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Genetic landscape clustering of a large DNA barcoding data set reveals shared patterns of genetic divergence among freshwater fishes of the Maroni Basin.

Mol Ecol Resour 2021 Apr 23. Epub 2021 Apr 23.

Herpetology and Ichthyology, Museum of Natural History of Geneva, Geneva, Switzerland.

The Maroni is one of the most speciose basins of the Guianas and hosts a megadiverse freshwater fish community. Although taxonomic references based on morphological identification exist for both the Surinamese and Guianese parts of the basin, there are still taxonomic uncertainties concerning the status of several species. We used COI sequences of 1284 fish in conjunction with morphological and biogeographical evidence to assist with species delineation and discovery in order to validate and standardize the current taxonomy. Read More

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Utility of venous blood gases for the assessment of traumatic shock: a prospective observational study.

Emerg Med J 2021 Mar 31. Epub 2021 Mar 31.

Department of Trauma, Westmead Hospital, Westmead, New South Wales, Australia.

Background: ABG samples are often obtained in trauma patients to assess shock severity. Venous blood gas (VBG) sampling, which is less invasive, has been widely used to assess other forms of shock. The study aim was to determine the agreement between VBG and ABG measurements in trauma. Read More

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Monitoring the effects of COVID-19 in emerging adults with pre-existing mood and anxiety disorders.

Early Interv Psychiatry 2021 Mar 3. Epub 2021 Mar 3.

Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada.

Aim: The COVID-19 quarantine closed many mental health services. Emerging adults with pre-existing mood or anxiety disorders were of concern for worsening symptoms. We sought to demonstrate a method for monitoring mental health status of a group of patients with reduced access to their usual mental health services during quarantine. Read More

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Red flags for the differential diagnosis of granulomatous mastitis: a case report.

J Med Case Rep 2020 Nov 10;14(1):215. Epub 2020 Nov 10.

Department of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, 44575 Garfield Road, Building UC4., Clinton Township, MI, 48038, USA.

Background: Granulomatous mastitis (GM) is a rare benign chronic inflammatory breast disease. GM presents as a heterogeneous illness with variable clinical presentations, and its diagnosis is usually made by exclusion. There are no guidelines for the treatment of GM. Read More

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November 2020

Analyzing 2,589 child neurology telehealth encounters necessitated by the COVID-19 pandemic.

Neurology 2020 09 9;95(9):e1257-e1266. Epub 2020 Jun 9.

From the Division of Neurology (S.C.R., S.E.F., A.K.G., J.X., P.D.G., M.K., M.S.P., U.S., M.P.F., S.E.M., M.P.M., S.K.K., D.J.S.., B.L.B., N.S.A., I.H.), Department of Biomedical and Health Informatics (A.K.G., J.X., P.D.G., M.K., I.H.), and The Epilepsy NeuroGenetics Initiative (A.K.G., J.X., P.D.G., M.K., M.P.F., S.K.K., N.S.A., I.H.), Children's Hospital of Philadelphia; and Departments of Neurology and Pediatrics (S.C.R., S.E.F., M.S.P., M.P.F., S.K.K., N.S.A., I.H.), Department of Biostatistics, Epidemiology and Informatics (N.S.A.), and Department of Anesthesia & Critical Care (N.S.A.), University of Pennsylvania Perelman School of Medicine, Philadelphia.

Objective: To assess the rapid implementation of child neurology telehealth outpatient care with the onset of the coronavirus disease 2019 (COVID-19) pandemic in March 2020.

Methods: This was a cohort study with retrospective comparison of 14,780 in-person encounters and 2,589 telehealth encounters, including 2,093 audio-video telemedicine and 496 scheduled telephone encounters, between October 1, 2019 and April 24, 2020. We compared in-person and telehealth encounters for patient demographics and diagnoses. Read More

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September 2020

Challenges of Developing a Natural Language Processing Method With Electronic Health Records to Identify Persons With Chronic Mobility Disability.

Arch Phys Med Rehabil 2020 10 21;101(10):1739-1746. Epub 2020 May 21.

Health Policy Research Center, Mongan Institute, Massachusetts General Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA. Electronic address:

Objective: To assess the utility of applying natural language processing (NLP) to electronic health records (EHRs) to identify individuals with chronic mobility disability.

Design: We used EHRs from the Research Patient Data Repository, which contains EHRs from a large Massachusetts health care delivery system. This analysis was part of a larger study assessing the effects of disability on diagnosis of colorectal cancer. Read More

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October 2020

Correction to: USMCA (NAFTA 2.0): tightening the constraints on the right to regulate for public health.

Global Health 2019 Jul 1;15(1):44. Epub 2019 Jul 1.

Department of Sociology and Political Science, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway.

Following publication of the original article [1], the authors flagged an error concerning two missing article references, which were unfortunately not provided prior to publication of the article. Read More

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Correction to: Malaria prevention in the city of Yaoundé: knowledge and practices of urban dwellers.

Malar J 2019 06 20;18(1):204. Epub 2019 Jun 20.

Institut de Recherche de Yaoundé (IRY), Organisation de Coordination pour la Lutte contre les Endémies en Afrique Centrale (OCEAC), P.O. Box 288, Yaoundé, Cameroon.

Following publication of the original article [1], the authors flagged an error concerning Table 3. Read More

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Factors associated with potentially serious incidental findings and with serious final diagnoses on multi-modal imaging in the UK Biobank Imaging Study: A prospective cohort study.

PLoS One 2019 17;14(6):e0218267. Epub 2019 Jun 17.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.

Background: Feedback of potentially serious incidental findings (PSIFs) to imaging research participants generates clinical assessment in most cases. Understanding the factors associated with increased risks of PSIFs and of serious final diagnoses may influence individuals' decisions to participate in imaging research and will inform the design of PSIFs protocols for future research studies. We aimed to determine whether, and to what extent, socio-demographic, lifestyle, other health-related factors and PSIFs protocol are associated with detection of both a PSIF and a final diagnosis of serious disease. Read More

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February 2020

Correction to: Performance of an ultra-sensitive Plasmodium falciparum HRP2-based rapid diagnostic test with recombinant HRP2, culture parasites, and archived whole blood samples.

Malar J 2019 02 4;18(1):33. Epub 2019 Feb 4.

Diagnostics Program, PATH, Seattle, WA, USA.

Following publication of the original article [1], the authors flagged an error concerning a reference to a product in the Methods section. Read More

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February 2019

Prospective Inclusion of Apparent Diffusion Coefficients in Multiparametric Prostate MRI Structured Reports: Discrimination of Clinically Insignificant and Significant Cancers.

AJR Am J Roentgenol 2019 01 1;212(1):109-116. Epub 2018 Nov 1.

1 Department of Radiology, University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390.

Objective: The purpose of this study was to assess the diagnostic performance of prospectively assigned mean apparent diffusion coefficient (ADC) values in multiparametric MRI (mpMRI) structured reports for discriminating clinically insignificant (International Society of Urological Pathology [ISUP] group 1) from clinically significant (ISUP groups 2-5) prostate cancer.

Materials And Methods: This single-center study included men with abnormal 3-T mpMRI findings (Prostate Imaging Reporting and Data System version 2 score, ≥ 3) who subsequently underwent radical prostatectomy or targeted biopsy with positive results. One of nine radiologists prospectively reported the mean ADC for each lesion during clinical interpretation. Read More

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January 2019

The prevention of violence in interdisciplinary programs implemented in Brazilian and Portuguese schools.

Cien Saude Colet 2018 Sep;23(9):2899-2908

Departamento de Estudos sobre Violência e Saúde Jorge Careli (Claves), Escola Nacional de Saúde Pública, Fiocruz. Rio de Janeiro RJ Brasil.

This paper aims to understand how and to what extent interdisciplinary teams supporting public schools in the Brazilian and Portuguese context characterize and develop violence prevention actions. The research was carried out from an exploratory study through interviews with 24 professionals and later, a thematic analysis was done. The results indicate that prevention is always pointed out as a possibility in the Portuguese Program; in the Brazilian program, in addition to prevention-oriented discourses, limits regarding the realization of preventive activities in schools are also mentioned. Read More

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September 2018

Automated Telephone Follow-up for Smoking Cessation in Smokers With Coronary Heart Disease: A Randomized Controlled Trial.

Nicotine Tob Res 2019 07;21(8):1051-1057

Division of Prevention and Rehabilitation, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Introduction: Smokers with coronary heart disease (CHD) benefit from in-hospital cessation treatment, but relapse is common without ongoing support postdischarge. The purpose of this study was to determine if smoking abstinence would be higher after hospital discharge in smokers who received automated telephone follow-up (ATF) and nurse-counseling, compared with a standard care (SC) control group.

Methods: A total of 440 smokers hospitalized with CHD were randomly assigned to the ATF group (n = 216) or to the SC group (n = 224). Read More

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The conundrums of human development - implications for the study of child and adolescent disorder.

Alice M Gregory

J Child Psychol Psychiatry 2017 Jul;58(7):749-752

The conundrums inherent in the study of child and adolescent development are likely never far from the minds of the readers of JCPP. The complexity of development is flagged clearly in this issue. Included papers remind us that the link between associations (here maternal depression and child internalising problems) can change over short time periods. Read More

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LS³: A Method for Improving Phylogenomic Inferences When Evolutionary Rates Are Heterogeneous among Taxa.

Mol Biol Evol 2016 06 23;33(6):1625-34. Epub 2016 Feb 23.

Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland Institute of Genetics and Genomics in Geneva (iGE3), Geneva, Switzerland

Phylogenetic inference artifacts can occur when sequence evolution deviates from assumptions made by the models used to analyze them. The combination of strong model assumption violations and highly heterogeneous lineage evolutionary rates can become problematic in phylogenetic inference, and lead to the well-described long-branch attraction (LBA) artifact. Here, we define an objective criterion for assessing lineage evolutionary rate heterogeneity among predefined lineages: the result of a likelihood ratio test between a model in which the lineages evolve at the same rate (homogeneous model) and a model in which different lineage rates are allowed (heterogeneous model). Read More

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Performance of Gram staining on blood cultures flagged negative by an automated blood culture system.

Eur J Clin Microbiol Infect Dis 2015 Aug 16;34(8):1539-41. Epub 2015 Apr 16.

Clinical Microbiology Laboratory, Baruch Padeh Medical Center, Poriya, Affiliated with the Faculty of Medicine, Bar-Ilan University, Galilee, Israel,

Blood is one of the most important specimens sent to a microbiology laboratory for culture. Most blood cultures are incubated for 5-7 days, except in cases where there is a suspicion of infection caused by microorganisms that proliferate slowly, or infections expressed by a small number of bacteria in the bloodstream. Therefore, at the end of incubation, misidentification of positive cultures and false-negative results are a real possibility. Read More

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Enhanced creatinine and estimated glomerular filtration rate reporting to facilitate detection of acute kidney injury.

Am J Clin Pathol 2015 Jan;143(1):42-9

From the Department of Pathology, Massachusetts General Hospital, Boston; Harvard Medical School, Boston, MA;

Objectives: While acute kidney injury (AKI) can be diagnosed based on specified increases in a patient's plasma creatinine level, standard creatinine reporting methods typically only flag creatinine results as abnormal when outside the reference range and often fail to identify rising creatinine values indicative of AKI. Here, we evaluate the impact of this limitation in standard creatinine reporting and develop and implement an enhanced creatinine reporting algorithm.

Methods: We evaluated 59,712 plasma creatinine results collected over approximately 3 months, using computational simulations and statistical analyses. Read More

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January 2015

Do elderly cancer patients have different care needs compared with younger ones?

Tumori 2011 May-Jun;97(3):374-9

Experimental Unit of Psychological Oncology, Department of Critical Area and Surgery, National Cancer Institute Giovanni Paolo II, Bari, Italy.

Aims And Background: The increasingly older population confronts oncologists with an imposing challenge: older cancer patients have specific healthcare needs both independent of and associated with the diagnosis of cancer. The aim of the present study is to examine whether elderly versus younger cancer patients have different needs with respect to attendance, treatment and information.

Methods And Study Design: This is an observational and cross-sectional study. Read More

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Effect of population screening for type 2 diabetes on mortality: long-term follow-up of the Ely cohort.

Diabetologia 2011 Feb 27;54(2):312-9. Epub 2010 Oct 27.

MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.

Aims/hypothesis: The aim of this study was to assess the impact of invitation to screening for type 2 diabetes and related cardiovascular risk factors on population mortality.

Methods: This was a parallel-group population-based cohort study including all men and women aged 40-65 years, free of known diabetes, registered with a single practice in Ely, UK (n = 4,936). In 1990-1992, approximately one-third (n = 1,705) were randomly selected to receive an invitation to screening for diabetes (with an OGTT) and related cardiovascular risk factors. Read More

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February 2011

WHO informal consultation on regulatory evaluation of therapeutic biological medicinal products held at WHO Headquarters, Geneva, 19-20 April 2007.

Biologicals 2008 Jul 22;36(4):269-76. Epub 2008 Jan 22.

World Health Organization, Department of Immunization, Vaccines and Biologicals, Quality, Safety and Standards, 20 Avenue Appia, CH-1211 Geneva, Switzerland.

This report reflects the discussion and conclusions of an informal consultation held on 19-20 April 2007 at the World Health Organization concerning the regulatory evaluation of therapeutic biological medicinal products. The objectives of this meeting were to discuss the current status of so-called "similar" biological medicinal products (biosimilars) and to review regulatory pathways and challenges in evaluating the quality, safety and efficacy of these products. Biosimilars are products that are subject to licensing with a reduced data package due to a proven 'similarity' to the licensed reference product. Read More

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Improving the use of research evidence in guideline development: 13. Applicability, transferability and adaptation.

Health Res Policy Syst 2006 Dec 8;4:25. Epub 2006 Dec 8.

INFORMA/CLARITY Research Group, SC Epidemiologia, Istitituto Regina Elena, Via Elio Chianesi 53, 00144 Rome, Italy.

Background: The World Health Organization (WHO), like many other organisations around the world, has recognised the need to use more rigorous processes to ensure that health care recommendations are informed by the best available research evidence. This is the thirteenth of a series of 16 reviews that have been prepared as background for advice from the WHO Advisory Committee on Health Research to WHO on how to achieve this.

Objectives: We reviewed the literature on applicability, transferability, and adaptation of guidelines. Read More

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December 2006

Preliminary testing of a just-in-time, user-defined values clarification exercise to aid lower literate women in making informed breast cancer treatment decisions.

Health Expect 2006 Sep;9(3):218-31

Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX 77098, USA.

Objective: To report on the initial testing of a values clarification exercise utilizing a jewellery box within a computerized patient decision aid (CPtDA) designed to assist women in making a surgical breast cancer treatment decision.

Design: Pre-post design, with patients interviewed after diagnosis, and then after completing the CPtDA sometime later at their preoperative visit.

Sample: Fifty-one female patients, who are low literate and naïve computer users, newly diagnosed with early stage breast cancer from two urban public hospitals. Read More

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September 2006

[The "Muenster classification" of high frequency hearing loss following cisplatin chemotherapy].

HNO 2007 Apr;55(4):299-306

Klinik und Poliklinik für Phoniatrie und Pädaudiologie, Universitätsklinikum Münster, Kardinal-von-Galen-Ring 10, 48149, Münster.

Background: Slight high frequency hearing loss following cisplatin chemotherapy can be proof of an ototoxic effect even when hearing ability is not yet clinically affected. To answer scientific questions, such as the relationship between cisplatin ototoxicity and drug regime or individual tolerance, early detection of ototoxicity and a classification relating to intensity and the affected frequencies are required. A search for relevant literature resulted the WHO-classification (1991) describing clinically relevant hearing loss and two high frequency hearing loss classifications published by Khan et al. Read More

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Cultural and ethical issues concerning research on American Indian youth.

Ethics Behav 2005 ;15(1):1-14

The George Warren Brown School of Social Work, Comorbidity and Addictions Center, Washington University, USA.

A study of American Indian youths illustrates competing pressures between research and ethics. A stakeholder-researcher team developed three plans to protect participants. The first allowed participants to skip potentially upsetting interview sections. Read More

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October 2005

After the MV Estonia ferry disaster A Swedish nationwide survey of the relatives of the MV Estonia victims.

Dialogues Clin Neurosci 2000 Mar;2(1):63-9

Psychiatric Clinic, Ersta Hospital, Stockholm, Sweden.

Just after midnight on the 28th of September 1994, the Estonian-flagged ro-ro passenger ferry MV Estonia was shipwrecked on its route between Tallinn and Stockholm. Out of about 1000 persons on board only 137 survived. This paper describes the work that the Psychiatric Clinic at Ersta Hospital performed with the relatives of the MV Estonia victims after the disaster, in addition, we present data from seven consecutive Swedish nationwide surveys based on a questionnaire, which started as a correspondence between the hospital and the relatives of the Estonia victims. Read More

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