characterize the involvement of the TMJ in this uncommon bone disorder. Read More

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Influence of the beam profile crosslinking setting on changes in corneal topography and tomography in progressive keratoconus: Preliminary results.

J Cataract Refract Surg 2018 Jun 31;44(6):718-724. Epub 2018 May 31.

From the Department of Ophthalmology (Herber, Spoerl, Pillunat, Raiskup), University Hospital Carl Gustav Carus, Dresden, and the Ernst-Abbe-University of Applied Sciences (Kunert), Jena, Germany; Department of Ophthalmology (Veliká, Raiskup), University Hospital Hradec Králové, Charles University, Prague, Czech Republic.

Purpose: To evaluate the effect of accelerated corneal crosslinking (CXL) with a "higher peripheral intensity" profile setting compared with a standard "top hat" profile setting performed using different CXL systems.

Setting: Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, Germany.

Design: Retrospective case series. Read More

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Posterior cornea and thickness changes after scleral lens wear in keratoconus patients.

Cont Lens Anterior Eye 2019 02 1;42(1):85-91. Epub 2018 May 1.

Department of Optics II (Optometry and Vision), Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid, Spain; Ocupharm Group Research, Department of Biochemistry and Molecular Biology IV, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid, Spain. Electronic address:

Purpose: To evaluate the changes in the corneal thickness, anterior chamber depth and posterior corneal curvature and aberrations after scleral lens wear in keratoconus patients with and without intrastromal corneal ring segments (ICRS).

Methods: Twenty-six keratoconus subjects (36.95 ± 8. Read More

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February 2019

The 7-Year Outcomes of Epithelium-Off Corneal Cross-linking in Progressive Keratoconus.

J Refract Surg 2018 Mar;34(3):181-186

Purpose: To evaluate the clinical results of epitheliumoff corneal cross-linking (CXL) during a 7-year follow-up.

Methods: This retrospective, non-randomized, single-center interventional study enrolled 34 consecutive eyes of 24 patients with progressive keratoconus undergoing CXL surgery with epithelium removal. Visual, refractive, corneal topographic, pachymetric, and anterior segment changes were evaluated at 1, 3, and 7 years after surgery. Read More

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Hydrodynamically Coupled Brownian Dynamics: A coarse-grain particle-based Brownian dynamics technique with hydrodynamic interactions for modeling self-developing flow of polymer solutions.

J Chem Phys 2018 Jan;148(3):034902

Computational Chemical Physics, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

We present a novel coarse-grain particle-based simulation technique for modeling self-developing flow of dilute and semi-dilute polymer solutions. The central idea in this paper is the two-way coupling between a mesoscopic polymer model and a phenomenological fluid model. As our polymer model, we choose Responsive Particle Dynamics (RaPiD), a Brownian dynamics method, which formulates the so-called "conservative" and "transient" pair-potentials through which the polymers interact besides experiencing random forces in accordance with the fluctuation dissipation theorem. Read More

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January 2018

A Model of the Effect of Lens Development on Refraction in Schoolchildren.

Ji C He

Optom Vis Sci 2017 12;94(12):1129-1137

New England College of Optometry, Boston, Massachusetts

Significance: The study provides a new theory on the mechanism underlying myopia development, and it could be useful in clinical practice to control myopia development in schoolchildren.

Purpose: To model the effect of the crystalline lens on refractive development in schoolchildren.

Methods: The Zemax 13 was used to calculate Zernike aberrations and refractions across 50° horizontal visual fields. Read More

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December 2017

Contact Lenses for Keratoconus- Current Practice.

Open Ophthalmol J 2017 31;11:241-251. Epub 2017 Jul 31.

Institute of Ophthalmology and Ocular Microsurgery 'Ophthalmica', Thessaloniki, Greece.

Background: Keratoconus is a chronic, bilateral, usuallly asymmetrical, non-inflammatory, ectatic disorder, being characterized by progressive steepening, thinning and apical scarring of the cornea. Initially, the patient is asymptomatic, but the visual acuity gradually decreases, resulting in significant vision loss due to the development of irregular astigmatism, myopia, corneal thinning and scarring. The classic treatment of visual rehabilitation in keratoconus is based on spectacles and contact lenses (CLs). Read More

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Cesk Slov Oftalmol Spring 2017;73(1):17-23

Introduction: Orthokeratology lenses present a special type of hard contact lenses, which is used especially for myopic correction. The lenses are applied during the night, when thanks to their special shape cause temporally (reversible) change of the cornea shape. During the day, there is not necessary to wear any other refractive correction. Read More

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Corneal Collagen Cross-Linking for Keratoconus in Pediatric Patients-Long-Term Results.

Cornea 2017 Feb;36(2):138-143

Department of Cornea and Refractive Surgery, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: To report the long-term outcome of corneal collagen cross-linking (CXL) for progressive keratoconus in pediatric patients.

Methods: "Epithelium-off" CXL was performed in pediatric eyes with progressive keratoconus. Spectacle-corrected distance visual acuity (CDVA), retinoscopy, topography, and tomography were documented preoperatively and postoperatively at 3 months, 6 months, 1 year, and annually thereafter. Read More

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February 2017