321 results match your criteria fif

Finding Information Framework: A Tool to Teach Life-Long Learning Skills.

PRiMER 2021 26;5:16. Epub 2021 May 26.

Hackensack Meridian School of Medicine.

Introduction: In this age of rapid information expansion, medical education can no longer be taught solely by information acquisition, but rather requires information management and information mastery at both the point of learning as well as at the clinical point of care. We must teach our trainees how to ask, categorize, and answer their own questions-skills required to be a life-long learner. We developed the Finding Information Framework (FIF), a conceptual algorithm as well as web-based tool and app, to guide medical students in asking and categorizing their questions and to link them directly to the most appropriate information resource for their questions. Read More

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Dosimetric Comparison of Whole Breast Radiotherapy Using Field-in-Field and Volumetric Modulated Arc Therapy Techniques in Left-Sided Breast Cancer Patients.

Cureus 2021 Jun 18;13(6):e15732. Epub 2021 Jun 18.

Department of Clinical and Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

Introduction The radiotherapy of left-sided breast cancers is challenging because of neighboring critical organs, posing an increased risk of complications. Various radiation delivery techniques have been used to deliver the desired dose of radiation to the target area while keeping the doses to nearby structures within constraints. The main aim of this study is to quantify doses delivered to the organs at risk (OARs) including heart, left lung, spinal cord, and contralateral breast, and to the planning target volume (PTV) using Field-in-Field (FIF) and Volumetric Modulated Arc Therapy (VMAT). Read More

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Differential diagnosis of a calcified cyst found in an 18th century female burial site at St. Nicholas Church cemetery (Libkovice, Czechia).

PLoS One 2021 2;16(7):e0254173. Epub 2021 Jul 2.

Division of Anthropology, Institute of Environmental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.

During archaeological excavations in burial sites, sometimes stoned organic objects are found, in addition to human remains. Those objects might be of a different origin, depending on various factors influencing members of a community (i.e. Read More

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Investigation into the Effect of Breast Volume on Irradiation Dose Distribution in Asian Women with Breast Cancer.

Acta Med Okayama 2021 Jun;75(3):307-314

Department of Oral and Maxillofacial Radiology, and Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

Reports on irradiation dose distribution in breast cancer radiotherapy with sufficient sample size are limited in Asian patients. Elucidating dose distribution in Asian patients is particularly important as their breast volume differs compared to patients in Europe and North America. Here, we examined dose distribution in the irradiation field relative to breast volume for three irradiation methods historically used in our facility. Read More

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A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain.

J Biol Chem 2021 Jun 15;297(1):100876. Epub 2021 Jun 15.

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA. Electronic address:

The Eph receptor tyrosine kinases and their ephrin ligands regulate many physiological and pathological processes. EphA4 plays important roles in nervous system development and adult homeostasis, while aberrant EphA4 signaling has been implicated in neurodegeneration. EphA4 may also affect cancer malignancy, but the regulation and effects of EphA4 signaling in cancer are poorly understood. Read More

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Rare Fetus-in-Fetu: Experience From a Large Tertiary Pediatric Referral Center.

Front Pediatr 2021 24;9:678479. Epub 2021 May 24.

Department of Pediatric Surgery, Maternal and Child Health Hospital of Hubei, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Fetus-in-fetu (FIF) is an extremely rare disease, and most prior publications are single case reports. Here, we describe the clinical characteristics, imaging manifestations, and the treatment and related complications of FIF from a large tertiary pediatric referral center. After institutional review board approval, patients with a diagnosis of FIF between January 2010 and November 2019 were further selected and reexamined. Read More

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Field-in-Field Technique With Intrafractionally Modulated Junction Shifts for Craniospinal Irradiation Planning With Three-Dimensional Conformal Radiation Therapy.

Cureus 2021 Apr 28;13(4):e14744. Epub 2021 Apr 28.

Oncology, Ziauddin University, Karachi, PAK.

Background: Planning craniospinal irradiation (CSI) with ''field-in-field'' (FIF) homogenization technique in combination with daily, intrafractional modulation of the field junctions is needed to avoid spinal cord overdose. Photon-based techniques for CSI may result in dose inhomogeneity within the treatment volume and usually require a weekly manual shift of the field junctions to minimize the possibility of spinal cord overdose. Nowadays, FIF technique is used to feather out the dose inhomogeneity caused by multiple fields. Read More

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P120 catenin potentiates constitutive E-cadherin dimerization at the plasma membrane and regulates trans binding.

Curr Biol 2021 May 15. Epub 2021 May 15.

Department of Biochemistry, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA; Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, USA; Department of Chemistry, University of Illinois, Urbana, IL 61801, USA. Electronic address:

Cadherins are essential adhesion proteins that regulate tissue cohesion and paracellular permeability by assembling dense adhesion plaques at cell-to-cell contacts. Adherens junctions are central to a wide range of tissue functions; identifying protein interactions that potentiate their assembly and regulation has been the focus of research for over 2 decades. Here, we present evidence for a new, unexpected mechanism of cadherin oligomerization on cells. Read More

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The contribution of patients' lung function to the inspiratory airflow rate achievable through a DPIs' simulator reproducing different intrinsic resistance rates.

Multidiscip Respir Med 2021 Jan 15;16(1):752. Epub 2021 Apr 15.

AdRes Health Economics and Outcome Research, Turin, Italy.

Background: The performance of DPIs depends on several physiological (patient-dependent) and technological (device-dependent) factors. The inspiratory airflow rate is the only active force generated and operating in the system for inducing the required pressure drop and eliciting the resistance-induced turbulence needed to disaggregate the powder through the device. The present study aimed to investigate in the most prevalent respiratory disorders whether and at what extent the inspiratory airflow rate achievable when inhaling through a DPIs' simulator reproducing different intrinsic resistance regimens (low, mid, and high resistance) is affected by peculiar changes in lung function and/or can be predicted by any specific lung function parameter. Read More

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January 2021

Predicted regulatory SNPs reveal potential drug targets and novel companion diagnostics in psoriasis.

J Transl Autoimmun 2021 5;4:100096. Epub 2021 Apr 5.

Laboratory of Regulatory SNPs, Personalized Medicine National Laboratory (LAMPER), Medical and Pharmaceutical Biotechnology, Research Center of Technology and Design Assistance of Jalisco State (CIATEJ A.C.), National Council of Science and Technology (CONACYT), C.P. 44270, Guadalajara, Jalisco, Mexico.

Psoriasis is an autoimmune disease associated with interleukins, their receptors, key transcription factors and more recently, antimicrobial peptides (AMPs). Cathelicidin LL-37 is an AMP proposed to play a fundamental role in psoriasis etiology. With our proprietary software SNPClinic v. Read More

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Differentiating focal interstitial fibrosis from adenocarcinoma in persistent pulmonary subsolid nodules (> 5 mm and < 20 mm): the role of coronal thin-section CT images.

Eur Radiol 2021 Apr 20. Epub 2021 Apr 20.

Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, 325, Section 2, Cheng-Gong Road, Nei-Hu, Taipei, 114, Taiwan.

Objectives: To investigate thin-section computed tomography (CT) features of pulmonary subsolid nodules (SSNs) with sizes between 5 and 20 mm to determine predictive factors for differentiating focal interstitial fibrosis (FIF) from adenocarcinoma.

Methods: From January 2017 to December 2018, 169 patients who had persistent SSNs 5-20 mm in size and underwent preoperative nodule localization were enrolled. Patient characteristics and thin-section CT features of the SSNs were reviewed and compared between the FIF and adenocarcinoma groups. Read More

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Frame to Improve the Fit of N95 Filtering Face Mask Respirators.

J Occup Environ Med 2021 Jun;63(6):e362-e366

Department of Respiratory and Interventional Pulmonology, Keck Medical Center of the University of Southern California (Mr Stemen); Caruso Department of Otolaryngology-Head and Neck Surgery (Dr Ge, Dr Ference); Department of Radiology (Dr Hwang); Department of Biomedical Engineering, Viterbi School of Engineering of the University of Southern California (Dr Hwang); Tetra Bio Distributed (Mr Qaddoumi, Dr Roden; Section of Infectious Disease, Department of Medicine (Dr Nanda), Keck School of Medicine of the University of Southern California, Los Angeles, California.

Objective: Test a device that can improve upon the seal of filtering face mask respirators (FFRs).

Methods: A 3-D prototype for a fit improvement frame (FIF) was created and quantitative fit testing was performed for FFRs with and without the FIF.

Results: Thirty eight volunteers underwent fit testing. Read More

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Life-Long Hyperbilirubinemia Exposure and Bilirubin Priming Prevent Metabolic Damage.

Front Pharmacol 2021 12;12:646953. Epub 2021 Mar 12.

Italian Liver Foundation (FIF), Trieste, Italy.

Unconjugated bilirubin (UCB) is more than the final product of heme catabolism. Mildly elevated systemic bilirubin concentrations, such as in Gilbert syndrome (GS), protect against various oxidative stress-mediated and metabolic diseases, including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, cancer, and age-related disease. The Gunn rat is an animal model of hereditary hyperbilirubinemia widely used in assessing the effect of high serum bilirubin concentration in various organs. Read More

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Cost-effectiveness analysis of radiotherapy techniques for whole breast irradiation.

PLoS One 2021 8;16(3):e0248220. Epub 2021 Mar 8.

Medical Physics Program, Department of Physics and Astronomy, Louisiana State University, Baton Rouge, Louisiana, United States of America.

Background: The current standard of care (SOC) for whole breast radiotherapy (WBRT) in the US is conventional tangential photon fields. Advanced WBRT techniques may provide similar tumor control and better normal tissue sparing, but it is controversial whether the medical benefits of an advanced technology are significant enough to justify its higher cost.

Objective: To analyze the cost-effectiveness of six advanced WBRT techniques compared with SOC. Read More

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Fetus in Fetu in an Adult Female and Brief Review of Literature.

Case Rep Radiol 2021 11;2021:6660277. Epub 2021 Feb 11.

Tulsi Hospital Pvt. Ltd., Tulsipur, Dang, Lumbini Province, Nepal.

Fetus in fetu (FIF) is a very rare condition in which malformed fetus is found within the body of a living twin, most commonly within the retroperitoneum. It is a parasitic fetal twin of a diamniotic, monozygotic type. It should be differentiated from teratoma by the presence of organized vertebral column and appropriately arranged other organs or limbs around it. Read More

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February 2021

Intra-abdominal fetus in fetu presenting at 31 weeks gestational age.

Radiol Case Rep 2021 Apr 30;16(4):863-866. Epub 2021 Jan 30.

Department of General Surgery, Children Hospital 1, Ho Chi Minh, Vietnam.

Fetus in fetu (FIF) is a rare anomaly of diamniotic monochorionic twins, in which a malformed fetus resides in its twin's body. This report shows a case with the prenatal diagnosis of FIF at Tu Du hospital. A 23-year-old woman, first-time pregnant, presented at the hospital with an abdominal mass in the fetus at 31 weeks and 4 days of gestation. Read More

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Dosimetric assessment of brass mesh bolus and transparent polymer-gel type bolus for commonly used breast treatment delivery techniques.

Med Dosim 2021 Jan 31. Epub 2021 Jan 31.

Department of Radiation Oncology, Stritch School of Medicine, Cardinal Bernardine Cancer Center, Loyola University Chicago, Maywood, IL, 60637 USA. Electronic address:

We investigated skin dose enhancements of brass mesh bolus (BMB) and a recently developed transparent polymer-gel bolus (PGB) for clinically relevant breast treatment delivery techniques. The dose enhancement of the breast surface with BMB and PGB were compared to that of tissue-equivalent bolus. Three breast treatment plans were generated on CT scans of an anthropomorphic chest phantom: tangential step-and-shoot 3D conformal (3DCRT) planned using Field-in-Field (FiF), tangential sliding-window 3DCRT using Electronic Compensator (EC), and volumetric modulated arc therapy (VMAT). Read More

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January 2021

Assessment of planning reproducibility in three-dimensional field-in-field radiotherapy technique for breast cancer: impact of surgery-simulation interval.

Sci Rep 2021 Jan 15;11(1):1556. Epub 2021 Jan 15.

Division of Medical Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

The three-dimensional field-in-field (3-D FIF) technique for radiotherapy is an advanced, state-of-the-art method that uses multileaf collimators to generate a homogeneous and conformal dose distribution via segmental subfields. The purpose of this study is to evaluate the dosimetric reproducibility of 3-D FIF plans using the original simulation computed tomography (iCT) scans and re-simulation CT (rCT) scans for whole breast irradiation (WBI) schedule. This study enrolled a total of 34 patients. Read More

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January 2021

Tridimensional dose evaluation of the respiratory motion influence on breast radiotherapy treatments using conformal radiotherapy, forward IMRT, and inverse IMRT planning techniques.

Phys Med 2021 Jan 10;81:60-68. Epub 2021 Jan 10.

Department of Physics, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, 14040-901, Monte Alegre, Ribeirão Preto, São Paulo, Brazil; Radiotherapy Department, Ribeirão Preto Medical School Hospital and Clinics, University of São Paulo, Av. Bandeirantes 3900, 14040-900, Monte Alegre, Ribeirão Preto, São Paulo, Brazil. Electronic address:

Purpose: To evaluate the respiratory motion influence on the tridimensional (3D) dose delivery to breast-shaped phantoms using conformal radiotherapy (3D-RT), Field-in Field (FiF), and IMRT planning techniques.

Methods: This study used breast-shaped phantoms filled with MAGIC-f gel dosimeter to simulate the breast, and an oscillation platform to simulate the respiratory motion. The platform allowed motion in the anterior-posterior direction with oscillation amplitudes of 0. Read More

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January 2021

Incidental radiation dose to internal mammary lymph nodal area in carcinoma breast patients treated with forward planning intensity-modulated radiation therapy technique: A single-institute dosimetric study.

J Cancer Res Ther 2020 Oct-Dec;16(6):1350-1353

Department of Radiation Oncology, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Introduction: Breast cancer (BC) is the most common cancer in Indian females. The irradiation of internal mammary lymph nodal area (IMLN) is recommended by latest guidelines and literature, even in patients with N1 nodal disease, but it is not routinely done in many institutes due to the risk of late lung and heart toxicities. The incidence of isolated IMLN recurrence <1%. Read More

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December 2020

Synchronous bilateral breast cancer patients treated with hypofractionated bilateral breast irradiation: A dosimetric and clinical study.

J Cancer Res Ther 2020 Oct-Dec;16(6):1309-1313

Department of Radiation Oncology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana,, India.

Background: Bilateral breast irradiation is technically challenging and there is limited information regarding optimal technique and outcomes. Hypofractionated Radiotherapy (HFRT) has emerged as the new standard of care in early breast cancer. However, there are concerns in using hypofractionation for bilateral breast irradiation due to larger volumes and potential toxicity. Read More

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February 2021

Plan quality assessment of modern radiotherapy delivery techniques in left-sided breast cancer: an analysis stratified by target delineation guidelines.

BJR Open 2020 11;2(1):20200007. Epub 2020 Dec 11.

Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, New Delhi, India.

Objective: This study compares planning techniques stratified by consensus delineation guidelines in patients undergoing whole-breast radiotherapy based on an objective plan quality assessment scale.

Methods: 10 patients with left-sided breast cancer were randomly selected, and target delineation for intact breast was performed using Tangent (RTOG 0413), ESTRO, and RTOG guidelines. Consensus Plan Quality Metric (PQM) scoring was defined and communicated to the physicist before commencing treatment planning. Read More

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December 2020

Fluorescence-based Methods for the Study of Protein-Protein Interactions Modulated by Ligand Binding.

Curr Pharm Des 2020 ;26(44):5668-5683

Department of Physics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States.

Background: The growing evidence that G protein-coupled receptors (GPCRs) not only form oligomers but that the oligomers also may modulate the receptor function provides a promising avenue in the area of drug design. Highly selective drugs targeting distinct oligomeric sub-states offer the potential to increase efficacy while reducing side effects. In this regard, determining the various oligomeric configurations and geometric sub-states of a membrane receptor is of utmost importance. Read More

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The Extent of Intracellular Accumulation of Bilirubin Determines Its Anti- or Pro-Oxidant Effect.

Int J Mol Sci 2020 Oct 30;21(21). Epub 2020 Oct 30.

Italian Liver Foundation (FIF), Bldg Q-AREA Science Park Basovizza, SS14 Km 163,5, 34149 Trieste, Italy.

Background: Severe hyperbilirubinemia can cause permanent neurological damage in particular in neonates, whereas mildly elevated serum bilirubin protects from various oxidative stress-mediated diseases. The present work aimed to establish the intracellular unconjugated bilirubin concentrations (iUCB) thresholds differentiating between anti- and pro-oxidant effects.

Methods: Hepatic (HepG2), heart endothelial (H5V), kidney tubular (HK2) and neuronal (SH-SY5Y) cell lines were exposed to increasing concentration of bilirubin. Read More

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October 2020

A case report of fetus in fetu with an aorta-like structure visualized by contrast-enhanced CT.

Radiol Case Rep 2020 Dec 13;15(12):2645-2648. Epub 2020 Oct 13.

Department of Pediatric Surgery, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan.

Fetus in fetu (FIF) is a rare congenital anomaly resulting from abnormal embyogenesis in monochorionic diamniotic twins and appears as a cystic mass containing fetus-like structures mainly in the retroperitoneum of infants. Although there is a theory that FIF is a highly differentiated teratoma, it is commonly distinguished from teratoma as a mass containing a vertebral axis with appropriate arrangement of limbs or other organs around this axis. Here we present a case of FIF with aorta-like structure visualized by contrast-enhanced computed tomography. Read More

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December 2020

Non-targeted identification of per- and polyfluoroalkyl substances at trace level in surface water using fragment ion flagging.

Chemosphere 2021 Feb 10;265:128599. Epub 2020 Oct 10.

Wageningen University & Research, Wageningen Food Safety Research, Wageningen, the Netherlands. Electronic address:

The extent of unidentified Per- and Poly-fluoroalkyl substances (PFASs) found in environmental samples has led to the development of non-targeted screening methods. The study presented here reports the use of liquid chromatography hyphenated with high resolution mass spectrometry to detect and identify unknown and unexpected PFASs by fragment ion flagging (FIF). By exploring all ion fragmentation spectra for several characteristic fragments including CF, CF, CF, CF, CF and CFO the presence of widely different PFAS species can be anticipated without the need for targeted screening methods. Read More

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February 2021

Preoperative diagnosis of a "humanoid" fetus in fetu using multimode ultrasound: a case report.

BMC Pediatr 2020 10 19;20(1):483. Epub 2020 Oct 19.

Department of Medical Ultrasound, West China Hospital, Sichuan University, No.37, Guo Xue Xiang, Chengdu, 610041, China.

Background: Fetus in fetu (FIF) is a rare congenital anomaly. The preoperative diagnosis of FIF and differentiating it from teratoma and other abdominal tumors can be challenging for radiologists. Clarification of the blood supply and the relationship with the surrounding vessels is especially helpful for successful surgery; however, multimode ultrasound (US) performed for FIF has rarely been explored. Read More

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October 2020

Continuous positive airway pressure with deep inspiration breath hold in left-sided breast radiation therapy.

Med Dosim 2021 Summer;46(2):127-131. Epub 2020 Oct 2.

Radiation Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.

A dosimetric study to evaluate the use of continuous positive airway pressure (CPAP), with free-breathing (CPAP-FB) or with deep inspiration breath hold (DIBH-CPAP) an adjunct and alternative to DIBH to reduce heart and lung dose in the radiation therapy (RT) of breast cancer planned for left side RT with regional nodes and internal mammary. A retrospective analysis of 10 left-sided breast cancer patients whose heart or lung dose constraints were not met after RT planning based on FB or DIBH simulations and were referred for CPAP-based planning. All patients were simulated using FB, DIBH, CPAP-FB, and CPAP-DIBH. Read More

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October 2020

Postmastectomy Radiation Therapy Planning After Immediate Implant-based Reconstruction Using the European Society for Radiotherapy and Oncology-Advisory Committee in Radiation Oncology Practice Consensus Guidelines for Target Volume Delineation.

Clin Oncol (R Coll Radiol) 2021 01 26;33(1):20-29. Epub 2020 Sep 26.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.

Aims: To evaluate how common radiation therapy techniques perform in the setting of the new European Society for Radiotherapy and Oncology-Advisory Committee in Radiation Oncology Practice (ESTRO-ACROP) delineation recommendations for immediate breast reconstruction (IBR).

Materials And Methods: Seven Danish radiation therapy centres and six international European centres participated in this project. Two breast cancer cases (one left-sided and one right-sided) with a retropectoral implant were chosen for radiation therapy planning using deep-inspiration breath-hold. Read More

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January 2021

Prenatal and postnatal MRI imaging findings of intracranial parasitic fetus: a case report.

Kai Zhu

Childs Nerv Syst 2021 05 23;37(5):1803-1806. Epub 2020 Sep 23.

Department of Radiology, Harbin Children Hospital, Harbin, 150010, People's Republic of China.

Fetus in fetu (FIF) is an extremely rare anomaly. It is predominantly seen retroperitoneally in 80% of cases but can present at atypical sites like the skull, sacrum, scrotum and the mouth. We reported a rare case of intracranial parasitic fetus. Read More

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