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Novel prenatally diagnosed compound heterozygous POMT2 variants in fetal congenital primary aqueduct stenosis.

Taiwan J Obstet Gynecol 2022 May;61(3):517-520

Department of Obstetrics and Gynecology, Taipei City Hospital, Women and Children Campus, Taiwan; Department of Biomedical Engineering, National Yang Ming Chiao Tung University - Yang Ming Campus, Taiwan. Electronic address:

Objective: To study the etiology of congenital hydrocephalus in genetic aqueduct stenosis.

Case Report: We report the case of a 31-year-old pregnant female, G2P0A1, with a history of hyperthyroidism under medical control. The patient received regular prenatal care, with no specific findings in the Level II ultrasound at 21 weeks of gestation. Read More

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Child Posttraumatic Stress after Parental Cancer: Associations with Individual and Family Factors.

J Pediatr Psychol 2022 May 20. Epub 2022 May 20.

Department of Clinical Psychology, Utrecht University, The Netherlands.

Objective: This study aimed to examine the severity of posttraumatic stress disorder (PTSD) symptoms in children of parents with cancer and to identify individual and family factors associated with these symptoms.

Methods: The sample consisted of 175 children (52% girls, aged M = 11.98, SD = 3. Read More

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Metabolomics-based study of the potential interventional effects of Xiao-Xu-Ming Decoction on cerebral ischemia/reperfusion rats.

J Ethnopharmacol 2022 May 17:115379. Epub 2022 May 17.

Department of Neurology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Wenzhou, China. Electronic address:

Ethnopharmacological Relevance: Xiao-Xu-Ming Decoction (XXMD) is a classical Chinese medicinal compound for the treatment of ischemic stroke, which has good efficacy in clinical studies and also plays a neuroprotective role in pharmacological studies.

Aim Of The Study: The purpose of this study is to investigate the potential and integral interventional effects of XXMD on cerebral ischemia/reperfusion rat model.

Materials And Methods: In this study, H-NMR metabolomics was used, combined with neurological functional assessments, cerebral infarct area measurements, and pathological staining including Nissl staining, immunofluorescence staining of NeuN and TUNEL, and immunohistochemical staining of MCT2, to analyze the metabolic effects of XXMD in the treatment of an ischemia/reperfusion rat model. Read More

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A comprehensive Triple Repeat Primed PCR (TR-PCR) and a Long-Range PCR (LR-PCR) agarose-based assay for improved genotyping of GAA repeats in Friedreich's Ataxia.

J Mol Diagn 2022 May 17. Epub 2022 May 17.

ARUP Institute for Clinical and Experimental Pathology, University of Utah, Salt Lake City, Utah; Department of Pathology, University of Utah, Salt Lake City, Utah.

Friedreich's ataxia (FRDA) is a rare autosomal recessive, neuro-muscular degenerative disease caused by an expansion of a trinucleotide (GAA) repeat in intron 1 of the FXN gene. It is common in the Caucasian population, characterized by progressive gait and limb ataxia, lack of tendon reflexes in the legs, loss of position sense, and hypertrophic cardiomyopathy. Detection and genotyping of the trinucleotide repeat length is important for the diagnosis and prognosis of the disease. Read More

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Receptor model-oriented sources and risks evaluation of metals in sediments of an industrial affected riverine system in Bangladesh.

Sci Total Environ 2022 May 17:156029. Epub 2022 May 17.

University of Chinese Academy of Sciences, Beijing 100049, China; Aquatic Eco-Health Group, Fujian Key Laboratory of Watershed Ecology, Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China.

Toxic metals in river sediments may represent significant ecological concerns, although there has been limited research on the source-oriented ecological hazards of metals in sediments. Surface sediments from an industrial affected Rupsa River were utilized in this study to conduct a complete investigation of toxic metals with source-specific ecological risk assessment. The findings indicated that the average concentration of Ni, Cr, Cd, Zn, As, Cu, Mn and Pb were 50. Read More

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Obesity affects the proteome profile of periodontal ligament submitted to mechanical forces induced by orthodontic tooth movement in rats.

J Proteomics 2022 May 17:104616. Epub 2022 May 17.

Department of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University - UNESP, Araraquara, São Paulo, Brazil; Department of Periodontology and Operative Dentistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. Electronic address:

The prevalence of obesity has increased significantly worldwide. Therefore, this study aimed to evaluate the influence of obesity on the proteomic profile of periodontal ligament (PDL) tissues of rat first maxillary molars (1 M) submitted to orthodontic tooth movement (OTM). Ten Holtzman rats were distributed into two groups (n = 5): the M group (OTM), and the OM group (obesity induction plus OTM). Read More

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Transgenerational effects of parental bisphenol S exposure on zebrafish (Danio rerio) reproduction.

Food Chem Toxicol 2022 May 17:113142. Epub 2022 May 17.

College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China. Electronic address:

Bisphenol S (BPS) is extensively used for production of polycarbonates and other commodities, and is often detected in environment and biota. Parental BPS exposure has been reported to interfere with reproductive development of offspring, but limited information is available on its multigenerational reproductive toxicity. In our present study, zebrafish (Danio rerio) were exposed to BPS (1 and 100 μg/L) from 3 hpf to 120 dpf, and the effects on reproduction, sex steroid hormones, DNA methylation levels and gene transcription involved in steroidogenesis and DNA methylation were investigated in unexposed F1-2 offspring. Read More

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Effects of anodal tDCS stimulation in predictable and unpredictable task switching performance: The possible involvement of the parietal cortex.

Neuroscience 2022 May 17. Epub 2022 May 17.

Key Laboratory for Behavior and Cognitive Neuroscience of Shaanxi Province, School of Psychology, Shaanxi Normal University, Xi'an 710062, China.

Transcranial direct current stimulation (tDCS) has been used to explore the causal relationship between specific brain regions and task switching. However, most studies have focused on the frontal cortex, and only few have examined other related cortices, e.g. Read More

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Effects of environmental factor fulvic acid on AgNPs food chain delivery and bioavailability.

Comp Biochem Physiol C Toxicol Pharmacol 2022 May 17:109369. Epub 2022 May 17.

School of Biological Engineering, Huainan Normal University, China.

Due to its antimicrobial activity, silver nanoparticles (AgNPs) have become the most commonly applied nanomaterials. However, the potential ecotoxicological toxicity of AgNPs in the environment is still unclear. Here we assessed the trophic transfer and toxicity of commercially manufactured polyvinyl pyrrolidone (PVP)-coated AgNPs using a model food chain from Escherichia coli (E. Read More

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A network analysis on the relationship between loneliness and schizotypy.

J Affect Disord 2022 May 17. Epub 2022 May 17.

Department of Psychology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.

Background: Schizotypy is a multidimensional personality trait related to the heightened risk for the development of schizophrenia spectrum disorders. While it has been suggested that loneliness may be associated with schizotypy in general, whether it relates to the specific schizotypal traits differentially remains unknown. Besides, as loneliness often co-occurs with depression and anxiety, it is important to delineate its relationship with schizotypy in consideration of these co-occurring emotional disturbances. Read More

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Mobile-enhanced transdiagnostic CBT for adolescents with mood or psychotic spectrum disorders.

J Affect Disord 2022 May 17. Epub 2022 May 17.

Semel Institute of Neuroscience and Human Behavior, USA; Department of Psychology, University of California, Los Angeles, CA, USA.

Background: Although transdiagnostic forms of cognitive-behavioral therapy (CBT) have been evaluated in depressive and anxiety disorders, few studies have examined their applicability in youth with more severe mood disorders, such as recurrent or persistent major depressive disorder, bipolar disorder, or psychotic spectrum disorders. This study examined the acceptability and initial efficacy of a mobile-enhanced Unified Protocol for Adolescents [UP-A] when including youth with more severe mood disorders or psychotic spectrum disorders.

Methods: We first adapted a mobile app (based on user-centered feedback from adolescents and their parents) to assist participants in reviewing session content, practicing skills learned in previous sessions, and monitoring progress. Read More

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Strontium-loaded titanium-15molybdenum surface improves physicochemical and biological properties in vitro.

Biomed Phys Eng Express 2022 May 20. Epub 2022 May 20.

Diagnosis and Surgery, Sao Paulo State University - UNESP, School of Dentistry at Araraquara, R. Humaitá, 1680, Araraquara, SP, 14801-903, BRAZIL.

The titanium alloy composition and microdesign affect the dynamic interplay between the bone cells and titanium surface in the osseointegration process. The current study aimed to evaluate the surface physicochemical properties, electrochemical stability, and the metabolic response of the MC3T3-E1 cells (pre-osteoblast cell line) cultured onto titanium-15molybdenum (Ti-15Mo) discs treated with phosphoric acid (HPO) and sodium hydroxide (NaOH) and/or strontium-loading by the hydrothermal method. The X-ray dispersive energy spectroscopy (EDS) and X-ray diffraction (XRD) analysis showed no trace of impurities and the possible formation of hydrated strontium oxide (HOSr), respectively. Read More

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Highly efficient removal of glyphosate from water by hierarchical-pore UiO-66: Selectivity and effects of natural water particles.

J Environ Manage 2022 May 17;316:115301. Epub 2022 May 17.

School of Resources and Environment, Anhui Agricultural University, Hefei, 230036, PR China; Hefei Scientific Observing and Experimental Station of Agro-Environment, Ministry of Agriculture, PR China. Electronic address:

The selective removal of glyphosate (GP) from aqueous environments is crucial for ensuring human health and environmental sustainability. The preparation of hierarchical-pore MOFs and the reasonable regulation of the pore size are effective strategies for achieving selective removal. In this study, we applied hierarchical-pore UiO-66 analogues (HUiO-66s) synthesized by the template technique through a mild method for the removal of GP from water. Read More

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Bidirectional Mendelian randomization to explore the causal relationships between Sleep traits, Parkinson's disease and Amyotrophic lateral sclerosis.

Sleep Med 2022 Apr 19;96:42-49. Epub 2022 Apr 19.

School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Objective: Sleep disturbances have been linked with Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) in observational studies, and the comorbidity of PD and ALS has been reported in clinical case reports, but the causalities remain unclear. This study aims to examine bidirectional causal relationships between sleep traits, PD and ALS.

Methods: Bidirectional two sample Mendelian randomisation (MR) analyses were conducted, with data from individuals of mainly European ancestry. Read More

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Palin parent-child interaction therapy with children with autism spectrum disorder and stuttering.

J Commun Disord 2022 May 17;97:106217. Epub 2022 May 17.

City, University of London, Northampton Square, Clerkenwell, London EC1V 0HB, United Kingdom; Michael Palin Centre, 13-15 Pine St, Farringdon, London EC1R 0JG, United Kingdom.

Introduction: It is estimated that 8% of children who stutter (CWS) have autism spectrum disorder (ASD) Briley & Ellis (2018). There is evidence that interventions for CWS and interventions for children with ASD can be effective, but there is little evidence to guide clinical decision making when working with CWS with a co-existing diagnosis of ASD. Palin Parent-Child Interaction (PCI) therapy Kelman & Nicholas (2020) is an evidence-based intervention for CWS, with the authors suggesting that the approach may be beneficial for CWS with ASD. Read More

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The analysis of dynamic gene expression patterns in peripheral blood of multiple sclerosis patients indicates possible diagnostic and prognostic biomarkers.

Mol Immunol 2022 May 17;147:147-156. Epub 2022 May 17.

School of Life Sciences, Forman Christian College (A Chartered University), Lahore 54600, Pakistan. Electronic address:

Introduction: Among numerous invasive procedures for the research of biomarkers, blood-based indicators are regarded as marginally non-invasive procedures in the diagnosis and prognosis of demyelinating disorders, including multiple sclerosis (MS). In this study, we looked into the blood-derived gene expression profiles of patients with multiple sclerosis to investigate their clinical traits and linked them with dysregulated gene expressions to establish diagnostic and prognostic indicators.

Methods: We included 51 patients with relapsing-remitting MS (RRMS, n = 31), clinically isolated syndrome (CIS, n = 12), primary progressive MS (PPMS, n = 8) and a control group (n = 51). Read More

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Design, synthesis and antitumour activity of novel 5(6)-amino-benzimidazolequinones containing a fused morpholine.

Eur J Med Chem 2022 May 11;238:114420. Epub 2022 May 11.

Institute of Pharmaceutical Research, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, 450001, China; State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou, 450001, China. Electronic address:

Based on the previous synthesis of tetracyclic and tricyclic benzimidazoles starting from 1,4:3,6-dianhydro-d-fructose and o-phenylenediamines, a series of 5(6)-amino substituted tetracyclic and tricyclic benzimidazolequinones were obtained through the oxidation of 4,7-dimethoxy-benzimidazole analogues with bis(trifluoroacetoxy)iodobenzene (PIFA) and subsequent substitution with various aliphatic and aromatic amines. Biological evaluations of the target benzimidazolequinones indicated that all the arylamino-substituted benzimidazolequinones possess potent antitumour activity against human gastric cancer cells (MGC-803), especially compound a21-2. Furthermore, compound a21-2 inhibits gastric cancer cells proliferation and cell colony formation. Read More

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Outcome of breast cancer patients treated with chemotherapy during pregnancy compared with non-pregnant controls.

Eur J Cancer 2022 May 17;170:54-63. Epub 2022 May 17.

German Breast Group, Neu-Isenburg, Germany.

Background: A diagnosis of breast cancer during pregnancy (PrBC) does not impact prognosis if standard treatment is offered. However, caution is warranted as gestational changes in pharmacokinetics may lead to reduced chemotherapy concentration.

Methods: Survival of PrBC patients treated with chemotherapy during pregnancy was compared to non-pregnant breast cancer patients treated with chemotherapy, diagnosed after 2000, excluding patients older than 45 years or with a postpartum diagnosis. Read More

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Relationships between paranoia and body image concern among community women.

J Psychiatr Res 2022 May 12;151:405-410. Epub 2022 May 12.

Centre for Mental Health, Faculty of Health, Arts & Design, Swinburne University of Technology, Hawthorn, VIC, Australia.

Previous research has indicated that lifetime body image concerns are associated with increased odds of paranoid ideation. In this study, we sought to replicate and extend this finding by exploring how paranoia relates to different aspects of body image concern using a comprehensive, cross-sectional design. Women without a mental health diagnosis (n = 119) completed online questionnaires assessing paranoia, shape and weight concerns, and figure ratings for how they "think" their body looks and how they "feel" in their body. Read More

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An analysis of Lilienfeld et al.'s (2015) problematic psychological terms.

J Gen Psychol 2022 May 20:1-19. Epub 2022 May 20.

Angelo State University.

The language psychologists and other mental health professionals utilize impacts the formation of public perceptions concerning the practice of psychology. Psychologists from Warren, Calkins, Dunlap, Gardiner, and Ruckmich to Lilienfeld et al. have raised concerns about the clarity and use of problematic psychological terms. Read More

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Prevalence of Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines.

JAMA Netw Open 2022 May 2;5(5):e2213070. Epub 2022 May 2.

Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston.

Importance: Germline testing guidelines are suggested for specific disease types or a family history of cancer, yet alterations are found in cancer types in which germline testing is not routinely indicated. The clinical role of identifying germline variants in these populations is valuable to patients and their at-risk relatives.

Objective: To evaluate the prevalence of germline findings in patients undergoing tumor/normal matched sequencing among cancer types lacking guidelines. Read More

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A 6-year retrospective review of psychiatric emergency service utilization by school-age children.

Clin Child Psychol Psychiatry 2022 May 20:13591045211070924. Epub 2022 May 20.

Department of Psychiatry, 1259University of Michigan, Ann Arbor, MI, USA.

To explore utilization patterns and associated clinical factors of school-age children who present to a psychiatric emergency department. This was a 6-year retrospective chart review study of children 5-12 years of age who presented to a psychiatric emergency service from July 2012 to June 2018 ( = 1654 patients). Demographic variables, clinical diagnoses, lifetime adverse events (physical abuse, sexual abuse, and bullying), and history of self-harm were documented for each visit. Read More

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An AIE-Active probe for detection and bioimaging of pH values based on lactone hydrolysis reaction.

J Fluoresc 2022 May 20. Epub 2022 May 20.

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry & Chemical Engineering, Hainan normal University, 571158, Haikou, China.

Cellular pH homeostasis is essential for many physiological and pathological processes. pH monitoring is helpful for the diagnosis, treatment and prevention of disorders and diseases. Herein, we developed a ratiometric fluorescent pH probe (TCC) based on a coumarin derivative containing a highly active lactone ring. Read More

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Hirayama Disease: A 15-Year-Old Male With Progressive Distal Right Upper Extremity Weakness.

Neurologist 2022 May 20. Epub 2022 May 20.

Department of Neurology, Mayo Clinic, Phoenix, AZ.

Introduction: Hirayama disease is a rare neuromuscular disorder characterized by abnormal forward displacement of the cervical spinal cord, resulting in focal ischemic changes of anterior horn cells.

Case Report: A 15-year-old male presented with 6 months of progressive right upper extremity weakness. Electromyography/nerve conduction study indicated a chronic neurogenic process involving the C8-T1 myotome. Read More

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Effect of Anterolateral Structure Augmentation on Graft Maturity After Anterior Cruciate Ligament Reconstruction: A Clinical and MRI Follow-up of 2 Years.

Am J Sports Med 2022 May 20:3635465221092768. Epub 2022 May 20.

Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Background: Anterolateral structure augmentation (ALSA) has been applied to prevent residual rotatory instability and lower clinical failure rates after anterior cruciate ligament (ACL) reconstruction (ACLR); however, the effect of combined ALSA on the maturity of ACL grafts remains unknown.

Purpose: To evaluate the graft maturity and patient-reported outcomes in patients who underwent double-bundle ACLR with or without ALSA.

Study Design: Cohort study; Level of evidence, 3. Read More

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