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Preparation of camptothecin micelles self-assembled from disodium glycyrrhizin and tannic acid with enhanced antitumor activity.

Eur J Pharm Biopharm 2021 Apr 17. Epub 2021 Apr 17.

National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P.R. China; Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P.R. China. Electronic address:

Natural compounds as carriers for hydrophobic drugs have been increasingly used in drug delivery systems. In this study, disodium glycyrrhizin (NaGA), tannic acid (TA) and camptothecin (CPT) were firstly used to prepare the camptothecin solid dispersion (CPT SD). When dissolved in a solution medium, NaGA self-assembled to form micelles and CPT was encapsulated in micelles, meanwhile, TA connected with NaGA through hydrogen bonds to form a contract shell. Read More

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Identification of Dysregulated microRNAs in Glioma Using RNA-sequencing.

Curr Med Sci 2021 Apr 20;41(2):356-367. Epub 2021 Apr 20.

School of Pre-clinical Medicine, Guangxi Medical University, Nanning, 530021, China.

Glioma is the most common malignant brain tumor in central nervous system. Despite advances in the treatment of glioma such as surgery and chemoradiotherapy, most patients are easy to relapse, resulting in adverse clinical outcomes. Hence, effective molecular-targeting treatment may be one of attractive strategies for glioma therapy. Read More

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Bioinformatic analysis identifying FGF1 gene as a new prognostic indicator in clear cell Renal Cell Carcinoma.

Cancer Cell Int 2021 Apr 17;21(1):222. Epub 2021 Apr 17.

Department of Pathology, The Second Hospital of ShanXi Medical University, ShanXi Province, No.382 WuYi Road, Tai Yuan, 030000, China.

Background: Clear cell renal cell carcinoma (ccRCC) has been the commonest renal cell carcinoma (RCC). Although the disease classification, diagnosis and targeted therapy of RCC has been increasingly evolving attributing to the rapid development of current molecular pathology, the current clinical treatment situation is still challenging considering the comprehensive and progressively developing nature of malignant cancer. The study is to identify more potential responsible genes during the development of ccRCC using bioinformatic analysis, thus aiding more precise interpretation of the disease METHODS: Firstly, different cDNA expression profiles from Gene Expression Omnibus (GEO) online database were used to screen the abnormal differently expressed genes (DEGs) between ccRCC and normal renal tissues. Read More

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KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated β-catenin pathway.

Cell Biosci 2021 Apr 15;11(1):73. Epub 2021 Apr 15.

Department of Surgery, The First Affiliated Hospital of Shanxi Medical University, 85 South Jiefang Road, Taiyuan, 030001, Shanxi, China.

Objective: Dysregulation of KLF7 participates in the development of various cancers, but it is unclear whether there is a link between HCC and aberrant expression of KLF7. The aim of this study was to investigate the role of KLF7 in proliferation and migration of hepatocellular carcinoma (HCC) cells.

Methods: CCK8, colony growth, transwell, cell cycle analysis and apoptosis detection were performed to explore the effect of KLF7, VPS35 and Ccdc85c on cell function in vitro. Read More

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Establishment and validation of a prognostic signature for lung adenocarcinoma based on metabolism-related genes.

Cancer Cell Int 2021 Apr 15;21(1):219. Epub 2021 Apr 15.

Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Background: Given that dysregulated metabolism has been recently identified as a hallmark of cancer biology, this study aims to establish and validate a prognostic signature of lung adenocarcinoma (LUAD) based on metabolism-related genes (MRGs).

Methods: The gene sequencing data of LUAD samples with clinical information and the metabolism-related gene set were obtained from The Cancer Genome Atlas (TCGA) and Molecular Signatures Database (MSigDB), respectively. The differentially expressed MRGs were identified by Wilcoxon rank sum test. Read More

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Impacts of Pharmacists-Managed Oncology Outpatient Clinic on Resolving Drug-Related Problems in Ambulatory Neoplasm Patients: A Prospective Study in China.

Inquiry 2021 Jan-Dec;58:469580211009662

Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Pharmacists are health care professionals who are actively involved in identifying and solving drug-related problems (DRPs) in neoplasm patients. However, the effectiveness of pharmaceutical services at outpatient clinic for neoplasm patients have not been reported in China. This study aims to describe and investigate the impacts of pharmacists-managed oncology outpatient clinic on ambulatory neoplasm patients. Read More

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Transferred Subspace Learning Based on Non-negative Matrix Factorization for EEG Signal Classification.

Front Neurosci 2021 24;15:647393. Epub 2021 Mar 24.

School of Computer Science and Technology, Qilu University of Technology (Shandong Academy of Science), Jinan, China.

EEG signal classification has been a research hotspot recently. The combination of EEG signal classification with machine learning technology is very popular. Traditional machine leaning methods for EEG signal classification assume that the EEG signals are drawn from the same distribution. Read More

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Force-, heat- and acid-induced fluorescent switching properties of an anthracene-based hydrazide derivative.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 29;256:119752. Epub 2021 Mar 29.

College of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen 518060, PR China.

A novel anthracene-based hydrazide derivative (3,4-ENS) was designed and synthesized, and 3,4-ENS can form stable organogel in dimethyl sulfoxide (DMSO) solvent. Firstly, 3,4-ENS xerogel from DMSO exhibits mechanofluorochromic property and its maximum emission shifts from 433 nm to 484 nm upon grinding. Secondly, DMSO xerogel exhibits thermofluorochromic behavior and its maximum emission shifts from 433 nm to 481 nm upon heating at 110 °C. Read More

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Design, synthesis, biological evaluation and molecular dynamics of LAR inhibitors.

Comput Biol Chem 2021 Mar 30;92:107481. Epub 2021 Mar 30.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China. Electronic address:

In this study, firstly, the pharmacophore model was established based on LAR inhibitors. ZINC database and drug-like database were screened by Hypo-1-LAR model, and the embryonic compound ZINC71414996 was obtained. Based on this compound, we designed 9 compounds. Read More

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The effects of MEX3A knockdown on proliferation, apoptosis and migration of osteosarcoma cells.

Cancer Cell Int 2021 Apr 8;21(1):197. Epub 2021 Apr 8.

Department of Orthopedics, Zhejiang Provincial People's Hospital. No, Xiacheng District, 158 Shangtang Road, Hangzhou, Zhejiang, China.

Background: Osteosarcoma is an aggressive malignant tumor which has attracted worldwide attention. MEX3A may be associated with tumors while has not yet seen its coverage on osteosarcoma. Herein, this study was to investigate the correlation between MEX3A and the progression of osteosarcoma. Read More

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Transmission analysis of COVID-19 with discrete time imported cases: Tianjin and Chongqing as cases.

Infect Dis Model 2021 31;6:618-631. Epub 2021 Mar 31.

Complex Systems Research Center, Shanxi University, Taiyuan, Shan'xi, 030006, China.

In 2020, an unexpectedly large outbreak of the coronavirus disease 2019 (COVID-19) epidemic was reported in mainland China. As we known, the epidemic was caused by imported cases in other provinces of China except for Hubei in 2020. In this paper, we developed a differential equation model with tracing isolation strategy with close contacts of newly confirmed cases and discrete time imported cases, to perform assessment and risk analysis for COVID-19 outbreaks in Tianjin and Chongqing city. Read More

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Silencing long non-coding RNA MIAT ameliorates myocardial dysfunction induced by myocardial infarction MIAT/miR-10a-5p/EGR2 axis.

Aging (Albany NY) 2021 Mar 26;13. Epub 2021 Mar 26.

Department of Neurology, Tangshan People’s Hospital, Tangshan 063001, P.R. China.

Long non-coding RNA (lncRNA) myocardial infarction-associated transcript (MIAT) has been widely-demonstrated to function as diagnostic markers for acute myocardial infarction (MI). This study was designed to explore the modulatory role of MIAT and its underlying molecular mechanism in MI. Firstly, MI mouse model was developed ligation of the descending branch of the left coronary artery, and cell model was established through exposure to hypoxic conditions Online prediction indicated that MIAT could bind to microRNA-10a-5p (miR-10a-5p), while miR-10a-5p was highlighted to bind to early growth response gene-2 (EGR2). Read More

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Prospective Image Quality and Lesion Assessment in the Setting of MR-Guided Radiation Therapy of Prostate Cancer on an MR-Linac at 1.5 T: A Comparison to a Standard 3 T MRI.

Cancers (Basel) 2021 Mar 26;13(7). Epub 2021 Mar 26.

Department of Radiation Oncology, Eberhard-Karls University, 72076 Tuebingen, Germany.

The objective of this study is to conduct a qualitative and a quantitative image quality and lesion evaluation in patients undergoing MR-guided radiation therapy (MRgRT) for prostate cancer on a hybrid magnetic resonance imaging and linear accelerator system (MR-Linac or MRL) at 1.5 Tesla. This prospective study was approved by the institutional review board. Read More

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Fluorescent Polyelectrolyte System to Track Anthocyanins Delivery inside Melanoma Cells.

Nanomaterials (Basel) 2021 Mar 19;11(3). Epub 2021 Mar 19.

Biochemistry Department, Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 3-5 Calea Manastur, 400372 Cluj-Napoca, Romania.

Over the past decades, there has been a growing interest in using natural molecules with therapeutic potential for biomedical applications. In this context, our aim is focused on anthocyanins (AN) as molecules with anticancer properties that could be used in melanoma local therapies. Due to their susceptibility to environmental changes, current study is based on the design and development of a fluorescent system for carrying and trafficking AN inside melanoma cells. Read More

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Optimization of Structure and Electrical Characteristics for Four-Layer Vertically-Stacked Horizontal Gate-All-Around Si Nanosheets Devices.

Nanomaterials (Basel) 2021 Mar 5;11(3). Epub 2021 Mar 5.

Advanced Integrated Circuits R&D Center, Institute of Microelectronic of the Chinese Academy of Sciences, Beijing 100029, China.

In this paper, the optimizations of vertically-stacked horizontal gate-all-around (GAA) Si nanosheet (NS) transistors on bulk Si substrate are systemically investigated. The release process of NS channels was firstly optimized to achieve uniform device structures. An over 100:1 selective wet-etch ratio of GeSi to Si layer was achieved for GeSi/Si stacks samples with different GeSi thickness (5 nm, 10 nm, and 20 nm) or annealing temperatures (≤900 °C). Read More

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Polydopamine-Assisted Rapid One-Step Immobilization of L-Arginine in Capillary as Immobilized Chiral Ligands for Enantioseparation of Dansyl Amino Acids by Chiral Ligand Exchange Capillary Electrochromatography.

Molecules 2021 Mar 23;26(6). Epub 2021 Mar 23.

School of Pharmacy, Southwest Medical University, Luzhou 646000, China.

Herein, a novel L-arginine (L-Arg)-modified polydopamine (PDA)-coated capillary (PDA/L-Arg@capillary) was firstly fabricated via the basic amino-acid-induced PDA co-deposition strategy and employed to constitute a new chiral ligand exchange capillary electrochromatography (CLE-CEC) method for the high-performance enantioseparation of D,L-amino acids (D,L-AAs) with L-Arg as the immobilized chiral ligand coordinating with the central metal ion Zn(II) as running buffer. Assisted by hydrothermal treatment, the robust immobilization of L-Arg on the capillary inner wall could be facilely achieved within 1 h, prominently improving the synthesis efficiency and simplifying the preparation procedure. The successful preparation of PDA/L-Arg coatings in the capillary was systematically characterized and confirmed using several methods. Read More

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Porous Media Computational Fluid Dynamics and the Role of the First Coil in the Embolization of Ruptured Intracranial Aneurysms.

J Clin Med 2021 Mar 24;10(7). Epub 2021 Mar 24.

Department of Neurosurgery and Neurooncology, Medical University of Lodz, Barlicki University Hospital, Kopcińskiego 22, 90-153 Lodz, Poland.

Background: The objective of our project was to identify a late recanalization predictor in ruptured intracranial aneurysms treated with coil embolization. This goal was achieved by means of a statistical analysis followed by a computational fluid dynamics (CFD) with porous media modelling approach. Porous media CFD simulated the hemodynamics within the aneurysmal dome after coiling. Read More

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The Synthesis Methodology of PEGylated FeO@Ag Nanoparticles Supported by Their Physicochemical Evaluation.

Molecules 2021 Mar 20;26(6). Epub 2021 Mar 20.

Institute of Materials Science, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Pawła II Av., 31-864 Krakow, Poland.

Many investigations are currently being performed to develop the effective synthesis methodology of magnetic nanoparticles with appropriately functionalized surfaces. Here, the novelty of the presented work involves the preparation of nano-sized PEGylated FeO@Ag particles, i.e. Read More

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Molecular genetic characteristic of mcr-9-harbouring Salmonella enterica Serotype Typhimurium isolated from raw milk: mcr-9 in Salmonella enterica Serotype Typhimurium from raw milk.

Int J Antimicrob Agents 2021 Mar 30:106332. Epub 2021 Mar 30.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.. Electronic address:

Among the 10 reported mcr genes, mcr-9 was firstly identified in Salmonella enterica Serotype Typhimurium, which was a leading cause of foodborne illness worldwide. But information about the prevalence and genetic features of mcr-9 is still lacking, especially among food samples. In this study, we found that mcr-9 had emerged in raw milk samples from China at a low prevalence rate of 0. Read More

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Low invasive estrous synchronization protocol for wild animals: an example with melengestrol acetate in brown brocket deer .

Anim Reprod 2021 Jan 6;17(4):e20200526. Epub 2021 Jan 6.

Núcleo de Pesquisa e Conservação de Cervídeos (NUPECCE), Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (UNESP), Jaboticabal, SP, Brasil.

Deer are sensitive to stressful stimuli by handling and their reproductive physiology could be altered by these procedures, making it necessary to develop less invasive protocols for ART. Melengestrol acetate (MGA), a synthetic progestin administered orally, appears as an alternative for estrous synchronization protocols (ESP), such as reported in cattle. Firstly, we compared two MGA doses (0. Read More

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January 2021

lncRNA-SUMO3 and lncRNA-HDMO13 modulate the inflammatory response by binding miR-21 and miR-142a-3p in grass carp.

Dev Comp Immunol 2021 Mar 27;121:104082. Epub 2021 Mar 27.

Key Laboratory of Freshwater Aquatic Genetic Resources Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai, China; Shanghai Engineering Research Center of Aquaculture, Shanghai Ocean University, Shanghai, China; National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, China. Electronic address:

Septicemia is a systemic inflammatory response to bacterial infection in grass carp (Ctenopharyngodon idella). It could lead to lethality. There is increasing evidence that long noncoding RNAs are involved in the regulation of inflammatory response. Read More

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The Availability of the α7-Nicotinic Acetylcholine Receptor in Early Identification of Vulnerable Atherosclerotic Plaques: A Study Using a Novel F-Label Radioligand PET.

Front Bioeng Biotechnol 2021 12;9:640037. Epub 2021 Mar 12.

Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.

It has been confirmed that the α7-nicotinic acetylcholine receptor (α7nAChR) is an important target for identifying vulnerable atherosclerotic plaques. Previously, we successfully designed and synthesized a series of F-labeled PET molecular probes targeting α7nAChR, which are mainly used in the diagnosis of Alzheimer's disease. Based on the characteristics of α7nAChR in blood vessels, we have firstly screened for a suitable novel F-labeled PET molecular probe ([F]YLF-DW), with high selectivity for α7nAChR over α4β2nAChR and a good effect for the imaging of atherosclerotic animal models, to effectively identify vulnerable atherosclerotic plaques at an early stage. Read More

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A series of carboxymethyl cellulose-based antimicrobial peptide mimics were synthesized for antimicrobial applications.

Carbohydr Polym 2021 Jun 16;261:117822. Epub 2021 Feb 16.

Guangdong Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China. Electronic address:

Inspired by antimicrobial peptides (AMP) which could alleviate drug resistance pressure, antimicrobial peptide mimics (AMPMs) were designed timely. Here, carboxymethyl cellulose (CMC) -based AMPMs were constructed by introducing different diamines on CMC effectively. Firstly, CMC was degraded to be oligomers with different molecular weights, followed by amination reactions with different diamines respectively. Read More

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New insights into co-treatment of mature landfill leachate with municipal sewage via integrated partial nitrification, Anammox and denitratation.

J Hazard Mater 2021 Mar 6;415:125506. Epub 2021 Mar 6.

National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Engineering Research Center of Beijing, Beijing University of Technology, Beijing 100124, PR China.

As a low consumption and high efficiency process, Partial Nitrification-Anammox/denitratation (PNAD) was applied to co-treat mature landfill leachate with municipal sewage for 300 days. Specifically, ammonia (670.2 ± 63. Read More

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Tian-Huang Formula, a Traditional Chinese Medicinal Prescription, Improves Hepatosteatosis and Glucose Intolerance Targeting AKT-SREBP Nexus in Diet-Induced Obese Rats.

Evid Based Complement Alternat Med 2021 6;2021:6617586. Epub 2021 Mar 6.

Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China.

The progressive increase of metabolic diseases underscores the necessity for developing effective therapies. Although we found Tian-Huang formula (THF) could alleviate metabolic disorders, the underlying mechanism remains to be fully understood. In the present study, firstly, male Sprague-Dawley rats were fed with high-fat diet plus high-fructose drink (HFF, the diet is about 60% of calories from fat and the drink is 12. Read More

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The clinical classification of patients with COVID-19 pneumonia was predicted by Radiomics using chest CT.

Medicine (Baltimore) 2021 Mar;100(12):e25307

Department of Radiology, PLA Central Theater General Hospital, Wuhan, Hubei, China.

Abstract: In 2020, the new type of coronal pneumonitis became a pandemic in the world, and has firstly been reported in Wuhan, China. Chest CT is a vital component in the diagnostic algorithm for patients with suspected or confirmed COVID-19 infection. Therefore, it is necessary to conduct automatic and accurate detection of COVID-19 by chest CT. Read More

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Tanshinone IIA regulates microRNA‑125b/foxp3/caspase‑1 signaling and inhibits cell viability of nasopharyngeal carcinoma.

Mol Med Rep 2021 May 24;23(5). Epub 2021 Mar 24.

School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

Nasopharyngeal carcinoma (NPC) is a common disease with high prevalence worldwide, affecting hundreds of thousands of patients every year. Although its progress can be inhibited by concurrent chemoradiotherapy and platinum‑based agents, there is also a need for novel drugs to treat NPC. The present study identified tanshinone IIA as a potent drug that could suppress the proliferation of HK1 cells by enhancing pyroptosis via regulation of the miR‑125b/foxp3/caspase‑1 signaling pathway. Read More

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Plant-parasitic nematode associated with wheat in central, eastern, and south-eastern Kazakhstan.

Plant Dis 2021 Mar 23. Epub 2021 Mar 23.

CIMMYT Turkey, CIMMYT Uluslararası Buğday ve Mısır Geliştirme Merkezi, Şehit Cem Ersever Caddesi No : 9/11, Tarla Bitkileri Araştırma Enstitüsü Kampüsü içi, Ankara, Ankara, Turkey, 06170;

Kazakhstan is one of the biggest wheat producers, however, its wheat production is far below the average international wheat production standard due to biotic and abiotic stressors. Plant-parasitic nematodes are devastating for cereal production systems worldwide. A comprehensive survey was conducted in 2019 to identify plant-parasitic nematodes associated with wheat in different locations of central, eastern, and south-eastern Kazakhstan. Read More

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MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer.

Theranostics 2021 19;11(9):4122-4136. Epub 2021 Feb 19.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Center for Comparative Respiratory Biology and Medicine, University of California Davis, Davis, California, USA.

Cigarette smoking is a major risk factor for lung cancer development and progression; however, the mechanism of how cigarette smoke activates signaling pathways in promoting cancer malignancy remains to be established. Herein, we aimed to determine the contribution of a signaling protein, myristoylated alanine-rich C kinase substrate (MARCKS), in smoke-mediated lung cancer. We firstly examined the levels of phosphorylated MARCKS (phospho-MARCKS) in smoke-exposed human lung cancer cells and specimens as well as non-human primate airway epithelium. Read More

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February 2021

The Prognostic Value of Radiomics Features Extracted From Computed Tomography in Patients With Localized Clear Cell Renal Cell Carcinoma After Nephrectomy.

Front Oncol 2021 5;11:591502. Epub 2021 Mar 5.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Background And Purpose: Radiomics is an emerging field of quantitative imaging. The prognostic value of radiomics analysis in patients with localized clear cell renal cell carcinoma (ccRCC) after nephrectomy remains unknown.

Methods: Computed tomography images of 167 eligible cases were obtained from the Cancer Imaging Archive database. Read More

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