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Hormonal stress responses of growth hormone and insulin-like growth factor-I in highly resistance trained women and men.

Growth Horm IGF Res 2021 Jun 6;59:101407. Epub 2021 Jun 6.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA.

The purpose of this study was to examine the responses of growth hormone (GH) and insulin-like growth factor-I (IGFI) to intense heavy resistance exercise in highly trained men and women to determine what sex-dependent responses may exist. Subjects were highly resistance trained men (N = 8, Mean ± SD; age, yrs., 21 ± 1, height, cm, 175. Read More

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Large variations in disease severity, death and ICU admission of 2993 patients infected with SARS-CoV-2: The potential impact of genetic vulnerability.

J Infect Public Health 2021 Apr 22;14(7):886-891. Epub 2021 Apr 22.

Health Informatics and Smart Health Department, Health Regulation Sector, Dubai Health Authority, Dubai, United Arab Emirates. Electronic address:

Background: The COVID-19 pandemic has had an immeasurable impact, affecting healthcare systems, the global economy, and society. Exploration of trends within the existing COVID-19 data may guide directions for further study and novel treatment development. As the world faces COVID-19 disease, it is essential to study its epidemiological and clinical characteristics further to better understand and aid in its detection and containment. Read More

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Impact of a pharmacist-led substance use disorder transitions of care clinic on postdischarge medication treatment retention.

J Subst Abuse Treat 2021 Apr 28;130:108440. Epub 2021 Apr 28.

VA Tennessee Valley Healthcare System, 1310 24th Avenue South, Nashville, TN 37212, United States.

Background: The Veterans Health Administration (VHA) has made significant improvements in increasing prescribing of medication treatment for opioid use disorder (MOUD) and medication treatment for alcohol use disorder (MAUD); however, several barriers to treatment retention remain. In an effort to improve MOUD/MAUD retention, a Veterans Affairs (VA) facility established a pharmacist-led substance use disorder (SUD) transitions of care telephone clinic for patients discharged from an inpatient hospitalization on MOUD/MAUD, including buprenorphine/naloxone (BUP/NAL) and extended-release (ER) naltrexone injections. Pharmacists within the clinic assess aspects of treatment retention such as medication tolerability, perceived barriers to continuing treatment, status of current prescriptions, and appointment coordination. Read More

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Examining factors that shape use and access to diverted prescription opioids during an overdose crisis: A qualitative study in Vancouver, Canada.

J Subst Abuse Treat 2021 Apr 20;130:108418. Epub 2021 Apr 20.

Department of Medicine, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver V6Z 1Y6, BC, Canada; British Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver V6Z 2A9, BC, Canada.

Objective: Prescription opioid (PO) diversion is widely regarded as a driver of overdose mortality. However, less is known about the rationale for using diverted POs during an overdose epidemic and how contextual factors (e.g. Read More

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Facilitators and barriers to post-overdose service delivery in Rhode Island emergency departments: A qualitative evaluation.

J Subst Abuse Treat 2021 Apr 14;130:108411. Epub 2021 Apr 14.

Department of Health Services, Policy, and Practice, School of Public Health, Brown University, 121 South Main Street, Providence, RI 02903, United States.

Background: Emergency departments (EDs) in the US have increasingly incorporated interventions that seek to reduce opioid-related morbidity and mortality. However, many of these interventions are underutilized. This study examined ED provider-identified barriers and facilitators to policy-prescribed service provision for patients treated for an opioid overdose in Rhode Island EDs, and opportunities to improve care delivery. Read More

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Extended-release naltrexone for youth with opioid use disorder.

J Subst Abuse Treat 2021 Apr 15;130:108407. Epub 2021 Apr 15.

Friends Research Institute, 1040 Park Avenue, Suite, 103 Baltimore, MD, USA. Electronic address:

Background: Few published research studies have examined the effectiveness of extended-release naltrexone (XR-NTX) for the treatment of opioid use disorder (OUD) among adolescents and young adults.

Methods: This two-group randomized controlled trial recruited 288 youth, ages 15-21, with moderate/severe OUD from a residential addiction treatment program in Baltimore, Maryland. The study randomized the youth within the first week of treatment entry to receive either XR-NTX or treatment-as-usual (TAU; either buprenorphine maintenance treatment or treatment without OUD medication following medically managed withdrawal) prior to discharge, with continued treatment in the community for 6 months. Read More

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Using daily diary methods to understand how college students in recovery use social support.

J Subst Abuse Treat 2021 Apr 14;130:108406. Epub 2021 Apr 14.

NLW Partners, Lubbock, TX, USA. Electronic address:

Collegiate Recovery Communities (CRCs) are important sources of support for college students building and maintaining recovery from substance use disorders. The current study used daily diary data from members of a CRC to examine with which sources of social support students engaged daily, and whether students connected with these sources more on days when they indicated higher-than-usual recovery difficulty, negative affect, and/or school stress. Results indicate that on days when students reported having greater difficulty with recovery maintenance than usual, they had higher odds of being in contact with family members and were expected to talk or spend time with family for longer than usual. Read More

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Buprenorphine use and disparities in access among emergency department patients with opioid use disorder: A cross-sectional study.

J Subst Abuse Treat 2021 Apr 20;130:108405. Epub 2021 Apr 20.

Cooper Medical School of Rowan University, 401 Broadway, Camden, NJ 08103, United States of America; Cooper University Hospital, Department of Emergency Medicine, Keleman 152, 1 Cooper Plaza, Camden, NJ 08103, United States of America. Electronic address:

Background: Buprenorphine, a partial mu-opioid agonist and kappa-opioid antagonist, is an approved treatment for opioid use disorder (OUD). Studies demonstrate that buprenorphine decreases cravings for other opioids, effectively ameliorates withdrawal symptoms, and decreases opioid overdose and mortality. However, buprenorphine remains under-utilized. Read More

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Eating-related pathology at the intersection of gender identity and expression, sexual orientation, and weight status: An intersectional Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA) of the Growing Up Today Study cohorts.

Soc Sci Med 2021 May 31;281:114092. Epub 2021 May 31.

Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA, 01655, USA. Electronic address:

The objective of this study was to investigate how gender identity, the overwhelmingly prioritized dimension of social identity/position in eating-related pathology research, intersects with gender expression, sexual orientation, and weight status to structure the social patterning of eating disorders and disordered eating behaviors among young people in the U.S. Data were drawn from the 2010/2011 Growing Up Today Study (GUTS; N = 11,090-13,307). Read More

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Effectiveness of behaviour change techniques used in hand hygiene interventions targeting older children - A systematic review.

Soc Sci Med 2021 May 31;281:114090. Epub 2021 May 31.

Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel St, Bloomsbury, London, WC1E 7HT, UK.

Background: Promoting good hand hygiene in older children is an important measure to reduce the burden of common diseases such as diarrhoea and acute respiratory infections. The evidence around what works to change this behaviour, however, is unclear.

Objectives: To aid future intervention design and effective use of resources, this review aims to identify the individual components used in hand hygiene interventions and assesses their contribution to intended behavioural change. Read More

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Comparative analysis of alfalfa (Medicago sativa L.) seedling transcriptomes reveals genotype-specific drought tolerance mechanisms.

Plant Physiol Biochem 2021 May 29;166:203-214. Epub 2021 May 29.

Agricultural College, Ningxia University, Yinchuan, 750021, China. Electronic address:

Drought is one of the main abiotic factors that affect alfalfa yield. The identification of genes that control this complex trait can provide important insights for alfalfa breeding. However, little is known about how alfalfa responds and adapts to drought stress, particularly in cultivars of differing drought tolerance. Read More

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Annual trends and health risks of antibiotics and antibiotic resistance genes in a drinking water source in East China.

Sci Total Environ 2021 May 29;791:148152. Epub 2021 May 29.

State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China; Shanghai Environmental Protection Key Laboratory on Environmental Standard and Risk Management of Chemical Pollutants, East China University of Science & Technology, Shanghai 200237, China; National Engineering Laboratory for Industrial Wastewater Treatment, East China University of Science & Technology, Shanghai 200237, China. Electronic address:

The extensive pollution of antibiotics and antibiotic resistance genes (ARGs) in drinking water has aroused worldwide concern. Successive monitoring of these pollutants has noteworthy significance for drinking water safety. Accordingly, this study conducted successive monitoring of antibiotics and ARGs from 2015 to 2017 in a drinking water source in East China. Read More

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Variation in the content and fluorescent composition of dissolved organic matter in soil water during rainfall-induced wetting and extract of dried soil.

Sci Total Environ 2021 Jun 9;791:148296. Epub 2021 Jun 9.

College of Natural Resources and Environment, Northwest A & F University, Yangling 712100, PR China. Electronic address:

Dissolved organic matter (DOM) is present in all soils, providing a readily available carbon source for microorganisms, which influences microbially mediated biogeochemical processes. Rainfall-induced wetting can alter the content and composition of soil DOM. However, conventional methods commonly used to extract DOM from soils involve air- or oven-drying followed by extraction with water, and the results vary considerably in terms of indexes used. Read More

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Music therapy enhances preterm infant's signs of engagement and sustains maternal singing in the NICU.

Infant Behav Dev 2021 Jun 9;64:101596. Epub 2021 Jun 9.

Psychology Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Hospitalized preterm infants are exposed to stressful stimuli and early parental separation, which can undermine their long-term development and mother-infant bonding. Family-centered music therapy can enable positive mother-infant interactions, mediated by maternal infant-directed singing. This study aimed to investigate the effects of music therapy on preterm infant's signs of engagement, namely Eye Opening (EO) and Smiling (SM), and maternal vocalizations. Read More

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Studying caregiver-infant co-regulation in dynamic, diverse cultural contexts: A call to action.

Infant Behav Dev 2021 Jun 9;64:101586. Epub 2021 Jun 9.

University of California, Davis, United States.

Caregivers and infants co-regulate their physiology, emotions, and behavior in a way that is dynamically responsive to each other and the contexts in which they live. This paper is an introduction and call to action for researchers interested in understanding how to study caregiver-infant interactions in the home and diverse cultural contexts, including marginalized communities. We argue that research will be more valid, culturally relevant, and tapped-in to the daily lives of caregivers and infants if there is partnership and collaboration with the caregivers in the design of the questions, data collection and analysis, and distribution of the findings. Read More

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Genome-wide DNA methylation patterns associated with general psychopathology in children.

J Psychiatr Res 2021 May 28;140:214-220. Epub 2021 May 28.

Department of Child and Adolescent Psychiatry/ Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.

Psychiatric symptoms are interrelated and found to be largely captured by a general psychopathology factor (GPF). Although epigenetic mechanisms, such as DNA methylation (DNAm), have been linked to individual psychiatric outcomes, associations with GPF remain unclear. Using data from 440 children aged 10 years participating in the Generation R Study, we examined the associations of DNAm with both general and specific (internalizing, externalizing) factors of psychopathology. Read More

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Mental health mediators of subjective cognitive concerns among World Trade Center responders.

J Psychiatr Res 2021 Jun 2;140:187-196. Epub 2021 Jun 2.

Icahn School of Medicine at Mount Sinai, Department of Environmental Medicine and Public Health, World Trade Center Health Program General Responder Data Center, 1 Gustave L. Levy Place, New York, NY, 10029, USA.

Decline in cognitive functioning among rescue and recovery workers who responded in the aftermath of the September 11, 2001, World Trade Center (WTC) attacks is of emerging interest. Responders are vulnerable to cognitive decline from exposure to airborne toxins present at the WTC site, as well as from WTC-related mental and physical health conditions. To better understand the relationship between occupational WTC exposure, mental health, physical health and subjective cognitive functioning, we examined the mediating role of health status in the association between exposure and subjective cognitive concerns in a multi-site, longitudinal investigation of the WTC General Responder cohort (n = 16,380 responders; n = 58,575 visits) for the period 2002-2015. Read More

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Effectiveness of sodium sulfite as an electron acceptor for bioenhanced treatment of salt-containing water produced from ASP flooding.

Chemosphere 2021 May 31;282:131002. Epub 2021 May 31.

College of Life Science, Northeast Forestry University, No. 26, Hexing Road, Harbin, 150040, China. Electronic address:

The wastewater produced from alkaline-surfactant-polymer (ASP) flooding is a complex multiphase mixture that contains oil, polymers, surfactants and other pollutants and is thus a salt-containing industrial waste recalcitrant to treatments. Through laboratory tests, this study assessed the effectiveness of using sodium sulfite as an electron acceptor for a modified anaerobic baffled reactor (ABR) for removing oil, suspended solids, polymers and surfactants from salt-containing wastewater produced from ASP flooding. During the 90-day operation, the method established in this study successively removed 52. Read More

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Performance evaluation of nanotubular halloysites from weathered pegmatites in removing heavy metals from water through novel artificial intelligence-based models and human-based optimization algorithm.

Chemosphere 2021 Jun 3;282:131012. Epub 2021 Jun 3.

Department of Exploration Geology, Faculty of Geosciences and Geoengineering, Hanoi University of Mining and Geology, 18 Vien st., Duc Thang ward, Bac Tu Liem dist., Hanoi, Viet Nam.

The efforts of this study aimed to evaluate the feasibility of the nanotubular halloysites in weathered pegmatites (NaHWP) for removing heavy metals (i.e., Cd, Pb) from water. Read More

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Speciation, controlling steps and pathways of silver release from the sludge generated from coagulation of wastewater spiked with silver nanoparticles.

Chemosphere 2021 Jun 4;282:131093. Epub 2021 Jun 4.

Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan, 250100, PR China.

Sludge generated in wastewater treatment facilities is an integral part for the introduction of silver nanoparticles (AgNPs) to the terrestrial environment, which would cause some adverse ecosystem responses. The understanding of silver release process from the sludge is important to evaluate their risks. In this study, the amount and speciation of the released silver were investigated by taking the sludge generated by wastewater coagulation with AgNPs added (denoted as sludge) an example, and kinetic analysis and density functional theory (DFT) calculations were first used to explore the controlling steps and pathways about the silver release. Read More

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Per- and poly-fluoroalkyl substance remediation from soil and sorbents: A review of adsorption behaviour and ultrasonic treatment.

Chemosphere 2021 May 28;282:131025. Epub 2021 May 28.

University of Surrey, Department of Chemical and Process Engineering, Surrey, England, GU2 7XH, UK. Electronic address:

Per- and poly-fluoroalkyl substances (PFAS) are xenobiotics, present at variable concentrations in soils and groundwater worldwide. Some of the current remediation techniques being researched or applied for PFAS-impacted soils involve solidification-stabilisation, soil washing, excavation and disposal to landfill, on site or in situ smouldering, thermal desorption, ball milling and incineration. Given the large volumes of soil requiring treatment, there is a need for a more environmentally friendly technique to remove and treat PFASs from soils. Read More

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Differential predictors of birth-related posttraumatic stress disorder symptoms in mothers and fathers - A longitudinal cohort study.

J Affect Disord 2021 May 27;292:121-130. Epub 2021 May 27.

Institute and Outpatient Clinics of Occupational and Social Medicine, Faculty of Medicine of the Technische Universität Dresden, Dresden, Germany; Department of Medicine, Faculty of Medicine, Medical School Hamburg, Hamburg, Germany; Department of Child Health and Development, Norwegian Institute of Public Health, Oslo, Norway. Electronic address:

Background: Evidence on risk factors of birth-related posttraumatic stress disorder (PTSD) symptoms in mothers is increasing, whereas fathers are less examined. This study aims to determine differential predictors of PTSD symptoms in mothers and fathers.

Methods: Data derive from the DREAM study, including 1,146 mothers and 828 fathers. Read More

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Depressive symptom trajectories and their relation to body mass index in women of child-bearing age: The Korea Nurses' Health Study.

J Affect Disord 2021 May 27;292:114-120. Epub 2021 May 27.

College of Nursing, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, South Korea. Electronic address:

Background: This study investigated the sub-trajectory groups of depressive symptoms in women of child-bearing age and the factors impacting latent class membership. Moreover, differences in body mass index (BMI) as an outcome variable were identified among the sub-trajectory groups.

Methods: Data from the Korea Nurses' Health Study (KNHS) were analyzed, comprising that from 6,918 participants who filled out surveys during modules 1, 5, and 7. Read More

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β3-Endonexin interacts with ninein in vascular endothelial cells to promote angiogenesis.

Biochem Biophys Res Commun 2021 Jun 9;566:75-79. Epub 2021 Jun 9.

School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China; School of Life Sciences, Shanghai University, Shanghai, China; Versiti Blood Research Institute, Milwaukee, WI, USA; Department of Biochemistry, Medical College of Milwaukee, Wisconsin, USA. Electronic address:

Anti-angiogenesis serves as an effective tumor therapy approach. In a previous study, we found that β3-endonexin expressed in vascular endothelial cells was involved in promoting proliferation and angiogenesis partially by facilitating VEGF expression. However, it still remains unclear if β3-endonexin in vascular endothelial cells also employs other mechanisms in regulating angiogenesis. Read More

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Cross-cohort generalizability of deep and conventional machine learning for MRI-based diagnosis and prediction of Alzheimer's disease.

Neuroimage Clin 2021 Jun 4;31:102712. Epub 2021 Jun 4.

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.

This work validates the generalizability of MRI-based classification of Alzheimer's disease (AD) patients and controls (CN) to an external data set and to the task of prediction of conversion to AD in individuals with mild cognitive impairment (MCI). We used a conventional support vector machine (SVM) and a deep convolutional neural network (CNN) approach based on structural MRI scans that underwent either minimal pre-processing or more extensive pre-processing into modulated gray matter (GM) maps. Classifiers were optimized and evaluated using cross-validation in the Alzheimer's Disease Neuroimaging Initiative (ADNI; 334 AD, 520 CN). Read More

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Pathological findings of the retrospective diagnosis of NIFTP (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) in 84 cases from Turkey and systematic review.

Ann Diagn Pathol 2021 Jun 9;53:151764. Epub 2021 Jun 9.

Kocaeli University, Medical Faculty, Pathology Department, Kocaeli, Turkey.

Aim: The terminology of "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) was introduced in 2016; and estimated to cause significant effects in the clinical management of thyroid nodules. The aim of our study is to review our cases that were previously diagnosed as non-invasive encapsulated follicular variant PTC (NI/E-FVPTC) which are compatible with NIFTP and to correlate their follow-up.

Method: All thyroidectomy cases evaluated in the last 15 years were screened, and possible NIFTP cases were determined among patients with NI/E-FVPTC and they were re-examined microscopically. Read More

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A retrospective evaluation of the indications, complications, and outcomes associated with epicardial pacemakers in 20 cats from a single institution.

J Vet Cardiol 2021 May 13;36:89-98. Epub 2021 May 13.

Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Dr. Madison, WI 53706, USA.

Introduction: The objective of this retrospective study was to describe the indications, complications, and long-term outcomes in a group of cats that received an epicardial pacing (EP) system.

Animals: Twenty client-owned cats.

Materials And Methods: Medical records were reviewed for signalment, presenting complaint, primary electrocardiogram (ECG) diagnosis, presence of structural heart disease, presence of congestive heart failure (CHF), presence of major or minor complications, and survival time. Read More

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Large-scale evaluation of the Positive and Negative Syndrome Scale (PANSS) symptom architecture in schizophrenia.

Asian J Psychiatr 2021 Jun 3;62:102732. Epub 2021 Jun 3.

Research Division, Institute of Mental Health, Singapore; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Feinstein Institute of Medical Research, The Zucker Hillside Hospital, New York, United States. Electronic address:

Although the Positive and Negative Syndrome Scale (PANSS) is widely utilized in schizophrenia research, variability in specific item loading exist, hindering reproducibility and generalizability of findings across schizophrenia samples. We aim to establish a common PANSS factor structure from a large multi-ethnic sample and validate it against a meta-analysis of existing PANSS models. Schizophrenia participants (N = 3511) included in the current study were part of the Singapore Translational and Clinical Research Program (STCRP) and the Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE). Read More

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A retrospective cohort study of medication dispensing at pharmacies: Administration matters!

Drug Alcohol Depend 2021 May 29;225:108792. Epub 2021 May 29.

Norwegian Centre for Addiction Research (SERAF), University of Oslo, Bygg 45, Ullevål sykehus, Kirkeveien 166, 0450, Oslo, Norway. Electronic address:

Background: Opioid agonist treatment (OAT) for opioid use disorders may be delivered at treatment clinics or dispensed from pharmacies, however the type of delivery may be associated with different risks and benefits. The aim of the study was to investigate whether dispensing of methadone or buprenorphine at pharmacies during treatment for opioid use disorders was associated with adverse outcomes.

Methods: Retrospective cohort study using a national, linked, population-level data set from Denmark. Read More

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