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Both arthroscopic and open posterior knee capsulotomy are effective in terms of extension recovery and functional improvement-systematic review.

Knee Surg Sports Traumatol Arthrosc 2021 Jun 12. Epub 2021 Jun 12.

Artromedical Orthopaedic Clinic, Antracytowa 1, 97-400, Belchatow, Poland.

Purpose: To assess the recovery of extension and improvement in functional scores after an arthroscopic or open posterior knee capsulotomy in the setting of an extension deficit.

Methods: A systematic search of articles published between 1980 and 2020 was performed in the MEDLINE/PubMed database, EMBASE/Ovid database and Web of Science database. The inclusion criteria consisted of patients with primary extension deficits > 5° who underwent an arthroscopic or open posterior knee capsulotomy. Read More

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Autoimmune Disease and Breast Implants: Systematic Review of Outcomes.

Ann Plast Surg 2021 Jun 10. Epub 2021 Jun 10.

From the Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY Division of Plastic and Reconstructive Surgery, NorthShore University HealthSystem, Chicago, IL Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI Medical Library, Memorial Sloan Kettering Cancer Center, New York, NY.

Abstract: Given that the use of breast implants for both cosmetic and reconstructive purposes is growing in the United States, an evaluation of factors that may affect the outcome of breast implant surgery is needed. A systematic review was conducted to evaluate the question: Does a personal or family history of autoimmune disease affect outcomes in breast implant surgery? The literature search yielded 2425 records, but after removal of duplicates, abstract screening, and full-text assessment, only 2 studies met the inclusion criteria for the final review. Both studies provided level III evidence and the average Methodological Index for Non-Randomized Studies score was 16. Read More

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Impact of A1 Asymmetry on the Woven EndoBridge Device in Anterior Communicating Artery Aneurysms.

AJNR Am J Neuroradiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Interventional Neuroradiology (J. Cortese, J. Caroff, J.-B.G., C.M., G.A., A.E., L.I., S.G., A.O., V.C., J.M., L.S.), NEURI Brain Vascular Center, Bicêtre Hospital, APHP, Paris Saclay University, Le Kremlin-Bicêtre, France.

Background And Purpose: Woven EndoBridge (WEB) devices are increasingly used to treat intracranial aneurysms. A1 asymmetry contributes to anterior communicating artery aneurysm formation and to treatment instability after coiling. We sought to evaluate whether A1 asymmetry had an impact on angiographic outcome in anterior communicating artery aneurysms treated with the WEB. Read More

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Cross-cultural adaptation to the Spanish context and evaluation of the content validity of the Second Victim Experience and Support Tool (SVEST-E) questionnaire.

Enferm Clin (Engl Ed) 2021 Jun 8. Epub 2021 Jun 8.

Servicio de Obstetricia y Ginecología, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Servicio Canario de Salud, Las Palmas, Spain; Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain.

Objectives: To carry out a cross-cultural adaptation of the Second Victim Experience and Support Tool (SVEST) questionnaire to the Spanish context, and to evaluate its content validity (CVI).

Methods: The translation and cultural adaptation of a measuring instrument by means of translation and back translation conducted through the participation of 20 health professionals. The content validation was carried out through the participation of 10 experts. Read More

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Association between discharges against medical advice and readmission in patients treated for drug injection-related skin and soft tissue infections.

J Subst Abuse Treat 2021 Jul 7;126:108465. Epub 2021 May 7.

Division of Substance Use Prevention and Harm Reduction, Philadelphia Department of Public Health, 123 South Broad Street, Philadelphia, PA 19109, USA. Electronic address:

Background: The prevalence of injection drug use (IDU)-related skin and soft tissue infections (SSTI) in Philadelphia has been steadily increasing since 2013. Patients seeking treatment for these infections are more likely to be discharged against medical advice (AMA), increasing the likelihood that they will end antibiotic treatment prematurely and require additional medical interventions.

Methods: The research team performed a nested case-control study using the Pennsylvania Health Care Cost Containment Council database for Philadelphia residents hospitalized for SSTI and substance use-related diagnoses between 2013 and 2018. Read More

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Patient Reported Traditional Chinese Medicine Spleen Deficiency Syndrome (TCM-SDS) Scale for Colorectal Cancer: Development and Validation in China.

Integr Cancer Ther 2021 Jan-Dec;20:15347354211020105

China Academy of Chinese Medical Sciences, Xiyuan Hospital, Haidian District, Beijing, P.R. China.

Introduction: Spleen Deficiency Syndrome (SDS) is recognized as one of the most common Traditional Chinse Medicine (TCM) syndromes in patients with colorectal cancer (CRC). However so far there is no existing patient-reported outcome (PRO) to evaluate SDS. Our study aimed to develop and validate a PRO TCM-SDS scale for CRC in China. Read More

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Autologous Matrix-Induced Chondrogenesis (AMIC) for Isolated Retropatellar Cartilage Lesions: Outcome after a Follow-Up of Minimum 2 Years.

Cartilage 2021 Jun 11:19476035211021908. Epub 2021 Jun 11.

Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Purpose: To evaluate autologous matrix-induced chondrogenesis (AMIC) for isolated focal retropatellar cartilage lesions and the influence of patellofemoral (PF) anatomy on clinical outcomes at a minimum of 2-year follow-up.

Methods: Twenty-nine consecutive patients (31 knees) who underwent retropatellar AMIC with a mean age of 27.9 ± 11. Read More

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Composite psychosocial risk based on the fear avoidance model in patients undergoing anterior cruciate ligament reconstruction: Cluster-based analysis.

Phys Ther Sport 2021 Jun 2;50:217-225. Epub 2021 Jun 2.

Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Musculoskeletal Research, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Physical Medicine and Rehabilitation, Osher Center for Integrative Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Objectives: To examine associations between preoperative fear-avoidance model (FAM) risk subgroup status and patient expectation of surgical success with postoperative outcomes at 6 and 12 months after anterior cruciate ligament reconstruction (ACLR).

Design: Cohort study.

Setting: Academic medical center. Read More

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The spectrum of acute leukoencephalopathy with restricted diffusion (ALERD): A case series and review of literature.

Eur J Paediatr Neurol 2021 Jun 6;33:86-93. Epub 2021 Jun 6.

Department of Pediatric Neurology, Rainbow Children's Hospital, Hyderabad, Telangana, India. Electronic address:

Introduction: The clinico-etiological spectrum of Acute leukoencephalopathy with restricted diffusion (ALERD) is not well known in Indian population. This is likely to vary between populations and ethnicities.

Methods: We retrospectively reviewed the clinicoetiological spectrum of ALERD at a tertiary care pediatric center, and described the clinical, imaging, etiological spectrum and short-term outcomes. Read More

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Tuberculosis of the spine in children - Does drug resistance affect surgical outcomes?

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Paediatric TB Clinic, Bai Jerbai Wadia Hospital for Children, Mumbai, India. Electronic address:

Background Context: The emergence of drug resistance has complicated the management of spinal tuberculosis (TB). While it is well known that the medical management of drug-resistant spinal TB is more difficult, the surgical outcomes of the same have not been studied sufficiently, particularly in children.

Purpose: To analyze the surgical outcomes in a cohort of children treated for spinal TB, and to thus assess whether drug resistant (DR) disease is associated with poorer surgical outcomes. Read More

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Prospective, Randomized, Double-Blinded Clinical Trial Comparing PEEK and Allograft Spacers in Patients Undergoing Transforaminal Lumbar Interbody Fusion Surgeries.

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Boulder Neurosurgical Associates, Boulder, Colorado, USA; Justin Parker Neurological Institute, Boulder, Colorado, USA. Electronic address:

Background Context: Allograft and polyether-ether-ketone (PEEK) radiographic, biomechanical, histological properties have been extensively studied and both spacers have their advantages and shortcomings. There are no comparative randomized or double-blinded spinal fusion clinical trials reported to date.

Purpose: The study's primary objective was to prospectively investigate clinical and radiological outcomes in patients undergoing lumbar interbody fusions and randomized to receive either PEEK or structural bone allografts. Read More

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In-hospital mortality among consecutive patients with ST-Elevation myocardial infarction in modern primary percutaneous intervention era ~ Insights from 15-year data of single-center hospital-based registry ~.

PLoS One 2021 11;16(6):e0252503. Epub 2021 Jun 11.

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Objective: To clarify the association of detailed angiographic findings with in-hospital outcome after primary percutaneous coronary intervention (p-PCI) for ST-elevation myocardial infarction (STEMI) in Japan.

Background: Data regarding the association of detailed angiographic findings with in-hospital outcome after STEMI are limited in the p-PCI era.

Methods: Between January-2004 and December-2018, 1735 patients with STEMI (mean age, 68. Read More

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End-to-End Automatic Morphological Classification of Intracranial Pressure Pulse Waveforms Using Deep Learning.

IEEE J Biomed Health Inform 2021 Jun 11;PP. Epub 2021 Jun 11.

Objective: Mean intracranial pressure (ICP) is commonly used in the management of patients with intracranial pathologies. However, the shape of the ICP signal over a single cardiac cycle, called ICP pulse waveform, also contains information on the state of the craniospinal space. In this study we aimed to propose an end-to-end approach to classification of ICP waveforms and assess its potential clinical applicability. Read More

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Medical abortion offered in pharmacy versus clinic-based settings.

Cochrane Database Syst Rev 2021 Jun 11;6:CD013566. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA.

Background: Medical abortion is usually offered in a clinic or hospital, but could potentially be offered in other settings such as pharmacies. In many countries, pharmacies are a common first point of access for women seeking reproductive health information and services. Offering medical abortion through pharmacies is a potential strategy to improve access to abortion. Read More

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Surgical Management of Thoracolumbar Spondylodiscitis in End-Stage Renal Disease.

Indian J Orthop 2021 May 6;55(Suppl 1):176-181. Epub 2020 May 6.

Department of Orthopaedics, M S Ramaiah Medical College, Bangalore, India.

Background: In recent times due to the advancement of haemodialysis techniques, there is increase in the life span of the patients with end-stage renal disease, which tends to increase the risk of complications of bacteraemia due to skin penetration for blood access and leading to propensity for more skeletal and spinal complications. Hence, early diagnosis of spine infection and early initiation of appropriate therapy are important in ensuring successful treatment and preventing further morbidity.

Materials And Methods: The study included 22 males and 12 females who were known case of end-stage renal disease undergoing haemodialysis therapy and diagnosed with spondylodiscitis based on the clinical and radiological signs. Read More

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Association between Health and Wealth among Kenyan Adults with Hypertension.

Glob J Health Sci 2021 5;13(4):86-94. Epub 2021 Mar 5.

Center for Advancing Population Science, Medical College of Wisconsin, Milwaukee, WI, United States.

Background: This paper examines the relationship between hypertension and wealth in a national sample of Kenyan adults.

Methods: Data from 27,552 individuals from the Demographic and Health Survey Program (DHS) for Kenya were analyzed. Wealth index, a cumulative measure of household standard of living, was the outcome. Read More

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Comparison of Preoperative Measurements with Intraoperative Aberrometry in Predicting Need for Correction in Eyes with Low Astigmatism Undergoing Cataract Surgery.

Clin Ophthalmol 2021 26;15:2189-2196. Epub 2021 May 26.

Harvard Eye Associates, Laguna Hills, CA, USA.

Purpose: To determine whether intraoperative aberrometry during cataract surgery measures higher levels of absolute astigmatism than preoperative biometry readings and which method yields a lower, final level of astigmatism if the two do not agree.

Patients And Methods: Retrospective record review of all patients who underwent uncomplicated cataract surgery from February 2015 to May 2019 with planned intraoperative aberrometry. Data analysis included preoperative keratometry, total astigmatism as measured by intraoperative aberrometry, intraocular lens model and power used, and postoperative manifest refraction ≥1 month after surgery. Read More

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[Value of radiographic assessment of lung edema score in evaluating the severity and prognosis of patients with acute respiratory distress syndrome].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):557-562

Department of Intensive Care Unit, Affiliated Nantong Third Hospital of Nantong University (Nantong Third People's Hospital), Nantong 226000, Jiangsu, China.

Objective: To explore the value of radiographic assessment of lung edema (RALE) score in evaluating the severity and prognosis of patients with acute respiratory distress syndrome (ARDS).

Methods: A retrospective study was conducted. Patients with ARDS admitted to the department of intensive care unit (ICU) of Affiliated Nantong Third Hospital of Nantong University from January 2016 to November 2020 were enrolled. Read More

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Individual prediction of motor vehicle accidents for patients with epilepsy.

Epilepsy Behav 2021 Jun 7;121(Pt A):108046. Epub 2021 Jun 7.

Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan 610041, People's Republic of China. Electronic address:

The objective of the study was to design a clinically useful tool to predict the risk of seizure-related motor vehicle accidents (MVAs) for people with epilepsy (PWE). Participants were patients who visited our epilepsy center in West China Hospital from October 2012 to October 2019 and were divided into a primary cohort and a validation cohort. Ultimately, we included 525 patients in the primary cohort and 86 patients in the validation cohort. Read More

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Feasibility and Outcomes of Multivisceral Resection in Locally Advanced Colorectal Cancer: Experience of a Tertiary Cancer Center in North-East India.

Ann Coloproctol 2021 Jun 10. Epub 2021 Jun 10.

Department of Surgical Oncology, Dr. B. Borooah Cancer Institute, Guwahati, India.

Purpose: Locally advanced colorectal cancer may require an en bloc resection of surrounding organs or structures to achieve complete tumor removal. This decision must weigh the risk of complications of multivisceral resection against the potential survival benefit. The purpose of this study is to review a single-center experience of feasibility of en bloc multivisceral resections for locally advanced colorectal carcinoma and to examine the effect of surgical experience on immediate outcome and rate of R0 resections. Read More

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Multi-feature fusion framework for sarcasm identification on twitter data: A machine learning based approach.

PLoS One 2021 10;16(6):e0252918. Epub 2021 Jun 10.

Faculty of Computer Science and Information Technology, Department of Information Systems, University of Malaya, Kuala Lumpur, Malaysia.

Sarcasm is the main reason behind the faulty classification of tweets. It brings a challenge in natural language processing (NLP) as it hampers the method of finding people's actual sentiment. Various feature engineering techniques are being investigated for the automatic detection of sarcasm. Read More

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[The relationships between different surgical approaches for maxillary sinus augmentation and implant failure and complications: a retrospective cohort study].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):214-218

Department of Oral and Maxillofacial Surgery, Hefei Stomatology Hospital. Hefei 230001, Anhui Province, China.

Purpose: To investigate the 5-year survival and complication rates of implants placed in grafted sinuses with different surgical approaches and analyze the causes for failure.

Methods: This study retrospectively observed the prognosis of patients who underwent maxillary sinus augmentation by means of lateral window technique(LWT) or transalveolar osteotomy technique (TOT) and simultaneously installed implants performed, in Hefei Stomatological Hospital. The primary predictor variables were surgical approaches, including LWT and TOT. Read More

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[A five-year experience for treating patients with chronic apical periodontitis with root canal treatment: a retrospective cohort study].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):124-128

Hefei Stomatology Hospital. Hefei 230001, Anhui Province, China.

Purpose: To investigate the clinical outcomes, including survival and periapical healing rates and failure causes, of root canal treatment for patients with periapical lesion.

Methods: A retrospective cohort study was conducted which enrolled patients admitted for the evaluation and management of periapical lesion with root canal treatment. The primary predictor variables were difficulty assessment of root canal therapy (DARCT),which was divided into lower(DARCT =3-4), medium (DARCT =5-7) and higher (DARCT =8-9) difficulty root canal, in terms of canal length, curvature and calcification. Read More

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Personalized, Electronic Health Record-Integrated Decision Aid for Stroke Prevention in Atrial Fibrillation: A Small Cluster Randomized Trial and Qualitative Analysis of Efficacy and Acceptability.

Circ Cardiovasc Qual Outcomes 2021 Jun 10:CIRCOUTCOMES120007329. Epub 2021 Jun 10.

The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH (J.B., C.L.P., C.H.S., M.C.).

Background: Shared decision-making in cardiology is increasingly recommended to improve patient-centeredness of care. Decision aids can improve patient knowledge and decisional quality but are infrequently used in real-world practice. This mixed-methods study tests the efficacy and acceptability of a decision aid integrated into the electronic health record (Integrated Decision Aid [IDeA]) and delivered by clinicians for patients with atrial fibrillation considering options to reduce stroke risk. Read More

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Dental Health Inequalities among Indigenous Populations: A Systematic Review and Meta-Analysis.

Caries Res 2021 Jun 9:1-20. Epub 2021 Jun 9.

Australian Research Centre for Population Oral Health, Adelaide Dental School, University of Adelaide, Adelaide, South Australia, Australia.

The aim of this systematic review and meta-analysis was to document the disparity in dental caries experiences among indigenous and nonindigenous populations globally by measuring dental caries prevalence and severity. An electronic database (MEDLINE) was initially searched using relevant keywords. This was followed by use of the search string in the following electronic databases: Scopus, EBSCOhost, Cochrane, and Open Grey. Read More

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Impact of intermediate to high-doses of methylprednisolone on mortality rate in patients with COVID-19 pneumonia-induced severe systemic inflammation.

Int J Clin Pract 2021 Jun 9:e14479. Epub 2021 Jun 9.

Medical Director, Doctor Peset University Hospital, Valencia, Spain.

Introduction: In addition to respiratory support needs, patients´ characteristics to guide indication or timing of corticosteroid treatment in COVID-19 patients are not completely established. This study aimed to evaluate the impact of methylprednisolone on mortality rate in patients with COVID-19 pneumonia-induced severe systemic inflammation (PI-SSI).

Methods: Between March 9 and May 5, 2020 (final follow-up July 2, 2020), a retrospective cohort study was conducted in hospitalized patients with COVID-19 PI-SSI (≥2 inflammatory biomarkers (IB): temperature ≥38ºC, lymphocyte ≤800cell/microL, C-reactive protein ≥100mg/L, lactate dehydrogenase ≥300units/L, ferritin ≥1000mcg/L, D-dimer ≥500ng/mL). Read More

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Association of Social and Behavioral Risk Factors With Mortality Among US Veterans With COVID-19.

JAMA Netw Open 2021 06 1;4(6):e2113031. Epub 2021 Jun 1.

San Francisco VA Medical Center, San Francisco, California.

Importance: The US Department of Veterans Affairs (VA) offers programs that reduce barriers to care for veterans and those with housing instability, poverty, and substance use disorder. In this setting, however, the role that social and behavioral risk factors play in COVID-19 outcomes is unclear.

Objective: To examine whether social and behavioral risk factors were associated with mortality among US veterans with COVID-19 and whether this association might be modified by race/ethnicity. Read More

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Association of Rideshare Use With Alcohol-Associated Motor Vehicle Crash Trauma.

JAMA Surg 2021 Jun 9. Epub 2021 Jun 9.

Department of Neurosurgery, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston.

Importance: Motor vehicle crashes (MVCs) are an important public health concern. Recent trends suggest that introducing rideshare services has decreased the incidence of MVCs. However, detailed analyses linking rideshare volume, convictions for impaired driving, and nonfatal MVC traumas remain inconclusive. Read More

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Exploring prevalence of wound infections and related patient characteristics in homecare using natural language processing.

Int Wound J 2021 Jun 9. Epub 2021 Jun 9.

School of Nursing, Columbia University, New York City, New York, USA.

We aimed to create and validate a natural language processing algorithm to extract wound infection-related information from nursing notes. We also estimated wound infection prevalence in homecare settings and described related patient characteristics. In this retrospective cohort study, a natural language processing algorithm was developed and validated against a gold standard testing set. Read More

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Pregnancy-related comorbidities and labor induction - the effectiveness and safety of dinoprostone compared to misoprostol.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Cracow, Poland.

Objectives: The aim of the study was to evaluate whether the presence of the disease in pregnancy influences the effectiveness and safety of delivery preinduction with prostaglandins: misoprostol vaginal insert and dinoprostone vaginal gel.

Material And Methods: This is aretrospective cohort study conducted of 560 pregnant women. The concomitant diseases mainly recorded were diabetes mellitus, hypertensive diseases, intrahepatic cholestasis of pregnancy, asthma, thrombocytopenia, and hypothyroidism. Read More

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