5,237 results match your criteria fits best


Delay - aware bandwidth estimation and intelligent video transcoder in mobile cloud.

Peer Peer Netw Appl 2021 May 1:1-23. Epub 2021 May 1.

Department of Information Science & Technology, Faculty of Information & Communication Engineering, College of Engineering Anna University, Chennai, India.

In recent years, smartphone users are interested in large volumes to view live videos and sharing video resources over social media (e.g., Youtube, Netflix). Read More

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Comparison of an artificial neural network and Gompertz model for predicting the dynamics of deaths from COVID-19 in México.

Nonlinear Dyn 2021 Apr 30:1-15. Epub 2021 Apr 30.

Facultad de Ciencias Químicas-Centro de Investigación en Recursos Energéticos y Sustentables, Universidad Veracruzana, Campus Coatzacoalcos, Av. Universidad km. 7.5, Col. Santa Isabel, Coatzacoalcos CP, 96538 Veracruz, México.

The present work is focused on modeling and predicting the cumulative number of deaths from COVID-19 in México by comparing an artificial neural network (ANN) with a Gompertz model applying multiple optimization algorithms for the estimation of coefficients and parameters, respectively. For the modeling process, the data published by the daily technical report COVID-19 in Mexico from March 19th to September 30th were used. The data published in the month of October were included to carry out the prediction. Read More

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Status epilepticus and diabetes ketoacidosis: uncommon clinical presentations of acromegaly.

Endocrinol Diabetes Metab Case Rep 2021 Apr 1;2021. Epub 2021 Apr 1.

Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.

Summary: Acromegaly is a rare disease caused by hypersecretion of the growth hormone (GH). Most cases are caused by either pituitary microadenoma or macroadenoma. The GH producing tumors present with clinical manifestations of acromegaly due to excessive GH secretion or symptoms resulting from mass effects of the enlarging tumor. Read More

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Comparison of Breast Cancer Staging Systems After Neoadjuvant Chemotherapy.

Ann Surg Oncol 2021 May 6. Epub 2021 May 6.

Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Background: No consensus exists for optimal staging following neoadjuvant chemotherapy (NAC). We compared the performance of the American Joint Committee on Cancer (AJCC) pathologic prognostic staging system, Residual Cancer Burden (RCB) Index, and the Neo-Bioscore in breast cancer patients after NAC.

Methods: Patients with stage I-III breast cancer who received NAC at Dana-Farber Cancer Institute from 2004 to 2014 were identified. Read More

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Reliability and minimal detectable change of the , an advanced motor skills test for children with cerebral palsy, Danish version.

Disabil Rehabil 2021 May 6:1-8. Epub 2021 May 6.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Purpose: To translate and cross-culturally adapt the , and investigate the reliability and minimal detectable change (MDC) of the Danish in children with cerebral palsy (CP).

Materials And Methods: A Danish version of the was created through a standardized translation process. Four physiotherapists evaluated face validity. Read More

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Drought Analysis in East Nusa Tenggara (Indonesia) Using Regional Frequency Analysis.

ScientificWorldJournal 2021 10;2021:6626102. Epub 2021 Apr 10.

Department of Statistics, Institut Teknologi Sepuluh Nopember, Jalan Raya ITS, Surabaya 60111, Indonesia.

Drought is a condition of a shortage of water that has an impact on economic activity. This research studies the severe drought area in Indonesia using Regional Frequency Analysis (RFA), based on daily precipitation data recorded at nine stations. The analysis reveals five homogeneous regions, based on discordancy and heterogeneity tests. Read More

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Cross-cultural adaptation and validation of the Arabic version of the BACS scale (the brief assessment of cognition in schizophrenia) among chronic schizophrenic inpatients.

BMC Psychiatry 2021 05 1;21(1):223. Epub 2021 May 1.

INSERM, University Limoges, CH Esquirol, IRD, U1094 Tropical Neuroepidemiology, Neurology, Limoges, France.

Background: Assessment of cognitive disorders in schizophrenia is becoming a part of clinical and research practice by using batteries that differ widely in their content. The Brief Assessment of Cognition in Schizophrenia (BACS) was developed to cover the main cognitive deficits of schizophrenia. The objective of this study was to assess concurrent validity of the Arabic version of the BACS with a standard neurocognitive battery of tests in Lebanese patients with schizophrenia and healthy controls. Read More

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Validation of the PHQ-9 in adults with dissociative seizures.

J Psychosom Res 2021 Apr 8;146:110487. Epub 2021 Apr 8.

Academic Neurology Unit, Royal Hallamshire Hospital, University of Sheffield, Sheffield, UK.

Background: The PHQ-9 is a self-administered depression screening instrument. Little is known about its utility and accuracy in detecting depression in adults with dissociative seizures (DS).

Objectives: Using the Mini - International Neuropsychiatric Interview as a reference, we evaluated the diagnostic accuracy of the PHQ-9 in adults with DS, and examined its convergent and discriminant validity and uniformity. Read More

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Predictive modelling as a tool for effective municipal waste management policy at different territorial levels.

J Environ Manage 2021 Apr 27;291:112584. Epub 2021 Apr 27.

Institute of Mathematics, Faculty of Mechanical Engineering, Brno University of Technology - VUT Brno, Technická 2896/2, 616 69, Brno, Czech Republic.

Nowadays, the European municipal waste management policy based on the circular economy paradigm demands the closing of material and financial loops at all territorial levels of public administration. The effective planning of treatment capacities (especially sorting plants, recycling, and energy recovery facilities) and municipal waste management policy requires an accurate prognosis of municipal waste generation, and therefore, the knowledge of behavioral, socio-economic, and demographic factors influencing the waste management (and recycling) behavior of households, and other municipal waste producers. To enable public bodies at different territorial levels to undertake an effective action resulting in circular economy we evaluated various factors influencing the generation of municipal waste fractions at regional, micro-regional and municipal level in the Czech Republic. Read More

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Awake craniotomy for epilepsy surgery on eloquent speech areas: a single-centre experience.

Epileptic Disord 2021 Apr 29. Epub 2021 Apr 29.

Department of Functional Neurosurgery, Hospices Civils de Lyon and University of Lyon, Lyon, France, University of Lyon, Lyon, France, Lyon's Neuroscience Research Centre, (INSERM U1028, CNRS UMR5292), University of Lyon, Lyon, France.

In patients with intractable partial epilepsy who are eligible for epilepsy surgery, the best seizure control requires complete resection of the epileptogenic zone. When the epileptogenic zone is located very near to, or even with the eloquent cortex, this can be a challenge. In this study, we investigated the efficacy of awake craniotomy techniques to completely resect these epileptic zones while preserving the neural functions. Read More

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The Role of Artificial Intelligence in Managing Multimorbidity and Cancer.

J Pers Med 2021 Apr 19;11(4). Epub 2021 Apr 19.

Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Traditional healthcare paradigms rely on the disease-centered approach aiming at reducing human nature by discovering specific drivers and biomarkers that cause the advent and progression of diseases. This reductive approach is not always suitable to understand and manage complex conditions, such as multimorbidity and cancer. Multimorbidity requires considering heterogeneous data to tailor preventing and targeting interventions. Read More

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Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme.

Cancers (Basel) 2021 Apr 14;13(8). Epub 2021 Apr 14.

Berlin Ultrahigh Field Facility, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.

Thermal intervention is a potent sensitizer of cells to chemo- and radiotherapy in cancer treatment. Glioblastoma multiforme (GBM) is a potential clinical target, given the cancer's aggressive nature and resistance to current treatment options. This drives research into optimization algorithms for treatment planning as well as radiofrequency (RF) applicator design for treatment delivery. Read More

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Preparation of Co-Processed Excipients for Controlled-Release of Drugs Assembled with Solid Lipid Nanoparticles and Direct Compression Materials.

Molecules 2021 Apr 6;26(7). Epub 2021 Apr 6.

Laboratorio de Investigación y Posgrado en Tecnología Farmacéutica, Universidad Nacional Autónoma de México, FES-Cuautitlán, Cuautitlán Izcalli 54745, Estado de México, Mexico.

The purpose of the study was to develop a novel, directly compressible, co-processed excipient capable of providing a controlled-release drug system for the pharmaceutical industry. A co-processed powder was formed by adsorption of solid lipid nanoparticles (SLN) as a controlled-release film onto a functional excipient, in this case, dicalcium phosphate dihydrate (DPD), for direct compression (Di-Tab). The co-processed excipient has advantages: easy to implement; solvent-free; industrial scaling-up; good rheological and compressibility properties; and the capability to form an inert platform. Read More

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Retrospective study for validation and improvement of numerical treatment planning of irreversible electroporation ablation for treatment of liver tumors.

IEEE Trans Biomed Eng 2021 Apr 27;PP. Epub 2021 Apr 27.

Objective: To determine the electric field threshold in our numerical model that best fits the local response to irreversible electroporation (IRE) ablation of hepatic tumors as seen in 6 week follow-up MRI. To numerically evaluate the heat generating effect of IRE and demonstrate the potential of treatment planning to avoid thermal damage and shorten procedures in the future.

Methods: In a retrospective study 18 cases of hepatic tumors treated with IRE ablation were numerically reconstructed and treatment outcome was computed with a numerical treatment planning framework. Read More

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Acute Necrotizing Encephalopathy as a Complication of Chikungunya Infection.

Neurol India 2021 Mar-Apr;69(2):490-492

Department of Neuroimaging and Interventional Neuroradiology (NIIR), National Institute of Mental Health and Neurosciences (NIMHANS) Bengaluru, Karnataka, India.

Background: Acute necrotizing encephalopathy (ANE) is a rapidly progressive encephalopathy seen commonly in children triggered by various prodromal viral infections, most common being influenza virus and Human herpes virus-6.

Objective: We report two rare cases of ANE preceded by Chikungunya infection.

Cases: A 13-year old girl presented with a three-day history of headache, fever, seizures, and altered sensorium. Read More

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Representing Tuberculosis Transmission with Complex Contagion: An Agent-Based Simulation Modeling Approach.

Med Decis Making 2021 Apr 27:272989X211007842. Epub 2021 Apr 27.

Department of Industrial and Systems Engineering, University of Wisconsin-Madison, Madison, WI, USA, PhD.

Objective: A recent study reported a tuberculosis (TB) outbreak in which, among newly infected individuals, exposure to additional active infections was associated with a higher probability of developing active disease. Referred to as , multiple reexposures to TB within a short period after initial infection is hypothesized to confer a greater likelihood of developing active infection in 1 y. The purpose of this article is to develop and validate an agent-based simulation model (ABM) to study the effect of complex contagion on population-level TB transmission dynamics. Read More

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Autoimmune Encephalitis in Late-Onset Seizures: When to Suspect and How to Treat.

Front Neurol 2021 7;12:633999. Epub 2021 Apr 7.

Department of Neurology, Epilepsy Center, University Medicine Greifswald, Greifswald, Germany.

This study was conducted to elucidate prevalence, clinical features, outcomes, and best treatment in patients with late-onset seizures due to autoimmune encephalitis (AE). This is a single-institution prospective cohort study (2012-2019) conducted at the Epilepsy Center at the University of Greifswald, Germany. A total of 225 patients aged ≥50 years with epileptic seizures were enrolled and underwent an MRI/CT scan, profiling of neural antibodies (AB) in serum and cerebrospinal fluid (CSF), and neuropsychological testing. Read More

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A Deep Learning Approach for Automatic Seizure Detection in Children With Epilepsy.

Front Comput Neurosci 2021 8;15:650050. Epub 2021 Apr 8.

Department of Electrical and Computer Engineering, University of Louisiana at Lafayette, Lafayette, LA, United States.

Over the last few decades, electroencephalogram (EEG) has become one of the most vital tools used by physicians to diagnose several neurological disorders of the human brain and, in particular, to detect seizures. Because of its peculiar nature, the consequent impact of epileptic seizures on the quality of life of patients made the precise diagnosis of epilepsy extremely essential. Therefore, this article proposes a novel deep-learning approach for detecting seizures in pediatric patients based on the classification of raw multichannel EEG signal recordings that are minimally pre-processed. Read More

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Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents.

ACS Chem Neurosci 2021 May 23;12(9):1716-1736. Epub 2021 Apr 23.

Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, MSD2080 Msida, Malta.

Temporal lobe epilepsy is the most common form of epilepsy, and current antiepileptic drugs are ineffective in many patients. The endocannabinoid system has been associated with an on-demand protective response to seizures. Blocking endocannabinoid catabolism would elicit antiepileptic effects, devoid of psychotropic effects. Read More

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Synergizing Mouse and Human Studies to Understand the Heterogeneity of Obesity.

Adv Nutr 2021 Apr 22. Epub 2021 Apr 22.

Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Obesity is routinely considered as a single disease state, which drives a "one-size-fits-all" approach to treatment. We recently convened the first annual University of North Carolina Interdisciplinary Nutrition Sciences Symposium to discuss the heterogeneity of obesity and the need for translational science to advance understanding of this heterogeneity. The symposium aimed to advance scientific rigor in translational studies from animal to human models with the goal of identifying underlying mechanisms and treatments. Read More

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Clarifying the Genetic Influences on Nicotine Dependence and Quantity of Use in Cigarette Smokers.

Behav Genet 2021 Apr 21. Epub 2021 Apr 21.

Virginia Commonwealth University, Richmond, USA.

Nicotine dependence and smoking quantity are both robustly associated with the CHRNA5-A3-B4 gene cluster in the 15q25 region, and SNP rs16969968 in particular. The purpose of this paper is to use structural equation modeling techniques (SEM) to disentangle the complex pattern of relationships between rs16969968, nicotine quantity (as measured by the number of cigarettes an individual smokes per day; CPD) and nicotine dependence (as measured by the Fagerström Test for Nicotine Dependence; FTND). CPD is an indicator, but also a potential cause, of FTND, complicating the interpretation of associations between these constructs and requires a more detailed investigation than standard GWAS or general linear regression models can provide. Read More

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Whole-Exome Sequencing for Identifying Genetic Causes of Intellectual Developmental Disorders.

Int J Gen Med 2021 13;14:1275-1282. Epub 2021 Apr 13.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510280, People's Republic of China.

Background: Intellectual developmental disorders (IDD) generally refers to the persistent impairment of cognitive activities and mental retardation caused by physical damage to the brain or incomplete brain development. We aimed to explore its genetic causes.

Methods: In this study, 21 IDD patients were recruited. Read More

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Comparison of Predictive Models and Impact Assessment of Lockdown for COVID-19 over the United States.

J Epidemiol Glob Health 2021 Feb 22. Epub 2021 Feb 22.

Department of Mathematics, Southern Methodist University, Dallas, TX 75275, USA.

The novel Coronavirus Disease 2019 (COVID-19) remains a worldwide threat to community health, social stability, and economic development. Since the first case was recorded on December 29, 2019, in Wuhan of China, the disease has rapidly extended to other nations of the world to claim many lives, especially in the USA, the United Kingdom, and Western Europe. To stay ahead of the curve consequent of the continued increase in case and mortality, predictive tools are needed to guide adequate response. Read More

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February 2021

A test of ab initio-generated, radial intermolecular potential energy functions for five axially-symmetric, hydrogen-bonded complexes BHF, where B = N, CO, PH, HCN and NH.

Authors:
Anthony C Legon

Phys Chem Chem Phys 2021 Mar 22;23(12):7271-7279. Epub 2021 Mar 22.

School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.

The radial potential energy functions for five axially symmetric, hydrogen-bonded complexes BHF (B = N, CO, PH, HCN and NH) have been calculated ab initio at the explicitly correlated level of theory CCSD(T)(F12c)/cc-pVTZ-F12 as a function of the hydrogen-bond distance r(ZH), where Z is the hydrogen-bond acceptor atom of B. The remaining geometric parameters were optimised at each point in the calculation. The functions so generated were then used to estimate the spectroscopic constants ω, ωx,α, and the v = 1 ← 0 transition wavenumber associated with the intermolecular stretching mode ν of each BHF by using two equivalent approaches. Read More

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Stereoelectroencephalography-guided radiofrequency thermocoagulation for hypothalamic hamartoma: Electroclinical patterns and the relationship with surgical prognosis.

Epilepsy Behav 2021 May 16;118:107957. Epub 2021 Apr 16.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Stereotactic and Functional Neurosurgery, Beijing Neurosurgical Institute, Beijing, China. Electronic address:

Background: Radiofrequency thermocoagulation (RFTC) guided by stereo-electroencephalography (SEEG) has been proved to be a safe method to reduce seizure frequency in patients with drug-resistant epilepsy. However, there are few reports addressing the value and safety of this procedure in hypothalamic hamartoma (HH).

Objective: To present the results of our experience using SEEG-guided RFTC in HH patients with drug-resistant epilepsy, and identify outcome predictors. Read More

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Antidepressants for people with epilepsy and depression.

Cochrane Database Syst Rev 2021 04 16;4:CD010682. Epub 2021 Apr 16.

Department of Health Data Science, University of Liverpool, Liverpool, UK.

Background: Depressive disorders are the most common psychiatric comorbidity in people with epilepsy, affecting around one-third, with a significant negative impact on quality of life. There is concern that people may not be receiving appropriate treatment for their depression because of uncertainty regarding which antidepressant or class works best, and the perceived risk of exacerbating seizures. This review aimed to address these issues, and inform clinical practice and future research. Read More

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One-Size-Fits All: A Scalable Solution to Formal Telemedicine Provider Training to Support the COVID-19 Pandemic Response.

Front Pediatr 2021 30;9:647458. Epub 2021 Mar 30.

Telehealth Programs, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.

Formalized training in telemedicine addresses barriers to provider adoption and engagement and assures a level of competence for independent practice. We previously developed a blended-model training program, customizable according to role and specialty; this method of training was not feasible in the pandemic response. We describe the development and implementation of a multi- and interdisciplinary telemedicine provider training program enabling the rapid scaling of telemedicine at our institution. Read More

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Posterior reversible encephalopathy syndrome in a patient with a metastatic pancreatic neuroendocrine tumour and ectopic Cushing's syndrome.

Endocrinol Diabetes Metab Case Rep 2021 Apr 14;2021. Epub 2021 Apr 14.

King's College Hospital National Health Service Foundation TrustLondon, UK.

Summary: We report a rare case of posterior reversible encephalopathy syndrome (PRES), precipitated by ectopic Cushing's syndrome, in a patient with a metastatic pancreatic neuroendocrine tumour. A 55-year-old female presented as a hypertensive emergency with seizures and severe biochemical disturbance, including alkalosis, hypokalaemia and hyperglycaemia. MRI showed vasogenic oedema in the parieto-occipital region, consistent with a diagnosis of PRES. Read More

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Korean Version of the Thought-Action Fusion Scale: The Evidence for Its Psychometric Properties.

Psychiatry Investig 2021 Apr 15;18(4):348-356. Epub 2021 Apr 15.

Counseling Center, University of Maryland, Baltimore County (UMBC), Baltimore, MD, USA.

Objective: The Thought-Action Fusion Scale (TAFS) is a self-reported instrument used to measure a cognitive bias, namely, thoughtaction fusion (TAF), in which intrusive thoughts have moral and actual consequences. The aim of this study is to investigate the reliability and validity of the Korean version of the 19-item TAFS (K-TAFS) in Korean samples.

Methods: In this study, 628 university students and 93 patients with obsessive-compulsive disorder (OCD) completed the K-TAFS and several other psychological scales. Read More

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