7,298 results match your criteria figo stage


Magnetic Resonance Imaging of Uterine Cervix: A Pictorial Essay.

Indian J Radiol Imaging 2021 Apr 4;31(2):454-467. Epub 2021 Aug 4.

Department of Radiology, Lifescan Imaging Centre, Mumbai, Maharashtra, India.

Uterine cervix is the lower constricted part of uterus which is best evaluated by magnetic resonance imaging (MRI) due to its higher soft tissue and contrast resolution. The cervical cancer is a common gynecological cancer causing much morbidity and mortality especially in developing countries. Cervical carcinomas mainly occurs in reproductive age group with prognosis mainly depending on the extent of disease at the time of diagnosis, hence it is important to identify these cancerous lesions early and stage them accurately for optimal treatment. Read More

View Article and Full-Text PDF

The importance of choosing the right strategy to treat small cell carcinoma of the cervix: a comparative analysis of treatments.

BMC Cancer 2021 Sep 23;21(1):1046. Epub 2021 Sep 23.

Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Shouwa-ku, Nagoya, Aichi, 466-8550, Japan.

Background: Standard treatments for small cell carcinoma of the cervix (SCCC) have not been established. In this study, we aimed to estimate the optimal treatment strategy for SCCC.

Methods: This was a multicenter retrospective study. Read More

View Article and Full-Text PDF
September 2021

Open Versus Minimally Invasive Radical Hysterectomy in Cervical Cancer: The CIRCOL Group Study.

Ann Surg Oncol 2021 Sep 20. Epub 2021 Sep 20.

Department of Gynecologic Oncology, Aristides Maltez Hospital, Salvador, Brazil.

Purpose: To analyze the survival outcomes of patients in a Brazilian cohort who underwent minimally invasive surgery (MIS) compared with open surgery for early stage cervical cancer.

Methods: A multicenter database was constructed, registering 1280 cervical cancer patients who had undergone radical hysterectomy from 2000 to 2019. For the final analysis, we included cases with a tumor ≤ 4 cm (stages Ia2 to Ib2, FIGO 2018) that underwent surgery from January 2007 to December 2017. Read More

View Article and Full-Text PDF
September 2021

Real-world data of 14 cases of brain metastases from gestational trophoblastic neoplasia and a literature review.

Arch Gynecol Obstet 2021 Sep 20. Epub 2021 Sep 20.

Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Institute of Women and Children's Health, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.

Objective: The aim of this study was to investigate the diagnosis, treatment, and prognosis of patients with brain metastases from gestational trophoblastic neoplasia (GTN) in the real world.

Methods: Analyzing the clinicopathological characteristics, treatment process, and prognosis of 14 GTN patients with brain metastases admitted to the West China Second University Hospital between January 2006 and December 2020.

Results: The median FIGO prognostic score was 15 points (range 11-21 points), with 12 cases having 13 points or more (extremely high risk). Read More

View Article and Full-Text PDF
September 2021

Diagnostic value of miR-153 and miR-203 in patients with cervical cancer and their correlation with human papillomavirus infection.

Am J Transl Res 2021 15;13(8):9736-9742. Epub 2021 Aug 15.

Department of Obstetrics and Gynecology, Huzhou Central Hospital Huzhou, Zhejiang Province, China.

Objective: To explore the diagnostic value of miR-153 and miR-203 in patients with cervical cancer (CC).

Methods: A total of 136 CC and suspected CC patients admitted to our hospital were enrolled in this prospective study. Among them, 80 cases had CC, 56 cases with cervical intraepithelial neoplasia, and 40 cases with cervicitis. Read More

View Article and Full-Text PDF

Role of SIX1, EYA2, and E-cadherin in ovarian carcinoma. Evidence on epithelial-mesenchymal transition from an immunohistochemical study.

Ann Diagn Pathol 2021 Sep 8;55:151815. Epub 2021 Sep 8.

Department of Pathology, Faculty of Medicine, Menoufia University, Egypt.

This study aims to investigate the expression of SIX1, EYA2, and E-cadherin in ovarian cancer (OC). It was conducted on 97 cases of surface epithelial tumors (SEOTs). Immunohistochemistry (IHC) staining for the three markers was applied to archival paraffin-embedded sections. Read More

View Article and Full-Text PDF
September 2021

The quality of intrapartum cardiotocography in preterm labour.

J Perinat Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Obstetrics and Gynaecology, Amsterdam University Medical Centre Location VUmc, Amsterdam, The Netherlands.

Objectives: The aim of this study is to determine the quality of the foetal heart rate (FHR) recording, defined as signal loss, during preterm labour below 28 weeks gestational age (GA) and contribute to the discussion if cardiotocography (CTG) is of value for the extreme preterm foetus.

Methods: From January 2010 to December 2019 a retrospective study was conducted with data of 95 FHR recordings of singletons born between 24 and 28 weeks GA at the Amsterdam University Medical Centre, location VUmc. FHR tracings had a duration of at least 30 min and were obtained via external ultrasound mode. Read More

View Article and Full-Text PDF
September 2021

HPV16 E6-specific T cell response and HLA-A alleles are related to the prognosis of patients with cervical cancer.

Infect Agent Cancer 2021 Sep 16;16(1):61. Epub 2021 Sep 16.

The Third Affiliated Hospital of Xinjiang Medical University, Key Laboratory of Cancer Immunotherapy and Radiotherapy, Chinese Academy of Medical Sciences, Urumqi, China.

Background: T cell epitopes are polypeptide fragments presented to T cell receptors by MHC molecules encoded by human leukocyte antigen (HLA) genes after antigen-presenting cell processing, which is the basis for the study of antigen immune mechanism and multi-epitope vaccine. This study investigated T cell response to HPV16 E6 and E7 in patients with cervical squamous cell carcinoma (CSCC). Also, the HLA-A allele distribution was compared among patients and evaluated as a factor to predict prognosis in these patients. Read More

View Article and Full-Text PDF
September 2021

Cancer-testis antigen ACRBP expression and serum immunoreactivity in ovarian cancer: Its association with prognosis.

Immun Inflamm Dis 2021 Sep 16. Epub 2021 Sep 16.

Department of Histology and Embryology, School of Preclinical Medicine, Guangxi Medical University, Nanning, China.

Introduction: Cancer testis (CT) antigens are attractive targets for cancer immunotherapy because of their expression restriction and immunogenicity. The acrosin binding protein (ACRBP) is a member of CT antigens. This study aimed to evaluate ACRBP expression and immunogenicity in ovarian cancer (OC). Read More

View Article and Full-Text PDF
September 2021

Stromal infiltrating mast cells identify immunoevasive subtype high-grade serous ovarian cancer with poor prognosis and inferior immunotherapeutic response.

Oncoimmunology 2021 11;10(1):1969075. Epub 2021 Sep 11.

Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Tumor infiltrating mast cells (TIMs), with pro- or anti-tumorigenic role in different types of malignancies, have been implicated in resistance to anti-PD1 therapy. Here, we aimed to identify the relevance of TIMs with the prognosis, immune contexture, and immunotherapy in high-grade serous ovarian cancer (HGSOC). Tissue microarrays containing 197 HGSOC patients were assessed by immunohistochemistry (IHC) for detecting the expression of mast cell tryptase and other immune markers. Read More

View Article and Full-Text PDF
September 2021

Management of locally advanced mesonephric carcinoma of the cervix in the setting of Mullerian Duct anomaly spectrum and unilateral renal agenesis: A case report and review of the literature.

Brachytherapy 2021 Sep 11. Epub 2021 Sep 11.

Department of Radiation Oncology, University of Washington, Seattle, WA. Electronic address:

Cervical mesonephric adenocarcinoma is a rare histologic cervical carcinoma variant arising from remnants of the mesonephric duct. Few clinical cases have been reported in the literature, and given the low rate of occurrence, the optimal management strategy is unknown. Most reported cases involve patients with either early stage (FIGO I) or metastatic disease. Read More

View Article and Full-Text PDF
September 2021

FIGO staging for carcinoma of the vulva: 2021 revision.

Int J Gynaecol Obstet 2021 Oct;155(1):43-47

Oxford Gynecological Cancer Center, Churchill Hospital, Oxford, UK.

To revise the FIGO staging for carcinoma of the vulva using a new approach that involves analyses of prospectively collected data. The FIGO Committee for Gynecologic Oncology reviewed the recent literature to gain an insight into the impact of the 2009 vulvar cancer staging revision. The Committee resolved to revise the staging with a goal of simplification and actively collaborated with the United States National Cancer Database to analyze prospectively collected data on carcinoma of the vulva. Read More

View Article and Full-Text PDF
October 2021

High-grade endometrial carcinoma limited to the endometrium or a polyp: is adjuvant treatment necessary?

Int J Gynecol Cancer 2021 Sep 13. Epub 2021 Sep 13.

Gynecology Oncology, CHU de Québec-Université Laval, Quebec, Quebec, Canada

Objective: High-grade endometrial carcinoma limited to the endometrium or a polyp is a rare clinical entity. Currently there is no consensus on standard treatment. Thus, the goal of this study was to evaluate the clinical outcomes of patients with type II endometrial carcinoma without myometrial infiltration or limited to a polyp. Read More

View Article and Full-Text PDF
September 2021

Prognostic significance of tumor laterality in advanced ovarian cancer.

Obstet Gynecol Sci 2021 Sep 14. Epub 2021 Sep 14.

Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan.

Objective: This study aimed to investigate the effect of incorporating tumor laterality into the International Federation of Gynecology and Obstetrics (FIGO) staging system for advanced ovarian cancer.

Methods: The clinical data of 131 patients with advanced ovarian cancer treated between 2008 and 2018 were retrospectively reviewed. To investigate the prognostic significance of tumor laterality, we divided the patients into unilateral and bilateral groups. Read More

View Article and Full-Text PDF
September 2021

Expression of selected molecular factors in two types of endometrial cancer.

Adv Clin Exp Med 2021 Sep 9. Epub 2021 Sep 9.

Department of Gynecological Oncology, Poznan University of Medical Sciences, Poland.

Background: Endometrial cancers (EC) are a heterogeneous group of malignant neoplasms differing in etiology, clinical-pathological features and prognosis.

Objectives: The aim of our study is to determine differences between the expression of selected molecular factors and find connections between them in order to isolate possible biomarkers influencing treatment options.

Material And Methods: The investigated data involved archival histological preparations obtained from uterine EC samples taken from 137 patients, treated surgically between 2007 and 2014. Read More

View Article and Full-Text PDF
September 2021

Clinicopathologic predictors of early relapse in advanced epithelial ovarian cancer: development of prediction models using nationwide data.

Cancer Epidemiol 2021 Sep 8:102008. Epub 2021 Sep 8.

Department of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, the Netherlands.

Objective: To identify clinicopathologic factors predictive of early relapse (platinum-free interval (PFI) of ≤6 months) in advanced epithelial ovarian cancer (EOC) in first-line treatment, and to develop and internally validate risk prediction models for early relapse.

Methods: All consecutive patients diagnosed with advanced stage EOC between 01-01-2008 and 31-12-2015 were identified from the Netherlands Cancer Registry. Patients who underwent cytoreductive surgery and platinum-based chemotherapy as initial EOC treatment were selected. Read More

View Article and Full-Text PDF
September 2021

Minimal Uterine Serous Carcinoma and Endometrial Polyp: A Close Clinicopathological Relationship.

Hum Pathol 2021 Sep 8. Epub 2021 Sep 8.

Department of Pathology, Yale University School of Medicine, New Haven, CT 06520.

Frequently involving an endometrial polyp, minimal uterine serous carcinoma (MUSC) represents the earliest recognizable forms of endometrial serous carcinoma. The aim of this study was to provide a comprehensive morphological and clinical outcome assessment of MUSC involving endometrial polyp. 77 fully staged MUSCs involving endometrial polyp were identified including 53 MUSCs confined to polyp and 24 non-polyp confined tumors. Read More

View Article and Full-Text PDF
September 2021

Primary High Grade Serous Carcinoma of the Fallopian Tube: A Case Report.

JNMA J Nepal Med Assoc 2020 Nov 22;58(231):927-929. Epub 2020 Nov 22.

Department of Obstetrics and Gynaecology, Norvic International Hospital, Kathmandu, Nepal.

A 49-year-old, perimenopausal nulliparous woman with lower abdominal pain and abnormal uterine bleeding. Clinical and radiological findings suggested a right adnexal tumor.  CA-125 level was moderately elevated. Read More

View Article and Full-Text PDF
November 2020

From FIGO-2009 to FIGO-2018 in women with early-stage cervical cancer; Does the revised staging reflect risk groups?

Gynecol Oncol 2021 Sep 6. Epub 2021 Sep 6.

Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark; Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

Objectives: We aimed to evaluate if the revised staging according to FIGO-2018 in early-stage cervical cancer correctly predicts the risk for nodal metastases.

Methods: We reallocated 245 women with early-stage cervical cancer from FIGO-2009 to FIGO-2018 stages using data from a national, prospective cohort study on sentinel lymph node (SLN) mapping. We used univariate and multivariate binary regression models to investigate the association between FIGO-2018 stages, tumor characteristics, and nodal metastases. Read More

View Article and Full-Text PDF
September 2021

Application of Immunoprofiling Using Multiplexed Immunofluorescence Staining Identifies the Prognosis of Patients with High-Grade Serous Ovarian Cancer.

Int J Mol Sci 2021 Sep 6;22(17). Epub 2021 Sep 6.

Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Immunoprofiling has an established impact on the prognosis of several cancers; however, its role and definition in high-grade serous ovarian cancer (HGSOC) are mostly unknown. This study is to investigate immunoprofiling which could be a prognostic factor in HGSOC. We produced tumor microarrays of 187 patients diagnosed with HGSOC. Read More

View Article and Full-Text PDF
September 2021

Detection of Serous Tubal Intraepithelial Carcinoma along with High Grade Serous Carcinoma of Both Ovaries.

Authors:
Hina Tariq

J Coll Physicians Surg Pak 2021 Sep;31(9):1108-1110

Department of Histopathology, Army Medical College, Rawalpindi, Pakistan.

High-grade serous carcinoma (HGSC) of ovary is the commonest of all ovarian malignant tumours and is associated with high mortality rate. Serous tubal intraepithelial carcinoma (STIC) is believed to be the precursor lesion. In literature, only 40-50% of HGSC shows concurrent STIC, even after thorough sampling. Read More

View Article and Full-Text PDF
September 2021

[Endocervical adenocarcinomas classified by International Endocervical Adenocarcinoma Criteria and Classification: a clinicopathological and prognostic analysis of 286 cases].

Zhonghua Bing Li Xue Za Zhi 2021 Sep;50(9):1014-1019

Department of Gynecological Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310002, China.

To investigate the clinicopathological and prognostic significance of International Endocervical Adenocarcinoma Criteria and Classification (IECC) in classifying endocervical adenocarcinomas among Chinese women. A total of 286 endocervical adenocarcinomas diagnosed from January 2013 to December 2019 at the Women's Hospital, Zhejiang University School of Medicine were identified and included. The cases were reviewed and reclassified based on IECC. Read More

View Article and Full-Text PDF
September 2021

[Clinicopathological features of malignant mixed mesodermal tumor: analysis of 50 cases].

Zhonghua Bing Li Xue Za Zhi 2021 Sep;50(9):1008-1013

Department of Pathology, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China.

To investigate the clinicpathological, immunohistochemical and molecular genetic features of malignant mixed mesodermal tumor (MMMT) in the female reproductive system. To analyze its histopathological characteristics, we performed a retrospective review of the MMMT cases diagnosed at PLA General Hospital, Beijing, China during 2005-2019 using its surgical and pathological databases. EnVision immunohistochemical staining was used to detect the expression of ER, PR, p16, p53 and MMR proteins. Read More

View Article and Full-Text PDF
September 2021

Overexpression of Epithelial Splicing Regulatory Protein 1 in Metastatic Lesions of Serous Ovarian Carcinoma Correlates with Poor Patient Prognosis.

Cancer Biother Radiopharm 2021 Sep 8. Epub 2021 Sep 8.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang City, China.

Epithelial splicing regulatory proteins (ESRPs) can regulate alternative splicing of RNA and play roles in tumorigenesis and development of various malignancies. In this study, bioinformatic analyses and immunohistochemistry (IHC) were used to investigate the function of ESPRs in serous ovarian carcinoma (SOC) oncogenesis and metastasis. The mRNA levels of ESRPs were analyzed by Oncomine and gene expression profiling interactive analysis (GEPIA). Read More

View Article and Full-Text PDF
September 2021

ConCerv: a prospective trial of conservative surgery for low-risk early-stage cervical cancer.

Int J Gynecol Cancer 2021 Sep 7. Epub 2021 Sep 7.

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Objective: The objective of the ConCerv Trial was to prospectively evaluate the feasibility of conservative surgery in women with early-stage, low-risk cervical cancer.

Methods: From April 2010 to March 2019, a prospective, single-arm, multicenter study evaluated conservative surgery in participants from 16 sites in nine countries. Eligibility criteria included: (1) FIGO 2009 stage IA2-IB1 cervical carcinoma; (2) squamous cell (any grade) or adenocarcinoma (grade 1 or 2 only) histology; (3) tumor size 2 cm; (4) no lymphovascular space invasion; (5) depth of invasion 10 mm; (6) negative imaging for metastatic disease; and (7) negative conization margins. Read More

View Article and Full-Text PDF
September 2021

Vulvar cancer in Botswana in women with and without HIV infection: patterns of treatment and survival outcomes.

Int J Gynecol Cancer 2021 Sep 7. Epub 2021 Sep 7.

Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Objectives: Vulvar cancer is a rare gynecological malignancy. However, the incidence of human papillomavirus (HPV)-associated vulvar disease is increasing, particularly in low- and middle-income countries. HIV infection is associated with an increased risk of HPV-associated vulvar cancer. Read More

View Article and Full-Text PDF
September 2021

Circ-ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA-128-3p/ZEB1 axis.

Biol Proced Online 2021 Sep 7;23(1):17. Epub 2021 Sep 7.

Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, NO.1 East Jianshe Road, Zhengzhou, 450052, Henan, China.

Aims: We focused on the detailed functions of circ-ABCB10 in cervical cancer (CC) development and its mechanisms.

Background: The increasing findings have proposed the central roles of circular RNAs (circRNAs) in the tumorigenesis of various human cancers. Circ-ABCB10 displays promising oncogenic effect in several tumors. Read More

View Article and Full-Text PDF
September 2021

Changes in gynecologic and breast cancer diagnoses during the first wave of the COVID-19 pandemic: analysis from a tertiary academic gyneco-oncological center in Germany.

Arch Gynecol Obstet 2021 Sep 7. Epub 2021 Sep 7.

Department of Obstetrics and Gynecology, University Hospital and CCC Munich, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.

Purpose: With the beginning of 2021, the world has been suffering from the COVID-19 pandemic for more than 1 year. More and more, we are able to evaluate side effects of the pandemic in the healthcare sector. A negative impact on cancer diagnoses is one of them. Read More

View Article and Full-Text PDF
September 2021

Long-term follow-up of 46 cases of primary fallopian tube carcinoma: a single institute study.

Ann Palliat Med 2021 Aug;10(8):9122-9135

Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Primary fallopian tube carcinoma (PFTC) is a rare malignancy. In recent years the incidence of PFTC has been rising. This study retrospectively analyzed 46 cases of PFTC to identify prognostic factors that may impact the survival of patients with PFTC and explored the clinical characteristics. Read More

View Article and Full-Text PDF

[Fertility preservation in cervical cancer, analysis of 30 years of practice and immersion in future developments.]

Gynecol Obstet Fertil Senol 2021 Sep 3. Epub 2021 Sep 3.

Département de chirurgie gynécologique, Institut Gustave Roussy, Villejuif, France; Unité INSERM U 10-30, Gustave Roussy, Villejuif, France et université Paris-Sud (Paris XI), Le Kremlin Bicêtre, France. Electronic address:

Objectives: The strategy of fertility preservation (FP) in cervical cancer has been challenged for several years and a therapeutic de-escalation seems to be necessary. In this context, we evaluated the oncological, fertility and obstetric outcomes of surgical techniques performed in our centre for FP.

Methods: This retrospective uni centric trial included 75 patients, managed at the Gustave Roussy Institute between 1995 and 2020, for cervical cancer (stage IB1 FIGO 2018) and having conducted a fertility preservation project after a complete pre-therapy work-up. Read More

View Article and Full-Text PDF
September 2021