843,128 results match your criteria field

Therapeutic review of cabotegravir/rilpivirine long-acting antiretroviral injectable and implementation considerations at an HIV specialty clinic.

Pharmacotherapy 2021 Jun 15. Epub 2021 Jun 15.

Indiana University Health, Indianapolis, Indiana, USA.

Cabotegravir/rilpivirine (CAB/RPV) was recently approved by the US Food and Drug Administration (FDA) as the first complete parenteral antiretroviral (ART) regimen for treatment of people living with HIV (PLWH). As a monthly intramuscular (IM) injection, this therapy constitutes a major departure from the traditional paradigm of oral therapy requiring (at least) daily administration that has defined HIV treatment for decades. Composed of a second-generation integrase inhibitor (INSTI) and nonnucleoside reverse transcriptase inhibitor (NNRTI), CAB/RPV has achieved high rates of sustained virologic suppression with a favorable safety profile for treatment-experienced PLWH following oral lead-in (OLI) during several clinical trials. Read More

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Detection of fixation points using a small visual landmark for brain-computer interfaces.

J Neural Eng 2021 Jun 15. Epub 2021 Jun 15.

Dept. of Biomedical Engineering, Tianjin University, School of Precision Instrument and Opto-Electronics Engineering, Tianjin 300072, Tianjin, 300072, CHINA.

Abstract- Objective: The speed of visual brain-computer interfaces (v-BCIs) has been greatly improved in recent years. However, the traditional v-BCI paradigms require users to directly gaze at the intensive flickering items, which would cause severe problems such as visual fatigue and excessive visual resource consumption in practical applications. Therefore, it is imperative to develop a user-friendly v-BCI. Read More

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Analysis of longitudinal head impact exposure and white matter integrity in returning youth football players.

J Neurosurg Pediatr 2021 Jun 15:1-10. Epub 2021 Jun 15.

Departments of1Biomedical Engineering.

Objective: The objective of this study was to characterize changes in head impact exposure (HIE) across multiple football seasons and to determine whether changes in HIE correlate with changes in imaging metrics in youth football players.

Methods: On-field head impact data and pre- and postseason imaging data, including those produced by diffusion tensor imaging (DTI), were collected from youth football athletes with at least two consecutive seasons of data. ANCOVA was used to evaluate HIE variations (number of impacts, peak linear and rotational accelerations, and risk-weighted cumulative exposure) by season number. Read More

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Does sponge pads wear affect the distribution of electric field generated by tDCS?

Adam Wysokiński

Clin Neurophysiol 2021 May 20;132(8):1782-1784. Epub 2021 May 20.

Medical University of Lodz, Department of Old Age Psychiatry and Psychotic Disorders, Czechosłowacka 8/10, 92-216 Łódź, Poland. Electronic address:

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Direct 3D ultrasound fusion for transesophageal echocardiography.

Comput Biol Med 2021 May 21;134:104502. Epub 2021 May 21.

Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital and Laboratory of Cardiac Imaging and 3D Printing, Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Background: Real-time three-dimensional transesophageal echocardiography (3D TEE) has been increasingly used in clinic for fast 3D analysis of cardiac anatomy and function. However, 3D TEE still suffers from the limited field of view (FoV). It is challenging to adopt conventional multi-view fusion methods to 3D TEE images because feature-based registration methods tend to fail in the ultrasound scenario, and conventional intensity-based methods have poor convergence properties and require an iterative coarse-to-fine strategy. Read More

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Lectins: Biological significance to biotechnological application.

Carbohydr Res 2021 Jun 8;506:108367. Epub 2021 Jun 8.

Department of Microbiology, Sikkim University, India. Electronic address:

Lectins are a set of non-enzymatic carbohydrate binding proteins appearing in all domains of life. They function to recognize, interact and bring about reversible binding of a specific sugar moiety present in a molecule. Since glycans are ubiquitous in nature and are an essential part of various biological process, the lectins are been investigated to understand the profile of these versatile but complex glycan molecule. Read More

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Fullerenol as a water-soluble MALDI-MS matrix for rapid analysis of small molecules and efficient quantification of saccharin sodium in foods.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jun 4;1178:122819. Epub 2021 Jun 4.

Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China. Electronic address:

Due to the strong background interferences in the low-mass region and poor reproducibility of conventional organic matrices, it is of great importance to develop a novel matrix for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) to qualitatively and quantitatively analyze small molecules. In this work, water-soluble fullerenol C(OH) was selected as a MALDI matrix for the analysis of low-molecular-weight compounds in consideration of optical absorption property, water solubility and stability. Compared with the traditional matrices, fullerenol demonstrated lower background interference and stronger peak intensity. Read More

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Physical field simulation of the ultrasonic radiation method: An investigation of the vessel, probe position and power.

Ultrason Sonochem 2021 Jun 9;76:105626. Epub 2021 Jun 9.

School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062, China.

In this paper, the effects of ultrasonic probe position, vessel shape, and ultrasonic input power on the sound pressure distribution in the reactor were investigated by solving the Helmholtz equation using COMSOL Multiphysis software. Three different types of glass containers were used in the study, which are beaker, Erlenmeyer flask, and round bottom flask. The maximum value of sound pressure in the three containers will gradually increase when the distance between the probe and the bottom of the container decreases. Read More

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Removal of trace DNA toxic compounds using a Poly(deep eutectic solvent)@Biomass based on multi-physical interactions.

J Hazard Mater 2021 Jun 9;418:126369. Epub 2021 Jun 9.

College of Pharmaceutical Science, Institute of Life Science and Green Development, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China. Electronic address:

DNA toxic compounds (DNA-T-Cs), even in trace amounts, seriously threaten human health and must be completely eliminated. However, the currently used separation media face great challenges in removing trace DNA-T-Cs. Based on the functional advantages of deep eutectic solvents (DESs) and the natural features of biomass (BioM), a series of Poly(DES)@BioMs functioning as adsorbents were prepared for the removal of aromatic/hetero-atomic DNA-T-Cs at the ppm level. Read More

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Foliar absorption and field herbicidal studies of atrazine-loaded polymeric nanoparticles.

J Hazard Mater 2021 Jun 7;418:126350. Epub 2021 Jun 7.

Institute of Science and Technology, São Paulo State University (UNESP), Av. Três de Março 511, 18087-180 Sorocaba, SP, Brazil. Electronic address:

Nanoparticles loaded with atrazine show weed control efficacy even with lower application doses of the active ingredient. Changes in the mode of action of the herbicide through the nanoformulation are key to understanding the efficiency of post-emergence activity of nanoatrazine. Here, we report the leaf absorption and translocation of nanoatrazine and atrazine employing radiometric techniques and compare their herbicidal effects in greenhouse and field conditions. Read More

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Development of highly sensitive one step-PCR tests for improved detection of B. bigemina and B. bovis.

Vet Parasitol 2021 Jun 8;296:109493. Epub 2021 Jun 8.

Instituto de Agrobiotecnología y Biología Molecular (IABIMO) INTA - CONICET, de Los Reseros y Dr. Nicolás Repetto s/n, P.O. Box 25 (B1712WAA), Castelar, Buenos Aires, Argentina.

Bovine babesiosis caused by Babesia bigemina and B. bovis is an economically relevant tick-borne disease distributed over tropical and subtropical world regions. Animals that recover from the clinical disease can remain persistently infected, and those carriers are epidemiologically relevant since they can act as a source of infection to other animals through the tick bite. Read More

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Interaction of nanoplastics with extracellular polymeric substances (EPS) in the aquatic environment: A special reference to eco-corona formation and associated impacts.

Water Res 2021 Jun 2;201:117319. Epub 2021 Jun 2.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510641, China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Nanoplastics (NPs) are plastic particles with sizes ranging between 1 and 1000 nm, exhibiting exceptional qualities such as large surface area, lightweight, durability; therefore, are widely used in cosmetics, paints, electronics, etc. NPs are inevitability released into the aquatic environment where they tend to interact with both, the extracellular polymeric substances (EPS) and other fractions of natural organic matter (NOM), respectively secreted by organisms (e.g. Read More

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Effect of chlorhexidine-loaded poly(amido amine) dendrimer on matrix metalloproteinase activities and remineralization in etched human dentin in vitro.

J Mech Behav Biomed Mater 2021 Jun 10;121:104625. Epub 2021 Jun 10.

Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, China. Electronic address:

To investigate the effect of chlorhexidine (CHX)-loaded carboxyl-terminated poly (amido amine) dendrimer (CHX-PAMAM-COOH) on matrix metalloproteinase (MMP) activities and remineralization in human dentin, CHX-PAMAM-COOH was prepared and characterized by Fourier-transform infrared spectroscopy. The inhibitory effects of CHX, PAMAM-COOH, and CHX-PAMAM-COOH on soluble recombinant human matrix metalloproteinase (rhMMP-2) and dentin-bound endogenous MMP activity were measured using an MMP Activity Assay Kit. In situ zymography was performed to evaluate the gelatinase activity in dentin pretreated with CHX, PAMAM-COOH, and CHX-PAMAM-COOH. Read More

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Small-molecule probes for fluorescent detection of cellular hypoxia-related nitroreductase.

J Pharm Biomed Anal 2021 Jun 9;203:114199. Epub 2021 Jun 9.

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China. Electronic address:

Nitroreductase is a reductase that catalyzes nitro aromatic compounds to aromatic amines. It effectively reduces nitro to hydroxylamine or amino when in the presence of nicotinamide adenine dinucleotide or nicotinamide adenine dinucleotide phosphate. In terms of tumor, nitroreductase is upregulated in hypoxic tumor cells, and its content is directly related to the degree of hypoxia. Read More

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The role of sexual dimorphism in susceptibility to SARS-CoV-2 infection, disease severity, and mortality: facts, controversies and future perspectives.

Microbes Infect 2021 Jun 12:104850. Epub 2021 Jun 12.

Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece. Electronic address:

Former studies have revealed intersex variability in immune response to infectious diseases, including Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological surveillance of the ongoing pandemic has demonstrated a male vulnerability to morbidity and mortality, despite similar infection rates between the two sexes. Divergence in the frequency of comorbidities between males and females, differences in hormonal profile, chromosomal composition and gender behavior have all been proposed as potential causative factors. Read More

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The funny current in genetically modified mice.

Prog Biophys Mol Biol 2021 Jun 12. Epub 2021 Jun 12.

Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France; LabEx Ion Channels Science and Therapeutics (ICST), France. Electronic address:

Since its first description in 1979, the hyperpolarization-activated funny current (I) has been the object of intensive research aimed at understanding its role in cardiac pacemaker activity and its modulation by the sympathetic and parasympathetic branches of the autonomic nervous system. I was described in isolated tissue strips of the rabbit sinoatrial node using the double-electrode voltage-clamp technique. Since then, the rabbit has been the principal animal model for studying pacemaker activity and I for more than 20 years. Read More

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Clinical chemistry score misses fewer deaths as compared to troponin T alone in a United States emergency department population.

Clin Biochem 2021 Jun 12. Epub 2021 Jun 12.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

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Stem cells and origins of cancer in the upper gastrointestinal tract.

Cell Stem Cell 2021 Jun 10. Epub 2021 Jun 10.

Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, College of Physicians and Surgeons, 1130 St. Nicholas Avenue, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, 1130 St. Nicholas Avenue, New York, NY 10032, USA. Electronic address:

The esophagus and stomach, joined by a unique transitional zone, contain actively dividing epithelial stem cells required for organ homeostasis. Upon prolonged inflammation, epithelial cells in both organs can undergo a cell fate switch leading to intestinal metaplasia, predisposing to malignancy. Here we discuss the biology of gastroesophageal stem cells and their role as cells of origin in cancer. Read More

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Stimuli-responsive surfaces for switchable wettability and adhesion.

J R Soc Interface 2021 Jun 16;18(179):20210162. Epub 2021 Jun 16.

Centre of Advanced Structural Ceramics, Department of Materials, Imperial College London, London SW7 2AZ, UK.

Diverse unique surfaces exist in nature, e.g. lotus leaf, rose petal and rice leaf. Read More

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Effects of Macrophage Regulation on Fat Grafting Survival: Improvement, Mechanisms, and Potential Application A Review.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Department of Cosmetic and Plastic Surgery, Oral and Maxillofacial Surgery, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Background: Autologous fat grafting has become a popular tool in plastic surgery to solve soft tissue defects and achieve skin rejuvenation, but the volume loss after transplantation remains a disturbing problem. In recent years, some new strategies have improved the outcome to some extent, but the fat graft retention is still far from ideal, so there remains a wide development prospect in this field. Macrophages are closely related to the local microenvironment and tissue regeneration, and their role in fat grafting has been increasingly highlighted. Read More

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Subspecialty Training of Neurology Residents and Junior Neurologists in the Baltic States.

Eur J Neurol 2021 Jun 15. Epub 2021 Jun 15.

Clinic of Neurology and Neurosurgery, Vilnius University, Vilnius, Lithuania.

Background: Neurology is a field of increasing subspecialization. There is no published data regarding the proportion of neurology subspecialists in the Baltic States. The aim of this cross-sectional study was to identify factors associated with neurology subspecialty choice, to examine possible differences between neurology residents' and junior neurologists' view of subspecialty, and to assess perceived subspecialty acquisition opportunities and subspecialty attractiveness. Read More

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Low-density aspen seedling establishment is widespread following recent wildfires in the western U.S.

Ecology 2021 Jun 15:e03436. Epub 2021 Jun 15.

Department of Wildland Resources and Ecology Center, Utah State University, Logan, UT, 84321, USA.

Sexual regeneration is increasingly recognized as an important regeneration pathway for aspen in the western U.S., a region previously thought to be too dry for seedling establishment except for during unusually wet periods. Read More

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BIO-LGCA: A cellular automaton modelling class for analysing collective cell migration.

PLoS Comput Biol 2021 Jun 15;17(6):e1009066. Epub 2021 Jun 15.

Centre for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, Germany.

Collective dynamics in multicellular systems such as biological organs and tissues plays a key role in biological development, regeneration, and pathological conditions. Collective tissue dynamics-understood as population behaviour arising from the interplay of the constituting discrete cells-can be studied with on- and off-lattice agent-based models. However, classical on-lattice agent-based models, also known as cellular automata, fail to replicate key aspects of collective migration, which is a central instance of collective behaviour in multicellular systems. Read More

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Development and psychometric properties of the Nursing Student Academic Resilience Inventory (NSARI): A mixed-method study.

PLoS One 2021 15;16(6):e0252473. Epub 2021 Jun 15.

Nursing Care Research Center, Semnan University of Medical Sciences, Semnan, Iran.

Introduction: Resilience has been proposed as a suitable solution to better deal with nursing students in cases of challenges but the complex and multidimensional nature of resilience has made its measurement challenging. This study aimed to develop and validate a new inventory theory-driven labeled Nursing Student Academic Resilience Inventory.

Methods: This study was performed with an exploratory sequential mixed-method design. Read More

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Cascaded frequency conversion under nonlinear stimulated Raman adiabatic passage: erratum.

Opt Lett 2021 Jun;46(12):3004

We present an erratum to our Letter [Opt. Lett.46, 1486 (2021)OPLEDP0146-959210. Read More

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Synthesis of vector nonuniformly correlated light beams by a single digital mirror device.

Opt Lett 2021 Jun;46(12):2996-2999

We present a stable and flexible way to generate the vector nonuniformly correlated (NUC) beams with a compact optical system that involves only a single digital mirror device and a common-path interferometer. The system provides near real-time generation and accurate control of the phase difference between the orthogonal field components of the vector NUC beams. We discuss the methodology based on the vectorial pseudo-mode decomposition of the cross-spectral density matrix of the beam. Read More

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Magnetically driven rotary microfilter fabricated by two-photon polymerization for multimode filtering of particles.

Opt Lett 2021 Jun;46(12):2968-2971

In this Letter, a magnetically driven rotary microfilter that enables switching the modes of filtering and passing is fabricated in microfluidic devices via two-photon polymerization using a femtosecond laser for selective filtering of particles. The high-quality integration of a microfilter is ensured by accurately formulating the magnetic photoresist and optimizing the processing parameters. By changing the direction of the external magnetic field, the fabricated microfilter can be remotely manipulated to rotate by desired angles, thereby achieving the "filtering" or "passing" mode on demand. Read More

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Transition between toroidic orders in dielectric metasurfaces by polarization of the incident wave.

Opt Lett 2021 Jun;46(12):2964-2967

We propose a design and perform a theoretical and experimental study of optical properties of a metasurface composed of hexagonal oligomers of dielectric particles that somewhat resemble characteristics of multiferroics. It can maintain both toroidic and antitoroidic orders in the dynamical response on irradiation by a linearly polarized plane wave. These orders originate from the dark states of toroidal dipole moments. Read More

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Jitter-free terahertz pulses from LiNbO.

Opt Lett 2021 Jun;46(12):2944-2947

Intense terahertz pulses are indispensable for modern science and technology, but time-critical applications require ultimate stability of the field cycles with respect to a reference clock. Here we report the nonlinear optical generation of terahertz single-cycle fields by femtosecond laser pulses under passive compensation of timing jitter. The converter is based on optical rectification in a slab with two silicon prisms for extracting and combining the emitted Cherenkov radiation from both sides into a single beam. Read More

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Spinning pupil aberration measurement for anisoplanatic deconvolution.

Opt Lett 2021 Jun;46(12):2884-2887

The aberrations in an optical microscope are commonly measured and corrected at one location in the field of view, within the so-called isoplanatic patch. Full-field correction is desirable for high-resolution imaging of large specimens. Here we present, to the best of our knowledge, a novel wavefront detector, based on pupil sampling with subapertures, measuring the aberrated wavefront phase at each position of the specimen. Read More

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