16,054 results match your criteria finding consensus


[Consensus on treatment of multisystemic inflammatory syndrome associated with COVID-19].

Arch Argent Pediatr 2021 Aug;119(4):S198-S211

Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Buenos Aires.

The pandemic caused by the SARS-CoV-2 virus declared by the WHO in March 11th 2020, affects a small number of pediatric patients, who mostly present mild respiratory compromise and favorable evolution. However began to be observed in previously healthy children, an increase in cases defined as "Multisystemic Inflammatory Syndrome" (MIS-C) or "Kawasaki-like" post-COVID 19 (KLC) that evolve to shock and require hospitalization in the Pediatric Intensive Care Unit. MIS-C and KL-C are characterized by fever; signs of inflammation, gastrointestinal symptoms, and cardiovascular dysfunction, associated with sever forms of presentation with higher incidence of hypotension and/or shock. Read More

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Les progrès dans la réalisation de la classification quantitative de la psychopathologie.

Ann Med Psychol (Paris) 2021 Jan 8;179(1):95-106. Epub 2021 Jan 8.

Department of Psychology, University of Iowa, Iowa City, IA, USA.

Shortcomings of approaches to classifying psychopathology based on expert consensus have given rise to contemporary efforts to classify psychopathology quantitatively. In this paper, we review progress in achieving a quantitative and empirical classification of psychopathology. A substantial empirical literature indicates that psychopathology is generally more dimensional than categorical. Read More

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January 2021

Independent Versus Transtibial Drilling in Anterior Cruciate Ligament Reconstruction: A Meta-analysis With Meta-regression.

Orthop J Sports Med 2021 Jul 12;9(7):23259671211015616. Epub 2021 Jul 12.

Clinica Ortopedica e Traumatologica II, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Background: Anterior cruciate ligament (ACL) reconstruction can be performed with different techniques for independent and transtibial (TT) drilling of femoral tunnels, but there is still no consensus on which approach leads to the best outcome.

Purpose: To assess whether the independent or TT drilling approach for ACL reconstruction leads to the best functional outcomes.

Study Design: Systematic review; Level of evidence, 2. Read More

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Diagnostic challenges in patients with temporal lobe seizures and features of autoimmune limbic encephalitis.

Eur J Neurol 2021 Jul 20. Epub 2021 Jul 20.

Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Bochum, Germany.

Background: Consensus criteria for autoimmune limbic encephalitis (ALE) allow for a diagnosis even without neural antibodies (Abs), but it remains unclear which clinical features should prompt neural Ab screening in temporal lobe epilepsy patients.

Methods: We identified 47 patients from a tertiary epilepsy center with mediotemporal lobe seizures and additional features suggestive of limbic involvement, including either memory deficits, psychiatric symptoms, mediotemporal MRI hyperintensities or inflammatory CSF. Neuronal Ab testing was carried out at two independent reference laboratories (Bielefeld-Bethel, Germany, and Barcelona, Spain). Read More

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The recurring features of molecular subtypes in distinct gastrointestinal malignancies-A systematic review.

Crit Rev Oncol Hematol 2021 Jul 17;164:103428. Epub 2021 Jul 17.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine (CEMM), Cancer Center Amsterdam and Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands; Oncode Institute, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Electronic address:

In colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC) and gastric cancer (GC) multiple studies of inter-tumor heterogeneity have identified molecular subtypes, which correlate with clinical features. Our aim was to investigate the attributes of molecular subtypes across three different gastrointestinal cancer types. We performed a systematic search for publications on molecular subtypes or classifications in PDAC and GC and compared the described subtypes with the established consensus molecular subtypes of CRC. Read More

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Quantifying age-related changes in brain and behavior: A longitudinal versus cross-sectional approach.

eNeuro 2021 Jul 19. Epub 2021 Jul 19.

Taub Institute, Columbia University, New York, NY

Cross-sectional versus longitudinal comparisons of age-related change have often revealed differing results. In the current study, we employed within-subject task-based fMRI to investigate changes in voxel-based activations and behavioral performance across the lifespan in the Reference Ability Neural Network (RANN) cohort, at both baseline and 5-year follow-up. We analyzed fMRI data from between 127 and 159 participants (20-80 years), on a battery of tests relating to each of four cognitive reference abilities (RAs). Read More

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A Review of Biomarkers for Ischemic Stroke Evaluation in Patients With Non-valvular Atrial Fibrillation.

Front Cardiovasc Med 2021 1;8:682538. Epub 2021 Jul 1.

Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide and results in a significantly increased ischemic stroke (IS) risk. IS risk stratification tools are widely being applied to guide anticoagulation treatment decisions and duration in patients with non-valvular AF (NVAF). The CHADS-VASc score is largely validated and currently recommended by renowned guidelines. Read More

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Antiviral Therapy for Varicella Zoster Virus (VZV) and Herpes Simplex Virus (HSV)-Induced Anterior Uveitis: A Systematic Review and Meta-Analysis.

Front Med (Lausanne) 2021 2;8:686427. Epub 2021 Jul 2.

Advanced Eye Centre, Post-Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Herpes simplex virus (HSV) and varicella zoster virus (VZV) are the most common ocular pathogens associated with infectious anterior uveitis. Currently, there are a number of antiviral agents administered to treat viral anterior uveitis (VAU). However, there is no consensus or guidelines about the most appropriate approach leading for the best treatment outcomes with fewer ocular complications. Read More

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Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care.

Front Neurol 2021 1;12:694872. Epub 2021 Jul 1.

Neurology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS; the most common phenotype of corticobasal degeneration) are tauopathies with a relentless course, usually starting in the mid-60s and leading to death after an average of 7 years. There is as yet no specific or disease-modifying treatment. Clinical deficits in PSP are numerous, involve the entire neuraxis, and present as several discrete phenotypes. Read More

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[Efficacy of multisensory training and rehabilitation in patients with balance disorders].

Zhonghua Yi Xue Za Zhi 2021 Jul;101(26):2050-2054

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

To analyze the clinical efficacy of multisensory training and rehabilitation treatment in patients with balance disorders. From January to December 2020, 95 patients with balance disorders in the Vertigo Center of Department of Otorhinolaryngology, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology were enrolled. All patients were treated according to the treatment guidelines of Chinese Medical Association or expert consensus. Read More

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The long and winding road: perspectives of people and parents of children with mitochondrial conditions negotiating management after diagnosis.

Orphanet J Rare Dis 2021 Jul 13;16(1):310. Epub 2021 Jul 13.

Department of Paediatrics, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia.

Background: The diagnostic odyssey for people with a rare disease is well known, but difficulties do not stop at diagnosis. Here we investigate the experience of people, or parents of children with a diagnosed mitochondrial respiratory chain disorder (MRCD) in the management of their disease. The work complements ongoing projects around implementation of consensus recommendations for management of people with MRCD. Read More

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Comparative effectiveness of endoscopic versus microscopic transsphenoidal surgery for patients with growth hormone secreting pituitary adenoma: An emulated trial.

Clin Neurol Neurosurg 2021 Jun 24;207:106781. Epub 2021 Jun 24.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China; Neurosurgical Institute of Fudan University, Shanghai, China; Shanghai Pituitary Tumor Center, Shanghai, China; State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Introduction: Previous studies failed to show the benefit of endoscopic surgery over microscopic surgery in terms of early endocrine remission. This study was to investigate whether early endocrine outcomes in patients with GH-secreting pituitary adenoma underwent endoscopic transsphenoidal surgery would be better than those operated by microscopic surgery.

Methods: An acromegaly database collected from 2010 to 2019 in a single institution was used to emulate a randomized trial. Read More

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Ascending aorta dissection in a new classification system: Clinicopathological features of 62 cases.

Pathol Res Pract 2021 Jul 3;224:153542. Epub 2021 Jul 3.

The Fingerland Department of Pathology, University Hospital Hradec Králové and Faculty of Medicine in Hradec Králové, Charles University, Czech Republic.

Herein we present a single institution 5-year experience with ascending aorta dissection biopsies depicting the clinicopathological features of 62 cases. To detect microscopic abnormalities in the aortic wall beside the dissection itself, we applied a new histopathological classification scheme from the consensus documents issued by The Society for Cardiovascular Pathology and The Association for the European Cardiovascular Pathology in 2015 and 2016. The most common finding was medial degeneration (MD) - 61 cases (98. Read More

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Telehealth in emergency medicine: A consensus conference to map the intersection of telehealth and emergency medicine.

Acad Emerg Med 2021 Jul 10. Epub 2021 Jul 10.

Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

Introduction: Telehealth has the potential to significantly change the specialty of emergency medicine (EM) and has rapidly expanded in EM during the COVID pandemic; however, it is unclear how EM should intersect with telehealth. The field lacks a unified research agenda with priorities for scientific questions on telehealth in EM.

Methods: Through the 2020 Society for Academic Emergency Medicine's annual consensus conference, experts in EM and telehealth created a research agenda for the topic. Read More

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Perspectives on ability to work from patients' receiving dialysis and caregivers: analysis of data from the global SONG initiative.

J Nephrol 2021 Jul 9. Epub 2021 Jul 9.

College of Medicine and Public Health, Flinders University, Adelaide, Australia.

Background: Patients receiving dialysis have low employment rates, which compounds poorer health and socioeconomic outcomes. Reasons for under- and unemployment remain underexplored. We aimed to describe the perspectives of patients receiving hemodialysis (HD) or peritoneal dialysis (PD) and their caregivers on ability to work. Read More

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Concordance-based approaches for the inference of relationships and molecular rates with phylogenomic datasets.

Syst Biol 2021 Jul 7. Epub 2021 Jul 7.

The Sainsbury Laboratory, University of Cambridge, 47 Bateman Street, Cambridge CB2 1LR, UK.

Gene tree conflict is common and finding methods to analyze and alleviate the negative effects that conflict has on species tree analysis is a crucial part of phylogenomics. This study aims to expand the discussion of inferring species trees and molecular branch lengths when conflict is present. Conflict is typically examined in two ways: inferring its prevalence, and inferring the influence of the individual genes (how strongly one gene supports any given topology compared to an alternative topology). Read More

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Weight loss interventions in living donor liver transplantation as a tool in expanding the donor pool: A systematic review and meta-analysis.

World J Gastroenterol 2021 Jun;27(24):3682-3692

Department of Gastroenterology and Transplant Hepatology, Cleveland Clinic, Cleveland, OH 44195, United States.

Background: With increasing rates of liver transplantation and a stagnant donor pool, the annual wait list removals have remained high. Living donor liver transplantation (LDLT) is an established modality in expanding the donor pool and is the primary method of liver donation in large parts of the world. Marginal living donors, including those with hepatic steatosis, have been used to expand the donor pool. Read More

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HIV-1 proviral landscape characterization varies by pipeline analysis.

J Int AIDS Soc 2021 Jul;24(7):e25725

Division of Infectious Diseases, Brigham and Woman's Hospital, Boston, MA, USA.

Introduction: HIV rebounds after cessation of antiretroviral therapy, representing a barrier to cure. To better understand the virus reservoir, analysis pipelines have been developed that categorize proviral sequences as intact or defective, and further determine the precise nature of the sequence defects that may be present. We investigated the effects that different analysis pipelines had on the characterization of HIV-1 proviral sequences. Read More

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Antimalarial drugs-are they beneficial in rheumatic and viral diseases?-considerations in COVID-19 pandemic.

Clin Rheumatol 2021 Jul 3. Epub 2021 Jul 3.

Department of Rheumatology, Rehabilitation and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

The majority of the medical fraternity is continuously involved in finding new therapeutic schemes, including antimalarial medications (AMDs), which can be useful in combating the 2019-nCoV: coronavirus disease (COVID-19). For many decades, AMDs have been widely used in the treatment of malaria and various other anti-inflammatory diseases, particularly to treat autoimmune disorders of the connective tissue. The review comprises in vitro and in vivo studies, original studies, clinical trials, and consensus reports for the analysis, which were available in medical databases (e. Read More

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Nutrition in the Actual COVID-19 Pandemic. A Narrative Review.

Nutrients 2021 Jun 3;13(6). Epub 2021 Jun 3.

Faculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain.

The pandemic of Coronavirus Disease 2019 (COVID-19) has shocked world health authorities generating a global health crisis. The present study discusses the main finding in nutrition sciences associated with COVID-19 in the literature. We conducted a consensus critical review using primary sources, scientific articles, and secondary bibliographic indexes, databases, and web pages. Read More

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Transcriptional Pausing and Activation at Exons-1 and -2, Respectively, Mediate the Gene Expression in Human Glioblastoma Cells.

Genes (Basel) 2021 Jun 8;12(6). Epub 2021 Jun 8.

Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

The therapeutically important DNA repair gene O-methylguanine DNA methyltransferase () is silenced by promoter methylation in human brain cancers. The co-players/regulators associated with this process and the subsequent progression of gene transcription beyond the non-coding exon 1 are unknown. As a follow-up to our recent finding of a predicted second promoter mapped proximal to the exon 2 [, (5), 2492], we addressed its significance in transcription. Read More

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Pitfalls in Tick and Tick-Borne Pathogens Research, Some Recommendations and a Call for Data Sharing.

Pathogens 2021 Jun 7;10(6). Epub 2021 Jun 7.

Research Group in Emerging Zoonoses, Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), 50013 Zaragoza, Spain.

An understanding of the relationships of ticks and tick-borne pathogens can only be achieved by integrating data from multiple studies. The publication of raw material is a necessary step for wide-area meta-analyses and study design, data collection and reporting require harmonization. This is an opinion paper, not a consensus position, and is open to debate. Read More

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A Giant Solid-Cystic Mesenteric Fibromatosis with Unusual Synchronous Skin Fibromatosis.

Arch Iran Med 2021 Apr 1;24(4):326-329. Epub 2021 Apr 1.

Department of Pathology, Pathology and Stem Cell Research Center, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Mesenteric fibromatosis (MF) is a rare, locally aggressive tumor without distant metastasis, which has a high recurrence rate. Based on its location, it is classified as intra-abdominal, from abdominal wall, and extra-abdominal. The incidence of cystic-solid, retroperitoneal tumors is very low in comparison to other MF forms. Read More

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SYmptom-Based STratification of DiabEtes Mellitus by Renal Function Decline (SYSTEM): A Retrospective Cohort Study and Modeling Assessment.

Front Med (Lausanne) 2021 14;8:682090. Epub 2021 Jun 14.

Department of Medicine, The University of Hong Kong, Hong Kong, China.

Previous UK Biobank studies showed that symptoms and physical measurements had excellent prediction on long-term clinical outcomes in general population. Symptoms and signs could intuitively and non-invasively predict and monitor disease progression, especially for telemedicine, but related research is limited in diabetes and renal medicine. This retrospective cohort study aimed to evaluate the predictive power of a symptom-based stratification framework and individual symptoms for diabetes. Read More

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Facilitators and barriers to the clinical administration of herbal medicine in Ghana: a qualitative study.

BMC Complement Med Ther 2021 Jun 30;21(1):182. Epub 2021 Jun 30.

Centre for Plant Medicine Research, Mampong Akuapem,, Ghana.

Background: Herbal medicine administration in conventional health care services is gaining popularity lately. Much has not been documented on the perceived enhancers and challenges to herbal medicine administration at the hospital. The study sought to explore the facilitators and barriers to the clinical administration of herbal medicine in Ghana. Read More

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Role of Integral Control for Enlarging Second-Order Delay Consensus Margin Under PID Protocols: None.

IEEE Trans Cybern 2021 Jun 30;PP. Epub 2021 Jun 30.

Proportional, integral, and derivative (PID) feedback control, as a popular control law, plays a central role in industrial processes and traditional control applications. In the context of multiagent systems, one may also wonder what the fundamental capability and limitation of PID control may be. This article attempts to provide an answer from the viewpoint of consensus robustness against uncertain delay. Read More

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Skin Closure Technique and Postprocedural Pain after Spinal Cord Stimulator Implantation: A Retrospective Review.

Pain Res Manag 2021 4;2021:9912861. Epub 2021 Jun 4.

Department of Anesthesiology and Perioperative Medicine, Division of Pain Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Spinal cord and dorsal root ganglion stimulation are minimally invasive surgical techniques used to treat an array of chronic pain disorders. There is a paucity of data related to defining best practices in these specific patient populations, and historically, providers have relied on consensus committees to opine on the best techniques for patient safety and experience. The most efficacious mechanism of surgical closure-specifically a running suture closure compared to a surgical staple closure-is debated. Read More

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COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes.

PLoS One 2021 29;16(6):e0253974. Epub 2021 Jun 29.

School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, United States of America.

Background: We conducted an overview of systematic reviews (SRs) summarizing the best evidence regarding the effect of COVID-19 on maternal and child health following Cochrane methods and PRISMA statement for reporting (PROSPERO-CRD42020208783).

Methods: We searched literature databases and COVID-19 research websites from January to October 2020. We selected relevant SRs reporting adequate search strategy, data synthesis, risk of bias assessment, and/or individual description of included studies describing COVID-19 and pregnancy outcomes. Read More

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Parameter-Free Consensus Embedding Learning for Multiview Graph-Based Clustering.

IEEE Trans Neural Netw Learn Syst 2021 Jun 29;PP. Epub 2021 Jun 29.

Finding a consensus embedding from multiple views is the mainstream task in multiview graph-based clustering, in which the key problem is to handle the inconsistence among multiple views. In this article, we consider clustering effectiveness and practical applicability collectively, and propose a parameter-free model to alleviate the inconsistence of multiple views cleverly. To be specific, the proposed model considers the diversities of multiple views as two-layers. Read More

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Understanding acceptability in the context of text messages to encourage medication adherence in people with type 2 diabetes.

BMC Health Serv Res 2021 Jun 28;21(1):608. Epub 2021 Jun 28.

Manchester Centre for Health Psychology, School of Health Sciences, University of Manchester, Coupland 1 Building, Oxford Road, Manchester, M13 9PL, UK.

Background: Acceptability is recognised as a key concept in the development of health interventions, but there has been a lack of consensus about how acceptability should be conceptualised. The theoretical framework of acceptability (TFA) provides a potential tool for understanding acceptability. It has been proposed that acceptability measured before use of an intervention (anticipated acceptability) may differ from measures taken during and after use (experienced acceptability), but thus far this distinction has not been tested for a specific intervention. Read More

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